GREMLIN Database
DUF4932 - Domain of unknown function (DUF4932)
PFAM: PF16286 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 335 (323)
Sequences: 1406 (1292)
Seq/√Len: 71.9
META: 0.876

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_D133_H7.7191.00
119_D123_D4.8001.00
15_V117_L4.5311.00
125_N128_E4.3551.00
293_L297_E3.6651.00
7_E127_R3.4741.00
234_T269_N3.4521.00
160_F279_R3.2261.00
279_R316_E2.8381.00
235_D269_N2.7341.00
224_E227_H2.6681.00
153_D284_H2.6461.00
181_Y184_G2.6061.00
323_P327_D2.5401.00
298_E306_E2.5331.00
158_E229_F2.5201.00
236_K326_E2.4701.00
161_F226_G2.3961.00
173_S176_P2.3551.00
54_P116_L2.3251.00
160_F316_E2.3081.00
311_L314_E2.2861.00
324_T327_D2.2731.00
178_L181_Y2.2721.00
223_H227_H2.1541.00
53_H123_D2.1531.00
231_N269_N2.1191.00
237_Y240_E2.1141.00
271_Y304_W2.0921.00
196_Y199_G2.0881.00
58_L116_L2.0761.00
184_G192_G2.0551.00
59_A113_F2.0211.00
53_H119_D2.0171.00
134_K138_E2.0131.00
16_F21_Y2.0091.00
178_L182_G2.0011.00
282_K313_E1.9601.00
72_A104_R1.9591.00
253_K257_R1.9441.00
275_A312_L1.9391.00
315_Y322_Y1.8601.00
121_Y127_R1.8411.00
245_A248_F1.8351.00
126_F130_F1.8311.00
177_G180_N1.8051.00
73_P76_L1.7881.00
156_W280_Y1.7791.00
17_R44_D1.7611.00
261_Y302_F1.7491.00
126_F137_Y1.6851.00
279_R283_D1.6711.00
287_E291_E1.6701.00
54_P119_D1.6481.00
14_I43_V1.6420.99
227_H261_Y1.6150.99
55_A116_L1.5930.99
71_D104_R1.5850.99
234_T241_I1.5600.99
181_Y185_P1.5590.99
311_L332_L1.5500.99
15_V55_A1.5480.99
176_P183_Y1.5340.99
158_E164_K1.5310.99
133_H137_Y1.5240.99
267_M271_Y1.5180.99
128_E132_S1.5180.99
314_E331_E1.5110.99
83_P89_L1.4880.99
157_L226_G1.4870.99
68_I73_P1.4730.99
184_G187_I1.4680.99
265_E269_N1.4570.99
271_Y305_I1.4510.99
234_T273_V1.4470.99
256_M259_Q1.4400.99
15_V59_A1.4370.99
175_L178_L1.4340.99
278_I290_A1.4270.99
82_I85_F1.4250.99
223_H274_R1.4220.99
87_L90_S1.4160.98
222_I280_Y1.4100.98
225_F228_S1.4040.98
19_A60_K1.3910.98
114_L118_R1.3870.98
70_Y260_A1.3550.98
50_Y124_S1.3470.98
176_P181_Y1.3450.98
235_D265_E1.3340.98
86_A89_L1.3280.98
227_H231_N1.3240.98
286_G289_A1.3140.98
47_F120_F1.3040.97
315_Y319_R1.3020.97
311_L328_F1.3010.97
87_L92_D1.2880.97
226_G273_V1.2710.97
87_L91_P1.2650.97
195_I199_G1.2580.97
179_G182_G1.2550.97
180_N183_Y1.2530.97
80_L83_P1.2430.97
224_E270_E1.2410.96
319_R323_P1.2380.96
4_E141_I1.2290.96
15_V56_V1.2260.96
279_R313_E1.2190.96
234_T329_Y1.2020.96
59_A62_L1.1990.96
173_S177_G1.1830.95
61_E65_K1.1760.95
85_F90_S1.1690.95
11_L126_F1.1690.95
224_E261_Y1.1660.95
18_L56_V1.1540.95
85_F88_R1.1280.94
227_H270_E1.1250.94
241_I333_I1.1240.94
135_P138_E1.1200.94
83_P86_A1.1180.94
178_L183_Y1.1050.93
21_Y63_R1.0980.93
194_E198_I1.0980.93
82_I87_L1.0960.93
86_A90_S1.0920.93
162_G319_R1.0920.93
177_G181_Y1.0810.93
175_L179_G1.0800.93
20_G23_E1.0740.92
38_P42_D1.0740.92
47_F129_F1.0730.92
279_R282_K1.0710.92
77_A80_L1.0680.92
314_E318_N1.0610.92
44_D48_A1.0590.92
294_L297_E1.0550.92
230_V273_V1.0520.92
224_E231_N1.0500.92
245_A249_F1.0470.91
131_K134_K1.0470.91
7_E121_Y1.0390.91
269_N276_V1.0390.91
160_F283_D1.0380.91
158_E168_Y1.0330.91
170_I173_S1.0300.91
177_G182_G1.0260.91
176_P180_N1.0180.90
183_Y192_G1.0170.90
9_V12_L1.0150.90
263_N266_T1.0130.90
180_N184_G1.0100.90
72_A266_T1.0060.90
77_A85_F1.0050.90
79_H82_I1.0040.90
84_D90_S1.0030.90
53_H116_L1.0000.89
16_F59_A0.9940.89
273_V277_V0.9870.89
305_I309_V0.9850.89
83_P87_L0.9820.89
129_F137_Y0.9800.88
274_R297_E0.9790.88
14_I18_L0.9770.88
247_L251_L0.9770.88
182_G185_P0.9700.88
322_Y328_F0.9630.88
170_I221_V0.9560.87
11_L15_V0.9430.86
74_M77_A0.9410.86
81_D84_D0.9400.86
8_R16_F0.9370.86
83_P88_R0.9370.86
278_I293_L0.9330.86
13_S16_F0.9300.86
85_F91_P0.9300.86
315_Y328_F0.9290.86
275_A315_Y0.9230.85
187_I192_G0.9220.85
176_P184_G0.9120.85
74_M78_L0.9070.84
39_Y129_F0.9060.84
88_R91_P0.9060.84
95_L101_L0.9040.84
41_K45_K0.9010.84
14_I46_Y0.9000.84
252_V267_M0.8980.84
172_I176_P0.8970.84
86_A92_D0.8930.83
256_M260_A0.8840.83
222_I277_V0.8810.82
278_I309_V0.8780.82
46_Y128_E0.8760.82
328_F332_L0.8720.82
47_F126_F0.8710.82
252_V304_W0.8690.82
273_V276_V0.8630.81
79_H83_P0.8620.81
6_D221_V0.8600.81
173_S178_L0.8570.81
269_N329_Y0.8540.80
129_F133_H0.8520.80
5_V130_F0.8490.80
286_G290_A0.8480.80
12_L73_P0.8450.80
70_Y73_P0.8440.80
234_T268_L0.8430.80
104_R107_K0.8420.79
46_Y50_Y0.8340.79
82_I86_A0.8340.79
12_L16_F0.8240.78
165_P168_Y0.8220.78
255_K258_K0.8190.78
173_S182_G0.8180.77
281_L286_G0.8150.77
14_I120_F0.8140.77
112_E116_L0.8130.77
55_A123_D0.8110.77
181_Y192_G0.8090.77
277_V281_L0.8050.76
154_L158_E0.8040.76
10_E137_Y0.8000.76
219_P273_V0.7990.76
230_V269_N0.7990.76
118_R121_Y0.7970.76
174_L182_G0.7970.76
194_E197_A0.7950.75
277_V293_L0.7940.75
244_A248_F0.7880.75
312_L325_F0.7850.75
275_A308_L0.7840.74
285_G289_A0.7800.74
309_V313_E0.7790.74
73_P77_A0.7780.74
238_K242_E0.7760.74
54_P58_L0.7760.74
248_F256_M0.7750.74
76_L79_H0.7730.73
55_A124_S0.7720.73
48_A51_K0.7720.73
68_I71_D0.7680.73
40_Y44_D0.7640.73
173_S183_Y0.7620.72
274_R302_F0.7570.72
255_K301_G0.7560.72
234_T265_E0.7550.72
55_A117_L0.7550.72
143_R204_D0.7550.72
239_D242_E0.7530.71
278_I305_I0.7530.71
93_P96_S0.7520.71
271_Y308_L0.7500.71
82_I89_L0.7490.71
252_V256_M0.7490.71
226_G276_V0.7460.71
248_F251_L0.7450.71
105_W156_W0.7430.70
39_Y43_V0.7430.70
183_Y191_D0.7410.70
264_W271_Y0.7410.70
101_L104_R0.7350.70
84_D87_L0.7350.70
153_D280_Y0.7340.69
310_E313_E0.7330.69
15_V19_A0.7330.69
270_E274_R0.7330.69
68_I105_W0.7330.69
144_F148_L0.7310.69
118_R122_K0.7300.69
105_W108_E0.7280.69
88_R92_D0.7280.69
136_L140_A0.7240.68
46_Y125_N0.7180.68
223_H270_E0.7170.68
190_G193_K0.7160.68
14_I47_F0.7150.67
17_R40_Y0.7140.67
90_S93_P0.7140.67
18_L120_F0.7140.67
199_G204_D0.7130.67
319_R322_Y0.7110.67
78_L81_D0.7080.67
328_F331_E0.7070.67
247_L271_Y0.7060.67
46_Y124_S0.7060.67
36_D41_K0.7050.66
280_Y284_H0.7050.66
13_S74_M0.7040.66
138_E142_A0.7010.66
12_L15_V0.7010.66
320_D323_P0.7000.66
85_F89_L0.6990.66
291_E295_E0.6990.66
18_L60_K0.6990.66
16_F73_P0.6980.66
167_S192_G0.6970.66
155_E159_K0.6910.65
223_H261_Y0.6890.65
273_V279_R0.6880.65
57_K60_K0.6870.64
173_S181_Y0.6860.64
325_F328_F0.6860.64
14_I17_R0.6830.64
103_R106_G0.6830.64
161_F276_V0.6800.64
69_S72_A0.6770.63
113_F117_L0.6770.63
46_Y126_F0.6730.63
197_A200_S0.6720.63
58_L112_E0.6720.63
164_K167_S0.6710.63
275_A282_K0.6690.62
71_D74_M0.6680.62
182_G187_I0.6670.62
76_L80_L0.6670.62
77_A83_P0.6660.62
218_L281_L0.6660.62
223_H277_V0.6630.62
230_V234_T0.6630.62
248_F267_M0.6620.62
184_G191_D0.6600.61
104_R108_E0.6580.61
157_L276_V0.6580.61
58_L61_E0.6560.61
161_F229_F0.6530.60
157_L222_I0.6530.60
121_Y161_F0.6510.60
278_I281_L0.6500.60
199_G221_V0.6450.60
152_D155_E0.6440.59
92_D96_S0.6440.59
20_G60_K0.6420.59
89_L94_D0.6410.59
5_V10_E0.6390.59
132_S263_N0.6380.59
231_N270_E0.6370.59
268_L272_L0.6370.59
15_V18_L0.6360.58
189_D192_G0.6350.58
220_L226_G0.6340.58
262_G266_T0.6330.58
68_I72_A0.6300.58
55_A59_A0.6300.58
33_N37_T0.6290.58
198_I202_S0.6270.57
231_N274_R0.6250.57
181_Y187_I0.6240.57
71_D76_L0.6240.57
83_P90_S0.6230.57
127_R131_K0.6220.57
144_F217_L0.6210.57
316_E328_F0.6190.56
14_I56_V0.6190.56
240_E333_I0.6180.56
162_G322_Y0.6170.56
6_D160_F0.6160.56
175_L180_N0.6150.56
170_I331_E0.6140.56
67_G71_D0.6120.56
56_V120_F0.6120.56
81_D87_L0.6110.55
139_K142_A0.6100.55
8_R12_L0.6100.55
241_I245_A0.6090.55
69_S73_P0.6090.55
21_Y59_A0.6090.55
52_N112_E0.6080.55
7_E126_F0.6080.55
256_M302_F0.6080.55
130_F137_Y0.6070.55
9_V264_W0.6030.54
194_E199_G0.6000.54
183_Y187_I0.5990.54
325_F329_Y0.5980.54
252_V260_A0.5950.53
19_A22_P0.5920.53
182_G274_R0.5920.53
277_V297_E0.5900.53
264_W267_M0.5890.53
31_Y34_K0.5890.53
76_L82_I0.5870.53
228_S277_V0.5860.52
226_G277_V0.5800.52
304_W307_E0.5800.52
329_Y333_I0.5790.52
276_V280_Y0.5780.51
81_D85_F0.5780.51
291_E294_L0.5780.51
259_Q300_R0.5770.51
219_P277_V0.5770.51
134_K145_R0.5750.51
47_F53_H0.5750.51
305_I308_L0.5750.51
197_A220_L0.5750.51
129_F209_P0.5750.51
130_F133_H0.5720.51
319_R324_T0.5720.51
242_E246_K0.5710.51
56_V59_A0.5700.50
117_L162_G0.5690.50
242_E264_W0.5680.50
309_V312_L0.5660.50
176_P179_G0.5640.50
230_V325_F0.5640.50
238_K265_E0.5630.50
178_L184_G0.5630.50
64_K135_P0.5620.49
8_R13_S0.5620.49
304_W308_L0.5610.49
188_N207_G0.5610.49
318_N322_Y0.5590.49
87_L93_P0.5580.49
68_I104_R0.5570.49
71_D75_S0.5570.49
298_E305_I0.5570.49
306_E310_E0.5570.49
52_N132_S0.5570.49
231_N235_D0.5560.49
196_Y200_S0.5560.49
9_V315_Y0.5550.49
238_K264_W0.5550.49
112_E115_K0.5550.49
283_D316_E0.5540.48
294_L298_E0.5530.48
261_Y312_L0.5530.48
156_W271_Y0.5520.48
160_F315_Y0.5520.48
225_F229_F0.5500.48
116_L119_D0.5490.48
320_D327_D0.5470.48
329_Y332_L0.5460.47
3_V141_I0.5440.47
5_V17_R0.5440.47
185_P228_S0.5440.47
288_E291_E0.5390.47
279_R312_L0.5370.46
139_K143_R0.5360.46
307_E311_L0.5350.46
230_V272_L0.5350.46
267_M280_Y0.5340.46
185_P189_D0.5320.46
246_K250_P0.5310.46
135_P206_D0.5310.46
315_Y325_F0.5300.46
182_G186_R0.5300.46
311_L315_Y0.5300.46
180_N302_F0.5280.45
98_S102_D0.5270.45
8_R223_H0.5270.45
247_L250_P0.5270.45
130_F172_I0.5260.45
96_S99_S0.5240.45
37_T198_I0.5230.45
100_S103_R0.5230.45
294_L306_E0.5230.45
7_E118_R0.5220.45
195_I200_S0.5210.44
294_L309_V0.5210.44
63_R69_S0.5210.44
179_G184_G0.5200.44
226_G230_V0.5190.44
135_P323_P0.5170.44
242_E265_E0.5170.44
115_K118_R0.5170.44
125_N131_K0.5160.44
217_L221_V0.5160.44
19_A31_Y0.5150.44
290_A293_L0.5130.43
233_L326_E0.5110.43
17_R280_Y0.5100.43
110_L114_L0.5100.43
80_L84_D0.5100.43
182_G188_N0.5090.43
167_S194_E0.5080.43
80_L89_L0.5080.43
197_A225_F0.5070.43
222_I276_V0.5060.43
94_D101_L0.5040.42
56_V126_F0.5030.42
44_D51_K0.5020.42
83_P91_P0.5020.42
323_P328_F0.5000.42
291_E306_E0.5000.42
321_K333_I0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jiuA 1 0.3045 11.1 0.964 Contact Map
2gb7A 2 0.191 10.9 0.964 Contact Map
4qhjA 2 0.3075 9.7 0.964 Contact Map
3vtwA 1 0.0955 7.4 0.966 Contact Map
4jixA 2 0.3284 7.1 0.967 Contact Map
2rioA 2 0.3373 6.2 0.967 Contact Map
2xfvA 2 0.1672 3.7 0.971 Contact Map
3lywA 1 0.0776 3.4 0.971 Contact Map
3evoA 5 0.1731 2.9 0.972 Contact Map
3n2qA 2 0.1791 2.8 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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