Sin3a_C - PFAM28P - GREMLIN Contacts

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Sin3a_C - C-terminal domain of Sin3a protein

PFAM:	PF16879	Sequences: FFGNDTFYVFFRLHQILYERLLKAKQAEAQVEEEIRRRKANKPAVDLGLIDKQPPDFGLDTSVEPEDYYPQFLEMLENLLDGEIDQSKFEDTLREMFGIKAYVLFTLDKLIQALVKQLQTIVSDEKCQELLQLYEYERSRKATTFQDEIVYRRNAEKLLKDENLFRIEWSPESKRLTIQLLDTDDETPEDDASMEERWSYYVESYVSSEPTEGVPRSELKPPFLKRNLRKYREDDEESEEEKAVSNGLECKICLNSYKLFYVPGTEDYL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	269 (268)
Sequences:	619 (441)
Seq/√Len:	27.0
META:	0.141

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
44_A	47_L	4.730	1.00
253_C	260_F	4.460	1.00
130_L	155_A	3.415	1.00
133_L	151_Y	3.055	1.00
201_Y	205_Y	2.819	1.00
44_A	49_L	2.780	1.00
198_W	201_Y	2.716	1.00
76_L	107_L	2.645	0.99
12_R	21_L	2.605	0.99
94_R	109_K	2.415	0.99
44_A	48_G	2.236	0.98
37_R	40_A	2.222	0.98
253_C	256_S	2.213	0.98
103_V	165_F	2.174	0.98
107_L	114_L	2.118	0.97
41_N	48_G	2.106	0.97
31_V	107_L	2.083	0.97
90_E	108_D	2.077	0.97
147_D	178_I	2.022	0.96
11_F	167_I	1.964	0.95
248_L	265_T	1.954	0.95
16_I	110_L	1.953	0.95
53_Q	60_D	1.939	0.95
93_L	104_L	1.924	0.95
84_I	167_I	1.902	0.95
76_L	89_F	1.893	0.94
79_L	109_K	1.862	0.94
48_G	51_D	1.857	0.94
44_A	50_I	1.831	0.93
8_Y	12_R	1.808	0.93
1_F	7_F	1.805	0.93
77_E	169_W	1.791	0.93
32_E	36_R	1.779	0.92
12_R	109_K	1.769	0.92
43_P	50_I	1.767	0.92
68_Y	96_M	1.760	0.92
137_E	148_E	1.752	0.92
89_F	106_T	1.743	0.92
254_L	260_F	1.733	0.91
108_D	115_V	1.716	0.91
248_L	267_D	1.691	0.90
163_N	182_D	1.691	0.90
111_I	115_V	1.686	0.90
152_R	211_T	1.676	0.90
90_E	109_K	1.673	0.90
249_E	262_V	1.667	0.90
24_A	72_F	1.653	0.89
7_F	18_Y	1.648	0.89
18_Y	25_K	1.632	0.89
219_L	222_P	1.600	0.88
126_K	152_R	1.588	0.87
248_L	251_K	1.586	0.87
34_E	38_R	1.585	0.87
169_W	174_K	1.580	0.87
237_E	240_E	1.577	0.87
11_F	176_L	1.561	0.86
165_F	180_L	1.541	0.85
98_G	101_A	1.534	0.85
12_R	69_Y	1.513	0.84
111_I	114_L	1.504	0.84
25_K	69_Y	1.474	0.83
13_L	117_Q	1.456	0.82
256_S	260_F	1.448	0.82
247_G	253_C	1.443	0.81
42_K	48_G	1.429	0.81
1_F	28_E	1.400	0.79
41_N	44_A	1.400	0.79
119_Q	162_E	1.397	0.79
110_L	261_Y	1.385	0.79
2_F	196_E	1.384	0.79
43_P	48_G	1.382	0.78
80_L	134_Y	1.374	0.78
260_F	263_P	1.364	0.78
152_R	252_I	1.363	0.77
1_F	26_Q	1.360	0.77
10_F	21_L	1.344	0.76
157_K	246_N	1.330	0.76
68_Y	156_E	1.321	0.75
262_V	266_E	1.321	0.75
93_L	101_A	1.306	0.74
250_C	262_V	1.301	0.74
72_F	93_L	1.296	0.74
111_I	172_E	1.293	0.74
48_G	159_L	1.287	0.73
198_W	205_Y	1.279	0.73
79_L	123_S	1.278	0.73
22_L	26_Q	1.273	0.72
72_F	89_F	1.266	0.72
65_P	68_Y	1.263	0.72
46_D	91_D	1.254	0.71
23_K	100_K	1.246	0.71
33_E	36_R	1.243	0.71
130_L	224_L	1.219	0.69
253_C	265_T	1.202	0.68
1_F	105_F	1.198	0.68
168_E	179_Q	1.193	0.67
8_Y	13_L	1.178	0.66
252_I	259_L	1.178	0.66
54_P	58_G	1.177	0.66
1_F	119_Q	1.172	0.66
205_Y	233_E	1.169	0.66
12_R	90_E	1.168	0.66
207_S	212_E	1.145	0.64
98_G	118_L	1.143	0.64
41_N	47_L	1.141	0.64
21_L	138_R	1.135	0.63
55_P	60_D	1.134	0.63
185_D	269_L	1.132	0.63
24_A	92_T	1.130	0.63
53_Q	56_D	1.129	0.63
110_L	114_L	1.126	0.63
119_Q	133_L	1.123	0.63
257_Y	260_F	1.121	0.62
218_E	232_R	1.119	0.62
106_T	162_E	1.118	0.62
189_E	205_Y	1.117	0.62
39_K	134_Y	1.103	0.61
17_L	107_L	1.096	0.61
177_T	217_S	1.093	0.60
33_E	121_I	1.087	0.60
89_F	165_F	1.075	0.59
21_L	94_R	1.063	0.58
202_V	206_V	1.063	0.58
41_N	51_D	1.062	0.58
45_V	50_I	1.046	0.57
10_F	134_Y	1.041	0.57
26_Q	171_P	1.038	0.56
144_T	269_L	1.038	0.56
81_D	162_E	1.034	0.56
98_G	105_F	1.034	0.56
32_E	35_I	1.032	0.56
33_E	37_R	1.028	0.56
114_L	130_L	1.011	0.54
82_G	127_C	1.010	0.54
162_E	182_D	1.009	0.54
80_L	83_E	1.005	0.54
90_E	115_V	0.997	0.53
149_I	161_D	0.996	0.53
4_N	81_D	0.990	0.53
198_W	257_Y	0.989	0.53
19_E	23_K	0.986	0.52
23_K	103_V	0.982	0.52
118_L	122_V	0.978	0.52
104_L	159_L	0.977	0.52
260_F	265_T	0.975	0.52
69_Y	97_F	0.966	0.51
237_E	241_E	0.962	0.51
100_K	118_L	0.960	0.51
10_F	116_K	0.956	0.50
144_T	147_D	0.954	0.50
77_E	161_D	0.954	0.50
45_V	48_G	0.952	0.50
51_D	61_T	0.951	0.50
74_E	107_L	0.950	0.50
240_E	243_A	0.949	0.50
81_D	105_F	0.949	0.50
15_Q	127_C	0.947	0.50
202_V	252_I	0.934	0.49
30_Q	257_Y	0.933	0.49
43_P	49_L	0.922	0.48
137_E	154_N	0.918	0.47
32_E	37_R	0.911	0.47
103_V	132_Q	0.909	0.47
164_L	205_Y	0.906	0.46
152_R	156_E	0.904	0.46
51_D	54_P	0.904	0.46
126_K	129_E	0.900	0.46
51_D	261_Y	0.900	0.46
260_F	264_G	0.897	0.46
28_E	105_F	0.894	0.46
178_I	252_I	0.893	0.46
116_K	166_R	0.892	0.45
128_Q	169_W	0.888	0.45
10_F	105_F	0.886	0.45
16_I	118_L	0.883	0.45
94_R	105_F	0.879	0.44
101_A	117_Q	0.877	0.44
261_Y	266_E	0.871	0.44
69_Y	257_Y	0.864	0.43
116_K	179_Q	0.860	0.43
187_T	212_E	0.859	0.43
4_N	218_E	0.859	0.43
197_R	250_C	0.857	0.43
1_F	243_A	0.857	0.43
98_G	262_V	0.856	0.43
110_L	178_I	0.854	0.43
205_Y	235_D	0.848	0.42
88_K	91_D	0.846	0.42
162_E	251_K	0.845	0.42
91_D	188_P	0.844	0.42
146_Q	184_D	0.838	0.41
108_D	166_R	0.836	0.41
15_Q	19_E	0.835	0.41
49_L	59_L	0.833	0.41
65_P	175_R	0.833	0.41
90_E	166_R	0.831	0.41
118_L	134_Y	0.830	0.41
261_Y	267_D	0.828	0.41
165_F	173_S	0.828	0.41
12_R	261_Y	0.819	0.40
165_F	230_K	0.819	0.40
7_F	105_F	0.815	0.40
215_P	218_E	0.815	0.40
156_E	203_E	0.814	0.40
106_T	117_Q	0.812	0.40
149_I	211_T	0.811	0.39
110_L	113_A	0.810	0.39
90_E	151_Y	0.810	0.39
75_M	207_S	0.806	0.39
245_S	268_Y	0.804	0.39
52_K	61_T	0.804	0.39
11_F	81_D	0.803	0.39
167_I	215_P	0.793	0.38
42_K	52_K	0.788	0.38
77_E	253_C	0.788	0.38
67_D	118_L	0.787	0.38
18_Y	114_L	0.787	0.38
256_S	267_D	0.785	0.38
105_F	119_Q	0.784	0.38
38_R	66_E	0.783	0.37
252_I	261_Y	0.782	0.37
12_R	108_D	0.782	0.37
246_N	265_T	0.782	0.37
20_R	94_R	0.780	0.37
27_A	72_F	0.777	0.37
17_L	226_R	0.777	0.37
105_F	162_E	0.773	0.37
86_Q	90_E	0.773	0.37
29_A	33_E	0.771	0.37
138_R	160_K	0.758	0.36
226_R	229_R	0.756	0.36
64_E	219_L	0.755	0.36
123_S	228_L	0.752	0.35
91_D	100_K	0.745	0.35
143_T	152_R	0.742	0.35
3_G	167_I	0.741	0.35
83_E	265_T	0.741	0.35
123_S	178_I	0.739	0.34
65_P	181_L	0.737	0.34
14_H	24_A	0.737	0.34
84_I	114_L	0.737	0.34
105_F	177_T	0.736	0.34
29_A	155_A	0.732	0.34
13_L	106_T	0.729	0.34
140_R	143_T	0.727	0.34
126_K	187_T	0.726	0.34
96_M	156_E	0.725	0.33
114_L	239_E	0.725	0.33
235_D	247_G	0.723	0.33
152_R	257_Y	0.722	0.33
50_I	56_D	0.721	0.33
134_Y	257_Y	0.720	0.33
82_G	106_T	0.713	0.33
71_Q	105_F	0.710	0.32
5_D	82_G	0.709	0.32
31_V	34_E	0.706	0.32
153_R	198_W	0.706	0.32
147_D	184_D	0.705	0.32
68_Y	167_I	0.703	0.32
1_F	24_A	0.702	0.32
36_R	39_K	0.701	0.32
176_L	215_P	0.699	0.32
71_Q	96_M	0.699	0.32
17_L	189_E	0.697	0.32
214_V	227_N	0.696	0.32
123_S	133_L	0.695	0.32
235_D	238_S	0.693	0.31
144_T	223_F	0.693	0.31
24_A	97_F	0.692	0.31
201_Y	211_T	0.691	0.31
11_F	190_D	0.689	0.31
170_S	175_R	0.686	0.31
33_E	220_K	0.682	0.31
54_P	59_L	0.681	0.31
110_L	182_D	0.680	0.31
161_D	175_R	0.679	0.30
80_L	183_T	0.679	0.30
143_T	148_E	0.677	0.30
152_R	185_D	0.676	0.30
99_I	135_E	0.675	0.30
43_P	47_L	0.671	0.30
179_Q	182_D	0.670	0.30
15_Q	150_V	0.670	0.30
239_E	242_K	0.669	0.30
7_F	82_G	0.664	0.30
72_F	101_A	0.662	0.29
18_Y	86_Q	0.660	0.29
185_D	211_T	0.660	0.29
7_F	102_Y	0.659	0.29
85_D	88_K	0.657	0.29
156_E	183_T	0.657	0.29
222_P	226_R	0.650	0.29
260_F	267_D	0.650	0.29
85_D	138_R	0.649	0.29
196_E	218_E	0.648	0.29
188_P	199_S	0.647	0.28
23_K	89_F	0.646	0.28
69_Y	119_Q	0.645	0.28
166_R	180_L	0.642	0.28
153_R	187_T	0.641	0.28
159_L	215_P	0.640	0.28
125_E	129_E	0.640	0.28
50_I	59_L	0.639	0.28
41_N	49_L	0.637	0.28
246_N	267_D	0.636	0.28
153_R	156_E	0.635	0.28
136_Y	154_N	0.632	0.28
49_L	159_L	0.631	0.28
190_D	203_E	0.630	0.27
10_F	14_H	0.630	0.27
107_L	137_E	0.629	0.27
86_Q	116_K	0.629	0.27
28_E	40_A	0.626	0.27
25_K	204_S	0.626	0.27
113_A	152_R	0.625	0.27
165_F	193_S	0.624	0.27
232_R	239_E	0.623	0.27
8_Y	109_K	0.623	0.27
39_K	47_L	0.620	0.27
69_Y	96_M	0.620	0.27
260_F	266_E	0.617	0.27
92_T	96_M	0.615	0.27
144_T	259_L	0.614	0.27
123_S	264_G	0.613	0.26
78_N	118_L	0.611	0.26
217_S	225_K	0.611	0.26
90_E	267_D	0.611	0.26
155_A	164_L	0.610	0.26
36_R	45_V	0.610	0.26
11_F	217_S	0.608	0.26
67_D	84_I	0.605	0.26
149_I	207_S	0.602	0.26
75_M	95_E	0.602	0.26
247_G	252_I	0.600	0.26
2_F	164_L	0.599	0.26
34_E	40_A	0.599	0.26
112_Q	124_D	0.598	0.26
162_E	266_E	0.597	0.26
63_V	265_T	0.596	0.25
200_Y	205_Y	0.593	0.25
218_E	222_P	0.593	0.25
226_R	247_G	0.590	0.25
97_F	101_A	0.590	0.25
101_A	160_K	0.584	0.25
3_G	140_R	0.581	0.25
217_S	221_P	0.578	0.24
112_Q	195_E	0.578	0.24
187_T	200_Y	0.578	0.24
72_F	182_D	0.576	0.24
256_S	259_L	0.575	0.24
198_W	254_L	0.574	0.24
250_C	259_L	0.574	0.24
68_Y	95_E	0.572	0.24
24_A	98_G	0.570	0.24
234_D	240_E	0.569	0.24
216_R	243_A	0.569	0.24
51_D	159_L	0.568	0.24
248_L	253_C	0.568	0.24
136_Y	140_R	0.566	0.24
222_P	248_L	0.565	0.24
171_P	174_K	0.564	0.24
19_E	82_G	0.563	0.24
10_F	111_I	0.560	0.23
229_R	253_C	0.558	0.23
85_D	171_P	0.557	0.23
232_R	235_D	0.556	0.23
200_Y	213_G	0.556	0.23
80_L	180_L	0.556	0.23
101_A	119_Q	0.554	0.23
129_E	152_R	0.553	0.23
93_L	167_I	0.551	0.23
102_Y	109_K	0.551	0.23
45_V	53_Q	0.550	0.23
188_P	195_E	0.550	0.23
141_K	185_D	0.547	0.23
42_K	47_L	0.546	0.23
199_S	255_N	0.545	0.23
75_M	92_T	0.539	0.22
114_L	145_F	0.538	0.22
99_I	269_L	0.534	0.22
73_L	156_E	0.528	0.22
118_L	225_K	0.527	0.22
101_A	156_E	0.526	0.22
230_K	264_G	0.526	0.22
75_M	84_I	0.526	0.22
12_R	20_R	0.525	0.22
129_E	134_Y	0.523	0.22
207_S	210_P	0.518	0.21
39_K	49_L	0.515	0.21
182_D	253_C	0.515	0.21
241_E	259_L	0.514	0.21
159_L	255_N	0.513	0.21
69_Y	201_Y	0.512	0.21
96_M	150_V	0.512	0.21
14_H	169_W	0.511	0.21
114_L	167_I	0.511	0.21
128_Q	188_P	0.505	0.21
24_A	55_P	0.504	0.21
68_Y	74_E	0.504	0.21
122_V	150_V	0.502	0.20
92_T	165_F	0.501	0.20
157_K	169_W	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4q86A	3	0.4498	71	0.945	Contact Map
2d5rA	1	0.3271	15.3	0.963	Contact Map
3ak8A	6	0.4387	8.1	0.967	Contact Map
2czyA	1	0.2862	6.1	0.969	Contact Map
3shgB	1	0.2268	5.8	0.969	Contact Map
4nuxA	1	0.2268	4.5	0.971	Contact Map
1g1eB	1	0.3197	4	0.971	Contact Map
1e91A	1	0.316	3.9	0.972	Contact Map
1v74B	1	0.3234	3.8	0.972	Contact Map
2c2uA	6	0.4572	3.8	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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