GREMLIN Database
17kDa_Anti_2 - 17 kDa outer membrane surface antigen
PFAM: PF16998 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (103)
Sequences: 2286 (1405)
Seq/√Len: 138.5
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_R104_G3.4781.00
33_D58_N2.7701.00
44_A54_V2.6771.00
88_V93_E2.4721.00
58_N61_T2.4531.00
57_E64_R2.3521.00
84_L95_W2.3401.00
82_D97_Q2.1791.00
43_D47_R2.1191.00
22_A25_A2.0411.00
16_V19_S2.0151.00
25_A29_P1.8751.00
83_F98_G1.8411.00
35_A39_A1.8381.00
27_A31_E1.7601.00
99_E111_R1.7521.00
30_T33_D1.7021.00
39_A43_D1.6801.00
78_R103_Q1.6541.00
13_D16_V1.5501.00
34_L37_A1.5471.00
34_L41_A1.5151.00
17_T20_I1.4461.00
25_A28_S1.4411.00
53_S68_T1.4401.00
83_F100_A1.4391.00
64_R88_V1.4301.00
31_E35_A1.4191.00
84_L97_Q1.4061.00
48_G51_D1.3191.00
89_R94_S1.3041.00
36_F67_V1.2941.00
31_E34_L1.2851.00
71_A82_D1.2841.00
28_S31_E1.2801.00
15_D20_I1.2721.00
86_S93_E1.2721.00
29_P32_S1.2581.00
65_G87_Y1.2471.00
46_T50_K1.2221.00
22_A26_A1.2201.00
70_L84_L1.2111.00
87_Y91_G1.1430.99
33_D40_A1.1390.99
15_D19_S1.1240.99
14_S20_I1.1140.99
46_T70_L1.1050.99
36_F39_A1.0980.99
36_F43_D1.0810.99
50_K72_S1.0750.99
81_R108_W1.0630.99
48_G54_V1.0590.99
26_A29_P1.0540.99
63_A87_Y1.0520.99
32_S36_F1.0260.99
43_D48_G1.0180.99
86_S95_W0.9970.98
13_D21_A0.9870.98
67_V86_S0.9840.98
19_S22_A0.9740.98
32_S92_G0.9680.98
17_T21_A0.9670.98
37_A41_A0.9490.98
33_D37_A0.9320.97
30_T34_L0.9210.97
58_N62_G0.9200.97
36_F40_A0.9140.97
64_R93_E0.9020.97
103_Q109_E0.8950.97
66_T88_V0.8940.97
32_S35_A0.8910.97
27_A30_T0.8870.97
55_P95_W0.8820.96
51_D69_P0.8690.96
35_A38_R0.8640.96
74_Y82_D0.8540.96
30_T60_D0.8420.95
20_I92_G0.8130.94
46_T51_D0.8120.94
16_V20_I0.8100.94
34_L38_R0.8100.94
58_N85_A0.8090.94
23_A27_A0.8040.94
72_S79_T0.7810.93
43_D46_T0.7790.93
55_P66_T0.7700.93
74_Y79_T0.7700.93
39_A42_S0.7690.93
13_D19_S0.7680.92
16_V21_A0.7570.92
40_A57_E0.7330.91
84_L88_V0.7270.90
101_C108_W0.7020.89
63_A89_R0.6860.88
87_Y96_L0.6840.87
45_L49_G0.6820.87
53_S67_V0.6620.86
63_A86_S0.6620.86
66_T99_E0.6530.85
18_G21_A0.6530.85
66_T96_L0.6530.85
65_G86_S0.6500.85
89_R92_G0.6360.83
103_Q107_R0.6340.83
20_I115_P0.6320.83
23_A52_A0.6240.82
53_S66_T0.6180.82
56_W80_C0.6150.81
80_C101_C0.6130.81
70_L76_D0.6090.81
40_A45_L0.6010.80
23_A26_A0.6000.80
85_A96_L0.5950.79
26_A75_Q0.5920.79
83_F110_V0.5890.78
45_L48_G0.5840.78
60_D105_D0.5810.77
29_P61_T0.5790.77
47_R51_D0.5790.77
18_G24_A0.5790.77
73_A79_T0.5750.77
112_S115_P0.5650.75
59_P69_P0.5630.75
38_R76_D0.5580.75
78_R110_V0.5560.74
91_G114_K0.5550.74
99_E103_Q0.5550.74
74_Y84_L0.5530.74
71_A76_D0.5520.74
54_V112_S0.5500.74
37_A40_A0.5480.73
86_S89_R0.5460.73
24_A27_A0.5430.73
13_D52_A0.5400.72
13_D60_D0.5390.72
72_S75_Q0.5390.72
111_R114_K0.5380.72
66_T70_L0.5350.72
22_A28_S0.5340.71
76_D84_L0.5320.71
71_A84_L0.5320.71
46_T49_G0.5300.71
69_P100_A0.5300.71
13_D31_E0.5250.70
38_R42_S0.5240.70
29_P33_D0.5210.70
58_N83_F0.5150.69
39_A54_V0.5140.68
50_K70_L0.5130.68
79_T102_R0.5070.67
29_P37_A0.5070.67
54_V70_L0.5030.67
13_D18_G0.5010.67
74_Y85_A0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd2A 1 0.8707 6 0.922 Contact Map
2hbpA 1 0.4224 5.4 0.924 Contact Map
2a2lA 5 0.3448 5.1 0.925 Contact Map
1k82A 1 0.8017 4.3 0.927 Contact Map
1o0eA 1 0.4397 4.3 0.928 Contact Map
1yalA 2 0.4397 4.1 0.928 Contact Map
4clcA 5 0.3707 4.1 0.928 Contact Map
3u6pA 1 0.7155 4.1 0.928 Contact Map
2xu3A 1 0.4397 3.9 0.929 Contact Map
3kwzA 1 0.4397 3.9 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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