GREMLIN Database
DUF4912 - Domain of unknown function (DUF4912)
PFAM: PF16258 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 117 (113)
Sequences: 7293 (5192)
Seq/√Len: 488.4
META: 0.928

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_G95_F3.9691.00
11_R15_W2.7511.00
42_R61_D2.6491.00
38_R63_E2.5761.00
4_D26_T2.5561.00
14_H109_D2.5411.00
85_E100_R2.5361.00
8_L84_V2.3751.00
45_D80_R2.2331.00
85_E97_S2.2111.00
81_S105_T2.0331.00
12_D15_W2.0001.00
6_L99_A1.9441.00
16_L75_V1.9141.00
61_D89_L1.8911.00
8_L18_A1.8751.00
15_W74_H1.8461.00
18_A84_V1.8141.00
83_R103_P1.8081.00
6_L84_V1.7731.00
40_V61_D1.7081.00
81_S103_P1.6541.00
77_R80_R1.5461.00
8_L16_L1.4861.00
65_H68_A1.4001.00
43_V73_I1.3881.00
62_I73_I1.3811.00
90_S94_R1.3741.00
79_G105_T1.3691.00
4_D99_A1.3601.00
51_F55_N1.3581.00
49_I57_H1.3401.00
83_R100_R1.3321.00
43_V60_F1.3061.00
17_F72_Y1.2901.00
88_Y98_L1.2791.00
15_W71_W1.2611.00
40_V89_L1.2361.00
79_G108_R1.2211.00
44_Y85_E1.1951.00
39_L66_P1.1791.00
16_L106_T1.1701.00
38_R89_L1.1631.00
86_L99_A1.1611.00
9_L17_F1.1591.00
4_D23_T1.1471.00
44_Y83_R1.1451.00
39_L88_Y1.1401.00
76_P82_Y1.1101.00
78_P109_D1.0911.00
60_F76_P1.0631.00
53_G56_A1.0591.00
51_F56_A1.0521.00
7_V19_Y1.0391.00
18_A41_L1.0291.00
30_L33_A1.0231.00
8_L104_V1.0211.00
97_S100_R1.0181.00
23_T26_T1.0141.00
52_D55_N1.0091.00
9_L19_Y1.0051.00
34_W37_A0.9921.00
46_V83_R0.9871.00
21_E69_R0.9841.00
14_H74_H0.9741.00
41_L84_V0.9671.00
45_D49_I0.9611.00
85_E95_F0.9491.00
110_G113_D0.9441.00
6_L18_A0.9441.00
82_Y106_T0.9361.00
49_I55_N0.9311.00
42_R87_G0.9261.00
43_V84_V0.9061.00
28_A31_G0.8941.00
30_L37_A0.8831.00
15_W76_P0.8821.00
30_L34_W0.8761.00
29_A33_A0.8491.00
49_I53_G0.8421.00
14_H78_P0.8361.00
6_L86_L0.8331.00
45_D57_H0.8131.00
75_V106_T0.8091.00
68_A71_W0.8051.00
33_A92_D0.7901.00
22_I86_L0.7801.00
90_S96_V0.7771.00
29_A32_A0.7721.00
5_R21_E0.7681.00
63_E89_L0.7631.00
16_L43_V0.7571.00
49_I52_D0.7461.00
73_I84_V0.7421.00
76_P106_T0.7331.00
87_G97_S0.7221.00
17_F70_N0.7211.00
51_F54_T0.7191.00
51_F57_H0.7171.00
58_S61_D0.7141.00
64_V86_L0.7041.00
24_P27_L0.7021.00
39_L86_L0.6981.00
1_Y21_E0.6971.00
64_V71_W0.6961.00
36_G91_P0.6921.00
56_A83_R0.6921.00
65_H71_W0.6901.00
48_G57_H0.6881.00
48_G80_R0.6881.00
66_P69_R0.6741.00
37_A88_Y0.6681.00
13_P17_F0.6671.00
50_D53_G0.6651.00
6_L41_L0.6631.00
2_G23_T0.6591.00
44_Y56_A0.6561.00
77_R82_Y0.6561.00
13_P107_P0.6551.00
44_Y61_D0.6521.00
46_V53_G0.6401.00
78_P107_P0.6391.00
30_L90_S0.6341.00
26_T99_A0.6311.00
60_F74_H0.6261.00
11_R17_F0.6180.99
34_W39_L0.6130.99
62_I71_W0.6110.99
33_A90_S0.6100.99
6_L101_S0.6100.99
22_I26_T0.6070.99
35_G91_P0.6050.99
58_S77_R0.6030.99
44_Y58_S0.5970.99
49_I56_A0.5920.99
60_F75_V0.5910.99
19_Y72_Y0.5800.99
7_V10_A0.5690.99
63_E68_A0.5690.99
32_A36_G0.5680.99
50_D55_N0.5670.99
31_G35_G0.5650.99
71_W74_H0.5650.99
14_H82_Y0.5620.99
31_G34_W0.5600.99
29_A34_W0.5600.99
16_L104_V0.5540.99
26_T86_L0.5510.99
19_Y70_N0.5460.99
18_A73_I0.5350.99
11_R72_Y0.5250.98
34_W88_Y0.5250.98
41_L73_I0.5230.98
13_P78_P0.5210.98
24_P35_G0.5180.98
47_T55_N0.5140.98
53_G57_H0.5140.98
15_W72_Y0.5140.98
27_L67_G0.5130.98
13_P19_Y0.5120.98
64_V69_R0.5120.98
5_R11_R0.5100.98
10_A104_V0.5090.98
28_A96_V0.5090.98
21_E72_Y0.5060.98
9_L72_Y0.5060.98
109_D112_S0.5050.98
37_A91_P0.5050.98
63_E66_P0.5010.98
40_V63_E0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3up1A 2 0.8462 33.2 0.876 Contact Map
4nn5B 1 0.8376 16.8 0.893 Contact Map
2rb8A 1 0.7692 14 0.896 Contact Map
4s0sD 1 0.735 13.1 0.897 Contact Map
3l5iA 1 0.7949 11.3 0.9 Contact Map
1mukA 1 0.8632 10.2 0.902 Contact Map
2cuiA 1 0.8718 10 0.903 Contact Map
4m4pA 1 0.8632 9.6 0.904 Contact Map
2b5iB 1 0.8376 9.4 0.904 Contact Map
1j8kA 1 0.7778 9 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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