GREMLIN Database
DUF4920 - Domain of unknown function (DUF4920)
PFAM: PF16267 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (79)
Sequences: 5230 (3391)
Seq/√Len: 381.6
META: 0.937

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_K63_E2.4501.00
24_Q56_A2.2851.00
16_E59_T2.2731.00
32_L62_V2.1991.00
14_K61_V2.1831.00
72_S75_E2.1741.00
73_V76_L2.0221.00
19_V55_A1.9661.00
73_V77_K1.9441.00
31_K41_R1.9281.00
26_K47_Y1.8671.00
18_K33_A1.7781.00
31_K39_T1.7271.00
20_T33_A1.6531.00
30_M51_V1.6331.00
12_T65_K1.6161.00
45_K48_G1.6121.00
16_E61_V1.5461.00
18_K59_T1.5311.00
21_E31_K1.5271.00
78_H81_E1.4581.00
22_V55_A1.4561.00
47_Y50_F1.4171.00
78_H82_D1.4131.00
76_L80_A1.4061.00
17_G32_L1.3831.00
75_E79_Y1.3641.00
12_T63_E1.3441.00
30_M60_V1.3131.00
10_T65_K1.2641.00
71_T76_L1.2461.00
24_Q53_K1.2211.00
15_V40_V1.2001.00
21_E56_A1.1801.00
19_V60_V1.1551.00
44_F50_F1.1271.00
44_F47_Y1.0891.00
20_T39_T1.0571.00
44_F51_V1.0531.00
51_V55_A1.0501.00
26_K50_F1.0171.00
8_G11_L1.0161.00
34_L39_T0.9821.00
80_A85_K0.9811.00
34_L37_G0.9641.00
77_K81_E0.9591.00
55_A58_K0.9411.00
55_A60_V0.9281.00
41_R79_Y0.9171.00
71_T79_Y0.9151.00
22_V54_D0.9121.00
21_E83_A0.9111.00
23_C28_C0.9031.00
72_S76_L0.8831.00
35_G38_E0.8631.00
34_L38_E0.8611.00
19_V30_M0.8601.00
30_M42_V0.8571.00
22_V56_A0.8551.00
44_F48_G0.7941.00
30_M44_F0.7641.00
73_V80_A0.7601.00
74_E77_K0.7571.00
8_G13_V0.7551.00
32_L60_V0.7541.00
77_K80_A0.7531.00
47_Y51_V0.7521.00
9_D67_F0.7511.00
20_T31_K0.7471.00
13_V17_G0.7411.00
42_V62_V0.7391.00
71_T75_E0.7221.00
81_E84_G0.7151.00
43_K79_Y0.7131.00
33_A36_D0.7111.00
53_K56_A0.7091.00
12_T16_E0.7061.00
15_V62_V0.7010.99
19_V22_V0.6910.99
69_K75_E0.6850.99
10_T67_F0.6790.99
9_D65_K0.6790.99
48_G51_V0.6760.99
70_E73_V0.6640.99
77_K84_G0.6600.99
43_K47_Y0.6570.99
22_V53_K0.6470.99
46_D50_F0.6410.99
9_D68_V0.6240.99
73_V79_Y0.6210.99
22_V51_V0.6150.99
34_L40_V0.6150.99
9_D12_T0.6080.99
11_L66_A0.6030.98
29_W53_K0.6020.98
42_V49_F0.5910.98
33_A37_G0.5860.98
8_G65_K0.5840.98
21_E24_Q0.5820.98
13_V16_E0.5630.98
19_V56_A0.5620.98
65_K69_K0.5610.98
54_D58_K0.5430.97
45_K49_F0.5430.97
81_E85_K0.5390.97
9_D13_V0.5350.97
8_G12_T0.5330.97
17_G57_G0.5300.97
17_G40_V0.5240.96
45_K65_K0.5160.96
26_K30_M0.5150.96
27_G46_D0.5150.96
66_A80_A0.5100.96
43_K75_E0.5090.96
79_Y82_D0.5090.96
43_K46_D0.5050.96
79_Y83_A0.5030.95
29_W83_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xgtA 2 0.9885 46 0.868 Contact Map
1n9wA 2 0.8851 45.6 0.869 Contact Map
1nnxA 1 0.8621 37.1 0.875 Contact Map
2vovA 1 0.4138 29.6 0.882 Contact Map
1e1oA 2 0.9425 27 0.884 Contact Map
4pg3A 2 0.977 23.2 0.887 Contact Map
4ycuA 3 0.9885 18.9 0.892 Contact Map
3m4pA 2 0.9885 15.8 0.896 Contact Map
1eovA 2 0.977 15.2 0.896 Contact Map
4up7A 2 0.977 14.6 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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