GREMLIN Database
DUF5053 - Domain of unknown function (DUF5053)
PFAM: PF16476 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 59 (58)
Sequences: 972 (622)
Seq/√Len: 81.6
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_R33_V2.6641.00
6_I11_Y2.5911.00
16_Y54_D2.3791.00
6_I55_I2.3261.00
52_L59_I2.2201.00
22_S25_Y2.1111.00
24_L28_L2.0741.00
42_E46_E1.9761.00
53_Q56_S1.9291.00
47_T50_N1.8471.00
2_D58_R1.7611.00
26_Q29_N1.6951.00
53_Q57_K1.6251.00
49_N53_Q1.5290.99
6_I15_T1.4560.99
46_E49_N1.4490.99
50_N53_Q1.3940.99
33_V38_A1.3460.99
46_E50_N1.3100.98
34_N38_A1.2030.97
27_R38_A1.1520.96
41_T44_E1.1400.96
50_N57_K1.0950.95
24_L40_F1.0770.95
24_L48_L1.0700.94
30_G39_K1.0640.94
21_R25_Y1.0630.94
21_R24_L1.0260.93
12_I51_A1.0240.93
10_S21_R0.9680.91
25_Y29_N0.9440.90
33_V36_K0.9280.89
11_Y15_T0.9250.89
43_E46_E0.9210.89
34_N37_P0.9150.88
45_L49_N0.8850.87
26_Q31_N0.8830.86
15_T18_G0.8750.86
9_W24_L0.8720.86
9_W12_I0.8480.84
54_D57_K0.8350.83
47_T51_A0.8210.82
4_L28_L0.8170.82
4_L8_S0.8120.81
12_I48_L0.8050.81
10_S13_A0.7930.80
49_N52_L0.7790.79
6_I58_R0.7780.79
18_G21_R0.7760.78
14_K19_K0.7500.76
27_R31_N0.7320.74
31_N56_S0.7010.71
27_R44_E0.6940.70
41_T52_L0.6930.70
16_Y19_K0.6900.70
42_E45_L0.6880.70
9_W25_Y0.6880.70
43_E50_N0.6700.68
56_S59_I0.6680.67
34_N40_F0.6670.67
19_K22_S0.6620.67
32_D37_P0.6590.66
42_E57_K0.6560.66
55_I59_I0.6430.64
4_L29_N0.6390.64
43_E47_T0.6380.64
28_L48_L0.6330.63
5_E14_K0.6220.62
54_D58_R0.6190.62
18_G50_N0.5990.59
20_S25_Y0.5920.58
49_N56_S0.5900.58
20_S51_A0.5880.58
10_S14_K0.5860.57
12_I24_L0.5690.55
39_K48_L0.5520.53
10_S15_T0.5460.52
42_E55_I0.5400.51
2_D9_W0.5300.50
3_I8_S0.5300.50
26_Q33_V0.5250.49
8_S48_L0.5240.49
19_K42_E0.5150.48
51_A55_I0.5120.48
3_I7_I0.5060.47
11_Y24_L0.5040.47
34_N58_R0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ecqA 1 0.9661 43 0.86 Contact Map
2aq4A 1 0.9831 32.4 0.869 Contact Map
3zg9B 1 0.9661 31.7 0.87 Contact Map
1zwwA 3 0.4068 30.9 0.87 Contact Map
1h8aC 1 1 28 0.873 Contact Map
4dezA 2 0.5932 25.7 0.875 Contact Map
4fczB 1 0.7458 24.5 0.876 Contact Map
2qguA 1 0.7288 24.2 0.877 Contact Map
3osgA 1 0.9831 23.1 0.878 Contact Map
2k9nA 1 1 20.8 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0038 seconds.