DUF5054 - PFAM28P - GREMLIN Contacts

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DUF5054 - Domain of unknown function (DUF5054)

PFAM:	PF16477	Sequences: PVVTQEIGDTWIHGVGSDPLKVARYRELLRLRDEWLAEGKLDPGDATDLAFLRRLLLVAEHTWGLDTKTYLRDFDNYDPADFAAARDTDVVDPDLPRKYEYIGAFAPNYKVVEASWAEQRAYLDDAVAALPAALRAEARAALAALRPAPPAGASKPLDPGEEIETGHFTVAFDPKGAIVRLRDKKSGREWASADHPLGLFRYQTFSAADYDRFFDQYIRNLTSRADWAIKDFGKPGLERAGAASRTRWLPSLAGLYVEEDADLLAELRFPDEAAEEYGAPRKVYLEYTLPKDAEPVIELTLSWFGKPANRLPEALWLSFNPIVPDPAGGWRLEKLGEWVSPLDVVRGGNRHLHAVSSVRYRDADGSLTIETLDAPLVAPGEPSLLNFSNDQPDLSGGVHFNLFNNAWGTNFPMWYEEDMRFRFVL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	425 (401)
Sequences:	664 (579)
Seq/√Len:	28.9
META:	0.843

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
371_T	374_A	4.901	1.00
315_L	403_F	4.263	1.00
415_Y	419_M	4.213	1.00
5_Q	343_D	3.859	1.00
67_T	112_V	3.792	1.00
31_L	35_W	3.529	1.00
259_E	291_K	3.481	1.00
86_R	113_E	3.228	1.00
369_I	400_F	3.001	1.00
79_P	307_P	2.987	1.00
408_G	413_M	2.873	1.00
117_A	121_A	2.826	1.00
15_V	22_V	2.814	1.00
180_R	189_E	2.775	1.00
355_V	371_T	2.677	1.00
400_F	423_F	2.601	0.99
207_A	211_D	2.599	0.99
373_D	422_R	2.547	0.99
164_E	184_K	2.499	0.99
150_P	153_A	2.468	0.99
192_S	195_H	2.416	0.99
149_P	153_A	2.416	0.99
347_G	389_N	2.383	0.99
70_Y	111_V	2.376	0.99
210_Y	385_L	2.374	0.99
401_N	404_N	2.368	0.99
200_F	283_V	2.361	0.99
198_G	317_L	2.297	0.99
18_D	21_K	2.263	0.99
221_L	228_A	2.208	0.98
62_T	410_N	2.203	0.98
22_V	375_P	2.188	0.98
10_T	349_N	2.188	0.98
66_D	231_D	2.160	0.98
15_V	63_W	2.140	0.98
9_D	14_G	2.116	0.98
135_R	139_R	2.112	0.98
298_E	424_V	2.101	0.98
68_K	231_D	2.079	0.97
318_S	399_H	2.066	0.97
266_E	282_K	2.065	0.97
172_F	263_L	2.063	0.97
303_W	419_M	2.048	0.97
384_L	411_F	2.000	0.97
16_G	376_L	1.993	0.97
300_T	420_R	1.968	0.96
354_A	375_P	1.967	0.96
79_P	309_N	1.956	0.96
252_L	265_A	1.934	0.96
333_E	356_S	1.889	0.95
200_F	269_F	1.876	0.95
74_F	230_K	1.841	0.95
149_P	152_G	1.828	0.94
205_F	314_A	1.825	0.94
127_V	142_L	1.825	0.94
205_F	384_L	1.819	0.94
200_F	315_L	1.814	0.94
374_A	421_F	1.802	0.94
283_V	301_L	1.785	0.94
352_L	379_P	1.774	0.94
34_E	38_E	1.770	0.93
11_W	14_G	1.765	0.93
349_N	391_Q	1.765	0.93
79_P	82_F	1.720	0.92
255_L	265_A	1.718	0.92
301_L	317_L	1.713	0.92
362_D	365_G	1.711	0.92
73_D	76_N	1.703	0.92
340_S	394_L	1.687	0.92
65_L	112_V	1.687	0.92
352_L	411_F	1.682	0.92
349_N	352_L	1.659	0.91
76_N	109_Y	1.658	0.91
165_T	289_L	1.657	0.91
34_E	141_A	1.653	0.91
170_V	289_L	1.642	0.91
27_E	141_A	1.624	0.90
382_P	401_N	1.619	0.90
79_P	83_A	1.613	0.90
27_E	30_R	1.605	0.89
86_R	416_E	1.589	0.89
30_R	422_R	1.587	0.89
231_D	408_G	1.568	0.88
66_D	69_T	1.564	0.88
332_L	355_V	1.541	0.87
18_D	120_R	1.541	0.87
385_L	406_A	1.538	0.87
237_L	312_P	1.536	0.87
82_F	86_R	1.534	0.87
191_A	197_L	1.520	0.87
203_Q	244_S	1.517	0.87
269_F	283_V	1.514	0.87
68_K	227_W	1.505	0.86
407_W	410_N	1.501	0.86
66_D	227_W	1.492	0.86
358_V	398_V	1.472	0.85
403_F	412_P	1.472	0.85
86_R	308_A	1.471	0.85
13_H	349_N	1.465	0.85
8_G	18_D	1.455	0.84
73_D	108_N	1.431	0.83
383_S	386_N	1.429	0.83
221_L	224_R	1.420	0.83
51_F	126_A	1.413	0.82
207_A	237_L	1.409	0.82
289_L	297_I	1.402	0.82
21_K	412_P	1.384	0.81
303_W	421_F	1.374	0.81
115_S	118_E	1.359	0.80
20_L	415_Y	1.353	0.80
11_W	19_P	1.339	0.79
263_L	289_L	1.338	0.79
348_G	353_H	1.334	0.79
183_D	186_S	1.313	0.77
35_W	138_A	1.307	0.77
202_Y	315_L	1.298	0.77
210_Y	214_F	1.284	0.76
13_H	16_G	1.281	0.76
1_P	11_W	1.277	0.75
29_L	335_L	1.276	0.75
40_K	127_V	1.269	0.75
168_F	289_L	1.262	0.75
35_W	137_E	1.257	0.74
177_A	199_L	1.250	0.74
14_G	19_P	1.246	0.74
68_K	408_G	1.245	0.73
148_A	369_I	1.221	0.72
25_Y	29_L	1.221	0.72
213_F	232_F	1.217	0.72
198_G	285_L	1.214	0.72
357_S	368_T	1.213	0.71
66_D	408_G	1.211	0.71
1_P	9_D	1.206	0.71
279_A	283_V	1.200	0.71
358_V	369_I	1.199	0.71
205_F	316_W	1.197	0.70
212_R	216_Q	1.196	0.70
406_A	412_P	1.194	0.70
124_D	128_A	1.193	0.70
374_A	402_L	1.189	0.70
338_W	359_R	1.189	0.70
374_A	400_F	1.188	0.70
202_Y	403_F	1.185	0.70
165_T	290_P	1.178	0.69
358_V	400_F	1.176	0.69
203_Q	316_W	1.175	0.69
7_I	345_V	1.175	0.69
384_L	406_A	1.170	0.69
115_S	227_W	1.166	0.68
40_K	273_A	1.157	0.68
6_E	21_K	1.154	0.68
60_E	64_G	1.148	0.67
119_Q	122_Y	1.141	0.67
204_T	277_Y	1.141	0.67
404_N	410_N	1.135	0.66
77_Y	116_W	1.130	0.66
214_F	224_R	1.127	0.66
39_G	367_L	1.127	0.66
32_R	52_L	1.115	0.65
24_R	124_D	1.108	0.64
253_A	268_R	1.106	0.64
39_G	174_P	1.105	0.64
9_D	19_P	1.101	0.64
332_L	377_V	1.098	0.64
310_R	348_G	1.098	0.64
87_D	110_K	1.094	0.63
372_L	422_R	1.086	0.63
9_D	12_I	1.081	0.62
250_P	269_F	1.080	0.62
214_F	229_I	1.078	0.62
15_V	375_P	1.078	0.62
208_A	211_D	1.076	0.62
29_L	123_L	1.073	0.62
379_P	384_L	1.066	0.61
1_P	19_P	1.066	0.61
401_N	423_F	1.065	0.61
118_E	227_W	1.062	0.61
405_N	409_T	1.061	0.61
404_N	407_W	1.058	0.61
331_R	338_W	1.050	0.60
131_P	388_S	1.038	0.59
6_E	18_D	1.037	0.59
287_Y	299_L	1.033	0.59
71_L	231_D	1.029	0.59
237_L	311_L	1.028	0.58
3_V	117_A	1.027	0.58
370_E	424_V	1.015	0.57
38_E	381_E	1.012	0.57
8_G	21_K	1.006	0.57
31_L	138_A	0.997	0.56
62_T	115_S	0.993	0.56
387_F	401_N	0.988	0.55
316_W	399_H	0.987	0.55
201_R	401_N	0.984	0.55
191_A	198_G	0.984	0.55
6_E	348_G	0.981	0.55
197_L	319_F	0.980	0.55
352_L	376_L	0.980	0.55
20_L	24_R	0.977	0.55
41_L	45_D	0.973	0.54
202_Y	313_E	0.972	0.54
401_N	413_M	0.971	0.54
57_L	79_P	0.970	0.54
204_T	209_D	0.968	0.54
1_P	14_G	0.966	0.54
172_F	265_A	0.964	0.54
120_R	278_G	0.960	0.53
213_F	351_H	0.959	0.53
119_Q	203_Q	0.958	0.53
390_D	393_D	0.958	0.53
351_H	391_Q	0.943	0.52
165_T	168_F	0.942	0.52
29_L	52_L	0.937	0.51
58_V	122_Y	0.933	0.51
206_S	213_F	0.933	0.51
61_H	64_G	0.933	0.51
180_R	200_F	0.931	0.51
290_P	298_E	0.931	0.51
163_I	263_L	0.930	0.51
56_L	309_N	0.930	0.51
227_W	410_N	0.928	0.51
205_F	411_F	0.925	0.51
274_A	307_P	0.922	0.50
349_N	380_G	0.918	0.50
150_P	154_S	0.912	0.50
68_K	115_S	0.897	0.48
334_K	353_H	0.894	0.48
402_L	421_F	0.890	0.48
113_E	413_M	0.889	0.48
260_D	288_T	0.888	0.48
4_T	343_D	0.884	0.47
198_G	299_L	0.882	0.47
227_W	231_D	0.881	0.47
147_P	301_L	0.880	0.47
25_Y	38_E	0.880	0.47
308_A	416_E	0.874	0.47
350_R	391_Q	0.874	0.47
77_Y	119_Q	0.873	0.46
405_N	410_N	0.873	0.46
65_L	70_Y	0.873	0.46
44_G	48_D	0.872	0.46
208_A	243_A	0.872	0.46
6_E	11_W	0.869	0.46
74_F	109_Y	0.866	0.46
5_Q	340_S	0.865	0.46
74_F	85_A	0.865	0.46
285_L	301_L	0.862	0.46
47_T	131_P	0.862	0.46
12_I	21_K	0.861	0.46
115_S	410_N	0.860	0.45
355_V	358_V	0.859	0.45
123_L	309_N	0.859	0.45
25_Y	59_A	0.858	0.45
406_A	411_F	0.856	0.45
286_E	300_T	0.856	0.45
206_S	232_F	0.854	0.45
330_W	379_P	0.853	0.45
128_A	135_R	0.851	0.45
188_R	362_D	0.847	0.44
113_E	308_A	0.846	0.44
1_P	12_I	0.845	0.44
88_T	108_N	0.844	0.44
54_R	125_D	0.843	0.44
169_T	180_R	0.843	0.44
160_G	355_V	0.841	0.44
235_P	408_G	0.840	0.44
24_R	123_L	0.838	0.44
76_N	108_N	0.838	0.44
58_V	416_E	0.837	0.44
410_N	414_W	0.837	0.44
18_D	310_R	0.836	0.44
80_A	127_V	0.835	0.44
67_T	416_E	0.832	0.43
204_T	321_P	0.829	0.43
346_R	360_Y	0.825	0.43
67_T	413_M	0.824	0.43
203_Q	401_N	0.822	0.43
8_G	55_L	0.819	0.42
109_Y	230_K	0.819	0.42
334_K	348_G	0.818	0.42
115_S	334_K	0.817	0.42
26_R	57_L	0.817	0.42
122_Y	126_A	0.815	0.42
310_R	334_K	0.814	0.42
82_F	308_A	0.813	0.42
371_T	421_F	0.811	0.42
116_W	319_F	0.809	0.42
350_R	380_G	0.809	0.42
129_A	355_V	0.809	0.42
6_E	9_D	0.809	0.42
399_H	422_R	0.808	0.42
188_R	365_G	0.802	0.41
161_E	178_I	0.800	0.41
162_E	169_T	0.796	0.41
309_N	412_P	0.795	0.41
66_D	115_S	0.795	0.41
162_E	179_V	0.794	0.40
225_A	229_I	0.793	0.40
181_L	190_W	0.790	0.40
169_T	355_V	0.790	0.40
251_S	285_L	0.789	0.40
274_A	281_R	0.789	0.40
15_V	376_L	0.787	0.40
404_N	409_T	0.786	0.40
22_V	63_W	0.784	0.40
191_A	195_H	0.784	0.40
140_A	143_A	0.781	0.39
6_E	334_K	0.779	0.39
149_P	282_K	0.779	0.39
32_R	48_D	0.779	0.39
82_F	277_Y	0.777	0.39
221_L	351_H	0.774	0.39
288_T	298_E	0.774	0.39
316_W	373_D	0.773	0.39
65_L	123_L	0.772	0.39
316_W	353_H	0.770	0.39
333_E	357_S	0.769	0.39
62_T	227_W	0.768	0.39
131_P	277_Y	0.759	0.38
316_W	384_L	0.757	0.38
226_D	230_K	0.753	0.37
1_P	6_E	0.753	0.37
358_V	375_P	0.749	0.37
282_K	305_G	0.748	0.37
82_F	305_G	0.747	0.37
51_F	70_Y	0.746	0.37
122_Y	236_G	0.745	0.37
31_L	127_V	0.745	0.37
203_Q	284_Y	0.744	0.37
62_T	68_K	0.743	0.37
66_D	71_L	0.742	0.37
40_K	137_E	0.742	0.37
183_D	190_W	0.739	0.36
121_A	124_D	0.738	0.36
209_D	311_L	0.738	0.36
73_D	109_Y	0.737	0.36
86_R	411_F	0.733	0.36
178_I	270_P	0.732	0.36
402_L	414_W	0.730	0.36
205_F	379_P	0.730	0.36
302_S	379_P	0.729	0.36
10_T	304_F	0.728	0.36
76_N	85_A	0.726	0.35
232_F	267_L	0.726	0.35
171_A	180_R	0.723	0.35
386_N	411_F	0.720	0.35
21_K	310_R	0.720	0.35
347_G	352_L	0.718	0.35
383_S	388_S	0.717	0.35
85_A	183_D	0.717	0.35
306_K	313_E	0.717	0.35
165_T	184_K	0.715	0.35
148_A	153_A	0.711	0.34
411_F	416_E	0.708	0.34
179_V	194_D	0.707	0.34
17_S	412_P	0.707	0.34
182_R	187_G	0.705	0.34
332_L	340_S	0.705	0.34
330_W	340_S	0.702	0.34
57_L	332_L	0.700	0.34
8_G	334_K	0.697	0.33
335_L	413_M	0.696	0.33
10_T	350_R	0.696	0.33
149_P	154_S	0.696	0.33
54_R	305_G	0.696	0.33
13_H	213_F	0.694	0.33
378_A	399_H	0.694	0.33
8_G	310_R	0.693	0.33
23_A	26_R	0.693	0.33
207_A	238_E	0.693	0.33
269_F	279_A	0.693	0.33
415_Y	421_F	0.693	0.33
21_K	122_Y	0.690	0.33
8_G	11_W	0.690	0.33
221_L	225_A	0.685	0.33
216_Q	347_G	0.684	0.33
68_K	413_M	0.680	0.32
122_Y	411_F	0.679	0.32
406_A	415_Y	0.679	0.32
288_T	300_T	0.678	0.32
8_G	348_G	0.678	0.32
110_K	184_K	0.678	0.32
200_F	255_L	0.677	0.32
229_I	233_G	0.677	0.32
108_N	351_H	0.676	0.32
75_D	119_Q	0.675	0.32
10_T	127_V	0.675	0.32
136_A	140_A	0.671	0.32
213_F	230_K	0.671	0.32
203_Q	209_D	0.671	0.32
35_W	130_L	0.670	0.32
362_D	367_L	0.666	0.31
153_A	256_Y	0.666	0.31
74_F	112_V	0.666	0.31
6_E	353_H	0.665	0.31
16_G	117_A	0.665	0.31
371_T	400_F	0.665	0.31
138_A	227_W	0.663	0.31
350_R	387_F	0.663	0.31
327_A	372_L	0.662	0.31
3_V	261_A	0.660	0.31
84_A	326_P	0.659	0.31
235_P	312_P	0.659	0.31
237_L	415_Y	0.659	0.31
76_N	81_D	0.659	0.31
172_F	255_L	0.658	0.31
82_F	230_K	0.658	0.31
67_T	74_F	0.657	0.31
310_R	353_H	0.656	0.31
3_V	260_D	0.656	0.31
17_S	321_P	0.653	0.30
40_K	134_L	0.652	0.30
197_L	321_P	0.647	0.30
167_H	290_P	0.646	0.30
21_K	120_R	0.643	0.30
179_V	189_E	0.639	0.30
279_A	403_F	0.637	0.29
326_P	362_D	0.637	0.29
108_N	413_M	0.636	0.29
74_F	111_V	0.636	0.29
9_D	17_S	0.636	0.29
170_V	297_I	0.636	0.29
77_Y	137_E	0.636	0.29
52_L	109_Y	0.635	0.29
24_R	44_G	0.634	0.29
164_E	169_T	0.634	0.29
77_Y	385_L	0.634	0.29
235_P	375_P	0.633	0.29
23_A	145_L	0.632	0.29
198_G	289_L	0.631	0.29
14_G	17_S	0.630	0.29
41_L	57_L	0.630	0.29
173_D	177_A	0.629	0.29
193_A	327_A	0.628	0.29
111_V	205_F	0.627	0.29
202_Y	306_K	0.627	0.29
212_R	384_L	0.626	0.29
4_T	339_V	0.626	0.29
151_A	154_S	0.625	0.29
163_I	172_F	0.625	0.29
69_T	116_W	0.624	0.29
234_K	312_P	0.623	0.28
122_Y	227_W	0.622	0.28
170_V	224_R	0.622	0.28
65_L	236_G	0.621	0.28
76_N	84_A	0.620	0.28
161_E	263_L	0.620	0.28
118_E	312_P	0.620	0.28
170_V	196_P	0.617	0.28
268_R	299_L	0.616	0.28
374_A	419_M	0.615	0.28
159_P	188_R	0.615	0.28
310_R	397_G	0.614	0.28
302_S	420_R	0.612	0.28
16_G	22_V	0.611	0.28
37_A	162_E	0.609	0.28
113_E	187_G	0.608	0.28
339_V	343_D	0.607	0.27
32_R	36_L	0.606	0.27
299_L	307_P	0.605	0.27
216_Q	386_N	0.605	0.27
11_W	60_E	0.605	0.27
77_Y	387_F	0.605	0.27
79_P	274_A	0.603	0.27
303_W	315_L	0.603	0.27
397_G	421_F	0.602	0.27
227_W	408_G	0.601	0.27
376_L	401_N	0.601	0.27
62_T	66_D	0.601	0.27
203_Q	384_L	0.600	0.27
109_Y	223_S	0.600	0.27
232_F	311_L	0.599	0.27
121_A	274_A	0.598	0.27
48_D	52_L	0.598	0.27
325_D	328_G	0.598	0.27
56_L	111_V	0.598	0.27
285_L	365_G	0.596	0.27
30_R	372_L	0.596	0.27
344_V	353_H	0.592	0.27
3_V	148_A	0.592	0.27
393_D	396_G	0.591	0.27
16_G	205_F	0.590	0.26
209_D	212_R	0.590	0.26
204_T	311_L	0.587	0.26
71_L	408_G	0.587	0.26
214_F	233_G	0.586	0.26
194_D	323_V	0.585	0.26
21_K	119_Q	0.585	0.26
224_R	229_I	0.585	0.26
59_A	413_M	0.581	0.26
48_D	51_F	0.581	0.26
405_N	411_F	0.580	0.26
9_D	62_T	0.580	0.26
151_A	251_S	0.580	0.26
45_D	48_D	0.580	0.26
264_L	326_P	0.579	0.26
311_L	330_W	0.578	0.26
252_L	255_L	0.577	0.26
305_G	418_D	0.576	0.26
10_T	217_Y	0.576	0.26
58_V	413_M	0.576	0.26
393_D	397_G	0.575	0.26
135_R	285_L	0.573	0.25
162_E	393_D	0.573	0.25
11_W	17_S	0.572	0.25
5_Q	254_G	0.572	0.25
12_I	17_S	0.571	0.25
351_H	383_S	0.570	0.25
27_E	140_A	0.568	0.25
58_V	119_Q	0.567	0.25
26_R	356_S	0.567	0.25
85_A	109_Y	0.567	0.25
396_G	399_H	0.565	0.25
159_P	175_K	0.565	0.25
71_L	109_Y	0.565	0.25
34_E	107_P	0.565	0.25
25_Y	53_R	0.564	0.25
345_V	374_A	0.563	0.25
228_A	233_G	0.563	0.25
198_G	287_Y	0.563	0.25
387_F	392_P	0.562	0.25
3_V	110_K	0.560	0.25
203_Q	210_Y	0.557	0.24
6_E	14_G	0.556	0.24
380_G	391_Q	0.555	0.24
58_V	86_R	0.555	0.24
17_S	131_P	0.555	0.24
68_K	410_N	0.554	0.24
168_F	417_E	0.553	0.24
13_H	231_D	0.552	0.24
145_L	248_W	0.551	0.24
170_V	178_I	0.551	0.24
415_Y	418_D	0.551	0.24
213_F	223_S	0.551	0.24
2_V	143_A	0.551	0.24
266_E	284_Y	0.551	0.24
187_G	208_A	0.550	0.24
51_F	55_L	0.547	0.24
402_L	407_W	0.547	0.24
251_S	268_R	0.547	0.24
178_I	191_A	0.545	0.24
226_D	300_T	0.544	0.24
136_A	266_E	0.543	0.24
35_W	41_L	0.542	0.24
56_L	289_L	0.542	0.24
53_R	383_S	0.541	0.24
149_P	377_V	0.540	0.24
171_A	179_V	0.539	0.23
132_A	305_G	0.539	0.23
236_G	335_L	0.539	0.23
13_H	17_S	0.539	0.23
260_D	285_L	0.538	0.23
32_R	190_W	0.537	0.23
30_R	373_D	0.536	0.23
150_P	283_V	0.535	0.23
402_L	409_T	0.535	0.23
184_K	290_P	0.535	0.23
192_S	371_T	0.535	0.23
201_R	382_P	0.533	0.23
191_A	398_V	0.532	0.23
75_D	203_Q	0.532	0.23
398_V	401_N	0.531	0.23
36_L	39_G	0.531	0.23
2_V	14_G	0.529	0.23
314_A	376_L	0.529	0.23
28_L	51_F	0.529	0.23
250_P	354_A	0.525	0.23
404_N	414_W	0.525	0.23
66_D	410_N	0.524	0.23
85_A	205_F	0.524	0.23
116_W	310_R	0.524	0.23
153_A	258_E	0.524	0.23
279_A	335_L	0.524	0.23
11_W	61_H	0.520	0.22
74_F	236_G	0.520	0.22
385_L	413_M	0.519	0.22
258_E	297_I	0.519	0.22
170_V	337_E	0.518	0.22
330_W	360_Y	0.517	0.22
288_T	347_G	0.515	0.22
163_I	317_L	0.515	0.22
224_R	228_A	0.514	0.22
55_L	385_L	0.513	0.22
127_V	357_S	0.512	0.22
203_Q	242_A	0.512	0.22
56_L	214_F	0.511	0.22
107_P	111_V	0.510	0.22
160_G	171_A	0.507	0.22
138_A	314_A	0.507	0.22
311_L	406_A	0.506	0.22
129_A	372_L	0.506	0.22
82_F	240_A	0.505	0.22
72_R	108_N	0.505	0.22
209_D	245_R	0.502	0.21
131_P	269_F	0.502	0.21
192_S	322_I	0.502	0.21
357_S	370_E	0.502	0.21
350_R	353_H	0.501	0.21
193_A	325_D	0.501	0.21
331_R	341_P	0.501	0.21
67_T	230_K	0.500	0.21
4_T	26_R	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wyhA	2	0.8729	95.3	0.954	Contact Map
3lvtA	2	0.8612	92.5	0.959	Contact Map
3bvxA	1	0.8588	42.7	0.974	Contact Map
4gywA	2	0.1647	12.5	0.98	Contact Map
4tq2A	2	0.3859	12.5	0.98	Contact Map
1qgiA	1	0.2094	9.8	0.981	Contact Map
4e79A	3	0.1341	6.7	0.982	Contact Map
2q1fA	1	0.1976	6.6	0.982	Contact Map
2xczA	3	0.1482	6.5	0.982	Contact Map
3dkqA	4	0.1459	6.4	0.982	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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