GREMLIN Database
PepSY_TM_like_2 - Putative PepSY_TM-like
PFAM: PF16357 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 197 (189)
Sequences: 4415 (3523)
Seq/√Len: 256.3
META: 0.836

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_D116_T5.1371.00
103_G106_G3.2651.00
29_I154_V2.6601.00
11_W14_S2.5611.00
4_R7_H2.4191.00
110_V121_V2.3991.00
76_W79_E2.3831.00
73_L77_L2.1001.00
29_I153_A2.0941.00
69_L73_L2.0931.00
5_Q8_I2.0751.00
65_D68_A2.0261.00
21_L160_S1.9831.00
128_W131_Y1.9671.00
8_I11_W1.9601.00
33_H150_D1.9371.00
163_G166_L1.9191.00
14_S17_F1.9111.00
128_W132_L1.9091.00
7_H14_S1.8831.00
158_L162_T1.8701.00
71_E74_A1.8481.00
96_E111_T1.8371.00
127_G131_Y1.8041.00
7_H11_W1.8021.00
32_N150_D1.7931.00
70_P74_A1.7771.00
83_I86_A1.7701.00
144_A147_W1.6811.00
25_A157_I1.6751.00
189_L193_L1.6641.00
47_E118_E1.6411.00
49_T118_E1.6391.00
21_L25_A1.6291.00
147_W151_I1.6251.00
131_Y192_A1.5961.00
31_L137_K1.5861.00
86_A89_D1.5851.00
169_G172_G1.5741.00
87_G90_A1.5621.00
175_R178_W1.5581.00
82_G85_G1.5271.00
79_E82_G1.4661.00
72_A76_W1.4401.00
62_A65_D1.4211.00
11_W15_A1.4101.00
169_G173_R1.4061.00
70_P76_W1.3991.00
143_K146_S1.3551.00
33_H36_W1.3401.00
78_R81_G1.3331.00
111_T120_E1.3231.00
76_W81_G1.3211.00
8_I12_I1.3171.00
70_P73_L1.3141.00
30_T133_N1.3131.00
178_W182_G1.3051.00
22_L157_I1.3001.00
71_E75_E1.2861.00
72_A75_E1.2831.00
74_A81_G1.2811.00
52_A55_L1.2721.00
47_E120_E1.2701.00
77_L81_G1.2681.00
26_V157_I1.2631.00
29_I33_H1.2451.00
168_K172_G1.2271.00
76_W80_E1.2191.00
178_W181_V1.2131.00
127_G130_A1.1671.00
57_A61_D1.1661.00
21_L156_L1.1651.00
3_L7_H1.1551.00
95_D115_A1.1551.00
64_A67_L1.1531.00
139_R142_G1.1481.00
74_A78_R1.1471.00
133_N139_R1.1441.00
173_R181_V1.1341.00
143_K147_W1.1321.00
61_D64_A1.1141.00
60_A64_A1.1121.00
24_F145_W1.1051.00
179_P183_L1.0961.00
48_G119_V1.0931.00
61_D65_D1.0911.00
74_A85_G1.0871.00
17_F21_L1.0861.00
164_L181_V1.0821.00
95_D114_R1.0761.00
13_S19_L1.0711.00
7_H12_I1.0701.00
165_F168_K1.0631.00
138_G149_I1.0551.00
69_L77_L1.0471.00
170_L173_R1.0421.00
99_V102_P1.0351.00
59_A63_E1.0241.00
67_L71_E1.0171.00
70_P79_E1.0161.00
174_R178_W0.9991.00
45_E120_E0.9951.00
29_I157_I0.9751.00
64_A68_A0.9711.00
151_I154_V0.9691.00
77_L80_E0.9591.00
93_S96_E0.9581.00
138_G141_T0.9461.00
75_E79_E0.9461.00
40_N43_V0.9441.00
60_A63_E0.9441.00
15_A18_L0.9331.00
100_S109_W0.9271.00
79_E84_D0.9161.00
74_A77_L0.9051.00
189_L192_A0.8981.00
81_G85_G0.8961.00
161_L165_F0.8891.00
141_T146_S0.8861.00
165_F169_G0.8841.00
78_R85_G0.8841.00
3_L8_I0.8831.00
81_G119_V0.8831.00
73_L76_W0.8831.00
30_T37_I0.8761.00
31_L138_G0.8711.00
84_D87_G0.8681.00
11_W17_F0.8661.00
28_G153_A0.8651.00
3_L165_F0.8641.00
79_E85_G0.8621.00
7_H13_S0.8580.99
15_A19_L0.8530.99
74_A79_E0.8510.99
90_A97_L0.8490.99
56_A59_A0.8480.99
21_L152_F0.8470.99
80_E83_I0.8450.99
27_T133_N0.8430.99
176_R180_L0.8380.99
6_L158_L0.8320.99
100_S103_G0.8300.99
80_E84_D0.8250.99
111_T122_E0.8230.99
4_R8_I0.8190.99
190_L193_L0.8120.99
112_I119_V0.8070.99
91_E94_D0.8060.99
12_I15_A0.8050.99
50_L54_L0.8050.99
190_L194_L0.8030.99
86_A90_A0.7960.99
14_S19_L0.7950.99
75_E80_E0.7940.99
22_L26_V0.7940.99
171_K176_R0.7930.99
125_D128_W0.7910.99
61_D66_K0.7830.99
44_T123_R0.7820.99
78_R82_G0.7790.99
70_P78_R0.7780.99
109_W122_E0.7780.99
50_L53_P0.7770.99
11_W18_L0.7770.99
72_A77_L0.7770.99
30_T139_R0.7760.99
63_E66_K0.7690.99
81_G87_G0.7660.99
186_L190_L0.7640.99
176_R179_P0.7630.99
95_D113_D0.7620.99
33_H145_W0.7620.99
14_S18_L0.7620.99
85_G89_D0.7570.99
110_V119_V0.7560.99
69_L72_A0.7560.99
55_L59_A0.7510.99
75_E78_R0.7500.99
13_S18_L0.7460.99
130_A134_D0.7460.99
134_D139_R0.7390.98
145_W150_D0.7350.98
24_F137_K0.7350.98
70_P77_L0.7340.98
74_A86_A0.7300.98
172_G175_R0.7300.98
98_Y102_P0.7280.98
126_R130_A0.7250.98
111_T115_A0.7210.98
108_A111_T0.7200.98
8_I14_S0.7120.98
81_G86_A0.7080.98
181_V185_L0.7080.98
72_A81_G0.7070.98
64_A69_L0.7040.98
164_L184_G0.7020.98
174_R181_V0.6920.98
167_L181_V0.6920.98
16_L21_L0.6900.98
57_A64_A0.6850.98
134_D137_K0.6840.98
133_N137_K0.6840.98
164_L167_L0.6770.97
171_K180_L0.6680.97
32_N149_I0.6640.97
42_R47_E0.6610.97
116_T119_V0.6580.97
102_P107_D0.6580.97
12_I16_L0.6510.97
82_G86_A0.6470.97
167_L177_G0.6460.96
66_K70_P0.6450.96
26_V132_L0.6390.96
25_A152_F0.6380.96
150_D153_A0.6350.96
25_A153_A0.6340.96
18_L185_L0.6290.96
188_P191_L0.6290.96
48_G51_P0.6290.96
25_A156_L0.6260.96
62_A67_L0.6230.96
185_L189_L0.6190.96
45_E122_E0.6160.95
90_A93_S0.6150.95
67_L70_P0.6140.95
62_A66_K0.6120.95
27_T141_T0.6110.95
77_L85_G0.6100.95
130_A137_K0.6090.95
13_S159_L0.6070.95
171_K174_R0.6060.95
7_H170_L0.6050.95
141_T152_F0.6030.95
172_G176_R0.6030.95
147_W154_V0.6020.95
77_L119_V0.6020.95
24_F149_I0.6010.95
13_S17_F0.6000.95
113_D118_E0.5980.95
28_G31_L0.5960.95
21_L159_L0.5930.94
101_F104_P0.5930.94
49_T52_A0.5860.94
67_L75_E0.5860.94
18_L21_L0.5850.94
59_A62_A0.5820.94
51_P76_W0.5760.94
166_L170_L0.5690.93
8_I13_S0.5680.93
157_I161_L0.5650.93
171_K178_W0.5640.93
74_A83_I0.5640.93
58_L61_D0.5610.93
58_L63_E0.5610.93
72_A79_E0.5590.92
77_L83_I0.5550.92
134_D142_G0.5550.92
57_A62_A0.5430.91
88_R94_D0.5410.91
104_P107_D0.5400.91
69_L76_W0.5390.91
6_L12_I0.5380.91
61_D68_A0.5360.91
102_P105_G0.5350.91
173_R178_W0.5340.91
57_A63_E0.5340.91
31_L134_D0.5320.91
175_R179_P0.5320.91
136_H163_G0.5310.90
173_R176_R0.5280.90
83_I87_G0.5270.90
13_S16_L0.5260.90
154_V158_L0.5260.90
59_A67_L0.5210.90
22_L161_L0.5190.89
111_T166_L0.5180.89
30_T129_I0.5140.89
103_G108_A0.5090.89
102_P139_R0.5090.89
35_A38_N0.5060.88
69_L85_G0.5040.88
168_K173_R0.5040.88
64_A72_A0.5010.88
78_R83_I0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4or2A 2 0.7665 34.9 0.923 Contact Map
2l2tA 2 0.2132 8.8 0.942 Contact Map
4wd8A 3 0.269 7.8 0.943 Contact Map
4ea3A 2 0.7107 7.2 0.944 Contact Map
2kgyA 1 0.4518 5 0.948 Contact Map
3c02A 3 0.2741 4.3 0.95 Contact Map
1kqfC 3 0.3299 3.8 0.951 Contact Map
2mpnA 2 0.3198 3.8 0.951 Contact Map
2gsmB 1 0.401 3.7 0.951 Contact Map
2jwaA 2 0.2234 2.8 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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