GREMLIN Database
RcpC - Flp pilus assembly protein RcpC/CpaB
PFAM: PF16976 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (108)
Sequences: 31530 (20243)
Seq/√Len: 1947.9
META: 0.931

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_R59_N4.1171.00
61_R93_E2.8861.00
95_T98_Q2.8181.00
11_M93_E2.7781.00
12_R35_D2.7161.00
8_P93_E2.3051.00
33_R61_R2.2101.00
37_L55_T2.0601.00
39_T53_T2.0171.00
13_A63_L1.9881.00
11_M95_T1.8771.00
107_S110_T1.8391.00
57_L60_V1.6751.00
90_V113_L1.6621.00
94_V102_L1.6541.00
15_S91_T1.6541.00
19_D22_S1.6491.00
104_L108_E1.6481.00
8_P11_M1.6291.00
60_V94_V1.6031.00
17_P21_V1.5871.00
13_A91_T1.5841.00
56_V105_A1.5691.00
28_I62_V1.5271.00
106_Q112_S1.5241.00
38_L109_G1.4981.00
4_A32_D1.4901.00
99_A114_A1.4261.00
53_T104_L1.3661.00
57_L102_L1.3591.00
36_V113_L1.3561.00
31_G61_R1.3061.00
37_L53_T1.2891.00
65_V90_V1.2751.00
55_T100_E1.2531.00
97_E101_K1.2491.00
98_Q101_K1.2401.00
15_S89_T1.2271.00
63_L93_E1.2261.00
103_A112_S1.2211.00
38_L105_A1.2111.00
29_L32_D1.1831.00
27_F64_A1.1621.00
36_V102_L1.1601.00
37_L114_A1.1541.00
57_L98_Q1.1401.00
94_V99_A1.1251.00
30_P64_A1.1091.00
38_L56_V1.1001.00
12_R96_P1.0851.00
11_M98_Q1.0601.00
17_P106_Q1.0331.00
36_V60_V1.0301.00
95_T99_A1.0281.00
37_L100_E1.0101.00
8_P61_R0.9911.00
60_V98_Q0.9891.00
75_D78_G0.9771.00
34_V113_L0.9681.00
73_T76_D0.9681.00
11_M61_R0.9561.00
28_I90_V0.9481.00
66_G91_T0.9471.00
14_V94_V0.9391.00
35_D58_Q0.9341.00
55_T58_Q0.9321.00
76_D79_G0.9221.00
72_T75_D0.9171.00
12_R114_A0.8841.00
18_V23_G0.8761.00
41_G44_G0.8641.00
16_V92_L0.8611.00
39_T103_A0.8581.00
7_L11_M0.8551.00
18_V22_S0.8461.00
17_P20_D0.8441.00
57_L94_V0.8421.00
20_D66_G0.8411.00
55_T114_A0.8411.00
39_T112_S0.8381.00
20_D88_S0.8371.00
14_V103_A0.8351.00
51_T108_E0.8291.00
100_E104_L0.8191.00
38_L108_E0.8151.00
35_D116_R0.8101.00
14_V102_L0.8091.00
83_V86_T0.8021.00
58_Q96_P0.8021.00
15_S24_V0.7841.00
103_A106_Q0.7781.00
15_S25_A0.7651.00
7_L93_E0.7571.00
36_V92_L0.7571.00
30_P65_V0.7511.00
19_D110_T0.7461.00
105_A111_L0.7391.00
38_L54_R0.7291.00
46_G49_G0.7291.00
54_R100_E0.7241.00
28_I32_D0.7221.00
34_V92_L0.7191.00
35_D55_T0.7181.00
62_V90_V0.7151.00
60_V92_L0.7111.00
20_D23_G0.7001.00
45_G48_G0.6991.00
17_P89_T0.6901.00
35_D59_N0.6861.00
39_T104_L0.6841.00
107_S112_S0.6841.00
14_V99_A0.6731.00
57_L101_K0.6591.00
22_S112_S0.6581.00
72_T82_V0.6521.00
64_A91_T0.6431.00
74_A80_K0.6271.00
42_A45_G0.6241.00
74_A77_D0.6231.00
75_D79_G0.6211.00
55_T96_P0.6201.00
103_A107_S0.6201.00
25_A89_T0.6141.00
16_V102_L0.6131.00
86_T89_T0.6081.00
81_P84_A0.6081.00
28_I65_V0.6051.00
82_V85_K0.6011.00
73_T78_G0.5921.00
51_T107_S0.5841.00
80_K83_V0.5811.00
73_T82_V0.5761.00
37_L103_A0.5741.00
72_T76_D0.5741.00
24_V28_I0.5731.00
66_G88_S0.5651.00
43_G46_G0.5651.00
79_G82_V0.5611.00
73_T77_D0.5591.00
96_P100_E0.5571.00
92_L102_L0.5491.00
42_A50_G0.5471.00
22_S107_S0.5441.00
37_L99_A0.5431.00
47_G50_G0.5401.00
72_T77_D0.5391.00
77_D80_K0.5371.00
76_D80_K0.5341.00
18_V90_V0.5331.00
72_T79_G0.5301.00
41_G49_G0.5221.00
41_G45_G0.5201.00
39_T108_E0.5201.00
43_G49_G0.5171.00
36_V56_V0.5171.00
42_A49_G0.5141.00
73_T80_K0.5111.00
66_G89_T0.5091.00
97_E100_E0.5081.00
72_T78_G0.5051.00
39_T107_S0.5021.00
53_T103_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ltlA 4 0.5431 76.8 0.807 Contact Map
4pofA 3 0.5603 67 0.82 Contact Map
4me3A 1 0.5172 65.5 0.822 Contact Map
3ja87 1 0.8534 59.1 0.829 Contact Map
4fdgB 1 0.8534 57.8 0.83 Contact Map
3ja85 1 0.8621 56.1 0.832 Contact Map
4r7yA 3 0.8448 49.9 0.838 Contact Map
3ja82 1 0.7759 44.9 0.843 Contact Map
3ja83 1 0.8448 43.6 0.844 Contact Map
3ja84 1 0.9914 33.5 0.854 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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