GREMLIN Database
DUF4907 - Domain of unknown function (DUF4907)
PFAM: PF16250 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (63)
Sequences: 2077 (1573)
Seq/√Len: 198.1
META: 0.946

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_D22_H5.0291.00
14_L19_L2.5761.00
63_E66_D2.3971.00
11_Y48_V2.2701.00
51_K64_E2.1281.00
36_K40_D2.0241.00
37_T40_D2.0201.00
15_V20_Y2.0101.00
42_E46_E1.9861.00
28_A62_I1.7481.00
60_V65_L1.7241.00
35_F44_V1.6591.00
38_K42_E1.6361.00
44_V60_V1.6011.00
25_S32_N1.5891.00
4_K8_G1.4421.00
62_I66_D1.4261.00
26_I35_F1.3991.00
12_D19_L1.3561.00
50_E54_K1.2971.00
5_T34_G1.2951.00
40_D44_V1.2731.00
49_I53_K1.2671.00
40_D43_K1.2301.00
48_V60_V1.1721.00
47_L60_V1.1311.00
28_A65_L1.0611.00
45_A49_I1.0521.00
9_W45_A1.0281.00
20_Y52_I1.0161.00
13_I49_I0.9740.99
51_K58_P0.9460.99
8_G34_G0.9440.99
43_K47_L0.8820.99
49_I52_I0.8650.99
62_I65_L0.8540.99
26_I29_I0.8450.99
9_W38_K0.8300.98
8_G29_I0.8080.98
12_D24_P0.8000.98
13_I48_V0.7980.98
7_N34_G0.7920.98
21_I52_I0.7910.98
33_K36_K0.7840.98
15_V53_K0.7830.98
5_T9_W0.7760.97
4_K7_N0.7760.97
19_L22_H0.7550.97
14_L22_H0.7440.97
50_E53_K0.7410.97
47_L66_D0.7320.96
27_P48_V0.7200.96
29_I33_K0.7030.95
14_L17_G0.6950.95
11_Y23_Q0.6840.95
5_T8_G0.6830.95
30_P34_G0.6800.95
9_W35_F0.6800.95
39_E43_K0.6760.94
15_V52_I0.6730.94
47_L51_K0.6670.94
47_L50_E0.6640.94
52_I55_G0.6580.94
7_N30_P0.6570.93
4_K9_W0.6530.93
26_I31_G0.6510.93
24_P56_E0.6400.93
7_N32_N0.6340.92
30_P62_I0.6330.92
25_S31_G0.6210.91
41_A52_I0.6110.91
9_W36_K0.6070.90
9_W58_P0.6010.90
11_Y28_A0.5980.90
42_E49_I0.5880.89
28_A60_V0.5850.89
50_E63_E0.5830.89
4_K38_K0.5750.88
6_N32_N0.5680.87
17_G46_E0.5600.87
30_P33_K0.5570.86
16_N30_P0.5570.86
56_E66_D0.5500.86
46_E53_K0.5500.86
44_V47_L0.5430.85
51_K57_P0.5290.83
13_I61_T0.5260.83
46_E50_E0.5240.83
52_I56_E0.5180.82
10_G34_G0.5120.81
9_W20_Y0.5110.81
23_Q64_E0.5100.81
31_G62_I0.5010.80
55_G66_D0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d3yA 1 0.8657 15.9 0.879 Contact Map
4l3tA 1 0.7164 14.9 0.88 Contact Map
3syxA 1 0.8209 12.8 0.884 Contact Map
1hr6B 1 0.9552 11.5 0.886 Contact Map
3amjB 1 0.8955 10.6 0.888 Contact Map
1gz6A 2 0.8507 10.1 0.889 Contact Map
1pp9B 2 0.8955 10.1 0.889 Contact Map
3ih6A 5 0.8657 9.6 0.89 Contact Map
3gwbA 2 0.8955 9 0.891 Contact Map
3amiA 2 0.9254 8.9 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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