GREMLIN Database
DUF4985 - Domain of unknown function
PFAM: PF16373 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 114 (111)
Sequences: 736 (495)
Seq/√Len: 47.0
META: 0.898

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_I53_E4.1501.00
24_M68_G3.7821.00
59_V65_V3.2411.00
77_N80_A3.1531.00
53_E91_A2.9701.00
27_A51_F2.8461.00
10_D13_N2.5071.00
86_K90_K2.2331.00
25_T55_A2.0260.99
80_A83_R2.0070.99
71_V102_H1.9860.99
100_L104_I1.8330.99
56_K65_V1.7890.99
85_V95_L1.7840.99
97_V112_L1.7430.98
20_L63_V1.7060.98
38_R44_E1.7010.98
32_V80_A1.6990.98
89_L95_L1.6970.98
45_W50_G1.6840.98
29_Y51_F1.6690.98
78_P111_A1.6640.98
51_F55_A1.6620.98
18_E62_D1.6610.98
56_K93_D1.5930.97
103_I112_L1.5840.97
20_L23_L1.3900.94
15_G18_E1.3510.93
27_A88_C1.3460.93
67_G92_T1.2980.91
71_V97_V1.2960.91
70_Y102_H1.2930.91
36_E80_A1.2720.90
87_A91_A1.2680.90
10_D14_T1.2650.90
7_A73_N1.2630.90
72_G102_H1.2620.90
79_E82_T1.2550.90
24_M55_A1.2460.89
23_L63_V1.2200.88
23_L59_V1.2090.88
44_E47_T1.1840.87
23_L48_V1.1630.86
46_Y73_N1.1580.86
61_G93_D1.1490.85
27_A92_T1.1230.84
35_E39_A1.1190.84
85_V112_L1.0970.82
81_F108_W1.0760.81
81_F112_L1.0550.80
59_V66_Y1.0550.80
48_V88_C1.0460.79
17_A62_D1.0350.78
61_G64_P1.0300.78
101_V105_N1.0200.77
14_T100_L0.9820.75
27_A55_A0.9650.73
32_V87_A0.9600.73
5_D10_D0.9400.71
58_V84_A0.9350.71
70_Y73_N0.9120.69
45_W95_L0.9030.68
37_A41_G0.8980.68
64_P67_G0.8920.67
49_E91_A0.8840.67
69_I96_M0.8800.66
102_H106_Y0.8750.66
74_Y81_F0.8740.66
27_A52_A0.8670.65
7_A11_Y0.8630.65
57_R60_K0.8320.62
32_V47_T0.8300.62
35_E38_R0.8080.60
31_T97_V0.8030.59
79_E105_N0.8020.59
17_A63_V0.8020.59
69_I91_A0.7990.59
70_Y81_F0.7930.58
24_M70_Y0.7850.57
3_D9_P0.7830.57
69_I72_G0.7780.57
7_A50_G0.7780.57
68_G96_M0.7650.55
52_A68_G0.7640.55
110_D113_K0.7480.54
59_V62_D0.7470.54
3_D61_G0.7430.53
7_A12_K0.7390.53
59_V63_V0.7290.52
14_T67_G0.7230.51
79_E111_A0.7210.51
54_L58_V0.7210.51
74_Y84_A0.7140.50
63_V88_C0.7140.50
65_V88_C0.7130.50
43_G88_C0.7100.50
18_E49_E0.7060.50
4_Y47_T0.7040.49
54_L112_L0.7020.49
13_N67_G0.6980.49
37_A47_T0.6940.48
36_E83_R0.6910.48
45_W67_G0.6880.48
34_I48_V0.6820.47
34_I47_T0.6820.47
37_A44_E0.6810.47
75_G103_I0.6750.47
10_D90_K0.6730.46
47_T68_G0.6710.46
31_T80_A0.6690.46
13_N39_A0.6690.46
31_T44_E0.6560.45
31_T46_Y0.6510.44
49_E90_K0.6480.44
32_V74_Y0.6460.44
39_A90_K0.6460.44
40_Y113_K0.6430.43
16_Y23_L0.6390.43
84_A100_L0.6260.42
30_P73_N0.6250.42
20_L64_P0.6210.41
85_V103_I0.6190.41
3_D57_R0.6110.40
74_Y106_Y0.6070.40
55_A61_G0.6050.40
36_E57_R0.5990.39
29_Y45_W0.5970.39
98_F102_H0.5960.39
5_D9_P0.5940.39
68_G87_A0.5940.39
108_W111_A0.5940.39
47_T92_T0.5890.38
82_T111_A0.5880.38
27_A66_Y0.5860.38
18_E60_K0.5790.37
5_D35_E0.5750.37
45_W51_F0.5710.37
103_I108_W0.5670.36
11_Y16_Y0.5630.36
50_G72_G0.5610.36
36_E44_E0.5580.35
4_Y34_I0.5570.35
69_I85_V0.5550.35
6_W25_T0.5450.34
45_W57_R0.5430.34
35_E79_E0.5420.34
48_V96_M0.5400.34
101_V104_I0.5370.33
41_G75_G0.5350.33
97_V102_H0.5350.33
22_F51_F0.5340.33
43_G59_V0.5320.33
96_M99_D0.5320.33
63_V69_I0.5300.33
49_E89_L0.5300.33
108_W112_L0.5250.32
23_L104_I0.5200.32
23_L88_C0.5200.32
42_S75_G0.5180.32
31_T78_P0.5160.32
29_Y102_H0.5100.31
11_Y15_G0.5060.31
13_N20_L0.5060.31
102_H105_N0.5010.30
4_Y15_G0.5010.30
13_N18_E0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ianA 1 0.9912 26.7 0.928 Contact Map
4q6tA 1 0.9825 26.7 0.928 Contact Map
1iv8A 1 0.807 17.8 0.933 Contact Map
4toqA 2 0.9035 16.6 0.934 Contact Map
3hjeA 1 0.7982 12.7 0.938 Contact Map
3ly0A 1 1 12.6 0.938 Contact Map
1edtA 2 0.7895 12 0.938 Contact Map
4tx6A 1 0.9649 11.3 0.939 Contact Map
1eokA 1 0.8333 11.2 0.939 Contact Map
4f9dA 1 0.7281 11 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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