OFeT_1 - PFAM28P - GREMLIN Contacts

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OFeT_1 - Ferrous iron uptake permease, iron-lead transporter

PFAM:	PF16955	Sequences: MDWAVFLAAFLASLVEFVEALTIVVLAVGVTRGWRPALGGAAGALVLLVIVAALGPLLTLVPIDALRLVVGVLLLLFGLRWLRKAILRFAGLKALHDEEEREGLATAFKAVLLEGLEVAFIVIAFGARGLLSAALGAAAAGVLVVALGAAVHRPLARVPENTLKFVVGVMLTSFGTFWAGEGLWPGSDLALLALFALYLAVSYLLVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	207 (193)
Sequences:	733 (569)
Seq/√Len:	40.9
META:	0.917

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
44_A	47_L	3.852	1.00
81_W	84_K	3.730	1.00
91_G	96_H	3.683	1.00
44_A	48_L	3.462	1.00
176_T	198_Y	3.436	1.00
91_G	97_D	2.574	1.00
88_R	91_G	2.547	1.00
93_K	96_H	2.524	1.00
46_V	108_F	2.480	1.00
194_L	198_Y	2.388	1.00
17_F	141_G	2.279	1.00
88_R	97_D	2.257	1.00
29_G	34_W	2.247	1.00
26_L	29_G	2.126	0.99
90_A	93_K	2.126	0.99
93_K	97_D	1.994	0.99
87_L	91_G	1.942	0.99
88_R	96_H	1.923	0.99
64_D	67_R	1.899	0.99
89_F	96_H	1.871	0.98
25_V	29_G	1.838	0.98
17_F	21_L	1.834	0.98
92_L	96_H	1.804	0.98
70_V	126_G	1.792	0.98
37_A	40_G	1.756	0.98
147_L	151_V	1.633	0.96
106_T	109_K	1.615	0.96
94_A	97_D	1.610	0.96
91_G	94_A	1.605	0.96
89_F	92_L	1.587	0.96
104_L	110_A	1.555	0.95
87_L	94_A	1.551	0.95
133_A	141_G	1.542	0.95
43_G	48_L	1.541	0.95
86_I	90_A	1.530	0.95
187_S	190_A	1.530	0.95
90_A	94_A	1.525	0.94
26_L	30_V	1.522	0.94
40_G	48_L	1.521	0.94
176_T	194_L	1.507	0.94
90_A	96_H	1.506	0.94
182_G	185_P	1.503	0.94
91_G	95_L	1.501	0.94
190_A	193_A	1.489	0.94
87_L	96_H	1.478	0.93
31_T	34_W	1.455	0.93
103_G	107_A	1.454	0.93
193_A	196_A	1.441	0.93
76_L	80_R	1.408	0.92
47_L	50_I	1.400	0.91
88_R	92_L	1.392	0.91
87_L	97_D	1.390	0.91
45_L	48_L	1.379	0.91
33_G	36_P	1.376	0.91
73_L	120_F	1.370	0.90
84_K	88_R	1.344	0.90
134_A	138_A	1.288	0.88
49_V	53_A	1.283	0.87
133_A	163_L	1.282	0.87
90_A	97_D	1.274	0.87
91_G	98_E	1.271	0.87
43_G	47_L	1.267	0.87
154_P	165_F	1.244	0.86
89_F	95_L	1.225	0.85
15_V	22_T	1.222	0.85
87_L	93_K	1.218	0.84
86_I	97_D	1.213	0.84
169_V	195_F	1.213	0.84
194_L	197_L	1.209	0.84
21_L	145_V	1.209	0.84
16_E	19_E	1.208	0.84
88_R	93_K	1.207	0.84
28_V	31_T	1.203	0.84
68_L	182_G	1.202	0.84
52_A	55_G	1.179	0.82
130_L	134_A	1.173	0.82
40_G	44_A	1.169	0.82
86_I	91_G	1.158	0.81
58_L	68_L	1.146	0.81
55_G	58_L	1.136	0.80
42_A	49_V	1.118	0.79
72_V	76_L	1.117	0.79
6_F	136_G	1.106	0.78
109_K	112_L	1.105	0.78
81_W	86_I	1.102	0.78
146_A	150_A	1.101	0.78
155_L	164_K	1.097	0.78
106_T	180_G	1.097	0.78
192_L	195_F	1.096	0.77
34_W	37_A	1.082	0.77
106_T	110_A	1.082	0.77
43_G	112_L	1.076	0.76
112_L	152_H	1.072	0.76
105_A	109_K	1.065	0.75
154_P	160_E	1.061	0.75
133_A	136_G	1.059	0.75
88_R	98_E	1.043	0.74
89_F	93_K	1.035	0.73
142_V	146_A	1.034	0.73
154_P	161_N	1.023	0.72
92_L	97_D	1.014	0.72
87_L	90_A	1.008	0.71
155_L	160_E	1.001	0.71
119_A	125_F	1.001	0.71
184_W	187_S	0.996	0.70
14_L	147_L	0.988	0.70
42_A	48_L	0.985	0.69
48_L	52_A	0.971	0.68
115_G	137_A	0.963	0.68
40_G	47_L	0.954	0.67
61_V	149_A	0.953	0.67
22_T	161_N	0.949	0.67
107_A	110_A	0.946	0.66
162_T	165_F	0.946	0.66
24_V	27_A	0.937	0.66
173_S	195_F	0.936	0.65
136_G	141_G	0.935	0.65
131_L	134_A	0.935	0.65
93_K	98_E	0.928	0.65
90_A	95_L	0.925	0.65
9_A	13_S	0.924	0.64
80_R	124_A	0.923	0.64
129_G	134_A	0.922	0.64
120_F	178_W	0.920	0.64
72_V	179_A	0.918	0.64
37_A	170_M	0.916	0.64
50_I	54_L	0.908	0.63
119_A	123_I	0.906	0.63
107_A	145_V	0.906	0.63
105_A	111_V	0.893	0.62
160_E	164_K	0.886	0.61
56_P	183_L	0.884	0.61
18_V	22_T	0.882	0.61
29_G	35_R	0.881	0.61
89_F	97_D	0.876	0.60
29_G	38_L	0.874	0.60
33_G	75_L	0.869	0.60
188_D	192_L	0.864	0.59
23_I	110_A	0.862	0.59
63_I	67_R	0.860	0.59
34_W	38_L	0.852	0.58
89_F	94_A	0.851	0.58
69_V	72_V	0.847	0.58
28_V	34_W	0.841	0.57
28_V	33_G	0.840	0.57
21_L	148_G	0.838	0.57
186_G	190_A	0.835	0.57
95_L	98_E	0.821	0.55
45_L	59_T	0.813	0.55
30_V	43_G	0.813	0.55
147_L	158_V	0.813	0.55
158_V	161_N	0.812	0.54
6_F	135_L	0.795	0.53
114_E	117_E	0.795	0.53
20_A	167_V	0.787	0.52
87_L	95_L	0.787	0.52
32_R	36_P	0.787	0.52
189_L	192_L	0.782	0.52
144_V	148_G	0.781	0.52
67_R	75_L	0.771	0.51
56_P	60_L	0.770	0.51
76_L	124_A	0.768	0.50
60_L	124_A	0.764	0.50
154_P	164_K	0.761	0.50
132_S	136_G	0.760	0.50
116_L	119_A	0.758	0.49
16_E	23_I	0.757	0.49
19_E	23_I	0.752	0.49
141_G	148_G	0.746	0.48
106_T	111_V	0.745	0.48
136_G	148_G	0.743	0.48
10_F	15_V	0.732	0.47
173_S	179_A	0.730	0.47
107_A	111_V	0.729	0.47
139_A	149_A	0.713	0.45
105_A	110_A	0.710	0.45
110_A	141_G	0.708	0.45
118_V	137_A	0.708	0.45
185_P	190_A	0.706	0.45
120_F	163_L	0.697	0.44
119_A	178_W	0.696	0.44
20_A	160_E	0.694	0.44
161_N	167_V	0.690	0.43
127_A	132_S	0.684	0.43
86_I	96_H	0.684	0.43
46_V	52_A	0.680	0.42
152_H	156_A	0.679	0.42
21_L	149_A	0.677	0.42
13_S	136_G	0.675	0.42
71_G	75_L	0.670	0.41
151_V	162_T	0.665	0.41
94_A	98_E	0.660	0.41
129_G	176_T	0.656	0.40
60_L	129_G	0.653	0.40
92_L	95_L	0.647	0.39
82_L	168_G	0.644	0.39
146_A	149_A	0.644	0.39
6_F	152_H	0.641	0.39
132_S	170_M	0.640	0.39
130_L	173_S	0.639	0.39
80_R	191_L	0.637	0.38
191_L	198_Y	0.633	0.38
65_A	69_V	0.632	0.38
69_V	135_L	0.631	0.38
20_A	144_V	0.631	0.38
153_R	156_A	0.629	0.38
84_K	87_L	0.627	0.38
86_I	89_F	0.626	0.38
104_L	142_V	0.626	0.38
7_L	153_R	0.623	0.37
42_A	47_L	0.620	0.37
36_P	173_S	0.613	0.36
130_L	148_G	0.612	0.36
134_A	141_G	0.611	0.36
129_G	132_S	0.610	0.36
15_V	161_N	0.610	0.36
86_I	98_E	0.610	0.36
186_G	193_A	0.609	0.36
82_L	85_A	0.605	0.36
85_A	88_R	0.604	0.36
185_P	189_L	0.604	0.36
6_F	9_A	0.603	0.36
167_V	174_F	0.603	0.36
81_W	88_R	0.601	0.35
31_T	35_R	0.600	0.35
67_R	79_L	0.595	0.35
38_L	41_A	0.594	0.35
38_L	142_V	0.593	0.35
184_W	194_L	0.593	0.35
80_R	116_L	0.592	0.35
140_A	163_L	0.589	0.34
87_L	98_E	0.589	0.34
153_R	172_T	0.588	0.34
124_A	136_G	0.587	0.34
122_V	159_P	0.583	0.34
190_A	194_L	0.582	0.34
12_A	15_V	0.582	0.34
54_L	58_L	0.580	0.34
38_L	42_A	0.577	0.33
166_V	169_V	0.575	0.33
141_G	173_S	0.573	0.33
9_A	136_G	0.572	0.33
71_G	81_W	0.572	0.33
68_L	116_L	0.570	0.33
161_N	164_K	0.570	0.33
125_F	179_A	0.570	0.33
24_V	40_G	0.569	0.33
89_F	98_E	0.568	0.33
113_L	155_L	0.565	0.32
115_G	121_I	0.565	0.32
118_V	164_K	0.564	0.32
13_S	22_T	0.563	0.32
191_L	195_F	0.561	0.32
18_V	161_N	0.561	0.32
15_V	20_A	0.560	0.32
59_T	146_A	0.559	0.32
186_G	196_A	0.557	0.32
188_D	191_L	0.557	0.32
10_F	125_F	0.557	0.32
98_E	102_E	0.554	0.31
55_G	77_F	0.553	0.31
170_M	179_A	0.551	0.31
41_A	44_A	0.549	0.31
20_A	154_P	0.548	0.31
57_L	61_V	0.543	0.31
192_L	196_A	0.543	0.31
177_F	181_E	0.542	0.31
116_L	128_R	0.530	0.30
33_G	37_A	0.527	0.29
35_R	157_R	0.527	0.29
130_L	136_G	0.525	0.29
115_G	148_G	0.524	0.29
144_V	167_V	0.518	0.29
103_G	106_T	0.515	0.28
68_L	150_A	0.514	0.28
104_L	111_V	0.514	0.28
155_L	161_N	0.513	0.28
158_V	163_L	0.512	0.28
175_G	182_G	0.511	0.28
95_L	170_M	0.511	0.28
149_A	196_A	0.511	0.28
66_L	118_V	0.511	0.28
188_D	193_A	0.510	0.28
124_A	129_G	0.509	0.28
35_R	40_G	0.506	0.28
101_R	128_R	0.505	0.28
15_V	19_E	0.503	0.28
27_A	37_A	0.502	0.27
69_V	193_A	0.501	0.27
17_F	152_H	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4w6vA	1	0.43	12.9	0.956	Contact Map
3l1lA	2	0.4251	6.3	0.962	Contact Map
3ne5A	3	0.715	5.9	0.962	Contact Map
3zuxA	1	0.343	5.8	0.962	Contact Map
4ezcA	3	0.4396	5.6	0.962	Contact Map
4mndA	2	0.3865	5.6	0.963	Contact Map
2lzrA	1	0.1836	5	0.963	Contact Map
3k3fA	3	0.5072	4.5	0.964	Contact Map
2cfqA	1	0.4734	4.4	0.965	Contact Map
3v5uA	1	0.6812	4.3	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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