GREMLIN Database
DUF5061 - 17 kDa common-antigen outer membrane protein
PFAM: PF16587 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 103 (96)
Sequences: 563 (466)
Seq/√Len: 47.5
META: 0.86

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_A28_L2.6531.00
66_Q72_Y2.5901.00
65_Y69_S2.5401.00
65_Y68_A2.4901.00
77_T80_V2.4081.00
93_Q97_S2.3171.00
23_A28_L2.2661.00
32_A59_V2.1841.00
45_T60_T2.1591.00
29_A32_A2.1381.00
35_Q39_T2.0270.99
69_S89_T1.9200.99
36_A40_A1.7260.98
38_E92_R1.7120.98
73_C91_C1.6810.98
34_Q37_L1.6480.98
71_R99_K1.6240.98
8_L11_A1.5940.97
63_R75_E1.5750.97
37_L61_P1.5540.97
12_G16_T1.4870.96
78_V83_G1.4460.95
69_S99_K1.4060.94
45_T58_T1.3690.93
34_Q90_A1.3650.93
27_A68_A1.3500.93
37_L67_A1.3190.92
53_S88_G1.3080.92
73_C98_W1.2860.91
6_A11_A1.2410.89
78_V87_Y1.2380.89
37_L90_A1.2100.88
40_A46_S1.2080.88
48_W57_G1.1580.86
71_R76_L1.1450.85
76_L79_T1.1380.85
61_P90_A1.1250.84
8_L13_C1.1140.84
59_V78_V1.1100.83
74_R93_Q1.1060.83
50_N57_G1.1010.83
33_A36_A1.0920.82
64_T74_R1.0850.82
14_A17_P1.0680.81
33_A68_A1.0570.80
79_T84_E1.0460.80
50_N53_S1.0420.79
27_A31_Q1.0370.79
30_A84_E1.0320.79
27_A32_A1.0290.78
48_W53_S1.0230.78
91_C98_W1.0120.77
49_A68_A0.9690.74
18_G92_R0.9580.73
76_L88_G0.9450.72
41_P94_P0.9360.72
38_E64_T0.9340.71
19_K27_A0.9290.71
28_L31_Q0.9210.70
18_G21_L0.9150.70
74_R96_G0.8960.68
24_A27_A0.8950.68
7_L15_T0.8930.68
13_C68_A0.8910.68
11_A17_P0.8850.67
65_Y89_T0.8830.67
76_L84_E0.8800.67
48_W95_D0.8760.66
76_L80_V0.8540.64
53_S56_S0.8540.64
44_Q47_T0.8460.64
33_A37_L0.8430.63
76_L100_I0.8420.63
69_S76_L0.8420.63
43_G53_S0.8370.63
66_Q89_T0.8350.63
35_Q67_A0.8330.63
36_A61_P0.8310.62
37_L42_T0.8030.60
86_A99_K0.8000.59
26_Q31_Q0.7900.58
23_A27_A0.7880.58
93_Q96_G0.7780.57
21_L29_A0.7750.57
35_Q97_S0.7720.57
90_A95_D0.7680.56
80_V83_G0.7670.56
6_A9_L0.7390.53
35_Q45_T0.7380.53
28_L35_Q0.7380.53
24_A30_A0.7370.53
52_D94_P0.7290.52
30_A39_T0.7240.52
27_A30_A0.7220.52
76_L83_G0.7160.51
51_P54_G0.7100.50
39_T71_R0.7100.50
50_N55_N0.7040.50
25_D57_G0.6970.49
32_A36_A0.6890.48
20_S23_A0.6880.48
78_V88_G0.6860.48
81_G85_A0.6780.47
53_S74_R0.6740.47
53_S89_T0.6680.46
68_A71_R0.6650.46
44_Q75_E0.6600.45
30_A69_S0.6590.45
23_A29_A0.6540.45
53_S76_L0.6510.45
36_A57_G0.6480.44
67_A76_L0.6430.44
67_A71_R0.6390.43
38_E72_Y0.6390.43
39_T72_Y0.6350.43
41_P44_Q0.6170.41
7_L11_A0.6030.40
80_V84_E0.6030.40
62_T69_S0.6000.40
77_T81_G0.5970.39
8_L78_V0.5960.39
10_L72_Y0.5960.39
71_R89_T0.5900.39
51_P92_R0.5830.38
25_D29_A0.5800.38
19_K22_D0.5660.36
75_E83_G0.5660.36
62_T100_I0.5660.36
40_A63_R0.5620.36
12_G84_E0.5540.35
21_L25_D0.5480.35
61_P75_E0.5470.35
24_A41_P0.5420.34
7_L92_R0.5330.33
42_T97_S0.5300.33
22_D95_D0.5270.33
63_R67_A0.5250.33
7_L23_A0.5240.33
12_G87_Y0.5230.33
24_A82_G0.5210.32
23_A30_A0.5200.32
46_S68_A0.5090.31
36_A44_Q0.5010.31
7_L25_D0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbiC 1 0.2621 26.2 0.878 Contact Map
1ru4A 1 0.9126 10.7 0.898 Contact Map
1w7fA 1 0.7087 10.2 0.899 Contact Map
3pmqA 1 0.4369 8.5 0.902 Contact Map
3draB 1 0.8932 6 0.909 Contact Map
3ucpA 1 0.534 5.2 0.911 Contact Map
1yr2A 1 0.699 5.2 0.911 Contact Map
4u6bA 3 0.4175 4.6 0.914 Contact Map
2mhkA 1 0.932 4.6 0.914 Contact Map
4fajA 1 0.5825 4.3 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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