GREMLIN Database
DUF5049 - Domain of unknown function (DUF5049)
PFAM: PF16468 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 57 (56)
Sequences: 1020 (680)
Seq/√Len: 90.9
META: 0.941

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_H48_E2.6111.00
22_D25_A2.5461.00
18_T25_A2.3891.00
12_I29_I2.3751.00
10_L14_D2.1821.00
17_L32_E2.0411.00
11_A35_F1.9201.00
8_Q38_L1.8251.00
6_K10_L1.8131.00
31_N40_D1.7611.00
27_Q43_E1.7401.00
17_L33_M1.7051.00
28_R32_E1.7001.00
18_T29_I1.5601.00
17_L29_I1.4701.00
40_D44_E1.4100.99
10_L13_R1.3590.99
15_T18_T1.3030.99
51_H57_E1.3010.99
9_I52_F1.2730.99
31_N39_V1.2330.98
29_I33_M1.1880.98
25_A29_I1.1800.98
28_R31_N1.1720.98
23_V46_R1.1580.97
30_A38_L1.1570.97
21_F54_L1.0240.95
23_V50_A1.0120.94
27_Q36_Y0.9760.93
15_T33_M0.9670.93
10_L52_F0.9390.92
23_V42_I0.9360.92
28_R36_Y0.9120.91
29_I32_E0.9060.90
27_Q40_D0.8790.89
38_L41_F0.8700.89
27_Q31_N0.8530.88
31_N36_Y0.8270.86
27_Q39_V0.8070.84
43_E46_R0.7900.83
12_I15_T0.7660.81
8_Q12_I0.7650.81
39_V43_E0.7370.79
31_N34_G0.7360.79
53_I56_G0.7340.78
12_I35_F0.7340.78
25_A28_R0.7260.78
38_L52_F0.7260.78
8_Q52_F0.7240.77
18_T22_D0.7210.77
15_T29_I0.7200.77
12_I16_G0.7130.76
40_D43_E0.7090.76
12_I33_M0.7080.76
4_K34_G0.7020.75
3_E7_E0.6900.74
40_D48_E0.6660.71
11_A33_M0.6470.69
39_V44_E0.6400.68
4_K8_Q0.6400.68
41_F45_H0.6370.68
50_A54_L0.6290.67
36_Y39_V0.6280.67
9_I13_R0.6280.67
15_T21_F0.6240.66
24_N45_H0.6180.66
5_I41_F0.6150.65
41_F48_E0.6100.65
24_N28_R0.6040.64
8_Q37_E0.5960.63
36_Y40_D0.5840.61
4_K7_E0.5630.59
7_E11_A0.5620.58
3_E6_K0.5590.58
3_E51_H0.5560.58
36_Y44_E0.5420.56
28_R43_E0.5420.56
10_L21_F0.5420.56
8_Q35_F0.5280.54
52_F55_T0.5220.53
24_N46_R0.5170.52
14_D26_V0.5140.52
28_R40_D0.5050.51
22_D42_I0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2miiA 1 0.9474 14.9 0.876 Contact Map
2qsfX 1 0.7193 12.9 0.879 Contact Map
4ddgA 3 0.9123 10.9 0.883 Contact Map
4fjvA 2 1 10.1 0.885 Contact Map
4q6vA 1 0.9474 9.4 0.887 Contact Map
2hjpA 4 0.7719 7.2 0.893 Contact Map
2zfyA 1 0.9123 6.5 0.894 Contact Map
4dhiB 1 0.9123 5.8 0.897 Contact Map
4lrvA 5 0.9298 5.6 0.897 Contact Map
3m03A 1 0.6491 5.2 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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