GREMLIN Database
OFeT_1 - Ferrous iron uptake permease, iron-lead transporter
PFAM: PF16955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 207 (193)
Sequences: 733 (569)
Seq/√Len: 40.9
META: 0.917

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_A47_L3.8521.00
81_W84_K3.7301.00
91_G96_H3.6831.00
44_A48_L3.4621.00
176_T198_Y3.4361.00
91_G97_D2.5741.00
88_R91_G2.5471.00
93_K96_H2.5241.00
46_V108_F2.4801.00
194_L198_Y2.3881.00
17_F141_G2.2791.00
88_R97_D2.2571.00
29_G34_W2.2471.00
26_L29_G2.1260.99
90_A93_K2.1260.99
93_K97_D1.9940.99
87_L91_G1.9420.99
88_R96_H1.9230.99
64_D67_R1.8990.99
89_F96_H1.8710.98
25_V29_G1.8380.98
17_F21_L1.8340.98
92_L96_H1.8040.98
70_V126_G1.7920.98
37_A40_G1.7560.98
147_L151_V1.6330.96
106_T109_K1.6150.96
94_A97_D1.6100.96
91_G94_A1.6050.96
89_F92_L1.5870.96
104_L110_A1.5550.95
87_L94_A1.5510.95
133_A141_G1.5420.95
43_G48_L1.5410.95
86_I90_A1.5300.95
187_S190_A1.5300.95
90_A94_A1.5250.94
26_L30_V1.5220.94
40_G48_L1.5210.94
176_T194_L1.5070.94
90_A96_H1.5060.94
182_G185_P1.5030.94
91_G95_L1.5010.94
190_A193_A1.4890.94
87_L96_H1.4780.93
31_T34_W1.4550.93
103_G107_A1.4540.93
193_A196_A1.4410.93
76_L80_R1.4080.92
47_L50_I1.4000.91
88_R92_L1.3920.91
87_L97_D1.3900.91
45_L48_L1.3790.91
33_G36_P1.3760.91
73_L120_F1.3700.90
84_K88_R1.3440.90
134_A138_A1.2880.88
49_V53_A1.2830.87
133_A163_L1.2820.87
90_A97_D1.2740.87
91_G98_E1.2710.87
43_G47_L1.2670.87
154_P165_F1.2440.86
89_F95_L1.2250.85
15_V22_T1.2220.85
87_L93_K1.2180.84
86_I97_D1.2130.84
169_V195_F1.2130.84
194_L197_L1.2090.84
21_L145_V1.2090.84
16_E19_E1.2080.84
88_R93_K1.2070.84
28_V31_T1.2030.84
68_L182_G1.2020.84
52_A55_G1.1790.82
130_L134_A1.1730.82
40_G44_A1.1690.82
86_I91_G1.1580.81
58_L68_L1.1460.81
55_G58_L1.1360.80
42_A49_V1.1180.79
72_V76_L1.1170.79
6_F136_G1.1060.78
109_K112_L1.1050.78
81_W86_I1.1020.78
146_A150_A1.1010.78
155_L164_K1.0970.78
106_T180_G1.0970.78
192_L195_F1.0960.77
34_W37_A1.0820.77
106_T110_A1.0820.77
43_G112_L1.0760.76
112_L152_H1.0720.76
105_A109_K1.0650.75
154_P160_E1.0610.75
133_A136_G1.0590.75
88_R98_E1.0430.74
89_F93_K1.0350.73
142_V146_A1.0340.73
154_P161_N1.0230.72
92_L97_D1.0140.72
87_L90_A1.0080.71
155_L160_E1.0010.71
119_A125_F1.0010.71
184_W187_S0.9960.70
14_L147_L0.9880.70
42_A48_L0.9850.69
48_L52_A0.9710.68
115_G137_A0.9630.68
40_G47_L0.9540.67
61_V149_A0.9530.67
22_T161_N0.9490.67
107_A110_A0.9460.66
162_T165_F0.9460.66
24_V27_A0.9370.66
173_S195_F0.9360.65
136_G141_G0.9350.65
131_L134_A0.9350.65
93_K98_E0.9280.65
90_A95_L0.9250.65
9_A13_S0.9240.64
80_R124_A0.9230.64
129_G134_A0.9220.64
120_F178_W0.9200.64
72_V179_A0.9180.64
37_A170_M0.9160.64
50_I54_L0.9080.63
119_A123_I0.9060.63
107_A145_V0.9060.63
105_A111_V0.8930.62
160_E164_K0.8860.61
56_P183_L0.8840.61
18_V22_T0.8820.61
29_G35_R0.8810.61
89_F97_D0.8760.60
29_G38_L0.8740.60
33_G75_L0.8690.60
188_D192_L0.8640.59
23_I110_A0.8620.59
63_I67_R0.8600.59
34_W38_L0.8520.58
89_F94_A0.8510.58
69_V72_V0.8470.58
28_V34_W0.8410.57
28_V33_G0.8400.57
21_L148_G0.8380.57
186_G190_A0.8350.57
95_L98_E0.8210.55
45_L59_T0.8130.55
30_V43_G0.8130.55
147_L158_V0.8130.55
158_V161_N0.8120.54
6_F135_L0.7950.53
114_E117_E0.7950.53
20_A167_V0.7870.52
87_L95_L0.7870.52
32_R36_P0.7870.52
189_L192_L0.7820.52
144_V148_G0.7810.52
67_R75_L0.7710.51
56_P60_L0.7700.51
76_L124_A0.7680.50
60_L124_A0.7640.50
154_P164_K0.7610.50
132_S136_G0.7600.50
116_L119_A0.7580.49
16_E23_I0.7570.49
19_E23_I0.7520.49
141_G148_G0.7460.48
106_T111_V0.7450.48
136_G148_G0.7430.48
10_F15_V0.7320.47
173_S179_A0.7300.47
107_A111_V0.7290.47
139_A149_A0.7130.45
105_A110_A0.7100.45
110_A141_G0.7080.45
118_V137_A0.7080.45
185_P190_A0.7060.45
120_F163_L0.6970.44
119_A178_W0.6960.44
20_A160_E0.6940.44
161_N167_V0.6900.43
127_A132_S0.6840.43
86_I96_H0.6840.43
46_V52_A0.6800.42
152_H156_A0.6790.42
21_L149_A0.6770.42
13_S136_G0.6750.42
71_G75_L0.6700.41
151_V162_T0.6650.41
94_A98_E0.6600.41
129_G176_T0.6560.40
60_L129_G0.6530.40
92_L95_L0.6470.39
82_L168_G0.6440.39
146_A149_A0.6440.39
6_F152_H0.6410.39
132_S170_M0.6400.39
130_L173_S0.6390.39
80_R191_L0.6370.38
191_L198_Y0.6330.38
65_A69_V0.6320.38
69_V135_L0.6310.38
20_A144_V0.6310.38
153_R156_A0.6290.38
84_K87_L0.6270.38
86_I89_F0.6260.38
104_L142_V0.6260.38
7_L153_R0.6230.37
42_A47_L0.6200.37
36_P173_S0.6130.36
130_L148_G0.6120.36
134_A141_G0.6110.36
129_G132_S0.6100.36
15_V161_N0.6100.36
86_I98_E0.6100.36
186_G193_A0.6090.36
82_L85_A0.6050.36
85_A88_R0.6040.36
185_P189_L0.6040.36
6_F9_A0.6030.36
167_V174_F0.6030.36
81_W88_R0.6010.35
31_T35_R0.6000.35
67_R79_L0.5950.35
38_L41_A0.5940.35
38_L142_V0.5930.35
184_W194_L0.5930.35
80_R116_L0.5920.35
140_A163_L0.5890.34
87_L98_E0.5890.34
153_R172_T0.5880.34
124_A136_G0.5870.34
122_V159_P0.5830.34
190_A194_L0.5820.34
12_A15_V0.5820.34
54_L58_L0.5800.34
38_L42_A0.5770.33
166_V169_V0.5750.33
141_G173_S0.5730.33
9_A136_G0.5720.33
71_G81_W0.5720.33
68_L116_L0.5700.33
161_N164_K0.5700.33
125_F179_A0.5700.33
24_V40_G0.5690.33
89_F98_E0.5680.33
113_L155_L0.5650.32
115_G121_I0.5650.32
118_V164_K0.5640.32
13_S22_T0.5630.32
191_L195_F0.5610.32
18_V161_N0.5610.32
15_V20_A0.5600.32
59_T146_A0.5590.32
186_G196_A0.5570.32
188_D191_L0.5570.32
10_F125_F0.5570.32
98_E102_E0.5540.31
55_G77_F0.5530.31
170_M179_A0.5510.31
41_A44_A0.5490.31
20_A154_P0.5480.31
57_L61_V0.5430.31
192_L196_A0.5430.31
177_F181_E0.5420.31
116_L128_R0.5300.30
33_G37_A0.5270.29
35_R157_R0.5270.29
130_L136_G0.5250.29
115_G148_G0.5240.29
144_V167_V0.5180.29
103_G106_T0.5150.28
68_L150_A0.5140.28
104_L111_V0.5140.28
155_L161_N0.5130.28
158_V163_L0.5120.28
175_G182_G0.5110.28
95_L170_M0.5110.28
149_A196_A0.5110.28
66_L118_V0.5110.28
188_D193_A0.5100.28
124_A129_G0.5090.28
35_R40_G0.5060.28
101_R128_R0.5050.28
15_V19_E0.5030.28
27_A37_A0.5020.27
69_V193_A0.5010.27
17_F152_H0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4w6vA 1 0.43 12.9 0.956 Contact Map
3l1lA 2 0.4251 6.3 0.962 Contact Map
3ne5A 3 0.715 5.9 0.962 Contact Map
3zuxA 1 0.343 5.8 0.962 Contact Map
4ezcA 3 0.4396 5.6 0.962 Contact Map
4mndA 2 0.3865 5.6 0.963 Contact Map
2lzrA 1 0.1836 5 0.963 Contact Map
3k3fA 3 0.5072 4.5 0.964 Contact Map
2cfqA 1 0.4734 4.4 0.965 Contact Map
3v5uA 1 0.6812 4.3 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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