GREMLIN Database
CBP_BcsS - Cellulose biosynthesis protein BcsS
PFAM: PF17036 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 144 (140)
Sequences: 1291 (1026)
Seq/√Len: 86.7
META: 0.921

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_D42_R5.0531.00
77_Y101_G4.0091.00
27_Y44_T3.9511.00
59_T62_T3.5251.00
80_R96_E3.2551.00
84_G113_H2.8711.00
36_D39_N2.7661.00
25_P46_V2.5731.00
26_D71_S2.4101.00
5_D49_K2.3631.00
79_A99_A2.2951.00
39_N104_G2.2311.00
48_L72_T2.1081.00
47_G72_T2.0151.00
13_K18_E1.9981.00
62_T92_Y1.9481.00
21_L52_A1.9061.00
70_Y75_D1.7621.00
63_M113_H1.7301.00
77_Y99_A1.6591.00
84_G127_S1.6581.00
17_L56_Y1.6561.00
22_F53_E1.5491.00
107_Q131_A1.4910.99
58_P63_M1.4890.99
20_K53_E1.4860.99
63_M92_Y1.4810.99
37_P43_G1.4600.99
23_A48_L1.4500.99
107_Q133_D1.4330.99
11_Q20_K1.4200.99
44_T90_R1.3920.99
26_D73_A1.3530.99
67_D78_W1.3470.99
55_W63_M1.3400.99
16_G60_P1.3320.99
130_Y138_S1.3220.99
41_V102_D1.3080.99
32_L36_D1.2930.99
96_E141_Y1.2910.99
27_Y46_V1.2650.98
39_N43_G1.2510.98
51_A67_D1.2220.98
92_Y113_H1.2170.98
30_H74_F1.1890.97
55_W115_T1.1850.97
72_T75_D1.1770.97
45_E73_A1.1750.97
12_F21_L1.1690.97
47_G71_S1.1640.97
97_A110_L1.1570.97
32_L42_R1.1570.97
23_A50_V1.1510.97
57_E92_Y1.1460.97
109_R127_S1.1260.96
63_M115_T1.0970.96
64_L83_L1.0890.96
84_G115_T1.0820.96
64_L68_A1.0700.95
41_V74_F1.0690.95
132_R135_D1.0530.95
78_W98_A1.0400.95
116_G125_S1.0340.94
100_L105_Y1.0210.94
36_D42_R1.0180.94
58_P62_T1.0160.94
28_Q76_S1.0000.93
59_T92_Y0.9940.93
99_A108_W0.9940.93
18_E53_E0.9920.93
89_D112_A0.9910.93
34_P37_P0.9900.93
65_S80_R0.9880.93
58_P84_G0.9870.93
85_W95_P0.9810.93
131_A139_G0.9750.92
11_Q18_E0.9690.92
58_P92_Y0.9590.92
22_F51_A0.9420.91
79_A101_G0.9400.91
19_V54_L0.9290.90
34_P43_G0.9220.90
12_F17_L0.9220.90
97_A108_W0.9130.90
36_D43_G0.9130.90
92_Y115_T0.9120.90
87_V93_V0.9030.89
54_L66_A0.8860.88
12_F15_G0.8730.87
63_M84_G0.8620.87
14_R17_L0.8590.87
101_G106_R0.8580.87
53_E69_S0.8560.86
30_H43_G0.8500.86
68_A77_Y0.8430.86
29_D50_V0.8360.85
30_H53_E0.8320.85
95_P113_H0.8300.85
115_T125_S0.8180.84
48_L71_S0.8180.84
121_P126_L0.8140.84
29_D44_T0.8130.83
45_E74_F0.8030.83
96_E127_S0.7860.81
93_V138_S0.7770.81
132_R136_G0.7770.81
100_L109_R0.7720.80
53_E56_Y0.7630.79
93_V114_L0.7550.79
41_V103_D0.7540.79
97_A118_K0.7530.79
38_G130_Y0.7520.78
36_D41_V0.7510.78
43_G102_D0.7470.78
75_D105_Y0.7430.78
51_A78_W0.7350.77
119_L122_L0.7330.77
57_E60_P0.7290.76
54_L112_A0.7290.76
77_Y106_R0.7280.76
29_D43_G0.7130.75
30_H39_N0.7130.75
56_Y69_S0.7080.74
39_N45_E0.7070.74
26_D30_H0.7040.74
47_G109_R0.7030.74
67_D92_Y0.7010.73
4_A10_Y0.7010.73
51_A127_S0.7010.73
37_P41_V0.7000.73
37_P53_E0.6960.73
5_D26_D0.6890.72
67_D102_D0.6880.72
23_A82_R0.6840.72
30_H126_L0.6820.71
58_P82_R0.6820.71
109_R113_H0.6710.70
7_L51_A0.6630.69
86_R89_D0.6580.69
66_A81_A0.6570.69
15_G86_R0.6510.68
76_S80_R0.6500.68
71_S76_S0.6410.67
58_P113_H0.6390.66
117_L122_L0.6390.66
71_S116_G0.6340.66
62_T105_Y0.6310.65
40_R83_L0.6250.65
39_N101_G0.6210.64
35_D38_G0.6140.63
53_E109_R0.6140.63
8_P72_T0.6130.63
133_D136_G0.6100.63
65_S86_R0.5950.61
111_G129_G0.5950.61
53_E67_D0.5940.61
126_L129_G0.5930.61
114_L128_A0.5930.61
49_K109_R0.5930.61
3_S30_H0.5930.61
31_R103_D0.5910.60
28_Q71_S0.5880.60
117_L120_G0.5830.59
12_F20_K0.5830.59
93_V112_A0.5810.59
31_R45_E0.5800.59
4_A142_G0.5750.58
82_R125_S0.5740.58
19_V27_Y0.5740.58
30_H41_V0.5730.58
6_A44_T0.5720.58
12_F19_V0.5650.57
32_L39_N0.5650.57
118_K124_W0.5650.57
34_P39_N0.5620.57
96_E111_G0.5610.56
114_L126_L0.5600.56
37_P42_R0.5550.56
20_K54_L0.5550.56
58_P115_T0.5540.56
6_A112_A0.5530.55
20_K67_D0.5530.55
9_G47_G0.5510.55
61_R90_R0.5460.54
66_A100_L0.5440.54
47_G73_A0.5420.54
100_L125_S0.5400.54
21_L107_Q0.5390.54
32_L43_G0.5350.53
26_D63_M0.5340.53
34_P77_Y0.5330.53
124_W142_G0.5320.53
36_D105_Y0.5270.52
101_G105_Y0.5240.52
16_G97_A0.5240.52
115_T118_K0.5210.51
88_F126_L0.5200.51
132_R138_S0.5180.51
18_E92_Y0.5150.50
30_H100_L0.5150.50
43_G123_E0.5150.50
34_P42_R0.5140.50
14_R19_V0.5140.50
8_P110_L0.5140.50
32_L35_D0.5130.50
17_L54_L0.5080.49
139_G142_G0.5060.49
71_S127_S0.5050.49
46_V106_R0.5010.48
57_E86_R0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i78A 2 0.8889 86.3 0.868 Contact Map
4rlcA 1 0.6042 80.1 0.878 Contact Map
1uynX 1 0.8056 76.5 0.881 Contact Map
3kvnX 1 0.9236 73.5 0.884 Contact Map
2x55A 1 0.8472 67.1 0.89 Contact Map
4rl8A 3 0.9792 64.5 0.891 Contact Map
3aehA 1 0.5625 64 0.892 Contact Map
3qraA 1 0.5833 58.4 0.895 Contact Map
3qq2A 2 0.5486 56.9 0.896 Contact Map
3sltA 1 0.6042 56.4 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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