GREMLIN Database
Sin3a_C - C-terminal domain of Sin3a protein
PFAM: PF16879 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 269 (268)
Sequences: 619 (441)
Seq/√Len: 27.0
META: 0.141

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_A47_L4.7301.00
253_C260_F4.4601.00
130_L155_A3.4151.00
133_L151_Y3.0551.00
201_Y205_Y2.8191.00
44_A49_L2.7801.00
198_W201_Y2.7161.00
76_L107_L2.6450.99
12_R21_L2.6050.99
94_R109_K2.4150.99
44_A48_G2.2360.98
37_R40_A2.2220.98
253_C256_S2.2130.98
103_V165_F2.1740.98
107_L114_L2.1180.97
41_N48_G2.1060.97
31_V107_L2.0830.97
90_E108_D2.0770.97
147_D178_I2.0220.96
11_F167_I1.9640.95
248_L265_T1.9540.95
16_I110_L1.9530.95
53_Q60_D1.9390.95
93_L104_L1.9240.95
84_I167_I1.9020.95
76_L89_F1.8930.94
79_L109_K1.8620.94
48_G51_D1.8570.94
44_A50_I1.8310.93
8_Y12_R1.8080.93
1_F7_F1.8050.93
77_E169_W1.7910.93
32_E36_R1.7790.92
12_R109_K1.7690.92
43_P50_I1.7670.92
68_Y96_M1.7600.92
137_E148_E1.7520.92
89_F106_T1.7430.92
254_L260_F1.7330.91
108_D115_V1.7160.91
248_L267_D1.6910.90
163_N182_D1.6910.90
111_I115_V1.6860.90
152_R211_T1.6760.90
90_E109_K1.6730.90
249_E262_V1.6670.90
24_A72_F1.6530.89
7_F18_Y1.6480.89
18_Y25_K1.6320.89
219_L222_P1.6000.88
126_K152_R1.5880.87
248_L251_K1.5860.87
34_E38_R1.5850.87
169_W174_K1.5800.87
237_E240_E1.5770.87
11_F176_L1.5610.86
165_F180_L1.5410.85
98_G101_A1.5340.85
12_R69_Y1.5130.84
111_I114_L1.5040.84
25_K69_Y1.4740.83
13_L117_Q1.4560.82
256_S260_F1.4480.82
247_G253_C1.4430.81
42_K48_G1.4290.81
1_F28_E1.4000.79
41_N44_A1.4000.79
119_Q162_E1.3970.79
110_L261_Y1.3850.79
2_F196_E1.3840.79
43_P48_G1.3820.78
80_L134_Y1.3740.78
260_F263_P1.3640.78
152_R252_I1.3630.77
1_F26_Q1.3600.77
10_F21_L1.3440.76
157_K246_N1.3300.76
68_Y156_E1.3210.75
262_V266_E1.3210.75
93_L101_A1.3060.74
250_C262_V1.3010.74
72_F93_L1.2960.74
111_I172_E1.2930.74
48_G159_L1.2870.73
198_W205_Y1.2790.73
79_L123_S1.2780.73
22_L26_Q1.2730.72
72_F89_F1.2660.72
65_P68_Y1.2630.72
46_D91_D1.2540.71
23_K100_K1.2460.71
33_E36_R1.2430.71
130_L224_L1.2190.69
253_C265_T1.2020.68
1_F105_F1.1980.68
168_E179_Q1.1930.67
8_Y13_L1.1780.66
252_I259_L1.1780.66
54_P58_G1.1770.66
1_F119_Q1.1720.66
205_Y233_E1.1690.66
12_R90_E1.1680.66
207_S212_E1.1450.64
98_G118_L1.1430.64
41_N47_L1.1410.64
21_L138_R1.1350.63
55_P60_D1.1340.63
185_D269_L1.1320.63
24_A92_T1.1300.63
53_Q56_D1.1290.63
110_L114_L1.1260.63
119_Q133_L1.1230.63
257_Y260_F1.1210.62
218_E232_R1.1190.62
106_T162_E1.1180.62
189_E205_Y1.1170.62
39_K134_Y1.1030.61
17_L107_L1.0960.61
177_T217_S1.0930.60
33_E121_I1.0870.60
89_F165_F1.0750.59
21_L94_R1.0630.58
202_V206_V1.0630.58
41_N51_D1.0620.58
45_V50_I1.0460.57
10_F134_Y1.0410.57
26_Q171_P1.0380.56
144_T269_L1.0380.56
81_D162_E1.0340.56
98_G105_F1.0340.56
32_E35_I1.0320.56
33_E37_R1.0280.56
114_L130_L1.0110.54
82_G127_C1.0100.54
162_E182_D1.0090.54
80_L83_E1.0050.54
90_E115_V0.9970.53
149_I161_D0.9960.53
4_N81_D0.9900.53
198_W257_Y0.9890.53
19_E23_K0.9860.52
23_K103_V0.9820.52
118_L122_V0.9780.52
104_L159_L0.9770.52
260_F265_T0.9750.52
69_Y97_F0.9660.51
237_E241_E0.9620.51
100_K118_L0.9600.51
10_F116_K0.9560.50
144_T147_D0.9540.50
77_E161_D0.9540.50
45_V48_G0.9520.50
51_D61_T0.9510.50
74_E107_L0.9500.50
240_E243_A0.9490.50
81_D105_F0.9490.50
15_Q127_C0.9470.50
202_V252_I0.9340.49
30_Q257_Y0.9330.49
43_P49_L0.9220.48
137_E154_N0.9180.47
32_E37_R0.9110.47
103_V132_Q0.9090.47
164_L205_Y0.9060.46
152_R156_E0.9040.46
51_D54_P0.9040.46
126_K129_E0.9000.46
51_D261_Y0.9000.46
260_F264_G0.8970.46
28_E105_F0.8940.46
178_I252_I0.8930.46
116_K166_R0.8920.45
128_Q169_W0.8880.45
10_F105_F0.8860.45
16_I118_L0.8830.45
94_R105_F0.8790.44
101_A117_Q0.8770.44
261_Y266_E0.8710.44
69_Y257_Y0.8640.43
116_K179_Q0.8600.43
187_T212_E0.8590.43
4_N218_E0.8590.43
197_R250_C0.8570.43
1_F243_A0.8570.43
98_G262_V0.8560.43
110_L178_I0.8540.43
205_Y235_D0.8480.42
88_K91_D0.8460.42
162_E251_K0.8450.42
91_D188_P0.8440.42
146_Q184_D0.8380.41
108_D166_R0.8360.41
15_Q19_E0.8350.41
49_L59_L0.8330.41
65_P175_R0.8330.41
90_E166_R0.8310.41
118_L134_Y0.8300.41
261_Y267_D0.8280.41
165_F173_S0.8280.41
12_R261_Y0.8190.40
165_F230_K0.8190.40
7_F105_F0.8150.40
215_P218_E0.8150.40
156_E203_E0.8140.40
106_T117_Q0.8120.40
149_I211_T0.8110.39
110_L113_A0.8100.39
90_E151_Y0.8100.39
75_M207_S0.8060.39
245_S268_Y0.8040.39
52_K61_T0.8040.39
11_F81_D0.8030.39
167_I215_P0.7930.38
42_K52_K0.7880.38
77_E253_C0.7880.38
67_D118_L0.7870.38
18_Y114_L0.7870.38
256_S267_D0.7850.38
105_F119_Q0.7840.38
38_R66_E0.7830.37
252_I261_Y0.7820.37
12_R108_D0.7820.37
246_N265_T0.7820.37
20_R94_R0.7800.37
27_A72_F0.7770.37
17_L226_R0.7770.37
105_F162_E0.7730.37
86_Q90_E0.7730.37
29_A33_E0.7710.37
138_R160_K0.7580.36
226_R229_R0.7560.36
64_E219_L0.7550.36
123_S228_L0.7520.35
91_D100_K0.7450.35
143_T152_R0.7420.35
3_G167_I0.7410.35
83_E265_T0.7410.35
123_S178_I0.7390.34
65_P181_L0.7370.34
14_H24_A0.7370.34
84_I114_L0.7370.34
105_F177_T0.7360.34
29_A155_A0.7320.34
13_L106_T0.7290.34
140_R143_T0.7270.34
126_K187_T0.7260.34
96_M156_E0.7250.33
114_L239_E0.7250.33
235_D247_G0.7230.33
152_R257_Y0.7220.33
50_I56_D0.7210.33
134_Y257_Y0.7200.33
82_G106_T0.7130.33
71_Q105_F0.7100.32
5_D82_G0.7090.32
31_V34_E0.7060.32
153_R198_W0.7060.32
147_D184_D0.7050.32
68_Y167_I0.7030.32
1_F24_A0.7020.32
36_R39_K0.7010.32
176_L215_P0.6990.32
71_Q96_M0.6990.32
17_L189_E0.6970.32
214_V227_N0.6960.32
123_S133_L0.6950.32
235_D238_S0.6930.31
144_T223_F0.6930.31
24_A97_F0.6920.31
201_Y211_T0.6910.31
11_F190_D0.6890.31
170_S175_R0.6860.31
33_E220_K0.6820.31
54_P59_L0.6810.31
110_L182_D0.6800.31
161_D175_R0.6790.30
80_L183_T0.6790.30
143_T148_E0.6770.30
152_R185_D0.6760.30
99_I135_E0.6750.30
43_P47_L0.6710.30
179_Q182_D0.6700.30
15_Q150_V0.6700.30
239_E242_K0.6690.30
7_F82_G0.6640.30
72_F101_A0.6620.29
18_Y86_Q0.6600.29
185_D211_T0.6600.29
7_F102_Y0.6590.29
85_D88_K0.6570.29
156_E183_T0.6570.29
222_P226_R0.6500.29
260_F267_D0.6500.29
85_D138_R0.6490.29
196_E218_E0.6480.29
188_P199_S0.6470.28
23_K89_F0.6460.28
69_Y119_Q0.6450.28
166_R180_L0.6420.28
153_R187_T0.6410.28
159_L215_P0.6400.28
125_E129_E0.6400.28
50_I59_L0.6390.28
41_N49_L0.6370.28
246_N267_D0.6360.28
153_R156_E0.6350.28
136_Y154_N0.6320.28
49_L159_L0.6310.28
190_D203_E0.6300.27
10_F14_H0.6300.27
107_L137_E0.6290.27
86_Q116_K0.6290.27
28_E40_A0.6260.27
25_K204_S0.6260.27
113_A152_R0.6250.27
165_F193_S0.6240.27
232_R239_E0.6230.27
8_Y109_K0.6230.27
39_K47_L0.6200.27
69_Y96_M0.6200.27
260_F266_E0.6170.27
92_T96_M0.6150.27
144_T259_L0.6140.27
123_S264_G0.6130.26
78_N118_L0.6110.26
217_S225_K0.6110.26
90_E267_D0.6110.26
155_A164_L0.6100.26
36_R45_V0.6100.26
11_F217_S0.6080.26
67_D84_I0.6050.26
149_I207_S0.6020.26
75_M95_E0.6020.26
247_G252_I0.6000.26
2_F164_L0.5990.26
34_E40_A0.5990.26
112_Q124_D0.5980.26
162_E266_E0.5970.26
63_V265_T0.5960.25
200_Y205_Y0.5930.25
218_E222_P0.5930.25
226_R247_G0.5900.25
97_F101_A0.5900.25
101_A160_K0.5840.25
3_G140_R0.5810.25
217_S221_P0.5780.24
112_Q195_E0.5780.24
187_T200_Y0.5780.24
72_F182_D0.5760.24
256_S259_L0.5750.24
198_W254_L0.5740.24
250_C259_L0.5740.24
68_Y95_E0.5720.24
24_A98_G0.5700.24
234_D240_E0.5690.24
216_R243_A0.5690.24
51_D159_L0.5680.24
248_L253_C0.5680.24
136_Y140_R0.5660.24
222_P248_L0.5650.24
171_P174_K0.5640.24
19_E82_G0.5630.24
10_F111_I0.5600.23
229_R253_C0.5580.23
85_D171_P0.5570.23
232_R235_D0.5560.23
200_Y213_G0.5560.23
80_L180_L0.5560.23
101_A119_Q0.5540.23
129_E152_R0.5530.23
93_L167_I0.5510.23
102_Y109_K0.5510.23
45_V53_Q0.5500.23
188_P195_E0.5500.23
141_K185_D0.5470.23
42_K47_L0.5460.23
199_S255_N0.5450.23
75_M92_T0.5390.22
114_L145_F0.5380.22
99_I269_L0.5340.22
73_L156_E0.5280.22
118_L225_K0.5270.22
101_A156_E0.5260.22
230_K264_G0.5260.22
75_M84_I0.5260.22
12_R20_R0.5250.22
129_E134_Y0.5230.22
207_S210_P0.5180.21
39_K49_L0.5150.21
182_D253_C0.5150.21
241_E259_L0.5140.21
159_L255_N0.5130.21
69_Y201_Y0.5120.21
96_M150_V0.5120.21
14_H169_W0.5110.21
114_L167_I0.5110.21
128_Q188_P0.5050.21
24_A55_P0.5040.21
68_Y74_E0.5040.21
122_V150_V0.5020.20
92_T165_F0.5010.20
157_K169_W0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q86A 3 0.4498 71 0.945 Contact Map
2d5rA 1 0.3271 15.3 0.963 Contact Map
3ak8A 6 0.4387 8.1 0.967 Contact Map
2czyA 1 0.2862 6.1 0.969 Contact Map
3shgB 1 0.2268 5.8 0.969 Contact Map
4nuxA 1 0.2268 4.5 0.971 Contact Map
1g1eB 1 0.3197 4 0.971 Contact Map
1e91A 1 0.316 3.9 0.972 Contact Map
1v74B 1 0.3234 3.8 0.972 Contact Map
2c2uA 6 0.4572 3.8 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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