GREMLIN Database
DUF4980 - Domain of unknown function (DUF4980)
PFAM: PF16352 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 108 (104)
Sequences: 872 (658)
Seq/√Len: 64.6
META: 0.922

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_V43_V3.8741.00
21_Q48_D2.9201.00
102_E105_R2.6691.00
11_V58_L2.6381.00
20_V54_V2.5901.00
31_V56_L2.4941.00
30_R69_D2.4931.00
97_D100_N2.3901.00
76_R80_G2.2341.00
28_R40_E2.0951.00
33_V66_V2.0621.00
26_E44_R2.0571.00
102_E106_P2.0301.00
75_D80_G2.0051.00
22_E52_Y1.9791.00
29_V43_V1.8461.00
81_L84_F1.8431.00
17_L53_W1.7921.00
34_D64_K1.7040.99
33_V64_K1.6220.99
30_R40_E1.6110.99
18_L68_L1.5620.99
17_L96_F1.5350.99
16_L58_L1.5060.99
56_L68_L1.4870.98
23_G44_R1.4470.98
50_V53_W1.3950.98
7_V11_V1.3750.97
50_V89_E1.3630.97
76_R79_T1.3460.97
18_L45_L1.3440.97
104_Y108_Y1.3030.96
29_V44_R1.2890.96
69_D87_W1.2890.96
13_K94_D1.2700.96
38_V41_F1.2570.96
98_T101_R1.2520.95
46_A94_D1.2500.95
57_D60_A1.2030.94
39_R56_L1.1730.94
14_K58_L1.1700.93
21_Q44_R1.1080.91
50_V85_V1.0980.91
11_V66_V1.0910.91
37_V40_E1.0650.90
29_V41_F1.0540.89
40_E43_V1.0520.89
75_D79_T1.0210.88
17_L55_P1.0070.87
51_D102_E0.9960.86
75_D78_S0.9850.86
17_L91_K0.9670.85
12_T62_K0.9640.85
33_V38_V0.9460.83
98_T102_E0.9300.82
20_V45_L0.9260.82
103_K106_P0.9250.82
77_R80_G0.9120.81
22_E26_E0.9090.81
28_R42_N0.9020.80
48_D88_K0.8960.80
16_L68_L0.8910.80
57_D66_V0.8860.79
20_V39_R0.8660.78
44_R52_Y0.8650.77
87_W92_L0.8650.77
39_R60_A0.8620.77
96_F104_Y0.8420.76
21_Q49_K0.8410.75
38_V61_F0.8300.75
28_R58_L0.8300.75
31_V85_V0.8300.75
4_H107_Q0.8250.74
53_W91_K0.8100.73
14_K57_D0.8000.72
80_G84_F0.7970.71
22_E44_R0.7970.71
34_D37_V0.7960.71
18_L90_I0.7960.71
29_V55_P0.7940.71
22_E51_D0.7760.69
32_L69_D0.7720.69
20_V41_F0.7640.68
31_V73_L0.7510.67
84_F92_L0.7480.67
21_Q43_V0.7380.66
10_T90_I0.7370.65
18_L70_I0.7310.65
101_R104_Y0.7300.65
42_N52_Y0.7290.65
14_K99_T0.7190.64
33_V94_D0.7150.63
30_R43_V0.7150.63
84_F87_W0.7030.62
32_L35_G0.7010.62
30_R37_V0.6970.61
7_V78_S0.6960.61
88_K93_S0.6950.61
53_W89_E0.6950.61
40_E61_F0.6850.60
10_T66_V0.6810.59
21_Q50_V0.6720.58
10_T65_K0.6620.57
41_F56_L0.6620.57
11_V31_V0.6590.57
14_K73_L0.6580.57
86_C92_L0.6550.56
8_R12_T0.6480.56
29_V64_K0.6420.55
26_E79_T0.6400.55
55_P61_F0.6310.54
70_I73_L0.6310.54
4_H35_G0.6310.54
92_L97_D0.6190.52
68_L90_I0.6070.51
15_Y55_P0.6060.51
83_D87_W0.6000.50
99_T107_Q0.5980.50
15_Y57_D0.5930.49
100_N105_R0.5870.49
27_A47_V0.5830.48
24_A44_R0.5810.48
25_P82_K0.5760.47
71_D78_S0.5750.47
103_K107_Q0.5750.47
17_L50_V0.5720.47
44_R54_V0.5690.46
52_Y55_P0.5680.46
105_R108_Y0.5680.46
99_T103_K0.5630.46
76_R104_Y0.5630.46
18_L27_A0.5630.46
49_K68_L0.5620.46
26_E52_Y0.5610.46
16_L88_K0.5560.45
72_F79_T0.5480.44
81_L92_L0.5430.43
34_D98_T0.5420.43
78_S81_L0.5420.43
87_W96_F0.5320.42
48_D77_R0.5320.42
11_V64_K0.5310.42
8_R34_D0.5310.42
85_V104_Y0.5300.42
34_D82_K0.5260.41
37_V65_K0.5150.40
27_A70_I0.5120.40
58_L108_Y0.5120.40
46_A50_V0.5090.40
9_V98_T0.5090.40
100_N108_Y0.5090.40
81_L85_V0.5070.39
47_V82_K0.5060.39
7_V43_V0.5040.39
59_S62_K0.5020.39
13_K88_K0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw7A 1 0.7685 14.7 0.921 Contact Map
4p02B 1 0.9352 13.2 0.923 Contact Map
3h2tA 2 0.8241 12 0.924 Contact Map
1o7dD 1 0.8704 9.5 0.927 Contact Map
3lr0A 2 0.5 8.5 0.929 Contact Map
3a3jA 1 0.4722 6.8 0.932 Contact Map
3te8A 2 0.5833 6.4 0.933 Contact Map
4dixA 1 0.7037 5.6 0.935 Contact Map
3mzfA 1 0.4815 5.4 0.935 Contact Map
1x1iA 1 0.6759 4.4 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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