GREMLIN Database
HisKA_7TM - N-terminal 7TM region of histidine kinase
PFAM: PF16927 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 220 (216)
Sequences: 26298 (23379)
Seq/√Len: 1590.8
META: 0.925

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_L64_G2.7241.00
55_L59_R2.5421.00
27_A74_H2.5321.00
34_A71_L2.4221.00
72_F172_A2.3961.00
154_Y166_K2.3091.00
148_V152_R2.2331.00
41_G57_W2.1841.00
27_A71_L2.1401.00
161_Y164_Q2.1021.00
30_L71_L2.0681.00
152_R156_R2.0291.00
50_D53_T2.0141.00
27_A78_A2.0101.00
91_L95_L2.0011.00
179_N183_L1.9741.00
80_T153_A1.8941.00
41_G60_L1.8881.00
72_F146_G1.8771.00
44_L57_W1.8731.00
202_S206_L1.8661.00
32_L203_G1.8001.00
108_N111_H1.7991.00
34_A67_F1.7891.00
76_A149_L1.7461.00
98_P101_T1.7341.00
191_G195_T1.7191.00
185_G188_P1.7081.00
76_A150_L1.7011.00
128_Y132_F1.6871.00
90_R93_L1.6841.00
74_H78_A1.6821.00
138_Y142_L1.6701.00
41_G64_G1.6681.00
163_R166_K1.6651.00
102_L106_L1.6501.00
179_N182_Y1.6481.00
42_Y46_L1.6341.00
101_T131_L1.5961.00
73_L77_L1.5751.00
108_N112_G1.5621.00
42_Y45_E1.5621.00
145_A149_L1.5511.00
73_L142_L1.5461.00
43_A47_L1.5071.00
53_T57_W1.5051.00
67_F99_A1.4961.00
120_G123_G1.4841.00
92_A95_L1.4611.00
76_A80_T1.4471.00
153_A165_L1.4401.00
34_A64_G1.4341.00
70_V74_H1.4301.00
193_D196_P1.4301.00
73_L145_A1.4171.00
207_A211_F1.4161.00
171_G205_L1.4111.00
67_F71_L1.4041.00
144_L148_V1.3861.00
59_R106_L1.3791.00
6_A43_A1.3651.00
178_G198_G1.3551.00
122_P125_E1.3401.00
73_L149_L1.3251.00
178_G182_Y1.3131.00
151_I155_R1.2951.00
175_P178_G1.2921.00
48_S57_W1.2891.00
13_A17_W1.2811.00
76_A146_G1.2801.00
59_R109_P1.2791.00
178_G183_L1.2731.00
135_F139_S1.2661.00
107_T111_H1.2591.00
62_Y65_I1.2591.00
11_G15_Y1.2551.00
29_A33_L1.2461.00
37_L41_G1.2441.00
74_H95_L1.2411.00
109_P112_G1.2411.00
214_R217_D1.2251.00
19_R25_A1.2111.00
61_Q65_I1.2061.00
137_A141_L1.2001.00
87_K90_R1.1971.00
77_L149_L1.1851.00
13_A32_L1.1841.00
121_F125_E1.1611.00
72_F76_A1.1591.00
104_L131_L1.1591.00
41_G45_E1.1511.00
127_E130_P1.1301.00
75_F79_Y1.1291.00
66_A102_L1.1281.00
6_A36_A1.1251.00
208_Y213_Y1.1211.00
59_R115_Y1.1181.00
19_R22_S1.1171.00
147_L176_L1.1141.00
154_Y165_L1.1091.00
131_L134_V1.0961.00
89_R92_A1.0951.00
66_A135_F1.0921.00
81_G161_Y1.0901.00
130_P133_W1.0901.00
140_Y179_N1.0891.00
62_Y132_F1.0861.00
48_S53_T1.0771.00
3_L43_A1.0751.00
10_L36_A1.0721.00
95_L98_P1.0691.00
119_G122_P1.0661.00
160_L164_Q1.0601.00
184_L188_P1.0571.00
6_A40_L1.0531.00
153_A157_S1.0511.00
24_G78_A1.0411.00
13_A36_A1.0391.00
55_L58_A1.0291.00
41_G61_Q1.0241.00
40_L44_L1.0161.00
118_S121_F1.0111.00
129_G133_W1.0081.00
184_L187_L1.0041.00
21_R24_G1.0021.00
56_F59_R0.9941.00
153_A161_Y0.9941.00
71_L74_H0.9871.00
175_P202_S0.9801.00
156_R159_G0.9781.00
97_I101_T0.9651.00
13_A16_V0.9651.00
192_I195_T0.9601.00
110_L113_L0.9591.00
199_F202_S0.9591.00
92_A96_I0.9541.00
116_V119_G0.9471.00
123_G126_Y0.9451.00
12_L16_V0.9441.00
58_A62_Y0.9391.00
101_T135_F0.9351.00
6_A10_L0.9351.00
58_A61_Q0.9321.00
97_I135_F0.9251.00
97_I100_L0.9211.00
152_R155_R0.9181.00
119_G123_G0.9081.00
167_Y205_L0.9061.00
94_L97_I0.9051.00
31_L71_L0.9041.00
33_L37_L0.9011.00
32_L36_A0.8961.00
13_A29_A0.8931.00
209_A215_L0.8911.00
66_A69_P0.8911.00
45_E61_Q0.8901.00
63_L106_L0.8891.00
198_G202_S0.8871.00
29_A32_L0.8831.00
117_S120_G0.8831.00
20_R23_P0.8801.00
157_S165_L0.8801.00
106_L109_P0.8751.00
163_R167_Y0.8651.00
90_R94_L0.8631.00
27_A31_L0.8571.00
202_S205_L0.8561.00
56_F60_L0.8511.00
9_S203_G0.8501.00
167_Y209_A0.8501.00
171_G206_L0.8491.00
121_F126_Y0.8451.00
52_E55_L0.8441.00
80_T149_L0.8401.00
38_W65_I0.8321.00
45_E58_A0.8261.00
82_R85_W0.8141.00
28_F32_L0.8081.00
122_P126_Y0.8051.00
91_L94_L0.7991.00
6_A9_S0.7981.00
83_R86_L0.7961.00
151_I169_L0.7961.00
69_P146_G0.7951.00
139_S142_L0.7931.00
77_L80_T0.7881.00
159_G163_R0.7851.00
5_A9_S0.7851.00
31_L35_V0.7851.00
24_G27_A0.7851.00
70_V95_L0.7811.00
99_A103_L0.7781.00
147_L172_A0.7781.00
23_P26_R0.7771.00
148_V151_I0.7761.00
191_G196_P0.7751.00
198_G201_L0.7751.00
145_A148_V0.7751.00
23_P27_A0.7741.00
160_L163_R0.7741.00
84_R88_R0.7731.00
140_Y144_L0.7731.00
48_S51_L0.7711.00
117_S122_P0.7701.00
199_F203_G0.7591.00
110_L114_F0.7561.00
102_L105_V0.7531.00
154_Y157_S0.7521.00
109_P113_L0.7501.00
22_S25_A0.7461.00
20_R25_A0.7391.00
85_W89_R0.7381.00
100_L104_L0.7291.00
19_R26_R0.7261.00
93_L96_I0.7251.00
25_A29_A0.7221.00
121_F124_L0.7201.00
203_G207_A0.7191.00
85_W90_R0.7141.00
118_S122_P0.7131.00
185_G189_L0.7051.00
28_F207_A0.7001.00
43_A46_L0.6931.00
94_L98_P0.6931.00
50_D54_A0.6931.00
180_L183_L0.6921.00
177_L180_L0.6921.00
194_L197_L0.6911.00
51_L54_A0.6871.00
39_S45_E0.6861.00
141_L145_A0.6851.00
49_T52_E0.6841.00
75_F168_L0.6791.00
146_G150_L0.6771.00
116_V122_P0.6691.00
83_R87_K0.6681.00
97_I142_L0.6671.00
147_L151_I0.6671.00
63_L67_F0.6631.00
26_R29_A0.6601.00
101_T105_V0.6601.00
10_L14_L0.6581.00
192_I196_P0.6581.00
73_L146_G0.6571.00
97_I138_Y0.6561.00
147_L169_L0.6561.00
178_G181_L0.6541.00
116_V120_G0.6521.00
67_F102_L0.6491.00
36_A40_L0.6491.00
9_S36_A0.6491.00
44_L48_S0.6471.00
51_L55_L0.6471.00
67_F70_V0.6441.00
69_P73_L0.6381.00
136_L140_Y0.6311.00
186_L189_L0.6291.00
48_S54_A0.6261.00
187_L190_P0.6221.00
18_R21_R0.6201.00
120_G124_L0.6191.00
89_R93_L0.6181.00
70_V98_P0.6171.00
175_P179_N0.6171.00
166_K170_L0.6161.00
113_L130_P0.6151.00
53_T56_F0.6141.00
136_L139_S0.6131.00
17_W29_A0.6131.00
166_K169_L0.6121.00
98_P142_L0.6101.00
177_L181_L0.6061.00
63_L102_L0.6041.00
27_A30_L0.6041.00
52_E56_F0.6011.00
31_L68_I0.6011.00
129_G132_F0.5991.00
84_R87_K0.5961.00
9_S13_A0.5891.00
208_Y212_R0.5871.00
66_A101_T0.5851.00
201_L204_L0.5811.00
133_W137_A0.5791.00
100_L103_L0.5781.00
61_Q64_G0.5711.00
26_R30_L0.5661.00
39_S42_Y0.5621.00
154_Y162_R0.5611.00
196_P199_F0.5601.00
30_L34_A0.5571.00
117_S121_F0.5561.00
57_W60_L0.5551.00
155_R158_S0.5511.00
98_P138_Y0.5491.00
74_H96_I0.5491.00
159_G162_R0.5471.00
88_R92_A0.5451.00
21_R26_R0.5431.00
85_W88_R0.5421.00
160_L214_R0.5421.00
20_R26_R0.5411.00
196_P200_L0.5411.00
200_L204_L0.5401.00
44_L47_L0.5371.00
45_E54_A0.5311.00
21_R25_A0.5311.00
12_L207_A0.5291.00
7_L11_G0.5221.00
80_T165_L0.5221.00
72_F202_S0.5211.00
190_P195_T0.5171.00
170_L174_I0.5171.00
157_S161_Y0.5141.00
194_L198_G0.5121.00
133_W136_L0.5111.00
205_L208_Y0.5101.00
84_R90_R0.5091.00
171_G209_A0.5061.00
118_S125_E0.5031.00
108_N113_L0.5031.00
130_P134_V0.5031.00
99_A102_L0.5011.00
149_L153_A0.5011.00
45_E49_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ks1B 1 0.1091 5.6 0.927 Contact Map
2l2tA 2 0.1136 5.3 0.928 Contact Map
3wajA 1 0.8091 4.2 0.931 Contact Map
4lz6A 1 0.9591 4.1 0.931 Contact Map
2jwaA 2 0.1045 3.7 0.933 Contact Map
4o6yA 2 0.6727 3.7 0.933 Contact Map
3j1zP 8 0.8727 3.6 0.933 Contact Map
2k1eA 3 0.45 3 0.936 Contact Map
3j2wE 1 0.0909 2.9 0.936 Contact Map
4zwjA 1 0.9909 2.9 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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