GREMLIN Database
SWIRM-assoc_1 - SWIRM-associated region 1
PFAM: PF16495 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (79)
Sequences: 657 (452)
Seq/√Len: 50.8
META: 0.298

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_A9_A4.8481.00
64_Q68_E3.3511.00
21_E29_L3.1731.00
21_E24_R2.9891.00
43_Q46_E1.8650.99
57_Q73_K1.7600.99
12_K16_D1.7330.99
74_K78_E1.6950.99
48_E54_E1.6760.98
76_V79_V1.6380.98
4_L7_A1.6250.98
10_K23_Q1.5800.98
52_E56_R1.5430.97
44_F71_A1.5150.97
52_E61_Q1.4900.97
42_K53_A1.4760.96
41_L63_Q1.4500.96
31_E35_K1.4040.95
53_A56_R1.3640.94
60_R63_Q1.3610.94
56_R76_V1.3600.94
67_L70_L1.3480.94
58_L71_A1.3270.94
8_A15_A1.3210.93
59_E65_L1.3070.93
27_A30_V1.2500.91
3_A29_L1.1820.89
31_E34_L1.1520.88
55_R58_L1.1500.87
57_Q67_L1.1380.87
7_A10_K1.1340.87
21_E33_Q1.1260.86
11_A47_L1.1190.86
34_L42_K1.1180.86
75_R78_E1.1150.86
36_K48_E1.0850.84
40_K68_E1.0730.83
23_Q34_L1.0430.82
39_L42_K1.0250.81
25_L36_K1.0220.80
48_E65_L1.0220.80
59_E62_R1.0180.80
23_Q29_L1.0130.80
8_A11_A1.0030.79
10_K20_R1.0000.79
44_F50_I0.9860.78
39_L44_F0.9830.78
66_F72_L0.9670.77
9_A12_K0.9580.76
33_Q78_E0.9570.76
41_L45_E0.9300.74
26_V64_Q0.9030.71
22_I33_Q0.8780.69
32_L52_E0.8580.68
22_I29_L0.8500.67
26_V32_L0.8380.66
18_E25_L0.8320.65
63_Q66_F0.8310.65
30_V52_E0.8250.64
18_E24_R0.8240.64
57_Q61_Q0.8220.64
10_K25_L0.8180.64
9_A56_R0.8030.62
36_K69_R0.7800.60
26_V29_L0.7650.59
59_E63_Q0.7610.58
51_L64_Q0.7590.58
16_D20_R0.7440.56
55_R59_E0.7260.55
50_I54_E0.7200.54
38_E53_A0.7130.53
27_A44_F0.7120.53
44_F59_E0.6990.52
60_R70_L0.6940.51
33_Q58_L0.6830.50
39_L51_L0.6730.49
72_L76_V0.6730.49
5_A25_L0.6610.48
30_V34_L0.6600.48
72_L78_E0.6590.48
56_R67_L0.6550.47
31_E66_F0.6470.47
12_K23_Q0.6470.47
67_L79_V0.6440.46
67_L71_A0.6400.46
23_Q27_A0.6370.45
47_L58_L0.6360.45
77_L80_Q0.6340.45
40_K47_L0.6330.45
10_K63_Q0.6180.44
67_L72_L0.6140.43
24_R38_E0.6120.43
20_R24_R0.6100.43
49_A60_R0.6070.42
71_A75_R0.6060.42
11_A32_L0.6060.42
25_L62_R0.6050.42
14_L68_E0.5950.41
58_L62_R0.5930.41
73_K77_L0.5820.40
20_R66_F0.5680.39
3_A14_L0.5670.38
6_A10_K0.5600.38
17_Q62_R0.5600.38
12_K79_V0.5600.38
30_V56_R0.5600.38
12_K21_E0.5570.37
37_L46_E0.5550.37
5_A8_A0.5470.37
33_Q37_L0.5330.35
38_E42_K0.5240.34
13_L34_L0.5190.34
16_D22_I0.5160.34
33_Q61_Q0.5100.33
3_A6_A0.5100.33
37_L40_K0.5050.33
35_K80_Q0.5020.32
21_E76_V0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cgkA 3 1 4.5 0.873 Contact Map
2jeeA 2 0.8916 2.6 0.888 Contact Map
2qagB 1 0.0964 2.3 0.891 Contact Map
3vkgA 2 0.9036 2.2 0.892 Contact Map
4r3zA 1 0.7229 1.8 0.897 Contact Map
4iloA 3 0.759 1.8 0.898 Contact Map
2wt7B 1 0.8193 1.8 0.898 Contact Map
2xv5A 2 0.6265 1.6 0.901 Contact Map
3q8tA 2 1 1.6 0.901 Contact Map
1gk6A 2 0.5663 1.5 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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