GREMLIN Database
DUF5054 - Domain of unknown function (DUF5054)
PFAM: PF16477 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 425 (401)
Sequences: 664 (579)
Seq/√Len: 28.9
META: 0.843

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
371_T374_A4.9011.00
315_L403_F4.2631.00
415_Y419_M4.2131.00
5_Q343_D3.8591.00
67_T112_V3.7921.00
31_L35_W3.5291.00
259_E291_K3.4811.00
86_R113_E3.2281.00
369_I400_F3.0011.00
79_P307_P2.9871.00
408_G413_M2.8731.00
117_A121_A2.8261.00
15_V22_V2.8141.00
180_R189_E2.7751.00
355_V371_T2.6771.00
400_F423_F2.6010.99
207_A211_D2.5990.99
373_D422_R2.5470.99
164_E184_K2.4990.99
150_P153_A2.4680.99
192_S195_H2.4160.99
149_P153_A2.4160.99
347_G389_N2.3830.99
70_Y111_V2.3760.99
210_Y385_L2.3740.99
401_N404_N2.3680.99
200_F283_V2.3610.99
198_G317_L2.2970.99
18_D21_K2.2630.99
221_L228_A2.2080.98
62_T410_N2.2030.98
22_V375_P2.1880.98
10_T349_N2.1880.98
66_D231_D2.1600.98
15_V63_W2.1400.98
9_D14_G2.1160.98
135_R139_R2.1120.98
298_E424_V2.1010.98
68_K231_D2.0790.97
318_S399_H2.0660.97
266_E282_K2.0650.97
172_F263_L2.0630.97
303_W419_M2.0480.97
384_L411_F2.0000.97
16_G376_L1.9930.97
300_T420_R1.9680.96
354_A375_P1.9670.96
79_P309_N1.9560.96
252_L265_A1.9340.96
333_E356_S1.8890.95
200_F269_F1.8760.95
74_F230_K1.8410.95
149_P152_G1.8280.94
205_F314_A1.8250.94
127_V142_L1.8250.94
205_F384_L1.8190.94
200_F315_L1.8140.94
374_A421_F1.8020.94
283_V301_L1.7850.94
352_L379_P1.7740.94
34_E38_E1.7700.93
11_W14_G1.7650.93
349_N391_Q1.7650.93
79_P82_F1.7200.92
255_L265_A1.7180.92
301_L317_L1.7130.92
362_D365_G1.7110.92
73_D76_N1.7030.92
340_S394_L1.6870.92
65_L112_V1.6870.92
352_L411_F1.6820.92
349_N352_L1.6590.91
76_N109_Y1.6580.91
165_T289_L1.6570.91
34_E141_A1.6530.91
170_V289_L1.6420.91
27_E141_A1.6240.90
382_P401_N1.6190.90
79_P83_A1.6130.90
27_E30_R1.6050.89
86_R416_E1.5890.89
30_R422_R1.5870.89
231_D408_G1.5680.88
66_D69_T1.5640.88
332_L355_V1.5410.87
18_D120_R1.5410.87
385_L406_A1.5380.87
237_L312_P1.5360.87
82_F86_R1.5340.87
191_A197_L1.5200.87
203_Q244_S1.5170.87
269_F283_V1.5140.87
68_K227_W1.5050.86
407_W410_N1.5010.86
66_D227_W1.4920.86
358_V398_V1.4720.85
403_F412_P1.4720.85
86_R308_A1.4710.85
13_H349_N1.4650.85
8_G18_D1.4550.84
73_D108_N1.4310.83
383_S386_N1.4290.83
221_L224_R1.4200.83
51_F126_A1.4130.82
207_A237_L1.4090.82
289_L297_I1.4020.82
21_K412_P1.3840.81
303_W421_F1.3740.81
115_S118_E1.3590.80
20_L415_Y1.3530.80
11_W19_P1.3390.79
263_L289_L1.3380.79
348_G353_H1.3340.79
183_D186_S1.3130.77
35_W138_A1.3070.77
202_Y315_L1.2980.77
210_Y214_F1.2840.76
13_H16_G1.2810.76
1_P11_W1.2770.75
29_L335_L1.2760.75
40_K127_V1.2690.75
168_F289_L1.2620.75
35_W137_E1.2570.74
177_A199_L1.2500.74
14_G19_P1.2460.74
68_K408_G1.2450.73
148_A369_I1.2210.72
25_Y29_L1.2210.72
213_F232_F1.2170.72
198_G285_L1.2140.72
357_S368_T1.2130.71
66_D408_G1.2110.71
1_P9_D1.2060.71
279_A283_V1.2000.71
358_V369_I1.1990.71
205_F316_W1.1970.70
212_R216_Q1.1960.70
406_A412_P1.1940.70
124_D128_A1.1930.70
374_A402_L1.1890.70
338_W359_R1.1890.70
374_A400_F1.1880.70
202_Y403_F1.1850.70
165_T290_P1.1780.69
358_V400_F1.1760.69
203_Q316_W1.1750.69
7_I345_V1.1750.69
384_L406_A1.1700.69
115_S227_W1.1660.68
40_K273_A1.1570.68
6_E21_K1.1540.68
60_E64_G1.1480.67
119_Q122_Y1.1410.67
204_T277_Y1.1410.67
404_N410_N1.1350.66
77_Y116_W1.1300.66
214_F224_R1.1270.66
39_G367_L1.1270.66
32_R52_L1.1150.65
24_R124_D1.1080.64
253_A268_R1.1060.64
39_G174_P1.1050.64
9_D19_P1.1010.64
332_L377_V1.0980.64
310_R348_G1.0980.64
87_D110_K1.0940.63
372_L422_R1.0860.63
9_D12_I1.0810.62
250_P269_F1.0800.62
214_F229_I1.0780.62
15_V375_P1.0780.62
208_A211_D1.0760.62
29_L123_L1.0730.62
379_P384_L1.0660.61
1_P19_P1.0660.61
401_N423_F1.0650.61
118_E227_W1.0620.61
405_N409_T1.0610.61
404_N407_W1.0580.61
331_R338_W1.0500.60
131_P388_S1.0380.59
6_E18_D1.0370.59
287_Y299_L1.0330.59
71_L231_D1.0290.59
237_L311_L1.0280.58
3_V117_A1.0270.58
370_E424_V1.0150.57
38_E381_E1.0120.57
8_G21_K1.0060.57
31_L138_A0.9970.56
62_T115_S0.9930.56
387_F401_N0.9880.55
316_W399_H0.9870.55
201_R401_N0.9840.55
191_A198_G0.9840.55
6_E348_G0.9810.55
197_L319_F0.9800.55
352_L376_L0.9800.55
20_L24_R0.9770.55
41_L45_D0.9730.54
202_Y313_E0.9720.54
401_N413_M0.9710.54
57_L79_P0.9700.54
204_T209_D0.9680.54
1_P14_G0.9660.54
172_F265_A0.9640.54
120_R278_G0.9600.53
213_F351_H0.9590.53
119_Q203_Q0.9580.53
390_D393_D0.9580.53
351_H391_Q0.9430.52
165_T168_F0.9420.52
29_L52_L0.9370.51
58_V122_Y0.9330.51
206_S213_F0.9330.51
61_H64_G0.9330.51
180_R200_F0.9310.51
290_P298_E0.9310.51
163_I263_L0.9300.51
56_L309_N0.9300.51
227_W410_N0.9280.51
205_F411_F0.9250.51
274_A307_P0.9220.50
349_N380_G0.9180.50
150_P154_S0.9120.50
68_K115_S0.8970.48
334_K353_H0.8940.48
402_L421_F0.8900.48
113_E413_M0.8890.48
260_D288_T0.8880.48
4_T343_D0.8840.47
198_G299_L0.8820.47
227_W231_D0.8810.47
147_P301_L0.8800.47
25_Y38_E0.8800.47
308_A416_E0.8740.47
350_R391_Q0.8740.47
77_Y119_Q0.8730.46
405_N410_N0.8730.46
65_L70_Y0.8730.46
44_G48_D0.8720.46
208_A243_A0.8720.46
6_E11_W0.8690.46
74_F109_Y0.8660.46
5_Q340_S0.8650.46
74_F85_A0.8650.46
285_L301_L0.8620.46
47_T131_P0.8620.46
12_I21_K0.8610.46
115_S410_N0.8600.45
355_V358_V0.8590.45
123_L309_N0.8590.45
25_Y59_A0.8580.45
406_A411_F0.8560.45
286_E300_T0.8560.45
206_S232_F0.8540.45
330_W379_P0.8530.45
128_A135_R0.8510.45
188_R362_D0.8470.44
113_E308_A0.8460.44
1_P12_I0.8450.44
88_T108_N0.8440.44
54_R125_D0.8430.44
169_T180_R0.8430.44
160_G355_V0.8410.44
235_P408_G0.8400.44
24_R123_L0.8380.44
76_N108_N0.8380.44
58_V416_E0.8370.44
410_N414_W0.8370.44
18_D310_R0.8360.44
80_A127_V0.8350.44
67_T416_E0.8320.43
204_T321_P0.8290.43
346_R360_Y0.8250.43
67_T413_M0.8240.43
203_Q401_N0.8220.43
8_G55_L0.8190.42
109_Y230_K0.8190.42
334_K348_G0.8180.42
115_S334_K0.8170.42
26_R57_L0.8170.42
122_Y126_A0.8150.42
310_R334_K0.8140.42
82_F308_A0.8130.42
371_T421_F0.8110.42
116_W319_F0.8090.42
350_R380_G0.8090.42
129_A355_V0.8090.42
6_E9_D0.8090.42
399_H422_R0.8080.42
188_R365_G0.8020.41
161_E178_I0.8000.41
162_E169_T0.7960.41
309_N412_P0.7950.41
66_D115_S0.7950.41
162_E179_V0.7940.40
225_A229_I0.7930.40
181_L190_W0.7900.40
169_T355_V0.7900.40
251_S285_L0.7890.40
274_A281_R0.7890.40
15_V376_L0.7870.40
404_N409_T0.7860.40
22_V63_W0.7840.40
191_A195_H0.7840.40
140_A143_A0.7810.39
6_E334_K0.7790.39
149_P282_K0.7790.39
32_R48_D0.7790.39
82_F277_Y0.7770.39
221_L351_H0.7740.39
288_T298_E0.7740.39
316_W373_D0.7730.39
65_L123_L0.7720.39
316_W353_H0.7700.39
333_E357_S0.7690.39
62_T227_W0.7680.39
131_P277_Y0.7590.38
316_W384_L0.7570.38
226_D230_K0.7530.37
1_P6_E0.7530.37
358_V375_P0.7490.37
282_K305_G0.7480.37
82_F305_G0.7470.37
51_F70_Y0.7460.37
122_Y236_G0.7450.37
31_L127_V0.7450.37
203_Q284_Y0.7440.37
62_T68_K0.7430.37
66_D71_L0.7420.37
40_K137_E0.7420.37
183_D190_W0.7390.36
121_A124_D0.7380.36
209_D311_L0.7380.36
73_D109_Y0.7370.36
86_R411_F0.7330.36
178_I270_P0.7320.36
402_L414_W0.7300.36
205_F379_P0.7300.36
302_S379_P0.7290.36
10_T304_F0.7280.36
76_N85_A0.7260.35
232_F267_L0.7260.35
171_A180_R0.7230.35
386_N411_F0.7200.35
21_K310_R0.7200.35
347_G352_L0.7180.35
383_S388_S0.7170.35
85_A183_D0.7170.35
306_K313_E0.7170.35
165_T184_K0.7150.35
148_A153_A0.7110.34
411_F416_E0.7080.34
179_V194_D0.7070.34
17_S412_P0.7070.34
182_R187_G0.7050.34
332_L340_S0.7050.34
330_W340_S0.7020.34
57_L332_L0.7000.34
8_G334_K0.6970.33
335_L413_M0.6960.33
10_T350_R0.6960.33
149_P154_S0.6960.33
54_R305_G0.6960.33
13_H213_F0.6940.33
378_A399_H0.6940.33
8_G310_R0.6930.33
23_A26_R0.6930.33
207_A238_E0.6930.33
269_F279_A0.6930.33
415_Y421_F0.6930.33
21_K122_Y0.6900.33
8_G11_W0.6900.33
221_L225_A0.6850.33
216_Q347_G0.6840.33
68_K413_M0.6800.32
122_Y411_F0.6790.32
406_A415_Y0.6790.32
288_T300_T0.6780.32
8_G348_G0.6780.32
110_K184_K0.6780.32
200_F255_L0.6770.32
229_I233_G0.6770.32
108_N351_H0.6760.32
75_D119_Q0.6750.32
10_T127_V0.6750.32
136_A140_A0.6710.32
213_F230_K0.6710.32
203_Q209_D0.6710.32
35_W130_L0.6700.32
362_D367_L0.6660.31
153_A256_Y0.6660.31
74_F112_V0.6660.31
6_E353_H0.6650.31
16_G117_A0.6650.31
371_T400_F0.6650.31
138_A227_W0.6630.31
350_R387_F0.6630.31
327_A372_L0.6620.31
3_V261_A0.6600.31
84_A326_P0.6590.31
235_P312_P0.6590.31
237_L415_Y0.6590.31
76_N81_D0.6590.31
172_F255_L0.6580.31
82_F230_K0.6580.31
67_T74_F0.6570.31
310_R353_H0.6560.31
3_V260_D0.6560.31
17_S321_P0.6530.30
40_K134_L0.6520.30
197_L321_P0.6470.30
167_H290_P0.6460.30
21_K120_R0.6430.30
179_V189_E0.6390.30
279_A403_F0.6370.29
326_P362_D0.6370.29
108_N413_M0.6360.29
74_F111_V0.6360.29
9_D17_S0.6360.29
170_V297_I0.6360.29
77_Y137_E0.6360.29
52_L109_Y0.6350.29
24_R44_G0.6340.29
164_E169_T0.6340.29
77_Y385_L0.6340.29
235_P375_P0.6330.29
23_A145_L0.6320.29
198_G289_L0.6310.29
14_G17_S0.6300.29
41_L57_L0.6300.29
173_D177_A0.6290.29
193_A327_A0.6280.29
111_V205_F0.6270.29
202_Y306_K0.6270.29
212_R384_L0.6260.29
4_T339_V0.6260.29
151_A154_S0.6250.29
163_I172_F0.6250.29
69_T116_W0.6240.29
234_K312_P0.6230.28
122_Y227_W0.6220.28
170_V224_R0.6220.28
65_L236_G0.6210.28
76_N84_A0.6200.28
161_E263_L0.6200.28
118_E312_P0.6200.28
170_V196_P0.6170.28
268_R299_L0.6160.28
374_A419_M0.6150.28
159_P188_R0.6150.28
310_R397_G0.6140.28
302_S420_R0.6120.28
16_G22_V0.6110.28
37_A162_E0.6090.28
113_E187_G0.6080.28
339_V343_D0.6070.27
32_R36_L0.6060.27
299_L307_P0.6050.27
216_Q386_N0.6050.27
11_W60_E0.6050.27
77_Y387_F0.6050.27
79_P274_A0.6030.27
303_W315_L0.6030.27
397_G421_F0.6020.27
227_W408_G0.6010.27
376_L401_N0.6010.27
62_T66_D0.6010.27
203_Q384_L0.6000.27
109_Y223_S0.6000.27
232_F311_L0.5990.27
121_A274_A0.5980.27
48_D52_L0.5980.27
325_D328_G0.5980.27
56_L111_V0.5980.27
285_L365_G0.5960.27
30_R372_L0.5960.27
344_V353_H0.5920.27
3_V148_A0.5920.27
393_D396_G0.5910.27
16_G205_F0.5900.26
209_D212_R0.5900.26
204_T311_L0.5870.26
71_L408_G0.5870.26
214_F233_G0.5860.26
194_D323_V0.5850.26
21_K119_Q0.5850.26
224_R229_I0.5850.26
59_A413_M0.5810.26
48_D51_F0.5810.26
405_N411_F0.5800.26
9_D62_T0.5800.26
151_A251_S0.5800.26
45_D48_D0.5800.26
264_L326_P0.5790.26
311_L330_W0.5780.26
252_L255_L0.5770.26
305_G418_D0.5760.26
10_T217_Y0.5760.26
58_V413_M0.5760.26
393_D397_G0.5750.26
135_R285_L0.5730.25
162_E393_D0.5730.25
11_W17_S0.5720.25
5_Q254_G0.5720.25
12_I17_S0.5710.25
351_H383_S0.5700.25
27_E140_A0.5680.25
58_V119_Q0.5670.25
26_R356_S0.5670.25
85_A109_Y0.5670.25
396_G399_H0.5650.25
159_P175_K0.5650.25
71_L109_Y0.5650.25
34_E107_P0.5650.25
25_Y53_R0.5640.25
345_V374_A0.5630.25
228_A233_G0.5630.25
198_G287_Y0.5630.25
387_F392_P0.5620.25
3_V110_K0.5600.25
203_Q210_Y0.5570.24
6_E14_G0.5560.24
380_G391_Q0.5550.24
58_V86_R0.5550.24
17_S131_P0.5550.24
68_K410_N0.5540.24
168_F417_E0.5530.24
13_H231_D0.5520.24
145_L248_W0.5510.24
170_V178_I0.5510.24
415_Y418_D0.5510.24
213_F223_S0.5510.24
2_V143_A0.5510.24
266_E284_Y0.5510.24
187_G208_A0.5500.24
51_F55_L0.5470.24
402_L407_W0.5470.24
251_S268_R0.5470.24
178_I191_A0.5450.24
226_D300_T0.5440.24
136_A266_E0.5430.24
35_W41_L0.5420.24
56_L289_L0.5420.24
53_R383_S0.5410.24
149_P377_V0.5400.24
171_A179_V0.5390.23
132_A305_G0.5390.23
236_G335_L0.5390.23
13_H17_S0.5390.23
260_D285_L0.5380.23
32_R190_W0.5370.23
30_R373_D0.5360.23
150_P283_V0.5350.23
402_L409_T0.5350.23
184_K290_P0.5350.23
192_S371_T0.5350.23
201_R382_P0.5330.23
191_A398_V0.5320.23
75_D203_Q0.5320.23
398_V401_N0.5310.23
36_L39_G0.5310.23
2_V14_G0.5290.23
314_A376_L0.5290.23
28_L51_F0.5290.23
250_P354_A0.5250.23
404_N414_W0.5250.23
66_D410_N0.5240.23
85_A205_F0.5240.23
116_W310_R0.5240.23
153_A258_E0.5240.23
279_A335_L0.5240.23
11_W61_H0.5200.22
74_F236_G0.5200.22
385_L413_M0.5190.22
258_E297_I0.5190.22
170_V337_E0.5180.22
330_W360_Y0.5170.22
288_T347_G0.5150.22
163_I317_L0.5150.22
224_R228_A0.5140.22
55_L385_L0.5130.22
127_V357_S0.5120.22
203_Q242_A0.5120.22
56_L214_F0.5110.22
107_P111_V0.5100.22
160_G171_A0.5070.22
138_A314_A0.5070.22
311_L406_A0.5060.22
129_A372_L0.5060.22
82_F240_A0.5050.22
72_R108_N0.5050.22
209_D245_R0.5020.21
131_P269_F0.5020.21
192_S322_I0.5020.21
357_S370_E0.5020.21
350_R353_H0.5010.21
193_A325_D0.5010.21
331_R341_P0.5010.21
67_T230_K0.5000.21
4_T26_R0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wyhA 2 0.8729 95.3 0.954 Contact Map
3lvtA 2 0.8612 92.5 0.959 Contact Map
3bvxA 1 0.8588 42.7 0.974 Contact Map
4gywA 2 0.1647 12.5 0.98 Contact Map
4tq2A 2 0.3859 12.5 0.98 Contact Map
1qgiA 1 0.2094 9.8 0.981 Contact Map
4e79A 3 0.1341 6.7 0.982 Contact Map
2q1fA 1 0.1976 6.6 0.982 Contact Map
2xczA 3 0.1482 6.5 0.982 Contact Map
3dkqA 4 0.1459 6.4 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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