GREMLIN Database
Stealth_CR4 - Stealth protein CR4, conserved region 4
PFAM: PF17103 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (45)
Sequences: 2097 (1588)
Seq/√Len: 236.7
META: 0.796

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_F35_Y3.8731.00
4_L34_S3.0061.00
29_R33_E2.5161.00
10_F16_N1.9221.00
11_F36_F1.8051.00
25_A29_R1.7651.00
4_L7_R1.7011.00
16_N24_V1.6161.00
6_R35_Y1.6091.00
23_E27_L1.5681.00
24_V27_L1.5121.00
11_F32_L1.3881.00
17_S24_V1.3211.00
10_F31_F1.2701.00
27_L30_D1.1941.00
17_S25_A1.1061.00
3_L8_Y1.0901.00
11_F35_Y1.0581.00
22_E29_R1.0531.00
3_L14_N1.0491.00
12_C17_S1.0491.00
8_Y18_D1.0101.00
13_L28_L1.0071.00
38_E41_P0.9911.00
26_A30_D0.9731.00
28_L32_L0.9441.00
25_A30_D0.9211.00
21_D27_L0.9181.00
30_D34_S0.9051.00
10_F17_S0.8930.99
15_D36_F0.8530.99
39_P46_P0.8530.99
23_E46_P0.8480.99
2_R8_Y0.8350.99
29_R46_P0.8080.99
10_F24_V0.8060.99
4_L30_D0.8000.99
7_R35_Y0.7900.99
9_D34_S0.7760.99
3_L11_F0.7750.99
2_R6_R0.7610.98
2_R13_L0.7280.98
2_R5_R0.7210.98
22_E25_A0.7080.97
12_C28_L0.7030.97
30_D44_L0.7030.97
39_P45_P0.6700.96
32_L36_F0.6520.96
39_P44_L0.6340.95
12_C27_L0.6220.95
14_N25_A0.6110.94
5_R23_E0.5990.93
3_L15_D0.5780.92
12_C36_F0.5760.92
6_R15_D0.5690.92
10_F15_D0.5680.92
9_D16_N0.5630.91
2_R11_F0.5630.91
10_F18_D0.5620.91
25_A28_L0.5610.91
22_E26_A0.5580.91
16_N19_P0.5420.90
5_R30_D0.5220.88
14_N40_S0.5210.88
22_E46_P0.5160.87
9_D17_S0.5080.86
16_N38_E0.5050.86
8_Y22_E0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vphA 4 0.9259 17.5 0.819 Contact Map
2p6hA 3 0.9259 17.1 0.82 Contact Map
1ve0A 3 0.9259 16.5 0.822 Contact Map
1vmhA 3 0.9074 9.1 0.841 Contact Map
2cu5A 3 0.9074 7.6 0.846 Contact Map
2p6cA 3 0.9259 7.2 0.848 Contact Map
4dx8H 1 0.7963 6.7 0.85 Contact Map
3u1wA 3 0.5741 5.7 0.855 Contact Map
1vmfA 3 0.9074 5.5 0.856 Contact Map
1vmjA 4 0.9259 4.8 0.86 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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