GREMLIN Database
VPS13_C - Vacuolar-sorting-associated 13 protein C-terminal
PFAM: PF16909 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 178 (171)
Sequences: 1055 (800)
Seq/√Len: 61.1
META: 0.421

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_D143_S8.3681.00
118_F144_L7.3371.00
118_F141_T4.7491.00
125_G136_G3.4971.00
143_S147_N3.1911.00
107_L155_S3.0321.00
99_D158_K2.8381.00
121_E139_K2.6521.00
11_P120_Y2.6011.00
125_G133_F2.3971.00
134_G138_A2.3151.00
63_L82_H2.1991.00
80_I84_K2.1661.00
129_G132_E2.1561.00
62_A120_Y2.0151.00
90_Q93_K1.9601.00
113_S143_S1.9381.00
3_Y67_N1.8941.00
60_L87_L1.8921.00
129_G133_F1.8541.00
171_T177_Q1.8391.00
110_N150_G1.8361.00
96_G105_V1.7921.00
164_G168_A1.7590.99
154_G158_K1.7050.99
76_L80_I1.6590.99
15_N57_P1.6460.99
152_V156_V1.6170.99
141_T144_L1.5730.99
108_F112_G1.5610.99
122_P136_G1.5220.98
126_L133_F1.5170.98
159_I162_S1.4790.98
73_S76_L1.4580.98
65_L68_V1.4080.97
107_L151_G1.4010.97
103_N106_G1.3830.97
100_F152_V1.3790.97
53_I56_A1.3670.97
82_H86_Q1.3240.96
88_L92_Y1.3200.96
128_Q132_E1.3120.96
121_E125_G1.2800.95
125_G129_G1.2770.95
71_S74_E1.2360.94
47_G51_G1.1970.93
44_N47_G1.1840.93
3_Y43_L1.1720.93
115_V120_Y1.1700.92
144_L147_N1.1670.92
95_L98_L1.1520.92
114_G140_G1.1510.92
94_I150_G1.1300.91
60_L83_Y1.1250.91
102_G162_S1.1230.91
162_S171_T1.1120.90
114_G136_G1.1070.90
110_N147_N1.1060.90
52_N98_L1.0910.90
150_G154_G1.0790.89
120_Y127_V1.0750.89
86_Q103_N1.0630.88
102_G107_L1.0620.88
22_P25_N1.0570.88
72_L76_L1.0540.88
168_A171_T1.0390.87
92_Y103_N1.0340.87
125_G130_P1.0290.87
17_S52_N1.0250.86
5_E13_K1.0140.86
10_S120_Y1.0070.85
16_L53_I0.9960.85
155_S162_S0.9920.85
51_G113_S0.9850.84
2_I79_I0.9850.84
7_L75_L0.9850.84
12_I16_L0.9830.84
113_S147_N0.9750.84
85_Q117_D0.9750.84
115_V119_F0.9710.83
164_G172_M0.9710.83
28_D174_K0.9690.83
133_F148_T0.9670.83
75_L101_L0.9660.83
74_E78_R0.9630.83
120_Y123_Y0.9540.82
174_K177_Q0.9510.82
173_D176_Y0.9390.81
129_G136_G0.9320.81
70_E75_L0.9120.79
59_K120_Y0.9100.79
114_G144_L0.9010.78
82_H111_L0.9000.78
17_S20_R0.8900.78
4_F7_L0.8820.77
154_G165_K0.8810.77
162_S175_E0.8800.77
121_E133_F0.8790.77
94_I139_K0.8760.76
29_K34_S0.8600.75
16_L30_L0.8550.75
164_G171_T0.8510.74
10_S121_E0.8490.74
146_K150_G0.8450.74
65_L108_F0.8350.73
136_G140_G0.8280.72
100_F149_V0.8230.72
127_V165_K0.8190.71
118_F147_N0.8170.71
155_S159_I0.8160.71
129_G141_T0.8150.71
81_K84_K0.8150.71
56_A82_H0.8110.71
112_G169_A0.8100.71
168_A176_Y0.8090.70
119_F122_P0.8080.70
126_L137_L0.8080.70
63_L70_E0.8070.70
93_K105_V0.8020.70
106_G161_G0.7980.69
117_D136_G0.7820.68
36_P39_L0.7780.67
133_F138_A0.7760.67
96_G114_G0.7710.67
10_S62_A0.7700.67
56_A97_S0.7680.66
65_L149_V0.7650.66
6_L13_K0.7630.66
148_T168_A0.7570.65
130_P133_F0.7500.65
106_G109_N0.7410.64
80_I111_L0.7400.64
83_Y146_K0.7350.63
65_L70_E0.7340.63
47_G92_Y0.7340.63
65_L112_G0.7290.62
23_R39_L0.7290.62
36_P58_I0.7270.62
136_G141_T0.7250.62
126_L130_P0.7230.62
122_P125_G0.7210.62
98_L150_G0.7170.61
97_S107_L0.7160.61
47_G50_L0.7130.61
167_L170_L0.7130.61
86_Q124_Q0.7090.60
47_G110_N0.7080.60
73_S135_E0.7070.60
51_G111_L0.7020.60
86_Q89_R0.6980.59
52_N166_G0.6970.59
14_L19_S0.6960.59
159_I166_G0.6960.59
127_V130_P0.6900.58
21_T24_S0.6890.58
40_L174_K0.6850.58
81_K85_Q0.6820.57
82_H148_T0.6810.57
22_P56_A0.6810.57
4_F177_Q0.6780.57
118_F136_G0.6780.57
169_A174_K0.6770.57
52_N56_A0.6740.56
109_N159_I0.6690.56
166_G170_L0.6680.56
4_F68_V0.6650.55
30_L35_N0.6650.55
63_L108_F0.6640.55
50_L151_G0.6610.55
11_P62_A0.6600.55
28_D137_L0.6520.54
34_S79_I0.6520.54
17_S83_Y0.6510.54
119_F123_Y0.6490.54
83_Y103_N0.6480.53
12_I75_L0.6440.53
63_L122_P0.6420.53
71_S163_L0.6410.53
64_E129_G0.6370.52
18_F119_F0.6360.52
116_K141_T0.6350.52
19_S146_K0.6320.52
53_I79_I0.6310.52
163_L169_A0.6280.51
140_G143_S0.6280.51
20_R46_L0.6270.51
134_G137_L0.6250.51
57_P97_S0.6250.51
70_E78_R0.6230.51
172_M177_Q0.6210.50
30_L36_P0.6130.50
111_L169_A0.6120.49
56_A167_L0.6070.49
90_Q98_L0.6020.48
154_G160_T0.6010.48
116_K120_Y0.5980.48
56_A104_P0.5980.48
15_N53_I0.5970.48
23_R28_D0.5940.47
122_P130_P0.5930.47
39_L81_K0.5910.47
8_H14_L0.5910.47
44_N48_M0.5890.47
96_G106_G0.5890.47
75_L154_G0.5880.47
168_A172_M0.5880.47
117_D122_P0.5870.47
14_L77_S0.5860.46
12_I19_S0.5820.46
45_S94_I0.5810.46
119_F127_V0.5770.45
53_I58_I0.5740.45
160_T164_G0.5730.45
163_L172_M0.5720.45
76_L84_K0.5690.45
4_F170_L0.5660.44
15_N59_K0.5640.44
70_E74_E0.5620.44
21_T30_L0.5620.44
99_D103_N0.5600.44
107_L159_I0.5590.43
105_V119_F0.5590.43
99_D165_K0.5570.43
3_Y19_S0.5560.43
105_V134_G0.5550.43
100_F119_F0.5540.43
82_H96_G0.5540.43
62_A79_I0.5530.43
124_Q130_P0.5520.43
75_L133_F0.5470.42
24_S29_K0.5460.42
46_L74_E0.5460.42
57_P134_G0.5460.42
73_S126_L0.5450.42
46_L109_N0.5430.42
53_I167_L0.5420.42
35_N38_S0.5380.41
151_G164_G0.5370.41
133_F136_G0.5370.41
99_D161_G0.5330.41
165_K169_A0.5260.40
97_S102_G0.5230.39
88_L108_F0.5220.39
90_Q121_E0.5200.39
9_L79_I0.5190.39
114_G118_F0.5160.39
122_P133_F0.5160.39
4_F12_I0.5140.39
115_V118_F0.5130.38
48_M154_G0.5110.38
150_G153_S0.5100.38
34_S58_I0.5080.38
37_L139_K0.5060.38
87_L141_T0.5050.38
60_L77_S0.5030.37
67_N89_R0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k4nA 1 0.2079 4.2 0.944 Contact Map
3zldB 1 0.1404 2.4 0.951 Contact Map
4ftbD 1 0.118 2.3 0.951 Contact Map
1f8vD 3 0.1629 2.2 0.952 Contact Map
1novD 1 0.1124 2 0.953 Contact Map
4irzA 1 0.3483 1.7 0.954 Contact Map
4chdA 1 0.3202 1.6 0.955 Contact Map
1v18B 1 0.1629 1.6 0.955 Contact Map
3fcsB 1 0.9438 1.5 0.956 Contact Map
3b4sA 6 0.4719 1.5 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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