GREMLIN Database
Goodbye - fungal STAND N-terminal Goodbye domain
PFAM: PF17109 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (121)
Sequences: 709 (559)
Seq/√Len: 50.8
META: 0.56

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_E15_D7.5391.00
71_E81_K3.5941.00
41_F45_R3.5671.00
73_A76_V3.2701.00
25_D29_D3.2311.00
20_Q24_C2.9381.00
114_F117_R2.5821.00
30_I104_L2.2141.00
45_R102_D2.0221.00
70_G73_A1.9570.99
8_Y12_T1.8700.99
41_F101_Y1.8270.99
71_E76_V1.7950.99
49_D53_K1.7220.99
32_A92_S1.7180.99
103_A106_D1.6690.98
26_S56_K1.6600.98
110_S120_I1.6470.98
114_F118_L1.6160.98
41_F44_F1.6090.98
55_L59_V1.6010.98
2_E6_Q1.5950.98
66_S73_A1.5840.98
98_S102_D1.5130.97
36_E39_Q1.4380.96
69_L96_G1.4010.95
1_W52_M1.4000.95
70_G74_S1.3970.95
71_E74_S1.3770.95
12_T16_L1.3760.95
115_L120_I1.3660.94
40_A43_E1.3400.94
35_Q100_S1.3180.93
32_A42_S1.3170.93
87_I91_L1.2210.90
1_W13_G1.2150.90
56_K60_S1.1780.89
2_E23_S1.1650.88
32_A53_K1.1430.87
77_F114_F1.1420.87
36_E40_A1.1410.87
6_Q10_K1.1410.87
6_Q32_A1.1120.86
72_G75_L1.0900.84
90_L94_A1.0690.83
58_T62_L1.0610.83
97_V100_S1.0580.83
71_E77_F1.0480.82
110_S113_N1.0470.82
8_Y44_F1.0400.82
35_Q39_Q1.0330.81
58_T61_V1.0270.81
14_I19_E0.9990.79
72_G76_V0.9960.79
104_L108_F0.9850.78
81_K85_A0.9830.78
22_Q25_D0.9730.77
112_E116_S0.9700.77
58_T83_I0.9530.75
82_A89_V0.9530.75
65_L84_F0.9400.74
42_S88_G0.9270.73
41_F102_D0.9210.73
50_K54_S0.9140.72
68_T89_V0.9140.72
3_S7_A0.9130.72
94_A111_I0.9030.71
100_S103_A0.9000.71
97_V118_L0.8910.70
64_T104_L0.8880.70
42_S46_G0.8880.70
90_L100_S0.8830.70
55_L71_E0.8820.70
14_I94_A0.8780.69
37_Q44_F0.8700.69
26_S29_D0.8690.69
63_Q66_S0.8460.66
73_A77_F0.8430.66
73_A80_A0.8390.66
3_S6_Q0.8390.66
3_S99_A0.8370.66
59_V62_L0.8310.65
86_A92_S0.8240.64
57_P88_G0.8230.64
87_I90_L0.8210.64
118_L121_Y0.8190.64
51_L110_S0.8160.64
35_Q48_D0.8160.64
62_L91_L0.8160.64
20_Q36_E0.8140.63
92_S120_I0.8120.63
43_E46_G0.8040.62
90_L118_L0.8030.62
27_V31_L0.7950.62
43_E53_K0.7910.61
80_A115_L0.7900.61
20_Q28_D0.7900.61
71_E75_L0.7880.61
97_V102_D0.7880.61
98_S101_Y0.7840.60
30_I111_I0.7760.60
50_K55_L0.7750.60
83_I86_A0.7720.59
27_V51_L0.7670.59
51_L54_S0.7640.58
116_S119_D0.7490.57
10_K13_G0.7470.57
1_W38_A0.7310.55
77_F87_I0.7290.55
61_V85_A0.7280.55
5_L33_V0.7210.54
50_K60_S0.7210.54
104_L116_S0.7080.53
36_E47_K0.7050.52
57_P65_L0.7050.52
79_P93_A0.7000.52
5_L12_T0.6940.51
82_A107_L0.6890.51
62_L116_S0.6850.50
87_I108_F0.6820.50
43_E95_K0.6810.50
7_A10_K0.6790.50
78_P83_I0.6770.50
113_N119_D0.6760.49
61_V115_L0.6740.49
108_F117_R0.6530.47
9_E13_G0.6500.47
95_K99_A0.6450.46
17_L25_D0.6390.46
29_D42_S0.6390.46
4_A8_Y0.6370.45
13_G89_V0.6340.45
21_L24_C0.6280.45
45_R98_S0.6260.44
77_F83_I0.6160.43
15_D57_P0.6150.43
28_D60_S0.6150.43
29_D89_V0.6140.43
95_K104_L0.6140.43
30_I35_Q0.6130.43
101_Y115_L0.5960.41
93_A117_R0.5940.41
61_V68_T0.5920.41
68_T113_N0.5910.41
41_F70_G0.5850.40
87_I94_A0.5810.40
13_G74_S0.5800.40
103_A110_S0.5780.40
44_F86_A0.5750.39
19_E23_S0.5670.38
100_S117_R0.5660.38
46_G103_A0.5650.38
3_S10_K0.5640.38
18_A24_C0.5630.38
62_L65_L0.5620.38
40_A108_F0.5580.38
88_G91_L0.5560.37
1_W54_S0.5550.37
17_L31_L0.5540.37
2_E14_I0.5510.37
36_E46_G0.5490.37
20_Q25_D0.5450.36
13_G48_D0.5380.36
107_L114_F0.5360.35
23_S32_A0.5330.35
99_A105_V0.5310.35
42_S76_V0.5280.35
65_L109_E0.5280.35
26_S62_L0.5230.34
96_G99_A0.5230.34
38_A53_K0.5170.34
30_I52_M0.5160.34
2_E11_Q0.5160.34
105_V114_F0.5150.33
94_A107_L0.5150.33
54_S59_V0.5140.33
26_S76_V0.5140.33
84_F104_L0.5120.33
63_Q95_K0.5100.33
8_Y45_R0.5060.33
9_E62_L0.5020.32
1_W86_A0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mh8A 1 0.3967 19.8 0.899 Contact Map
1ciyA 1 0.5207 19.4 0.899 Contact Map
4fzsA 2 0.7107 15.7 0.904 Contact Map
1ji6A 1 0.5124 14.7 0.905 Contact Map
2c9kA 1 0.5124 12.7 0.907 Contact Map
4btfA 1 0.3636 12.2 0.908 Contact Map
3eb7A 2 0.5455 12 0.909 Contact Map
4bzjA 2 0.9339 10.5 0.911 Contact Map
2rr7A 1 0.6364 9.8 0.912 Contact Map
1gqiA 2 0.3884 9.3 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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