GREMLIN Database
CcmF_C - Cytochrome c-type biogenesis protein CcmF C-terminal
PFAM: PF16327 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 323 (321)
Sequences: 16982 (11292)
Seq/√Len: 630.3
META: 0.89

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_D241_T5.1371.00
214_E219_T3.4251.00
221_T243_S3.4041.00
122_A141_A2.9481.00
237_R255_E2.9021.00
147_I184_L2.8171.00
239_T253_Y2.7331.00
241_T248_P2.6331.00
189_F193_I2.6081.00
212_S219_T2.5931.00
205_V213_V2.5681.00
212_S221_T2.4451.00
273_S303_R2.4231.00
243_S248_P2.4171.00
36_A97_L2.3891.00
208_K211_E2.3871.00
62_E68_K2.3361.00
228_V235_A2.3301.00
13_A17_W2.3001.00
239_T251_T2.2981.00
108_R112_L2.2691.00
121_A144_A2.2431.00
174_R321_S2.2401.00
188_V311_L2.2321.00
226_T239_T2.1981.00
240_F294_V2.1911.00
240_F281_V2.1371.00
195_G301_L2.0531.00
229_Q234_T2.0211.00
228_V237_R2.0051.00
242_V279_L1.9941.00
221_T241_T1.9901.00
160_E164_G1.9811.00
50_T79_V1.9751.00
88_L190_V1.9651.00
252_L270_A1.9641.00
223_D239_T1.9431.00
254_P270_A1.9341.00
47_A80_F1.9041.00
73_P77_N1.8931.00
241_T251_T1.8891.00
213_V296_V1.8801.00
207_L213_V1.8751.00
117_A148_A1.8671.00
207_L211_E1.8461.00
214_E217_G1.8201.00
237_R253_Y1.8131.00
248_P251_T1.7761.00
229_Q260_P1.7691.00
226_T237_R1.7511.00
208_K291_A1.7441.00
139_G194_A1.7411.00
222_F225_V1.7271.00
17_W20_P1.7251.00
39_L90_L1.6761.00
91_M186_V1.6711.00
227_E236_V1.6391.00
272_R277_R1.6371.00
147_I187_A1.6231.00
160_E165_A1.6171.00
161_S164_G1.6021.00
82_P86_P1.5851.00
162_L165_A1.5751.00
219_T243_S1.5721.00
102_A106_S1.5671.00
160_E163_A1.5621.00
136_A198_A1.5581.00
258_F265_P1.5541.00
250_G272_R1.5491.00
220_L240_F1.5381.00
61_S69_I1.5171.00
200_S299_K1.5101.00
281_V296_V1.4891.00
235_A255_E1.4821.00
78_R82_P1.4781.00
159_R162_L1.4751.00
234_T260_P1.4741.00
303_R307_L1.4731.00
98_A102_A1.4701.00
143_A191_I1.4561.00
92_G149_T1.4471.00
275_L307_L1.4401.00
277_R298_V1.4341.00
47_A83_L1.4251.00
233_Y257_R1.3931.00
97_L102_A1.3861.00
159_R163_A1.3831.00
3_F7_V1.3781.00
252_L281_V1.3771.00
201_T298_V1.3661.00
109_R112_L1.3661.00
144_A148_A1.3551.00
133_S136_A1.3491.00
57_Y61_S1.3401.00
140_L195_G1.3301.00
224_G239_T1.3201.00
230_G233_Y1.3191.00
178_G315_G1.2931.00
43_L86_P1.2901.00
181_L318_L1.2891.00
9_G13_A1.2711.00
153_E157_R1.2641.00
256_K267_T1.2641.00
2_A6_L1.2591.00
243_S246_G1.2581.00
310_L314_L1.2581.00
151_L155_W1.2511.00
227_E234_T1.2361.00
147_I191_I1.2361.00
206_R291_A1.2341.00
112_L116_A1.2271.00
197_S200_S1.2241.00
105_A109_R1.2101.00
185_G311_L1.2101.00
159_R164_G1.1991.00
220_L296_V1.1941.00
117_A121_A1.1861.00
152_L156_R1.1791.00
201_T216_G1.1711.00
164_G167_R1.1681.00
196_S200_S1.1631.00
217_G244_R1.1551.00
92_G145_W1.1521.00
192_G308_G1.1361.00
274_G277_R1.1311.00
185_G312_M1.1301.00
150_I153_E1.1291.00
202_E295_R1.1271.00
44_L87_L1.1131.00
207_L212_S1.1101.00
163_A167_R1.1061.00
203_R213_V1.1051.00
114_P152_L1.0961.00
80_F84_M1.0811.00
51_V80_F1.0801.00
220_L242_V1.0761.00
16_A19_A1.0691.00
51_V55_T1.0521.00
222_F238_A1.0511.00
161_S165_A1.0501.00
2_A5_A1.0391.00
52_L56_L1.0361.00
209_P222_F1.0331.00
287_L290_G1.0321.00
176_R180_Y1.0301.00
215_V220_L1.0281.00
258_F263_G1.0251.00
118_A141_A1.0231.00
223_D251_T1.0221.00
106_S110_R1.0151.00
84_M190_V1.0131.00
203_R215_V1.0131.00
153_E176_R1.0121.00
160_E168_R1.0091.00
155_W158_A1.0081.00
12_L16_A1.0051.00
164_G168_R1.0001.00
243_S247_K0.9991.00
88_L146_V0.9971.00
207_L294_V0.9941.00
165_A168_R0.9901.00
302_V305_I0.9901.00
132_R137_L0.9871.00
122_A126_A0.9811.00
192_G305_I0.9811.00
120_V124_L0.9781.00
215_V296_V0.9761.00
147_I151_L0.9731.00
61_S65_T0.9711.00
75_Y79_V0.9651.00
47_A84_M0.9651.00
218_Y279_L0.9611.00
91_M94_G0.9601.00
143_A187_A0.9591.00
307_L311_L0.9551.00
103_S106_S0.9541.00
13_A16_A0.9511.00
12_L15_F0.9471.00
219_T246_G0.9451.00
159_R165_A0.9431.00
243_S249_V0.9401.00
4_L8_I0.9381.00
205_V294_V0.9351.00
244_R247_K0.9341.00
169_L177_Y0.9341.00
162_L166_L0.9341.00
216_G298_V0.9251.00
125_L129_G0.9241.00
274_G304_W0.9241.00
238_A283_L0.9241.00
105_A108_R0.9231.00
256_K265_P0.9151.00
15_F19_A0.9101.00
140_L191_I0.9101.00
275_L303_R0.9061.00
5_A9_G0.9061.00
29_S101_R0.9031.00
45_V48_A0.9011.00
150_I184_L0.9001.00
158_A165_A0.9001.00
125_L144_A0.8881.00
166_L170_R0.8871.00
186_V189_F0.8841.00
137_L141_A0.8841.00
167_R170_R0.8811.00
220_L281_V0.8761.00
126_A132_R0.8741.00
204_D295_R0.8741.00
150_I180_Y0.8731.00
304_W307_L0.8731.00
43_L87_L0.8721.00
286_P289_D0.8681.00
57_Y69_I0.8661.00
113_W116_A0.8631.00
119_L123_L0.8601.00
16_A20_P0.8591.00
31_V35_S0.8571.00
104_L108_R0.8541.00
184_L188_V0.8531.00
209_P224_G0.8531.00
145_W149_T0.8521.00
114_P148_A0.8461.00
126_A137_L0.8451.00
30_L35_S0.8421.00
77_N197_S0.8411.00
150_I187_A0.8401.00
36_A94_G0.8351.00
47_A51_V0.8341.00
269_A282_V0.8301.00
147_I150_I0.8291.00
154_L177_Y0.8281.00
282_V297_Y0.8251.00
188_V307_L0.8241.00
186_V312_M0.8241.00
225_V238_A0.8201.00
283_L292_W0.8181.00
84_M193_I0.8131.00
31_V36_A0.8111.00
113_W117_A0.8111.00
240_F254_P0.8061.00
257_R268_E0.8051.00
148_A151_L0.8011.00
191_I195_G0.7991.00
233_Y255_E0.7971.00
126_A129_G0.7971.00
287_L291_A0.7961.00
118_A122_A0.7951.00
195_G199_F0.7921.00
8_I11_S0.7921.00
79_V82_P0.7911.00
8_I12_L0.7901.00
186_V190_V0.7881.00
185_G308_G0.7871.00
152_L155_W0.7861.00
244_R249_V0.7771.00
148_A152_L0.7741.00
220_L279_L0.7691.00
193_I196_S0.7681.00
140_L144_A0.7661.00
219_T223_D0.7661.00
275_L304_W0.7631.00
56_L60_I0.7561.00
247_K250_G0.7551.00
278_D299_K0.7501.00
225_V236_V0.7491.00
173_P176_R0.7451.00
37_L41_N0.7421.00
177_Y180_Y0.7411.00
135_L138_L0.7411.00
154_L180_Y0.7361.00
189_F305_I0.7321.00
146_V187_A0.7321.00
218_Y244_R0.7321.00
115_A119_L0.7321.00
64_L67_G0.7321.00
50_T83_L0.7291.00
222_F294_V0.7271.00
40_N94_G0.7271.00
282_V295_R0.7211.00
280_Y297_Y0.7211.00
118_A144_A0.7201.00
201_T215_V0.7181.00
123_L127_L0.7161.00
283_L294_V0.7141.00
9_G12_L0.7131.00
200_S297_Y0.7121.00
275_L278_D0.7121.00
86_P89_L0.7111.00
196_S302_V0.7111.00
71_V75_Y0.7101.00
54_G75_Y0.7101.00
282_V299_K0.7101.00
168_R171_R0.7091.00
10_G14_L0.7081.00
110_R156_R0.7081.00
149_T153_E0.7041.00
249_V272_R0.7011.00
191_I301_L0.6961.00
242_V252_L0.6961.00
97_L107_L0.6951.00
143_A147_I0.6951.00
154_L157_R0.6951.00
112_L115_A0.6941.00
212_S243_S0.6941.00
278_D303_R0.6941.00
62_E66_G0.6941.00
7_V10_G0.6911.00
162_L167_R0.6891.00
108_R111_L0.6891.00
153_E156_R0.6881.00
50_T82_P0.6881.00
86_P90_L0.6861.00
150_I154_L0.6861.00
118_A148_A0.6841.00
162_L168_R0.6831.00
122_A137_L0.6831.00
115_A118_A0.6801.00
85_L89_L0.6751.00
153_E180_Y0.6741.00
88_L91_M0.6731.00
136_A199_F0.6721.00
91_M95_P0.6701.00
29_S35_S0.6701.00
158_A166_L0.6701.00
134_L138_L0.6691.00
49_A53_L0.6691.00
228_V233_Y0.6681.00
210_G223_D0.6681.00
190_V194_A0.6671.00
195_G198_A0.6661.00
35_S39_L0.6631.00
217_G298_V0.6631.00
17_W21_L0.6611.00
3_F11_S0.6611.00
81_V190_V0.6601.00
242_V250_G0.6581.00
149_T152_L0.6581.00
222_F240_F0.6561.00
18_R22_L0.6561.00
89_L93_V0.6561.00
11_S15_F0.6561.00
106_S109_R0.6551.00
245_D249_V0.6531.00
234_T258_F0.6531.00
22_L25_G0.6521.00
146_V150_I0.6501.00
85_L142_L0.6501.00
14_L18_R0.6491.00
143_A194_A0.6481.00
189_F308_G0.6481.00
19_A22_L0.6471.00
226_T253_Y0.6431.00
217_G245_D0.6431.00
163_A168_R0.6421.00
161_S168_R0.6381.00
190_V193_I0.6381.00
88_L186_V0.6371.00
223_D243_S0.6341.00
10_G13_A0.6331.00
118_A145_W0.6321.00
158_A169_L0.6311.00
279_L298_V0.6311.00
139_G143_A0.6301.00
167_R171_R0.6301.00
18_R21_L0.6301.00
121_A125_L0.6291.00
125_L140_L0.6291.00
102_A107_L0.6291.00
116_A120_V0.6281.00
91_M146_V0.6271.00
227_E235_A0.6271.00
252_L272_R0.6261.00
222_F292_W0.6251.00
201_T217_G0.6251.00
257_R266_T0.6241.00
31_V104_L0.6241.00
159_R168_R0.6231.00
61_S67_G0.6231.00
185_G315_G0.6221.00
215_V298_V0.6201.00
46_V50_T0.6201.00
71_V74_P0.6181.00
174_R318_L0.6171.00
84_M87_L0.6161.00
7_V11_S0.6151.00
163_A166_L0.6131.00
200_S300_P0.6081.00
230_G235_A0.6051.00
182_A312_M0.6051.00
269_A280_Y0.6051.00
39_L43_L0.6031.00
193_I197_S0.6021.00
21_L25_G0.5991.00
251_T254_P0.5971.00
189_F312_M0.5961.00
145_W150_I0.5941.00
59_L68_K0.5931.00
245_D248_P0.5921.00
50_T54_G0.5911.00
61_S64_L0.5911.00
121_A148_A0.5891.00
47_A87_L0.5881.00
286_P292_W0.5881.00
172_L177_Y0.5871.00
139_G142_L0.5871.00
194_A198_A0.5861.00
256_K285_E0.5851.00
9_G16_A0.5851.00
309_G313_A0.5851.00
133_S198_A0.5841.00
130_G133_S0.5801.00
288_D291_A0.5781.00
266_T269_A0.5781.00
75_Y80_F0.5781.00
92_G95_P0.5771.00
48_A52_L0.5771.00
171_R174_R0.5761.00
36_A39_L0.5761.00
256_K284_G0.5751.00
62_E65_T0.5731.00
87_L91_M0.5731.00
6_L9_G0.5731.00
150_I157_R0.5721.00
31_V102_A0.5681.00
181_L314_L0.5661.00
173_P177_Y0.5631.00
122_A125_L0.5631.00
37_L40_N0.5631.00
218_Y277_R0.5621.00
225_V292_W0.5611.00
154_L158_A0.5601.00
25_G28_F0.5601.00
273_S278_D0.5591.00
125_L128_L0.5591.00
118_A121_A0.5571.00
184_L311_L0.5571.00
168_R172_L0.5561.00
253_Y270_A0.5561.00
203_R214_E0.5531.00
286_P290_G0.5531.00
172_L176_R0.5521.00
124_L128_L0.5511.00
315_G319_A0.5501.00
61_S66_G0.5491.00
98_A106_S0.5481.00
149_T157_R0.5471.00
238_A294_V0.5471.00
217_G277_R0.5461.00
218_Y242_V0.5461.00
46_V53_L0.5461.00
260_P265_P0.5431.00
15_F18_R0.5410.99
60_I63_A0.5380.99
213_V220_L0.5380.99
178_G319_A0.5370.99
139_G190_V0.5370.99
126_A199_F0.5360.99
286_P291_A0.5340.99
206_R293_T0.5340.99
235_A257_R0.5340.99
79_V84_M0.5330.99
53_L57_Y0.5330.99
77_N81_V0.5300.99
28_F31_V0.5290.99
145_W153_E0.5260.99
182_A186_V0.5250.99
153_E172_L0.5240.99
232_N235_A0.5240.99
109_R113_W0.5220.99
303_R309_G0.5190.99
160_E167_R0.5160.99
83_L86_P0.5150.99
46_V83_L0.5140.99
284_G297_Y0.5140.99
176_R179_G0.5110.99
111_L114_P0.5100.99
204_D293_T0.5070.99
133_S137_L0.5070.99
274_G303_R0.5050.99
270_A281_V0.5030.99
5_A8_I0.5010.99
81_V84_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zy9A 2 0.2693 13.8 0.961 Contact Map
2mgyA 1 0.483 13.7 0.961 Contact Map
3cfuA 1 0.3282 8.1 0.965 Contact Map
3mcbA 1 0.1672 7.6 0.965 Contact Map
4ryoA 1 0.4303 5.6 0.967 Contact Map
3mceA 2 0.1827 5.3 0.968 Contact Map
4uc1A 3 0.4489 5.3 0.968 Contact Map
4p79A 1 0.2848 5 0.968 Contact Map
3mp7B 1 0.1672 4.4 0.969 Contact Map
2lomA 1 0.1579 4.2 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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