GREMLIN Database
DUF5058 - Domain of unknown function (DUF5058)
PFAM: PF16481 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 224 (223)
Sequences: 991 (771)
Seq/√Len: 51.6
META: 0.768

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_V222_I6.7031.00
31_A41_L6.1161.00
30_R33_E4.8861.00
32_K38_K4.8811.00
28_W41_L4.2291.00
28_W45_I3.7341.00
74_L117_A3.7241.00
37_D40_K3.3741.00
28_W32_K3.3611.00
149_D152_W3.2371.00
190_L194_L2.9921.00
9_A13_I2.9311.00
38_K42_K2.8141.00
124_I127_G2.7711.00
201_L204_K2.6831.00
62_G85_A2.5921.00
28_W31_A2.5811.00
9_A77_L2.4861.00
25_R29_K2.4091.00
45_I48_S2.3841.00
152_W156_L2.3781.00
108_M116_I2.3201.00
184_I188_A2.2471.00
137_K140_K2.2371.00
10_G14_L2.2341.00
17_L21_V2.1591.00
87_Y123_G2.1101.00
66_L75_P2.1001.00
92_A103_L1.9981.00
169_L189_L1.8680.99
99_M112_A1.8370.99
41_L45_I1.7940.99
56_S59_I1.6990.99
199_L218_I1.6830.99
69_S89_L1.6760.98
203_A211_L1.6570.98
11_I14_L1.6440.98
93_T97_E1.6380.98
70_L75_P1.6200.98
30_R34_L1.5670.98
95_A116_I1.5480.97
194_L198_I1.5480.97
32_K41_L1.4690.96
76_W79_L1.4590.96
4_F8_L1.4270.96
97_E129_I1.4240.96
198_I211_L1.4080.95
21_V25_R1.3700.95
65_A89_L1.3560.94
220_M224_M1.3420.94
131_V135_T1.3390.94
187_I202_L1.3300.94
191_V195_V1.3210.94
75_P80_S1.3130.93
13_I75_P1.2920.93
18_A22_F1.2810.93
76_W80_S1.2560.92
163_G196_M1.2540.92
44_A48_S1.2470.92
96_A134_F1.2160.90
6_W72_G1.1970.90
138_L141_G1.1970.90
138_L142_L1.1920.90
3_P7_I1.1910.90
220_M223_G1.1800.89
74_L120_M1.1780.89
196_M215_A1.1740.89
61_I221_L1.1620.88
43_K46_R1.1600.88
7_I11_I1.1470.88
134_F137_K1.1420.87
10_G202_L1.1410.87
101_V105_G1.1370.87
36_M41_L1.1160.86
25_R33_E1.1120.86
31_A34_L1.1120.86
202_L208_I1.1050.86
74_L95_A1.0780.84
202_L206_K1.0760.84
109_T112_A1.0720.84
91_A119_V1.0640.83
141_G144_K1.0480.83
205_K211_L1.0450.82
218_I222_I1.0420.82
130_L134_F1.0300.81
96_A108_M1.0260.81
219_S223_G1.0200.81
51_F212_K1.0070.80
31_A60_L1.0070.80
85_A89_L1.0060.80
48_S51_F1.0040.80
188_A192_S0.9890.79
206_K211_L0.9840.78
45_I49_A0.9770.78
54_G214_F0.9750.78
144_K147_K0.9740.78
24_L45_I0.9730.78
201_L205_K0.9580.76
21_V28_W0.9560.76
209_K218_I0.9510.76
187_I191_V0.9470.76
122_L145_L0.9390.75
6_W73_P0.9260.74
109_T115_T0.9240.74
22_F25_R0.9230.74
74_L121_T0.9210.74
66_L95_A0.9160.73
128_L131_V0.9090.73
195_V223_G0.9090.73
17_L111_Q0.9080.73
31_A36_M0.9040.72
22_F42_K0.8990.72
20_S64_I0.8930.71
82_I103_L0.8850.71
73_P196_M0.8770.70
58_A84_S0.8760.70
159_A163_G0.8760.70
201_L206_K0.8680.69
133_L137_K0.8660.69
175_K193_A0.8580.68
114_A118_W0.8560.68
202_L211_L0.8540.68
23_F27_A0.8410.67
203_A208_I0.8400.67
6_W54_G0.8390.66
95_A112_A0.8390.66
20_S91_A0.8320.66
179_G182_G0.8320.66
52_S163_G0.8310.66
7_I10_G0.8240.65
54_G127_G0.8240.65
52_S56_S0.8220.65
198_I202_L0.8190.65
101_V112_A0.8180.64
28_W38_K0.8170.64
146_K150_P0.8160.64
192_S223_G0.8140.64
96_A116_I0.8090.64
46_R213_E0.8070.63
79_L120_M0.8000.63
87_Y91_A0.7990.63
195_V219_S0.7930.62
54_G58_A0.7900.62
51_F163_G0.7900.62
90_M93_T0.7780.61
42_K46_R0.7700.60
149_D214_F0.7630.59
183_W187_I0.7500.58
82_I131_V0.7490.58
96_A101_V0.7480.58
200_G221_L0.7460.57
187_I223_G0.7440.57
93_T123_G0.7400.57
2_S9_A0.7390.57
53_I111_Q0.7380.57
14_L18_A0.7370.56
101_V113_F0.7350.56
53_I223_G0.7330.56
58_A217_P0.7310.56
5_L205_K0.7300.56
4_F7_I0.7290.56
29_K197_A0.7290.56
95_A128_L0.7220.55
44_A54_G0.7210.55
79_L91_A0.7200.55
210_W218_I0.7190.55
197_A201_L0.7190.55
65_A73_P0.7120.54
12_V81_V0.7100.54
173_L186_L0.7080.53
60_L166_S0.7070.53
40_K44_A0.7070.53
16_V19_Q0.7040.53
200_G215_A0.7040.53
38_K41_L0.7030.53
204_K207_K0.7030.53
51_F164_M0.7020.53
181_G194_L0.7000.53
33_E37_D0.6990.52
48_S52_S0.6990.52
84_S89_L0.6970.52
136_K140_K0.6960.52
182_G185_P0.6940.52
24_L27_A0.6930.52
74_L119_V0.6920.52
56_S187_I0.6900.52
17_L57_I0.6890.51
13_I70_L0.6890.51
62_G87_Y0.6870.51
63_V136_K0.6870.51
122_L126_G0.6840.51
118_W122_L0.6830.51
174_A177_G0.6830.51
138_L157_S0.6820.51
131_V217_P0.6820.51
43_K191_V0.6800.51
206_K218_I0.6770.50
127_G165_F0.6770.50
31_A35_G0.6730.50
29_K33_E0.6710.50
160_A214_F0.6710.50
185_P188_A0.6690.49
119_V135_T0.6630.49
62_G89_L0.6630.49
29_K122_L0.6620.49
20_S125_I0.6620.49
199_L213_E0.6590.48
113_F161_F0.6570.48
11_I198_I0.6560.48
191_V194_L0.6550.48
176_G179_G0.6540.48
127_G164_M0.6530.48
98_A112_A0.6500.47
208_I211_L0.6490.47
68_A221_L0.6420.47
179_G183_W0.6410.46
196_M220_M0.6390.46
5_L74_L0.6380.46
5_L140_K0.6370.46
94_I98_A0.6370.46
19_Q118_W0.6350.46
28_W36_M0.6340.46
39_E43_K0.6310.45
32_K42_K0.6310.45
209_K212_K0.6290.45
70_L84_S0.6280.45
58_A216_L0.6280.45
193_A196_M0.6260.45
90_M168_F0.6230.45
42_K202_L0.6230.45
66_L193_A0.6220.44
82_I115_T0.6200.44
72_G75_P0.6200.44
56_S121_T0.6160.44
67_S116_I0.6120.43
130_L190_L0.6060.43
62_G124_I0.6050.43
102_S140_K0.6040.43
5_L211_L0.6030.43
51_F161_F0.6010.42
142_L146_K0.6010.42
188_A223_G0.6000.42
84_S90_M0.6000.42
132_P167_A0.5960.42
77_L121_T0.5940.42
29_K39_E0.5900.41
172_Y220_M0.5900.41
191_V222_I0.5870.41
60_L85_A0.5860.41
5_L56_S0.5850.41
42_K49_A0.5840.41
34_L75_P0.5840.41
51_F59_I0.5830.41
134_F223_G0.5810.40
53_I198_I0.5810.40
63_V95_A0.5800.40
13_I175_K0.5790.40
163_G220_M0.5780.40
14_L150_P0.5760.40
29_K36_M0.5730.40
34_L40_K0.5720.39
10_G170_G0.5720.39
130_L142_L0.5720.39
51_F124_I0.5710.39
122_L198_I0.5700.39
58_A132_P0.5700.39
34_L198_I0.5700.39
48_S62_G0.5690.39
24_L28_W0.5690.39
155_I203_A0.5680.39
84_S220_M0.5680.39
73_P210_W0.5680.39
210_W214_F0.5670.39
46_R107_G0.5670.39
32_K35_G0.5650.39
63_V79_L0.5650.39
199_L211_L0.5640.39
213_E221_L0.5640.39
70_L74_L0.5630.39
67_S82_I0.5610.38
91_A95_A0.5600.38
99_M111_Q0.5600.38
57_I85_A0.5580.38
29_K202_L0.5570.38
7_I144_K0.5550.38
116_I120_M0.5550.38
122_L207_K0.5530.38
153_G165_F0.5530.38
40_K80_S0.5520.37
111_Q114_A0.5520.37
67_S165_F0.5460.37
70_L121_T0.5460.37
102_S105_G0.5450.37
203_A212_K0.5450.37
99_M159_A0.5410.36
26_K29_K0.5410.36
160_A164_M0.5380.36
95_A115_T0.5380.36
46_R194_L0.5380.36
129_I209_K0.5360.36
13_I77_L0.5330.36
147_K150_P0.5330.36
10_G132_P0.5320.36
117_A121_T0.5300.35
99_M147_K0.5280.35
66_L89_L0.5280.35
34_L37_D0.5270.35
90_M154_D0.5260.35
210_W219_S0.5250.35
111_Q115_T0.5190.34
62_G108_M0.5160.34
1_N73_P0.5150.34
91_A120_M0.5150.34
18_A143_K0.5140.34
199_L203_A0.5130.34
56_S85_A0.5110.34
124_I160_A0.5110.34
115_T118_W0.5110.34
36_M39_E0.5100.33
180_L183_W0.5100.33
92_A156_L0.5080.33
27_A52_S0.5050.33
152_W164_M0.5050.33
106_A109_T0.5050.33
99_M115_T0.5050.33
25_R37_D0.5040.33
101_V104_G0.5040.33
93_T165_F0.5030.33
133_L162_L0.5020.33
195_V199_L0.5020.33
23_F31_A0.5020.33
162_L166_S0.5000.33
47_S87_Y0.5000.33
111_Q197_A0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lorA 1 0.3214 26.4 0.955 Contact Map
3wdoA 1 0.3705 13.8 0.96 Contact Map
2nq2A 2 0.7857 12.4 0.961 Contact Map
4tphA 2 0.3482 11.3 0.962 Contact Map
4xnjA 1 0.3661 11 0.962 Contact Map
3ne5A 3 0.4777 9 0.963 Contact Map
1jb0I 1 0.1696 6.9 0.965 Contact Map
4pypA 1 0.3348 6.5 0.966 Contact Map
2cfqA 1 0.3571 5.5 0.967 Contact Map
2cwqA 4 0.2946 4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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