GREMLIN Database
PURE - N5-carboxyaminoimidazole ribonucleotide mutase
UniProt: O06456 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 158 (151)
Sequences: 3162 (1432)
Seq/√Len: 116.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_A48_Y2.5681.00
53_E141_K2.4191.00
127_R144_S2.3471.00
113_V124_L2.3331.00
71_P101_I2.2861.00
95_L99_L2.2671.00
83_I113_V2.2581.00
106_Y119_K2.2331.00
7_I74_V2.1651.00
58_E132_K2.1651.00
46_M77_L2.1591.00
6_V21_V2.1321.00
3_K58_E2.1191.00
27_F126_I2.1071.00
43_E50_K2.0101.00
34_R44_F1.9721.00
53_E137_A1.9431.00
25_K31_Y1.9101.00
5_A57_I1.8911.00
129_L136_L1.8501.00
21_V31_Y1.8221.00
17_M63_G1.7681.00
29_I126_I1.7561.00
26_Q146_D1.7271.00
88_P91_N1.7001.00
47_Q51_E1.6841.00
18_R22_E1.6671.00
17_M85_V1.6551.00
32_E55_R1.6021.00
53_E79_S1.5981.00
114_A117_G1.5851.00
83_I128_I1.5691.00
88_P93_N1.5641.00
3_K30_D1.5621.00
143_F147_M1.5611.00
92_L115_I1.5591.00
149_N153_S1.5561.00
145_E149_N1.5491.00
44_F152_L1.5341.00
51_E54_K1.5191.00
36_V45_M1.5131.00
98_L102_V1.4701.00
88_P116_G1.4641.00
41_T151_V1.4571.00
130_G136_L1.4561.00
142_K146_D1.4541.00
126_I136_L1.4541.00
23_I122_A1.4201.00
79_S141_K1.4191.00
135_E139_K1.3931.00
21_V33_A1.3781.00
138_D142_K1.3511.00
145_E148_R1.3411.00
83_I111_A1.3351.00
146_D150_D1.2911.00
19_E22_E1.2891.00
28_G139_K1.2800.99
79_S137_A1.2630.99
60_I80_L1.2110.99
48_Y57_I1.1930.99
23_I119_K1.1770.99
27_F139_K1.1740.99
32_E57_I1.1710.99
19_E119_K1.1520.99
98_L115_I1.1220.99
50_K77_L1.1150.99
49_A60_I1.1140.99
41_T44_F1.1130.99
43_E77_L1.1110.99
58_E133_Y1.1050.98
45_M74_V1.1040.98
23_I26_Q1.0880.98
89_S93_N1.0640.98
21_V25_K1.0580.98
15_E18_R1.0560.98
22_E26_Q1.0520.98
66_G90_K1.0350.98
123_L126_I1.0250.98
14_W21_V1.0010.97
128_I131_I1.0010.97
43_E47_Q0.9930.97
111_A124_L0.9690.97
58_E131_I0.9640.96
45_M49_A0.9490.96
16_Y88_P0.9420.96
16_Y116_G0.9400.96
4_V59_V0.9310.96
23_I123_L0.9270.96
14_W33_A0.9190.95
146_D149_N0.9180.95
45_M73_M0.9120.95
141_K145_E0.9070.95
79_S140_I0.9060.95
16_Y87_I0.9030.95
23_I27_F0.9010.95
106_Y117_G0.9000.95
122_A126_I0.8960.95
51_E55_R0.8920.94
136_L139_K0.8920.94
43_E46_M0.8870.94
36_V44_F0.8850.94
90_K97_S0.8830.94
20_A63_G0.8770.94
148_R152_L0.8770.94
140_I144_S0.8680.94
73_M76_S0.8670.94
84_G101_I0.8660.94
63_G87_I0.8640.93
138_D141_K0.8570.93
32_E48_Y0.8560.93
119_K143_F0.8460.93
43_E148_R0.8450.93
130_G140_I0.8400.93
66_G97_S0.8390.92
137_A141_K0.8360.92
49_A74_V0.8330.92
49_A52_A0.8270.92
36_V73_M0.8220.92
91_N95_L0.8210.92
150_D153_S0.8140.91
144_S147_M0.8050.91
11_K35_V0.8020.91
20_A61_I0.8000.91
3_K133_Y0.7950.90
142_K145_E0.7850.90
5_A32_E0.7830.90
27_F143_F0.7650.89
83_I124_L0.7590.88
108_V144_S0.7560.88
22_E25_K0.7510.88
59_V129_L0.7490.87
47_Q50_K0.7470.87
17_M118_A0.7430.87
46_M50_K0.7430.87
133_Y136_L0.7340.86
89_S97_S0.7280.86
95_L115_I0.7170.85
62_A74_V0.7160.85
5_A60_I0.7100.85
149_N152_L0.7070.84
134_K137_A0.7070.84
147_M150_D0.7020.84
44_F148_R0.6960.83
123_L144_S0.6900.83
7_I48_Y0.6840.82
11_K14_W0.6820.82
92_L102_V0.6790.82
58_E137_A0.6740.81
44_F151_V0.6630.80
92_L98_L0.6620.80
7_I60_I0.6620.80
44_F47_Q0.6610.80
16_Y19_E0.6600.80
26_Q143_F0.6570.80
8_M17_M0.6530.79
91_N115_I0.6480.79
53_E130_G0.6460.79
48_Y55_R0.6440.78
4_V29_I0.6400.78
106_Y114_A0.6400.78
24_L126_I0.6380.78
59_V128_I0.6360.77
127_R140_I0.6340.77
124_L128_I0.6290.77
11_K15_E0.6250.76
109_P140_I0.6230.76
5_A55_R0.6220.76
49_A77_L0.6170.75
62_A71_P0.6160.75
63_G85_V0.6160.75
126_I129_L0.6080.74
95_L102_V0.6070.74
92_L95_L0.6070.74
14_W18_R0.6060.74
122_A127_R0.6030.74
66_G106_Y0.6010.73
135_E138_D0.6000.73
11_K150_D0.5980.73
113_V128_I0.5940.73
45_M71_P0.5930.72
29_I136_L0.5890.72
42_P76_S0.5840.71
46_M49_A0.5830.71
49_A80_L0.5810.71
57_I80_L0.5710.70
97_S100_S0.5710.70
89_S99_L0.5700.69
63_G122_A0.5700.69
9_G13_D0.5690.69
62_A101_I0.5630.69
26_Q139_K0.5600.68
89_S114_A0.5580.68
71_P84_G0.5560.68
113_V117_G0.5540.67
11_K108_V0.5540.67
25_K28_G0.5520.67
3_K57_I0.5510.67
102_V115_I0.5470.66
52_A60_I0.5470.66
45_M101_I0.5460.66
59_V113_V0.5450.66
57_I60_I0.5420.66
6_V33_A0.5420.66
84_G109_P0.5380.65
130_G137_A0.5380.65
26_Q119_K0.5380.65
136_L140_I0.5370.65
19_E116_G0.5360.65
50_K54_K0.5330.64
47_Q145_E0.5330.64
23_I143_F0.5310.64
93_N99_L0.5290.64
126_I139_K0.5270.64
15_E19_E0.5200.62
135_E145_E0.5190.62
10_S13_D0.5160.62
138_D145_E0.5120.61
36_V77_L0.5120.61
58_E129_L0.5100.61
11_K33_A0.5080.61
108_V140_I0.5070.61
11_K113_V0.5060.60
83_I125_A0.5060.60
39_H70_L0.5020.60
35_V87_I0.5020.60
59_V125_A0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o4vA 5 0.9937 100 0.133 Contact Map
3lp6A 5 1 100 0.138 Contact Map
3trhA 5 1 100 0.139 Contact Map
4ay3A 2 1 100 0.139 Contact Map
1u11A 6 1 100 0.14 Contact Map
3kuuA 5 1 100 0.141 Contact Map
3orsA 5 1 100 0.141 Contact Map
4grdA 5 1 100 0.143 Contact Map
3oowA 5 0.9937 100 0.148 Contact Map
3rg8A 6 0.981 100 0.178 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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