GREMLIN Database
DUF4911 - Domain of unknown function (DUF4911)
PFAM: PF16256 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 57 (55)
Sequences: 3606 (2537)
Seq/√Len: 342.1
META: 0.933

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_R37_L2.9881.00
4_D7_D2.5171.00
9_A13_F2.4391.00
43_E47_R2.0711.00
38_I46_V1.9091.00
51_E54_K1.7061.00
3_V11_L1.6581.00
21_L42_F1.5711.00
2_R31_A1.5571.00
15_L24_V1.5501.00
28_D31_A1.5281.00
27_L35_E1.5131.00
21_L49_L1.4701.00
11_L34_V1.4541.00
15_L46_V1.4531.00
7_D10_Y1.4301.00
49_L53_L1.3881.00
12_K16_E1.3691.00
36_L46_V1.3341.00
38_I43_E1.3261.00
10_Y14_I1.2941.00
39_A42_F1.2871.00
23_V37_L1.2851.00
48_E52_S1.2511.00
42_F45_E1.2351.00
22_A46_V1.2251.00
47_R51_E1.1911.00
21_L45_E1.1791.00
8_I34_V1.1411.00
44_E48_E1.1221.00
25_R35_E1.1141.00
21_L46_V1.0251.00
1_F34_V1.0021.00
13_F25_R0.9501.00
15_L22_A0.9291.00
14_I49_L0.9241.00
22_A36_L0.8921.00
18_Y49_L0.8621.00
38_I42_F0.8391.00
48_E51_E0.8271.00
16_E27_L0.8081.00
27_L33_L0.8081.00
45_E48_E0.8061.00
8_I32_G0.7711.00
10_Y20_G0.7701.00
1_F50_L0.7601.00
24_V34_V0.7260.99
2_R33_L0.7190.99
52_S55_K0.7080.99
29_P32_G0.7030.99
8_I22_A0.6910.99
8_I26_T0.6880.99
5_R30_K0.6870.99
26_T29_P0.6830.99
44_E55_K0.6820.99
20_G23_V0.6690.99
51_E55_K0.6670.99
3_V7_D0.6600.99
24_V36_L0.6340.98
14_I18_Y0.6310.98
14_I17_A0.6300.98
12_K23_V0.5950.98
9_A12_K0.5770.97
28_D32_G0.5730.97
1_F38_I0.5650.97
17_A32_G0.5640.97
8_I24_V0.5610.97
16_E25_R0.5520.96
3_V27_L0.5500.96
23_V35_E0.5500.96
14_I53_L0.5430.96
3_V9_A0.5370.96
10_Y49_L0.5320.95
12_K24_V0.5290.95
19_D42_F0.5190.95
20_G34_V0.5160.95
7_D37_L0.5120.94
15_L49_L0.5080.94
18_Y53_L0.5050.94
6_E9_A0.5040.94
35_E51_E0.5020.94
11_L53_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gjfA 2 1 31.4 0.796 Contact Map
1vjqA 2 1 23 0.809 Contact Map
1ayeA 1 1 20.2 0.814 Contact Map
1pcaA 1 1 17.3 0.819 Contact Map
2boaA 1 1 14.5 0.826 Contact Map
3f3fC 2 0.9298 11.6 0.833 Contact Map
3na7A 1 0.9123 11.5 0.833 Contact Map
3lapA 6 0.9474 11.3 0.834 Contact Map
3v4gA 5 0.8246 9.7 0.839 Contact Map
4p10A 1 0.9825 9.6 0.839 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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