GREMLIN Database
DUF4917 - Domain of unknown function (DUF4917)
PFAM: PF16263 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 310 (306)
Sequences: 989 (812)
Seq/√Len: 46.4
META: 0.703

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
274_S304_A3.8381.00
245_L263_I3.6461.00
63_Y73_D3.4391.00
247_I252_L3.3051.00
111_T167_F3.0361.00
257_E261_D2.9501.00
270_K298_E2.7351.00
60_N65_I2.7181.00
119_L194_L2.5411.00
81_L211_F2.4471.00
241_I245_L2.4401.00
9_I13_P2.4311.00
125_L166_V2.4131.00
82_I211_F2.4031.00
9_I251_S2.3851.00
21_F35_K2.3251.00
113_F236_S2.3111.00
57_S71_R2.2661.00
274_S278_G2.2501.00
2_L245_L2.2371.00
102_C124_A2.2101.00
246_V272_A2.2091.00
193_P196_D2.2011.00
30_L34_L2.1801.00
289_L293_R2.1671.00
133_G136_F2.1631.00
287_E290_I2.1091.00
3_L7_F2.0811.00
286_A293_R2.0340.99
137_K141_N1.9980.99
41_L49_V1.9740.99
275_V282_I1.9340.99
11_Y98_Q1.9330.99
282_I289_L1.9310.99
9_I16_S1.8860.99
38_F49_V1.8790.99
282_I293_R1.8730.99
115_L259_I1.8300.99
50_L74_Y1.8170.99
150_Y153_W1.8080.99
11_Y102_C1.7930.99
247_I250_H1.7890.99
270_K274_S1.7860.99
63_Y70_I1.7750.99
86_A199_R1.7730.98
286_A290_I1.7580.98
33_E69_K1.7560.98
178_D226_H1.7460.98
283_I290_I1.7420.98
282_I290_I1.7300.98
115_L250_H1.7250.98
245_L268_I1.7200.98
282_I286_A1.7190.98
286_A289_L1.7170.98
194_L198_I1.6730.98
79_E83_E1.6650.98
102_C120_L1.6640.98
272_A277_P1.6600.98
248_F302_F1.6420.98
270_K300_H1.6390.97
63_Y274_S1.6020.97
54_E219_Q1.5970.97
137_K140_F1.5940.97
85_V211_F1.5820.97
274_S277_P1.5790.97
284_N287_E1.5690.97
92_H193_P1.5650.97
168_Y227_N1.5520.96
288_R291_A1.5390.96
135_R138_D1.5290.96
273_V277_P1.5140.96
31_S76_A1.4980.96
78_K208_Y1.4960.96
121_L124_A1.4720.95
31_S34_L1.4550.95
276_Y304_A1.4500.95
82_I213_S1.4370.95
45_D115_L1.4340.94
134_L138_D1.4300.94
43_T46_F1.4000.94
180_G226_H1.3980.94
71_R75_E1.3900.94
105_F109_F1.3830.93
134_L140_F1.3770.93
5_N8_S1.3670.93
175_L183_I1.3590.93
61_K71_R1.3540.93
221_L225_R1.3420.92
4_G8_S1.3320.92
283_I293_R1.3290.92
238_L262_A1.3290.92
183_I227_N1.3140.91
103_R128_G1.2900.91
2_L259_I1.2740.90
234_Y262_A1.2660.90
1_L4_G1.2560.89
285_R289_L1.2540.89
287_E292_K1.2540.89
133_G137_K1.2520.89
280_Q283_I1.2500.89
238_L266_S1.2460.89
238_L241_I1.2460.89
177_F208_Y1.2450.89
270_K273_V1.2440.89
134_L137_K1.2420.89
268_I272_A1.2410.89
88_V259_I1.2360.89
283_I289_L1.2320.89
101_A107_S1.2260.88
216_T219_Q1.2230.88
24_A123_W1.2210.88
51_R55_T1.2210.88
151_V154_R1.1990.87
91_E94_E1.1960.87
281_A284_N1.1900.87
85_V203_L1.1860.87
15_F24_A1.1820.86
167_F233_C1.1760.86
272_A278_G1.1590.85
225_R228_D1.1560.85
132_L136_F1.1550.85
283_I286_A1.1550.85
106_L121_L1.1530.85
284_N288_R1.1430.84
232_F236_S1.1410.84
201_A207_E1.1400.84
13_P18_G1.1360.84
287_E293_R1.1300.84
247_I301_F1.1300.84
104_K218_E1.1020.82
105_F310_W1.1010.82
21_F77_L1.0990.82
167_F232_F1.0890.81
294_K297_L1.0870.81
42_G257_E1.0870.81
151_V187_T1.0870.81
115_L169_L1.0850.81
21_F49_V1.0800.81
290_I293_R1.0790.81
123_W174_H1.0780.81
7_F114_T1.0700.80
140_F145_D1.0680.80
253_G260_L1.0680.80
243_G266_S1.0670.80
251_S255_N1.0590.80
247_I271_V1.0580.80
8_S17_Y1.0570.79
231_S235_R1.0480.79
131_G134_L1.0460.79
46_F81_L1.0340.78
192_I200_E1.0340.78
90_P109_F1.0320.78
112_V236_S1.0310.78
18_G44_K1.0300.78
20_L46_F1.0280.78
169_L174_H1.0260.77
288_R293_R1.0220.77
21_F44_K1.0210.77
24_A30_L1.0190.77
287_E291_A1.0180.77
64_G218_E1.0080.76
244_S270_K1.0060.76
34_L77_L1.0030.76
70_I79_E1.0010.76
38_F46_F0.9960.75
153_W156_P0.9870.75
250_H253_G0.9830.74
125_L168_Y0.9800.74
93_S96_P0.9680.73
15_F120_L0.9620.73
23_F88_V0.9620.73
34_L302_F0.9590.72
78_K113_F0.9590.72
89_H123_W0.9520.72
242_G273_V0.9490.72
15_F123_W0.9360.71
120_L178_D0.9330.70
81_L85_V0.9320.70
36_K39_E0.9240.70
54_E74_Y0.9230.70
114_T169_L0.9220.69
121_L166_V0.9160.69
134_L139_G0.9160.69
109_F246_V0.9110.68
232_F235_R0.9110.68
136_F140_F0.9100.68
187_T190_T0.9070.68
1_L49_V0.9060.68
56_A268_I0.9000.68
186_L201_A0.8980.67
285_R288_R0.8920.67
177_F226_H0.8920.67
281_A285_R0.8880.67
130_D269_K0.8880.67
119_L123_W0.8870.66
281_A290_I0.8840.66
110_G303_D0.8820.66
269_K298_E0.8810.66
2_L8_S0.8780.66
12_D98_Q0.8780.66
102_C186_L0.8770.66
169_L233_C0.8720.65
238_L243_G0.8700.65
267_K272_A0.8660.65
81_L213_S0.8600.64
285_R293_R0.8590.64
68_A101_A0.8590.64
168_Y172_A0.8560.64
102_C121_L0.8520.63
239_A262_A0.8490.63
248_F255_N0.8460.63
79_E106_L0.8460.63
7_F169_L0.8450.63
130_D133_G0.8430.62
2_L6_G0.8420.62
34_L73_D0.8380.62
271_V274_S0.8290.61
48_L253_G0.8260.61
41_L255_N0.8250.61
293_R297_L0.8230.61
80_A181_G0.8220.60
149_D216_T0.8200.60
52_A113_F0.8190.60
2_L5_N0.8180.60
224_I230_L0.8180.60
49_V203_L0.8170.60
122_Y224_I0.8140.60
131_G136_F0.8120.60
120_L123_W0.8110.59
282_I288_R0.8100.59
288_R292_K0.8090.59
54_E194_L0.8080.59
132_L137_K0.8030.59
182_E261_D0.8030.59
11_Y121_L0.8030.59
283_I287_E0.8020.59
100_A204_D0.7940.58
198_I201_A0.7910.58
183_I233_C0.7910.58
159_N163_Q0.7900.57
280_Q284_N0.7870.57
175_L229_Y0.7850.57
149_D155_E0.7840.57
1_L9_I0.7820.57
19_S168_Y0.7820.57
299_V307_A0.7790.56
280_Q296_P0.7770.56
24_A174_H0.7740.56
7_F113_F0.7720.56
10_A120_L0.7690.55
113_F241_I0.7690.55
43_T304_A0.7680.55
112_V136_F0.7620.55
282_I285_R0.7620.55
128_G233_C0.7600.54
63_Y246_V0.7600.54
138_D145_D0.7540.54
20_L214_E0.7520.54
302_F309_V0.7460.53
135_R140_F0.7440.53
284_N290_I0.7370.52
173_L177_F0.7350.52
45_D109_F0.7350.52
126_M168_Y0.7340.52
93_S166_V0.7320.52
271_V279_D0.7320.52
139_G165_L0.7280.51
248_F306_S0.7280.51
48_L59_V0.7240.51
106_L124_A0.7210.51
297_L300_H0.7210.51
30_L259_I0.7170.50
242_G263_I0.7140.50
46_F89_H0.7120.50
211_F225_R0.7110.50
289_L292_K0.7100.50
46_F214_E0.7100.50
66_D72_E0.7100.50
19_S48_L0.7090.49
46_F49_V0.7080.49
52_A55_T0.7080.49
198_I235_R0.7040.49
197_Q203_L0.7030.49
120_L212_V0.7020.49
120_L174_H0.7020.49
54_E233_C0.7010.49
91_E198_I0.7010.49
9_I215_G0.6970.48
103_R107_S0.6930.48
260_L266_S0.6930.48
279_D289_L0.6920.48
268_I274_S0.6880.47
105_F123_W0.6870.47
43_T274_S0.6870.47
80_A84_A0.6840.47
152_V236_S0.6800.47
17_Y250_H0.6790.47
151_V155_E0.6790.47
59_V66_D0.6740.46
90_P178_D0.6730.46
7_F63_Y0.6720.46
254_E302_F0.6710.46
248_F276_Y0.6710.46
50_L213_S0.6710.46
49_V98_Q0.6700.46
149_D175_L0.6680.45
170_H220_K0.6670.45
33_E73_D0.6620.45
136_F139_G0.6610.45
114_T206_G0.6610.45
263_I303_D0.6600.45
141_N189_N0.6600.45
37_L76_A0.6580.44
1_L215_G0.6560.44
286_A294_K0.6540.44
53_L276_Y0.6530.44
41_L52_A0.6520.44
34_L105_F0.6510.44
228_D232_F0.6510.44
205_K222_A0.6510.44
102_C177_F0.6490.44
200_E271_V0.6490.44
95_I166_V0.6480.43
280_Q286_A0.6470.43
249_G258_H0.6460.43
7_F10_A0.6450.43
113_F227_N0.6450.43
70_I78_K0.6440.43
172_A175_L0.6420.43
249_G256_D0.6410.43
273_V279_D0.6410.43
50_L99_L0.6390.43
1_L6_G0.6360.42
83_E221_L0.6350.42
112_V125_L0.6350.42
211_F246_V0.6330.42
100_A271_V0.6310.42
285_R291_A0.6290.42
143_D152_V0.6250.41
122_Y185_K0.6240.41
238_L259_I0.6240.41
51_R211_F0.6220.41
253_G289_L0.6220.41
97_E100_A0.6190.41
34_L259_I0.6140.40
292_K298_E0.6130.40
284_N291_A0.6110.40
80_A304_A0.6100.40
69_K73_D0.6090.40
68_A72_E0.6080.40
75_E78_K0.6050.39
103_R196_D0.6040.39
138_D141_N0.6040.39
77_L90_P0.6030.39
116_N212_V0.6010.39
63_Y223_R0.5980.39
67_D79_E0.5980.39
178_D234_Y0.5980.39
28_G218_E0.5970.39
60_N248_F0.5960.39
56_A72_E0.5950.38
7_F86_A0.5950.38
245_L302_F0.5940.38
221_L234_Y0.5940.38
213_S266_S0.5940.38
21_F24_A0.5930.38
105_F115_L0.5900.38
217_S252_L0.5890.38
56_A60_N0.5870.38
32_P112_V0.5850.37
121_L177_F0.5850.37
15_F174_H0.5850.37
146_F154_R0.5840.37
120_L304_A0.5840.37
24_A46_F0.5820.37
257_E264_N0.5790.37
223_R226_H0.5780.37
245_L271_V0.5770.37
142_P145_D0.5750.37
200_E288_R0.5750.37
179_A184_R0.5730.36
243_G269_K0.5710.36
102_C274_S0.5700.36
130_D134_L0.5680.36
132_L135_R0.5670.36
289_L302_F0.5670.36
162_S259_I0.5670.36
61_K97_E0.5660.36
127_H239_A0.5660.36
141_N145_D0.5650.36
48_L52_A0.5630.35
147_D153_W0.5630.35
280_Q288_R0.5610.35
50_L88_V0.5600.35
78_K233_C0.5600.35
252_L273_V0.5570.35
178_D186_L0.5560.35
270_K278_G0.5530.35
110_G241_I0.5520.34
88_V231_S0.5510.34
174_H203_L0.5510.34
5_N17_Y0.5510.34
178_D182_E0.5490.34
208_Y276_Y0.5480.34
126_M187_T0.5470.34
131_G135_R0.5430.34
101_A240_S0.5430.34
212_V223_R0.5420.34
271_V280_Q0.5420.34
90_P246_V0.5400.33
185_K215_G0.5390.33
114_T223_R0.5390.33
50_L260_L0.5370.33
183_I210_L0.5360.33
274_S302_F0.5360.33
146_F229_Y0.5350.33
61_K200_E0.5350.33
260_L264_N0.5340.33
133_G140_F0.5320.33
94_E191_G0.5320.33
126_M215_G0.5320.33
283_I288_R0.5320.33
42_G261_D0.5310.33
105_F139_G0.5310.33
7_F121_L0.5300.33
77_L272_A0.5290.32
5_N15_F0.5270.32
37_L84_A0.5260.32
38_F89_H0.5260.32
1_L5_N0.5260.32
166_V207_E0.5250.32
22_E26_D0.5250.32
72_E269_K0.5240.32
142_P149_D0.5220.32
233_C262_A0.5210.32
268_I277_P0.5210.32
9_I18_G0.5200.32
133_G196_D0.5190.32
7_F102_C0.5180.32
119_L304_A0.5170.31
282_I292_K0.5170.31
132_L140_F0.5170.31
184_R207_E0.5160.31
15_F116_N0.5140.31
9_I198_I0.5140.31
28_G32_P0.5130.31
274_S306_S0.5120.31
302_F308_G0.5120.31
103_R120_L0.5110.31
13_P273_V0.5100.31
199_R235_R0.5100.31
3_L114_T0.5100.31
108_N246_V0.5070.31
267_K292_K0.5070.31
228_D302_F0.5070.31
200_E205_K0.5030.30
281_A288_R0.5030.30
100_A280_Q0.5020.30
21_F53_L0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wctD 1 0.3387 40.3 0.964 Contact Map
3i5tA 2 0.3645 39.8 0.964 Contact Map
1x9fA 1 0.3355 31.5 0.966 Contact Map
1qgpA 1 0.2097 29.5 0.967 Contact Map
2epjA 2 0.3419 28.3 0.967 Contact Map
2zs0C 1 0.3323 26.1 0.968 Contact Map
1x9fC 1 0.4032 21.8 0.969 Contact Map
3ruyA 2 0.3387 20.5 0.969 Contact Map
3i4jA 2 0.3097 19.8 0.969 Contact Map
2eo5A 3 0.3548 18.9 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.