GREMLIN Database
DUF4964 - Domain of unknown function (DUF4964)
PFAM: PF16334 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (70)
Sequences: 1562 (1061)
Seq/√Len: 126.8
META: 0.929

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_G74_F4.0081.00
45_K48_D3.8081.00
49_S52_R3.4071.00
43_A49_S3.2791.00
64_L71_T3.1861.00
27_A42_P3.1501.00
33_H37_F3.0941.00
39_I51_T2.3841.00
42_P52_R2.2461.00
24_R28_V2.1801.00
46_L75_M2.0151.00
50_P60_P1.7041.00
42_P56_G1.5481.00
73_R78_E1.5361.00
39_I59_H1.4921.00
39_I61_L1.3321.00
66_R71_T1.2941.00
34_D53_H1.2130.99
38_S41_S1.2090.99
43_A52_R1.1810.99
32_T53_H1.1780.99
16_A20_A1.1770.99
42_P49_S1.1340.99
52_R58_P1.1160.99
50_P62_T1.0760.99
50_P58_P1.0680.99
24_R44_D1.0450.98
19_A22_A1.0310.98
36_Y56_G0.9860.98
18_A21_Q0.9540.97
65_I74_F0.9420.97
15_F18_A0.9400.97
37_F56_G0.9260.96
25_P28_V0.9200.96
38_S55_T0.9050.96
38_S54_W0.9010.96
63_G75_M0.8900.96
64_L74_F0.8870.95
37_F51_T0.8860.95
15_F19_A0.8780.95
47_T64_L0.8660.95
77_K80_A0.8640.95
33_H56_G0.8360.94
31_V53_H0.8140.93
51_T60_P0.7910.92
66_R81_P0.7830.91
30_L61_L0.7800.91
35_P38_S0.7790.91
27_A50_P0.7670.91
23_L57_K0.7660.91
80_A83_K0.7640.90
50_P77_K0.7600.90
81_P84_P0.7530.90
41_S51_T0.7350.89
47_T84_P0.7070.87
58_P79_P0.6830.85
34_D41_S0.6620.83
29_P40_W0.6580.83
15_F20_A0.6470.82
32_T57_K0.6470.82
67_V84_P0.6420.81
23_L28_V0.6350.80
16_A19_A0.6240.79
25_P41_S0.6240.79
50_P65_I0.6220.79
27_A52_R0.6000.77
64_L80_A0.6000.77
40_W53_H0.5850.75
31_V37_F0.5850.75
50_P78_E0.5770.74
47_T51_T0.5740.73
25_P30_L0.5720.73
42_P60_P0.5690.73
24_R46_L0.5640.72
62_T73_R0.5640.72
26_P74_F0.5590.71
49_S77_K0.5540.71
41_S53_H0.5530.71
32_T59_H0.5510.70
70_K83_K0.5510.70
30_L37_F0.5490.70
31_V55_T0.5470.70
18_A58_P0.5450.69
33_H53_H0.5450.69
43_A48_D0.5440.69
22_A27_A0.5410.69
67_V72_Y0.5380.68
66_R82_L0.5350.68
25_P43_A0.5280.67
57_K77_K0.5280.67
36_Y75_M0.5250.67
19_A81_P0.5250.67
71_T79_P0.5240.66
39_I47_T0.5200.66
65_I82_L0.5180.66
53_H61_L0.5180.66
39_I55_T0.5180.66
28_V43_A0.5160.65
65_I83_K0.5150.65
33_H51_T0.5140.65
69_G77_K0.5130.65
33_H60_P0.5130.65
31_V61_L0.5040.63
18_A70_K0.5040.63
37_F62_T0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u6dA 2 0.7586 10.5 0.922 Contact Map
4g6tB 1 0.3333 8.4 0.925 Contact Map
3vsfA 1 0.931 8.2 0.926 Contact Map
3k7lA 1 0.4828 8.2 0.926 Contact Map
1yr2A 1 0.6552 7.5 0.927 Contact Map
2qarB 2 0.6552 5.7 0.931 Contact Map
2rsxA 1 0.7471 5.2 0.932 Contact Map
2ivfA 1 0.954 5.1 0.932 Contact Map
3g5cA 1 0.4023 4.8 0.934 Contact Map
3k7nA 1 0.4138 4.6 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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