GREMLIN Database
DUF4956 - Domain of unknown function (DUF4956)
PFAM: PF16316 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 172 (170)
Sequences: 6065 (4466)
Seq/√Len: 342.5
META: 0.907

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_N138_E4.9931.00
144_E150_K4.6211.00
140_I144_E2.6711.00
158_R167_L2.6391.00
30_N82_G2.5731.00
85_N99_N2.4371.00
140_I154_V2.3961.00
141_A144_E2.3541.00
141_A145_E2.2571.00
142_D146_R2.2321.00
136_R140_I2.0291.00
143_L151_I2.0101.00
10_R14_Y2.0011.00
15_R18_R1.9551.00
77_L106_I1.9271.00
31_I105_V1.9251.00
95_L99_N1.8831.00
10_R15_R1.8481.00
10_R23_V1.7751.00
99_N103_L1.7571.00
91_S94_E1.7261.00
121_K124_T1.6921.00
118_E152_K1.6891.00
137_E141_A1.6761.00
6_F11_F1.6661.00
136_R154_V1.6311.00
153_R171_Y1.6151.00
40_L43_V1.5941.00
32_I80_A1.5921.00
147_T151_I1.5731.00
142_D145_E1.5691.00
68_P71_E1.5241.00
125_Y142_D1.5191.00
6_F10_R1.5111.00
28_L106_I1.4921.00
96_L99_N1.4791.00
93_A97_I1.4691.00
154_V168_L1.4621.00
39_L43_V1.4591.00
4_V81_I1.4491.00
41_S46_S1.4491.00
133_P142_D1.4341.00
144_E147_T1.4301.00
107_F111_K1.4161.00
10_R16_R1.4141.00
12_I16_R1.4121.00
44_K49_L1.4111.00
120_S169_K1.3851.00
132_K145_E1.3831.00
101_L105_V1.3711.00
9_V15_R1.3461.00
41_S49_L1.3411.00
160_D163_R1.3221.00
11_F15_R1.3191.00
162_L165_T1.3161.00
9_V13_Y1.2971.00
128_I164_D1.2681.00
160_D165_T1.2581.00
127_K130_L1.2551.00
9_V18_R1.2511.00
120_S171_Y1.2461.00
124_T167_L1.2281.00
8_L103_L1.2251.00
132_K135_N1.2201.00
6_F27_I1.2131.00
30_N34_F1.2031.00
128_I131_I1.1971.00
5_I30_N1.1871.00
26_F78_A1.1861.00
17_S30_N1.1801.00
126_D146_R1.1121.00
50_A58_S1.1101.00
62_F69_I1.1011.00
51_L83_L1.0911.00
45_L48_G1.0861.00
121_K126_D1.0821.00
51_L55_A1.0781.00
139_L154_V1.0661.00
96_L100_A1.0631.00
93_A96_L1.0631.00
45_L55_A1.0621.00
9_V12_I1.0451.00
119_S122_L1.0341.00
14_Y20_R1.0321.00
124_T165_T1.0271.00
32_I37_I1.0201.00
42_S46_S1.0081.00
98_L102_I1.0061.00
44_K48_G0.9941.00
38_F42_S0.9941.00
81_I85_N0.9891.00
95_L103_L0.9881.00
100_A104_L0.9691.00
125_Y131_I0.9661.00
111_K115_L0.9661.00
151_I154_V0.9651.00
124_T158_R0.9561.00
121_K127_K0.9451.00
139_L142_D0.9411.00
130_L135_N0.9381.00
5_I27_I0.9351.00
138_E141_A0.9331.00
12_I15_R0.9301.00
118_E153_R0.9271.00
157_G169_K0.9241.00
48_G57_F0.9231.00
5_I78_A0.9221.00
10_R18_R0.9161.00
36_V76_F0.9141.00
30_N35_L0.9121.00
22_F26_F0.9121.00
41_S44_K0.9041.00
123_I126_D0.9001.00
147_T159_I0.8971.00
9_V14_Y0.8921.00
56_I83_L0.8911.00
103_L107_F0.8861.00
34_F38_F0.8781.00
89_K93_A0.8771.00
14_Y19_R0.8641.00
34_F85_N0.8621.00
92_Y95_L0.8591.00
5_I9_V0.8551.00
143_L154_V0.8541.00
29_L59_I0.8441.00
13_Y16_R0.8371.00
33_V50_A0.8311.00
120_S125_Y0.8291.00
53_L59_I0.8201.00
108_L113_W0.8191.00
9_V27_I0.8161.00
10_R13_Y0.8051.00
95_L98_L0.8051.00
11_F14_Y0.8051.00
4_V8_L0.8041.00
17_S20_R0.8031.00
43_V47_L0.7981.00
94_E98_L0.7821.00
147_T170_V0.7721.00
9_V16_R0.7591.00
136_R139_L0.7591.00
105_V109_L0.7541.00
78_A82_G0.7481.00
110_E113_W0.7310.99
22_F75_L0.7290.99
92_Y96_L0.7230.99
27_I31_I0.7220.99
146_R156_I0.7200.99
16_R19_R0.7130.99
22_F32_I0.7120.99
6_F9_V0.7110.99
122_L167_L0.7110.99
144_E152_K0.7080.99
100_A103_L0.7050.99
84_I95_L0.7040.99
8_L106_I0.7040.99
14_Y17_S0.7020.99
3_V6_F0.7020.99
128_I161_F0.7020.99
156_I159_I0.7010.99
101_L104_L0.6980.99
97_I100_A0.6970.99
142_D147_T0.6970.99
13_Y18_R0.6960.99
28_L77_L0.6920.99
82_G86_G0.6900.99
24_F27_I0.6860.99
30_N78_A0.6830.99
146_R161_F0.6830.99
129_E132_K0.6780.99
88_G92_Y0.6750.99
129_E135_N0.6750.99
44_K86_G0.6730.99
155_E171_Y0.6710.99
46_S89_K0.6680.99
36_V80_A0.6670.99
33_V76_F0.6640.99
156_I166_A0.6640.99
21_D24_F0.6620.99
31_I35_L0.6620.99
143_L147_T0.6550.99
29_L33_V0.6500.99
97_I101_L0.6480.99
45_L51_L0.6400.99
37_I41_S0.6400.99
52_G55_A0.6390.99
15_R20_R0.6380.99
89_K92_Y0.6350.98
136_R156_I0.6340.98
146_R150_K0.6300.98
12_I103_L0.6290.98
51_L80_A0.6280.98
149_L152_K0.6270.98
120_S124_T0.6240.98
46_S87_A0.6240.98
26_F30_N0.6230.98
139_L143_L0.6230.98
104_L108_L0.6210.98
88_G91_S0.6200.98
90_I94_E0.6180.98
32_I36_V0.6170.98
51_L60_I0.6110.98
158_R169_K0.6110.98
7_I12_I0.6100.98
33_V37_I0.6030.98
71_E75_L0.6020.98
23_V26_F0.6010.98
16_R20_R0.5990.98
138_E142_D0.5990.98
144_E154_V0.5960.98
130_L142_D0.5950.98
130_L138_E0.5940.98
8_L14_Y0.5930.98
64_T69_I0.5890.98
115_L118_E0.5810.97
113_W116_K0.5800.97
21_D25_T0.5780.97
14_Y18_R0.5750.97
125_Y130_L0.5710.97
119_S124_T0.5690.97
64_T72_M0.5690.97
62_F73_T0.5670.97
65_A72_M0.5650.97
94_E97_I0.5570.97
29_L73_T0.5530.96
6_F14_Y0.5530.96
25_T29_L0.5520.96
126_D164_D0.5500.96
24_F28_L0.5480.96
96_L110_E0.5480.96
50_A87_A0.5450.96
33_V79_I0.5420.96
109_L112_P0.5390.96
158_R165_T0.5320.95
60_I64_T0.5310.95
98_L103_L0.5310.95
138_E145_E0.5290.95
126_D161_F0.5260.95
56_I66_I0.5220.95
128_I162_L0.5190.95
45_L49_L0.5160.95
32_I77_L0.5160.95
5_I10_R0.5160.95
27_I34_F0.5160.95
99_N109_L0.5120.94
136_R142_D0.5100.94
44_K51_L0.5100.94
146_R164_D0.5100.94
53_L77_L0.5080.94
22_F68_P0.5070.94
7_I10_R0.5050.94
123_I127_K0.5040.94
49_L52_G0.5030.94
29_L62_F0.5030.94
27_I30_N0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.3314 8.6 0.936 Contact Map
3fgxA 2 0.1395 6.7 0.939 Contact Map
4c7rA 3 0.8256 5.8 0.941 Contact Map
4dx5A 3 0.7209 5.6 0.941 Contact Map
3giaA 1 0.7035 4.2 0.945 Contact Map
4k0jA 3 0.6279 4 0.945 Contact Map
4nwbA 2 0.2733 4 0.945 Contact Map
2l2tA 2 0.2558 3.9 0.946 Contact Map
2nr9A 2 0.6744 3.6 0.947 Contact Map
2jwaA 2 0.1221 3.5 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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