DUF4892 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF4892 - Domain of unknown function (DUF4892)

PFAM:	PF16234	Sequences: DVPGSKDHPLLPRFPGSEIVDYEQKAFDEYRLPLGSIRKISGRLRFEKSVRLEGKLTRITYELPDGRSALEVFRNYREALQKAGAELLFSCEGRDCGSSNLWANDVFGNAILYGPDDQQRYLAARLARPEGDVYVALYAITRGNRRVYLHVEQLEADAPLGELLPTPATLLRQLRSTGELDLP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	183 (164)
Sequences:	616 (496)
Seq/√Len:	38.7
META:	0.737

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
91_C	96_C	5.490	1.00
60_T	150_H	3.872	1.00
5_S	19_I	2.679	1.00
77_R	90_S	2.563	1.00
7_D	13_R	2.512	1.00
19_I	59_I	2.470	1.00
86_E	125_R	2.143	0.99
13_R	61_Y	2.106	0.99
69_A	139_A	2.084	0.99
19_I	61_Y	2.075	0.99
58_R	152_E	2.062	0.99
13_R	22_Y	2.016	0.99
119_Q	138_Y	1.986	0.99
87_L	124_A	1.952	0.99
72_V	139_A	1.939	0.98
18_E	62_E	1.922	0.98
34_L	123_A	1.792	0.97
32_L	52_L	1.751	0.97
56_L	154_L	1.742	0.97
99_S	113_Y	1.708	0.97
75_N	79_A	1.680	0.96
159_P	164_L	1.664	0.96
22_Y	59_I	1.646	0.96
30_Y	123_A	1.645	0.96
99_S	104_N	1.581	0.95
123_A	136_A	1.558	0.94
7_D	19_I	1.556	0.94
138_Y	142_R	1.547	0.94
104_N	113_Y	1.537	0.94
103_A	107_F	1.533	0.94
103_A	112_L	1.520	0.93
127_A	132_D	1.504	0.93
137_L	151_V	1.484	0.93
112_L	119_Q	1.476	0.92
99_S	103_A	1.465	0.92
102_W	114_G	1.448	0.92
102_W	112_L	1.432	0.91
13_R	19_I	1.432	0.91
102_W	119_Q	1.424	0.91
149_L	153_Q	1.421	0.91
102_W	107_F	1.399	0.90
99_S	138_Y	1.368	0.89
88_L	123_A	1.366	0.89
52_L	134_Y	1.363	0.89
72_V	76_Y	1.359	0.89
99_S	102_W	1.339	0.88
114_G	119_Q	1.336	0.88
19_I	22_Y	1.326	0.88
61_Y	76_Y	1.301	0.86
29_E	67_R	1.295	0.86
39_K	44_L	1.288	0.86
5_S	22_Y	1.283	0.86
70_L	74_R	1.282	0.86
12_P	79_A	1.280	0.86
74_R	77_R	1.279	0.86
67_R	71_E	1.270	0.85
53_E	154_L	1.269	0.85
42_G	54_G	1.268	0.85
1_D	5_S	1.256	0.84
1_D	13_R	1.256	0.84
7_D	61_Y	1.252	0.84
109_N	145_R	1.248	0.84
161_G	164_L	1.245	0.84
140_I	144_N	1.229	0.83
34_L	88_L	1.217	0.83
14_F	89_F	1.209	0.82
104_N	114_G	1.201	0.82
77_R	81_Q	1.191	0.81
37_I	106_V	1.177	0.80
30_Y	52_L	1.174	0.80
158_A	161_G	1.170	0.80
100_N	104_N	1.167	0.80
60_T	119_Q	1.161	0.79
98_S	101_L	1.137	0.78
23_E	29_E	1.125	0.77
107_F	142_R	1.109	0.76
128_R	131_G	1.106	0.76
35_G	46_F	1.100	0.76
32_L	123_A	1.094	0.75
100_N	113_Y	1.093	0.75
97_G	138_Y	1.090	0.75
157_D	162_E	1.089	0.75
159_P	163_L	1.063	0.73
96_C	119_Q	1.056	0.73
30_Y	60_T	1.055	0.73
30_Y	34_L	1.053	0.72
61_Y	149_L	1.046	0.72
100_N	114_G	1.033	0.71
153_Q	157_D	1.029	0.71
31_R	49_S	1.029	0.71
102_W	142_R	1.025	0.70
97_G	119_Q	1.020	0.70
103_A	114_G	1.004	0.69
94_R	114_G	0.994	0.68
26_A	55_K	0.989	0.68
128_R	132_D	0.983	0.67
84_G	136_A	0.979	0.67
104_N	142_R	0.978	0.67
61_Y	151_V	0.967	0.66
103_A	142_R	0.959	0.65
39_K	47_E	0.952	0.65
14_F	72_V	0.949	0.64
96_C	104_N	0.943	0.64
104_N	107_F	0.941	0.64
104_N	119_Q	0.938	0.63
60_T	102_W	0.929	0.63
19_I	137_L	0.925	0.62
1_D	4_G	0.922	0.62
19_I	57_T	0.922	0.62
29_E	33_P	0.916	0.61
64_P	67_R	0.915	0.61
55_K	155_E	0.897	0.60
79_A	83_A	0.885	0.59
112_L	116_D	0.881	0.58
35_G	47_E	0.867	0.57
98_S	115_P	0.861	0.57
64_P	73_F	0.859	0.57
1_D	7_D	0.856	0.56
91_C	104_N	0.852	0.56
7_D	22_Y	0.848	0.56
158_A	164_L	0.845	0.55
99_S	112_L	0.844	0.55
53_E	74_R	0.840	0.55
93_G	119_Q	0.822	0.53
53_E	66_G	0.821	0.53
152_E	157_D	0.803	0.52
77_R	122_L	0.800	0.51
39_K	115_P	0.796	0.51
60_T	146_R	0.791	0.50
25_K	78_E	0.787	0.50
60_T	112_L	0.783	0.50
99_S	144_N	0.783	0.50
158_A	162_E	0.779	0.49
13_R	57_T	0.777	0.49
72_V	75_N	0.769	0.48
139_A	149_L	0.769	0.48
159_P	162_E	0.762	0.48
99_S	114_G	0.757	0.47
4_G	7_D	0.755	0.47
88_L	148_Y	0.746	0.46
32_L	134_Y	0.746	0.46
91_C	119_Q	0.745	0.46
17_S	155_E	0.744	0.46
60_T	138_Y	0.742	0.46
22_Y	61_Y	0.741	0.46
27_F	53_E	0.738	0.46
54_G	154_L	0.735	0.45
44_L	110_A	0.733	0.45
14_F	67_R	0.733	0.45
36_S	43_R	0.731	0.45
91_C	107_F	0.727	0.45
71_E	74_R	0.724	0.44
27_F	36_S	0.719	0.44
37_I	99_S	0.718	0.44
3_P	6_K	0.713	0.43
93_G	116_D	0.708	0.43
56_L	137_L	0.708	0.43
65_D	78_E	0.707	0.43
32_L	125_R	0.702	0.42
14_F	75_N	0.702	0.42
135_V	153_Q	0.699	0.42
85_A	126_L	0.693	0.42
9_P	22_Y	0.692	0.42
155_E	158_A	0.690	0.41
10_L	47_E	0.682	0.41
64_P	147_V	0.675	0.40
111_I	115_P	0.673	0.40
71_E	163_L	0.673	0.40
126_L	156_A	0.672	0.40
125_R	132_D	0.668	0.39
62_E	110_A	0.659	0.39
64_P	122_L	0.658	0.39
16_G	29_E	0.652	0.38
50_V	134_Y	0.649	0.38
1_D	22_Y	0.648	0.38
64_P	139_A	0.640	0.37
13_R	59_I	0.637	0.37
149_L	156_A	0.635	0.37
41_S	134_Y	0.634	0.37
23_E	78_E	0.633	0.37
13_R	17_S	0.630	0.36
5_S	11_L	0.630	0.36
46_F	49_S	0.629	0.36
150_H	154_L	0.625	0.36
94_R	113_Y	0.623	0.36
99_S	107_F	0.623	0.36
155_E	159_P	0.622	0.36
91_C	99_S	0.615	0.35
130_E	136_A	0.612	0.35
37_I	101_L	0.611	0.35
160_L	163_L	0.607	0.34
62_E	146_R	0.604	0.34
76_Y	149_L	0.604	0.34
76_Y	137_L	0.595	0.33
94_R	148_Y	0.594	0.33
96_C	107_F	0.591	0.33
99_S	119_Q	0.589	0.33
74_R	79_A	0.587	0.33
22_Y	86_E	0.586	0.33
100_N	112_L	0.578	0.32
133_V	155_E	0.578	0.32
12_P	83_A	0.574	0.32
10_L	95_D	0.571	0.31
105_D	108_G	0.570	0.31
35_G	116_D	0.568	0.31
135_V	164_L	0.567	0.31
51_R	66_G	0.566	0.31
133_V	156_A	0.565	0.31
2_V	5_S	0.562	0.31
16_G	66_G	0.562	0.31
74_R	128_R	0.555	0.30
112_L	138_Y	0.555	0.30
32_L	88_L	0.550	0.30
119_Q	142_R	0.549	0.30
153_Q	163_L	0.548	0.30
57_T	155_E	0.547	0.30
15_P	51_R	0.547	0.30
29_E	117_D	0.545	0.30
62_E	65_D	0.542	0.29
73_F	137_L	0.542	0.29
24_Q	57_T	0.540	0.29
70_L	155_E	0.538	0.29
6_K	62_E	0.538	0.29
75_N	149_L	0.535	0.29
3_P	56_L	0.535	0.29
93_G	99_S	0.534	0.29
104_N	112_L	0.533	0.29
48_K	84_G	0.529	0.28
126_L	133_V	0.529	0.28
122_L	156_A	0.528	0.28
112_L	142_R	0.527	0.28
28_D	55_K	0.526	0.28
52_L	68_S	0.524	0.28
21_D	37_I	0.521	0.28
14_F	62_E	0.520	0.28
118_Q	139_A	0.517	0.27
42_G	114_G	0.517	0.27
93_G	103_A	0.514	0.27
11_L	83_A	0.514	0.27
57_T	73_F	0.511	0.27
16_G	53_E	0.511	0.27
98_S	113_Y	0.509	0.27
153_Q	159_P	0.507	0.27
103_A	119_Q	0.507	0.27
103_A	116_D	0.505	0.27
33_P	106_V	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1doiA	5	0.6721	7.5	0.958	Contact Map
1k8kE	1	0.5519	7.2	0.958	Contact Map
4j07A	3	0.541	4.8	0.962	Contact Map
2mj3A	1	0.5464	4.5	0.962	Contact Map
2wlbA	2	0.4918	4.3	0.962	Contact Map
2ra6A	2	0.4317	3.4	0.964	Contact Map
3ff2A	2	0.6011	3	0.965	Contact Map
1q9uA	2	0.6175	2.9	0.966	Contact Map
1b9rA	1	0.541	2.9	0.966	Contact Map
3j7yP	1	0.388	2.9	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.