GREMLIN Database
DUF4986 - Domain of unknown function
PFAM: PF16375 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (84)
Sequences: 2177 (1574)
Seq/√Len: 171.7
META: 0.921

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_S16_G5.2151.00
11_D16_G3.2561.00
9_I77_D3.1701.00
15_M18_I2.9871.00
70_E75_I2.9161.00
70_E74_R2.8951.00
49_K68_E2.5121.00
52_T68_E2.3781.00
44_K56_S2.2621.00
55_L69_L2.0821.00
81_M84_W1.9001.00
45_P50_P1.8461.00
49_K52_T1.5871.00
38_D41_S1.5561.00
55_L58_L1.4961.00
8_L77_D1.4941.00
43_L69_L1.4591.00
37_A40_A1.4571.00
42_K57_G1.4061.00
45_P48_G1.3771.00
6_K22_P1.3691.00
47_A50_P1.3421.00
46_V52_T1.3371.00
54_T66_D1.3231.00
24_L29_A1.2751.00
52_T74_R1.2461.00
42_K56_S1.1941.00
5_L76_H1.1791.00
35_D38_D1.1611.00
72_F80_Y1.1281.00
46_V50_P1.1151.00
46_V49_K1.0551.00
75_I78_A1.0410.99
5_L78_A1.0290.99
52_T70_E1.0270.99
54_T68_E1.0230.99
55_L59_I1.0120.99
57_G66_D1.0070.99
62_N65_K0.9970.99
36_D40_A0.9960.99
59_I64_P0.9950.99
21_G72_F0.9550.99
59_I62_N0.9300.99
3_E24_L0.9160.99
7_G10_A0.9130.99
3_E6_K0.9060.98
36_D39_I0.9050.98
29_A81_M0.8950.98
45_P52_T0.8900.98
60_M67_L0.8560.98
23_L67_L0.8520.98
70_E78_A0.8510.98
23_L39_I0.8430.98
33_V60_M0.8400.98
4_D22_P0.8220.97
7_G14_R0.8090.97
76_H84_W0.8090.97
64_P67_L0.7880.96
1_G4_D0.7850.96
1_G78_A0.7810.96
26_L29_A0.7760.96
6_K9_I0.7740.96
80_Y83_Y0.7650.96
67_L70_E0.7620.96
14_R17_H0.7500.95
12_D16_G0.7440.95
28_K63_P0.7410.95
46_V54_T0.7410.95
34_G42_K0.7390.95
30_P84_W0.7310.94
34_G39_I0.7280.94
61_P64_P0.7170.94
31_I61_P0.7120.94
17_H21_G0.6950.93
72_F82_M0.6920.93
20_S23_L0.6900.93
44_K47_A0.6860.92
32_L81_M0.6830.92
7_G18_I0.6790.92
31_I34_G0.6760.92
42_K58_L0.6740.92
46_V68_E0.6630.91
45_P49_K0.6550.91
44_K54_T0.6400.90
14_R18_I0.6300.89
34_G40_A0.6270.89
29_A64_P0.6230.88
23_L29_A0.6080.87
23_L27_D0.6010.86
41_S67_L0.5980.86
24_L78_A0.5910.86
27_D61_P0.5890.85
65_K68_E0.5880.85
10_A14_R0.5870.85
13_S17_H0.5810.85
7_G15_M0.5780.84
60_M65_K0.5760.84
70_E76_H0.5750.84
75_I79_R0.5710.84
15_M23_L0.5700.83
9_I34_G0.5690.83
22_P28_K0.5690.83
9_I60_M0.5690.83
72_F76_H0.5680.83
48_G65_K0.5650.83
48_G52_T0.5610.82
39_I42_K0.5580.82
30_P81_M0.5560.82
29_A78_A0.5550.82
18_I23_L0.5520.81
8_L11_D0.5490.81
41_S75_I0.5450.81
3_E35_D0.5390.80
47_A66_D0.5310.79
20_S81_M0.5280.79
47_A54_T0.5270.78
44_K48_G0.5260.78
32_L60_M0.5250.78
21_G25_P0.5120.76
17_H76_H0.5120.76
43_L61_P0.5100.76
15_M20_S0.5090.76
45_P53_F0.5050.75
38_D42_K0.5030.75
9_I59_I0.5000.75
44_K57_G0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nsxA 2 0.7738 10.3 0.912 Contact Map
2my1A 1 0.7738 7 0.918 Contact Map
3rwnA 3 0.631 5.4 0.922 Contact Map
4fxtA 2 0.6786 5.4 0.922 Contact Map
4iykA 1 0.6786 4.9 0.923 Contact Map
4a8cA 5 0.7619 4.6 0.925 Contact Map
1qzvF 1 0 4.1 0.927 Contact Map
4j7hA 3 0.9167 4 0.927 Contact Map
3cyyA 2 0.5714 3.2 0.931 Contact Map
3o6qA 2 0.881 3.1 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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