GREMLIN Database
DUF4936 - Domain of unknown function (DUF4936)
PFAM: PF16290 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (84)
Sequences: 1920 (1445)
Seq/√Len: 157.7
META: 0.938

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_R50_T3.1911.00
34_R56_E3.0291.00
15_R19_R2.8111.00
10_D13_A2.5401.00
64_F68_L2.3491.00
7_A10_D2.2831.00
11_A51_W2.1421.00
77_L81_L1.9561.00
6_V14_A1.9171.00
41_D50_T1.8411.00
1_Y36_L1.6011.00
69_A73_A1.5921.00
4_Y18_V1.5671.00
24_A27_A1.5421.00
22_Q25_L1.5371.00
85_R90_F1.5161.00
1_Y54_V1.4951.00
35_L51_W1.4221.00
68_L72_V1.4071.00
13_A17_A1.3831.00
67_A71_A1.3341.00
18_V77_L1.2891.00
66_A70_A1.2801.00
12_A16_A1.2721.00
36_L54_V1.2661.00
72_V77_L1.2601.00
18_V35_L1.2351.00
24_A74_A1.2101.00
65_E69_A1.2091.00
5_R86_H1.2041.00
76_G79_A1.1961.00
26_A32_R1.1891.00
15_R35_L1.1691.00
15_R37_R1.1641.00
17_A80_L1.1211.00
71_A75_A1.1071.00
30_G33_G1.0960.99
78_A84_P1.0720.99
23_A26_A1.0690.99
79_A85_R1.0690.99
21_L25_L1.0570.99
41_D49_Q1.0440.99
58_V64_F1.0430.99
70_A74_A1.0000.99
22_Q33_G0.9930.99
4_Y51_W0.9860.99
5_R14_A0.9750.99
37_R40_D0.9750.99
20_A24_A0.9680.99
3_Y37_R0.9460.98
11_A35_L0.9330.98
15_R51_W0.9290.98
85_R88_E0.9280.98
22_Q80_L0.9200.98
20_A23_A0.9130.98
18_V22_Q0.9030.98
2_V22_Q0.8920.98
25_L31_V0.8760.97
64_F72_V0.8720.97
6_V49_Q0.8480.97
21_L75_A0.8340.97
24_A28_R0.8320.97
24_A75_A0.8290.97
39_R89_R0.8220.96
39_R65_E0.8220.96
62_A65_E0.8200.96
28_R31_V0.8130.96
29_T33_G0.8070.96
3_Y8_P0.8000.96
27_A71_A0.7960.96
62_A66_A0.7950.96
16_A19_R0.7880.95
63_A72_V0.7830.95
22_Q55_Y0.7790.95
65_E68_L0.7730.95
17_A77_L0.7720.95
2_V38_R0.7670.95
4_Y36_L0.7630.94
20_A74_A0.7510.94
50_T86_H0.7510.94
31_V57_G0.7490.94
42_P76_G0.7410.94
83_G86_H0.7270.93
5_R41_D0.7260.93
8_P13_A0.7160.92
19_R26_A0.7150.92
73_A78_A0.7150.92
15_R36_L0.7140.92
57_G60_D0.7030.92
3_Y22_Q0.6960.91
12_A78_A0.6850.91
69_A78_A0.6780.90
64_F70_A0.6690.90
26_A59_A0.6610.89
26_A61_A0.6480.88
7_A12_A0.6480.88
31_V56_E0.6460.88
37_R49_Q0.6420.88
11_A84_P0.6400.87
63_A66_A0.6380.87
77_L82_A0.6290.87
22_Q35_L0.6240.86
51_W82_A0.6240.86
67_A70_A0.6120.85
81_L84_P0.5910.83
31_V58_V0.5900.83
39_R61_A0.5860.82
14_A70_A0.5850.82
19_R23_A0.5830.82
62_A69_A0.5780.82
73_A87_V0.5780.82
40_D49_Q0.5600.80
13_A79_A0.5440.78
65_E72_V0.5420.77
11_A37_R0.5330.76
28_R33_G0.5320.76
62_A68_L0.5250.75
20_A56_E0.5250.75
26_A66_A0.5230.75
28_R74_A0.5170.74
34_R89_R0.5140.74
21_L77_L0.5100.73
63_A68_L0.5060.72
61_A66_A0.5030.72
16_A20_A0.5020.72
63_A75_A0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gffA 2 0.956 90.4 0.815 Contact Map
3fgvA 2 0.9231 90 0.817 Contact Map
2omoA 2 0.956 88.2 0.823 Contact Map
1y0hA 2 0.956 87.7 0.824 Contact Map
3bm7A 2 0.956 87.3 0.826 Contact Map
4dpoA 2 0.956 86.1 0.828 Contact Map
4zosA 2 0.956 85.4 0.83 Contact Map
3e8oA 2 0.956 84.8 0.832 Contact Map
4hl9A 2 0.956 84.8 0.832 Contact Map
2pd1A 5 0.9451 84 0.833 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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