GREMLIN Database
DUF4924 - Domain of unknown function (DUF4924)
PFAM: PF16271 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 179 (178)
Sequences: 1481 (1115)
Seq/√Len: 83.5
META: 0.893

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_E55_R3.7661.00
6_Q10_E3.5351.00
47_D50_Q2.9011.00
138_V156_I2.6001.00
30_G35_R2.5931.00
54_I58_Y2.4501.00
35_R39_N2.4241.00
2_L54_I2.2851.00
37_E42_S2.2561.00
33_I62_I2.2341.00
29_Y39_N2.1941.00
66_R71_E2.1871.00
109_A158_Q2.1461.00
113_I131_C2.1221.00
70_V76_L2.0791.00
46_L50_Q2.0721.00
64_M78_I2.0311.00
32_D35_R1.9801.00
70_V80_K1.9601.00
63_D67_E1.9331.00
24_D136_Y1.9191.00
87_N126_N1.8991.00
30_G72_E1.8351.00
168_D172_K1.8191.00
167_S171_K1.8041.00
99_D169_Y1.7541.00
170_Y174_K1.7481.00
22_V58_Y1.7211.00
26_I36_I1.7161.00
46_L54_I1.6831.00
117_R127_E1.6681.00
135_L163_L1.6641.00
112_F115_E1.6621.00
105_L165_L1.6581.00
171_K175_E1.6511.00
112_F158_Q1.6221.00
172_K177_E1.6211.00
56_D60_N1.5641.00
5_Q53_E1.5501.00
106_Y127_E1.5441.00
23_E75_H1.5301.00
89_L173_D1.5150.99
88_D92_R1.4750.99
90_H102_Y1.4500.99
31_F62_I1.4470.99
150_P154_E1.4450.99
45_D51_K1.4320.99
29_Y35_R1.4090.99
65_M70_V1.3970.99
169_Y172_K1.3890.99
13_A167_S1.3770.99
64_M81_N1.3730.99
26_I61_L1.3570.99
16_L79_N1.3460.99
13_A132_F1.3300.99
153_E157_K1.3230.99
83_I132_F1.3090.98
19_M79_N1.2810.98
138_V142_R1.2750.98
41_I55_R1.2390.98
7_K10_E1.2220.98
131_C162_F1.2200.98
112_F155_A1.2180.98
82_V85_E1.2110.97
105_L109_A1.2010.97
87_N91_L1.1800.97
117_R130_T1.1690.97
20_W83_I1.1520.97
33_I59_E1.1490.97
134_A159_I1.1460.96
152_T155_A1.1440.96
116_L137_G1.1440.96
31_F71_E1.1390.96
8_R170_Y1.1300.96
33_I41_I1.1210.96
2_L50_Q1.1090.96
13_A163_L1.0980.95
8_R174_K1.0970.95
46_L51_K1.0840.95
77_Q81_N1.0690.95
41_I54_I1.0590.94
110_L114_V1.0500.94
99_D165_L1.0500.94
40_I44_Y1.0460.94
84_I88_D1.0460.94
64_M68_E1.0450.94
35_R38_K1.0360.94
116_L159_I1.0300.94
114_V117_R1.0220.93
44_Y54_I1.0000.93
139_L142_R0.9960.92
48_E51_K0.9940.92
160_S164_A0.9920.92
116_L134_A0.9830.92
88_D91_L0.9810.92
68_E77_Q0.9720.92
3_I44_Y0.9640.91
11_N14_E0.9630.91
20_W132_F0.9600.91
134_A156_I0.9590.91
22_V26_I0.9570.91
150_P153_E0.9560.91
20_W129_E0.9470.90
91_L95_K0.9430.90
85_E92_R0.9360.90
5_Q9_K0.9350.90
34_D38_K0.9160.89
48_E52_E0.9140.89
16_L82_V0.9130.89
6_Q9_K0.9120.89
50_Q54_I0.9120.89
82_V174_K0.9040.88
149_S152_T0.9040.88
52_E55_R0.9030.88
101_F104_A0.9020.88
125_E133_N0.9010.88
141_L152_T0.9010.88
173_D176_G0.8960.88
39_N43_R0.8950.88
113_I130_T0.8850.87
25_L40_I0.8790.87
19_M76_L0.8780.87
100_P104_A0.8750.87
109_A162_F0.8720.86
61_L64_M0.8720.86
137_G141_L0.8710.86
109_A112_F0.8630.86
22_V54_I0.8600.86
65_M76_L0.8520.85
34_D37_E0.8450.85
1_M4_A0.8430.84
114_V127_E0.8310.84
168_D171_K0.8280.83
60_N78_I0.8240.83
81_N84_I0.8200.83
60_N64_M0.8180.83
41_I51_K0.8150.82
50_Q53_E0.8130.82
63_D66_R0.8090.82
76_L79_N0.8060.82
4_A7_K0.8050.82
153_E156_I0.8010.81
159_I163_L0.8000.81
68_E78_I0.8000.81
42_S51_K0.7930.81
26_I62_I0.7820.80
147_E150_P0.7820.80
80_K129_E0.7790.80
97_P175_E0.7760.79
138_V153_E0.7690.79
79_N132_F0.7680.79
31_F70_V0.7670.78
108_K161_K0.7650.78
3_I18_Y0.7610.78
60_N63_D0.7590.78
81_N88_D0.7550.77
85_E170_Y0.7470.77
8_R82_V0.7440.76
86_L132_F0.7420.76
103_N107_Y0.7400.76
163_L167_S0.7390.76
70_V73_K0.7390.76
28_A136_Y0.7380.76
83_I128_I0.7380.76
78_I81_N0.7290.75
158_Q162_F0.7260.75
104_A108_K0.7200.74
127_E131_C0.7150.73
151_E154_E0.7140.73
164_A168_D0.7100.73
113_I128_I0.6970.72
2_L46_L0.6970.72
157_K161_K0.6950.71
109_A156_I0.6930.71
154_E157_K0.6870.70
31_F36_I0.6840.70
16_L83_I0.6700.69
165_L169_Y0.6680.68
85_E88_D0.6660.68
142_R153_E0.6650.68
110_L117_R0.6610.68
16_L86_L0.6610.68
107_Y110_L0.6600.67
56_D66_R0.6590.67
115_E155_A0.6560.67
26_I33_I0.6550.67
115_E119_K0.6530.67
98_K103_N0.6400.65
77_Q80_K0.6360.65
173_D178_L0.6310.64
120_S124_D0.6310.64
83_I126_N0.6290.64
127_E130_T0.6200.63
24_D28_A0.6200.63
137_G140_L0.6190.62
25_L29_Y0.6130.62
85_E174_K0.6110.61
133_N137_G0.6090.61
128_I132_F0.6090.61
49_E53_E0.6080.61
157_K160_S0.6060.61
107_Y114_V0.6030.60
21_Q25_L0.5990.60
106_Y126_N0.5990.60
32_D66_R0.5960.60
84_I87_N0.5950.59
24_D143_L0.5950.59
22_V94_L0.5930.59
38_K42_S0.5920.59
52_E56_D0.5910.59
32_D71_E0.5900.59
105_L162_F0.5860.58
40_I46_L0.5840.58
113_I162_F0.5810.58
94_L103_N0.5800.57
70_V82_V0.5760.57
87_N106_Y0.5750.57
64_M76_L0.5710.56
82_V89_L0.5710.56
89_L174_K0.5690.56
36_I51_K0.5680.56
10_E171_K0.5660.56
43_R132_F0.5660.56
20_W130_T0.5610.55
114_V130_T0.5590.55
96_S99_D0.5560.54
135_L156_I0.5560.54
31_F66_R0.5550.54
92_R173_D0.5540.54
17_L133_N0.5520.54
61_L140_L0.5510.54
64_M77_Q0.5500.54
163_L171_K0.5490.53
10_E31_F0.5490.53
70_V81_N0.5490.53
36_I40_I0.5480.53
158_Q161_K0.5470.53
11_N58_Y0.5460.53
138_V148_I0.5450.53
117_R131_C0.5430.53
165_L168_D0.5410.52
134_A138_V0.5390.52
36_I139_L0.5380.52
115_E135_L0.5360.52
33_I55_R0.5360.52
101_F108_K0.5360.52
110_L127_E0.5310.51
122_G125_E0.5310.51
7_K16_L0.5280.51
128_I162_F0.5280.51
119_K152_T0.5240.50
101_F105_L0.5220.50
69_G81_N0.5220.50
100_P103_N0.5220.50
16_L20_W0.5210.50
155_A158_Q0.5190.49
13_A98_K0.5150.49
20_W23_E0.5140.49
29_Y134_A0.5130.49
45_D54_I0.5120.49
120_S123_K0.5120.49
89_L93_L0.5110.48
71_E123_K0.5080.48
92_R176_G0.5080.48
147_E153_E0.5060.48
2_L53_E0.5020.47
92_R96_S0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ce2A 1 0.8492 39.8 0.948 Contact Map
2j69A 1 0.5642 18.1 0.956 Contact Map
2au5A 1 0.6034 7 0.964 Contact Map
1fioA 1 0.5922 5.6 0.965 Contact Map
2ilkA 2 0.7486 5.3 0.965 Contact Map
3ghgA 2 0.8603 5.2 0.966 Contact Map
4i1aA 2 0.6034 5.2 0.966 Contact Map
2qr4A 2 0.7263 5.1 0.966 Contact Map
3o60A 2 0.8883 4.7 0.966 Contact Map
1deqA 1 0.838 4.2 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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