GREMLIN Database
DUF4926 - Domain of unknown function (DUF4926)
PFAM: PF16277 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (57)
Sequences: 10657 (6047)
Seq/√Len: 801.0
META: 0.963

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_R55_Q3.3881.00
28_Y35_E2.5141.00
1_E26_E2.3991.00
52_P55_Q2.2761.00
17_R20_D2.0851.00
10_D18_R2.0411.00
35_E50_T1.9671.00
7_L16_L1.8891.00
10_D17_R1.8871.00
14_H49_V1.8451.00
34_Y53_A1.7501.00
40_D44_R1.7441.00
2_L26_E1.7081.00
4_V23_T1.6431.00
6_A21_V1.6071.00
6_A57_R1.5471.00
8_T18_R1.5011.00
29_A33_A1.2761.00
45_T48_V1.2661.00
11_L55_Q1.2651.00
28_Y33_A1.2501.00
20_D46_Y1.2381.00
39_V45_T1.2051.00
26_E35_E1.1941.00
11_L14_H1.1341.00
27_V34_Y1.0831.00
7_L38_F1.0211.00
40_D46_Y1.0141.00
51_L55_Q1.0081.00
22_G36_V1.0051.00
34_Y56_L0.9981.00
27_V32_E0.9631.00
28_Y48_V0.9451.00
29_A32_E0.9421.00
32_E53_A0.9151.00
23_T39_V0.8951.00
22_G38_F0.8681.00
38_F47_A0.8571.00
8_T57_R0.8531.00
24_V34_Y0.8221.00
36_V56_L0.8211.00
5_V56_L0.8191.00
30_P33_A0.8031.00
4_V39_V0.8011.00
25_V37_E0.7571.00
51_L56_L0.7531.00
33_A50_T0.7501.00
31_G53_A0.7281.00
14_H47_A0.7261.00
41_A46_Y0.7231.00
7_L51_L0.7051.00
39_V48_V0.7031.00
11_L51_L0.6981.00
4_V21_V0.6701.00
2_L23_T0.6471.00
27_V30_P0.6411.00
33_A53_A0.6141.00
35_E49_V0.6121.00
20_D57_R0.6031.00
11_L15_G0.6021.00
39_V46_Y0.5961.00
3_D34_Y0.5781.00
1_E27_V0.5781.00
16_L47_A0.5741.00
46_Y57_R0.5731.00
33_A52_P0.5731.00
37_E48_V0.5711.00
5_V22_G0.5671.00
53_A56_L0.5601.00
28_Y50_T0.5501.00
37_E45_T0.5461.00
5_V36_V0.5441.00
16_L38_F0.5391.00
39_V44_R0.5331.00
24_V36_V0.5271.00
21_V41_A0.5221.00
11_L16_L0.5201.00
32_E52_P0.5201.00
2_L24_V0.5141.00
40_D43_G0.5131.00
20_D43_G0.5111.00
1_E28_Y0.5041.00
12_P16_L0.5011.00
27_V31_G0.5001.00
25_V45_T0.5001.00
31_G52_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y35A 1 0.8103 64.1 0.761 Contact Map
3pieA 1 0.931 54.2 0.774 Contact Map
1w36D 1 0.1207 35.6 0.798 Contact Map
4l0jA 2 0.8966 21.3 0.819 Contact Map
3e1sA 1 0.8621 13.6 0.835 Contact Map
4hczA 1 0.7931 12.9 0.836 Contact Map
2ldmA 1 0.8103 11 0.841 Contact Map
3p8dA 2 0.8103 10.9 0.842 Contact Map
2eyqA 1 0.931 10.4 0.843 Contact Map
4fibA 1 0.9483 10.4 0.843 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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