GREMLIN Database
DUF4913 - Domain of unknown function (DUF4913)
PFAM: PF16259 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (97)
Sequences: 917 (662)
Seq/√Len: 67.3
META: 0.569

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_Q34_E4.0851.00
41_R69_D3.6251.00
61_S67_H3.3121.00
40_A64_W3.0141.00
29_C35_H2.8691.00
29_C85_C2.6651.00
35_H85_C2.6351.00
8_V42_L2.5161.00
61_S71_H2.4981.00
38_A75_L2.4641.00
2_P6_E2.3811.00
43_E47_R2.3191.00
46_W50_E2.2021.00
38_A82_F2.1471.00
18_R37_E2.0361.00
3_S6_E1.9261.00
16_Y72_M1.7381.00
4_V42_L1.7271.00
70_P73_A1.7271.00
52_L59_G1.5440.99
5_E9_E1.4810.99
67_H71_H1.4740.99
50_E53_R1.4250.98
11_Y15_V1.4100.98
7_W49_W1.3980.98
4_V8_V1.3940.98
49_W63_W1.3720.98
62_V66_D1.3390.97
52_L58_T1.3380.97
52_L62_V1.3360.97
7_W11_Y1.2700.96
46_W53_R1.2530.96
75_L82_F1.2510.96
11_Y40_A1.1920.95
65_R70_P1.1120.92
8_V13_L1.0970.92
54_L59_G1.0830.91
87_P90_H1.0670.91
6_E10_E1.0660.91
48_A52_L1.0460.90
7_W72_M1.0440.90
86_S90_H1.0250.89
42_L75_L1.0150.88
64_W68_L0.9980.88
12_L72_M0.9920.87
47_R60_M0.9900.87
22_G25_R0.9660.86
9_E13_L0.9450.85
74_V81_P0.8960.81
36_P39_V0.8920.81
51_A57_G0.8900.81
85_C90_H0.8880.81
52_L56_P0.8820.80
68_L76_L0.8770.80
68_L72_M0.8650.79
62_V65_R0.8600.79
64_W71_H0.8530.78
90_H93_P0.8510.78
43_E46_W0.8500.78
16_Y76_L0.8400.77
70_P74_V0.8390.77
37_E82_F0.8250.76
7_W12_L0.8080.74
45_L71_H0.7860.72
52_L67_H0.7840.72
12_L42_L0.7750.71
1_Y10_E0.7740.71
11_Y50_E0.7680.70
44_A60_M0.7490.68
39_V42_L0.7440.68
30_P91_R0.7330.67
82_F85_C0.7310.67
41_R71_H0.7230.66
37_E69_D0.7200.65
74_V77_D0.7130.65
3_S60_M0.7120.64
87_P95_R0.7040.64
19_R78_P0.6980.63
55_D62_V0.6970.63
12_L16_Y0.6970.63
42_L63_W0.6960.63
16_Y64_W0.6870.62
72_M79_D0.6630.59
16_Y46_W0.6530.58
7_W53_R0.6440.57
11_Y46_W0.6440.57
48_A57_G0.6390.56
24_A79_D0.6350.56
18_R72_M0.6300.55
7_W50_E0.6260.55
92_P95_R0.6200.54
21_G25_R0.6160.53
56_P59_G0.6160.53
21_G24_A0.6140.53
76_L83_A0.6140.53
57_G71_H0.6100.53
48_A67_H0.6050.52
15_V39_V0.6000.52
35_H90_H0.5990.51
58_T62_V0.5980.51
11_Y49_W0.5940.51
47_R62_V0.5930.51
47_R55_D0.5930.51
45_L67_H0.5890.50
5_E10_E0.5880.50
21_G89_R0.5860.50
77_D81_P0.5850.50
86_S91_R0.5840.50
18_R49_W0.5820.49
1_Y49_W0.5800.49
7_W45_L0.5800.49
1_Y21_G0.5680.48
87_P91_R0.5680.48
84_G87_P0.5670.48
45_L68_L0.5650.47
56_P95_R0.5630.47
62_V67_H0.5630.47
47_R53_R0.5620.47
79_D83_A0.5600.47
86_S89_R0.5560.46
29_C90_H0.5530.46
14_P57_G0.5530.46
41_R61_S0.5480.45
72_M76_L0.5470.45
36_P58_T0.5460.45
43_E54_L0.5420.45
48_A61_S0.5360.44
68_L77_D0.5350.44
40_A83_A0.5340.44
23_G84_G0.5330.44
69_D74_V0.5270.43
41_R67_H0.5240.43
34_E92_P0.5220.42
51_A84_G0.5190.42
12_L25_R0.5180.42
22_G88_D0.5170.42
60_M64_W0.5170.42
20_V87_P0.5160.42
94_H98_P0.5150.42
49_W53_R0.5110.41
89_R93_P0.5080.41
1_Y51_A0.5060.41
20_V89_R0.5030.40
16_Y61_S0.5030.40
25_R84_G0.5010.40
15_V36_P0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgwS 1 0.0857 32.7 0.904 Contact Map
3sdoA 2 0.8857 5.3 0.934 Contact Map
1e9gA 2 0.8952 4.6 0.935 Contact Map
1tvlA 2 0.8857 3 0.941 Contact Map
3f7fA 2 0.3333 2.7 0.942 Contact Map
1kqpA 2 0.419 2.5 0.943 Contact Map
3ec3A 1 0.1905 2.3 0.945 Contact Map
3f6dA 2 0.3143 2.3 0.945 Contact Map
3nivA 2 0.2571 2.1 0.946 Contact Map
1nhyA 1 0.3333 2.1 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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