GREMLIN Database
DUF4892 - Domain of unknown function (DUF4892)
PFAM: PF16234 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 183 (164)
Sequences: 616 (496)
Seq/√Len: 38.7
META: 0.737

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_C96_C5.4901.00
60_T150_H3.8721.00
5_S19_I2.6791.00
77_R90_S2.5631.00
7_D13_R2.5121.00
19_I59_I2.4701.00
86_E125_R2.1430.99
13_R61_Y2.1060.99
69_A139_A2.0840.99
19_I61_Y2.0750.99
58_R152_E2.0620.99
13_R22_Y2.0160.99
119_Q138_Y1.9860.99
87_L124_A1.9520.99
72_V139_A1.9390.98
18_E62_E1.9220.98
34_L123_A1.7920.97
32_L52_L1.7510.97
56_L154_L1.7420.97
99_S113_Y1.7080.97
75_N79_A1.6800.96
159_P164_L1.6640.96
22_Y59_I1.6460.96
30_Y123_A1.6450.96
99_S104_N1.5810.95
123_A136_A1.5580.94
7_D19_I1.5560.94
138_Y142_R1.5470.94
104_N113_Y1.5370.94
103_A107_F1.5330.94
103_A112_L1.5200.93
127_A132_D1.5040.93
137_L151_V1.4840.93
112_L119_Q1.4760.92
99_S103_A1.4650.92
102_W114_G1.4480.92
102_W112_L1.4320.91
13_R19_I1.4320.91
102_W119_Q1.4240.91
149_L153_Q1.4210.91
102_W107_F1.3990.90
99_S138_Y1.3680.89
88_L123_A1.3660.89
52_L134_Y1.3630.89
72_V76_Y1.3590.89
99_S102_W1.3390.88
114_G119_Q1.3360.88
19_I22_Y1.3260.88
61_Y76_Y1.3010.86
29_E67_R1.2950.86
39_K44_L1.2880.86
5_S22_Y1.2830.86
70_L74_R1.2820.86
12_P79_A1.2800.86
74_R77_R1.2790.86
67_R71_E1.2700.85
53_E154_L1.2690.85
42_G54_G1.2680.85
1_D5_S1.2560.84
1_D13_R1.2560.84
7_D61_Y1.2520.84
109_N145_R1.2480.84
161_G164_L1.2450.84
140_I144_N1.2290.83
34_L88_L1.2170.83
14_F89_F1.2090.82
104_N114_G1.2010.82
77_R81_Q1.1910.81
37_I106_V1.1770.80
30_Y52_L1.1740.80
158_A161_G1.1700.80
100_N104_N1.1670.80
60_T119_Q1.1610.79
98_S101_L1.1370.78
23_E29_E1.1250.77
107_F142_R1.1090.76
128_R131_G1.1060.76
35_G46_F1.1000.76
32_L123_A1.0940.75
100_N113_Y1.0930.75
97_G138_Y1.0900.75
157_D162_E1.0890.75
159_P163_L1.0630.73
96_C119_Q1.0560.73
30_Y60_T1.0550.73
30_Y34_L1.0530.72
61_Y149_L1.0460.72
100_N114_G1.0330.71
153_Q157_D1.0290.71
31_R49_S1.0290.71
102_W142_R1.0250.70
97_G119_Q1.0200.70
103_A114_G1.0040.69
94_R114_G0.9940.68
26_A55_K0.9890.68
128_R132_D0.9830.67
84_G136_A0.9790.67
104_N142_R0.9780.67
61_Y151_V0.9670.66
103_A142_R0.9590.65
39_K47_E0.9520.65
14_F72_V0.9490.64
96_C104_N0.9430.64
104_N107_F0.9410.64
104_N119_Q0.9380.63
60_T102_W0.9290.63
19_I137_L0.9250.62
1_D4_G0.9220.62
19_I57_T0.9220.62
29_E33_P0.9160.61
64_P67_R0.9150.61
55_K155_E0.8970.60
79_A83_A0.8850.59
112_L116_D0.8810.58
35_G47_E0.8670.57
98_S115_P0.8610.57
64_P73_F0.8590.57
1_D7_D0.8560.56
91_C104_N0.8520.56
7_D22_Y0.8480.56
158_A164_L0.8450.55
99_S112_L0.8440.55
53_E74_R0.8400.55
93_G119_Q0.8220.53
53_E66_G0.8210.53
152_E157_D0.8030.52
77_R122_L0.8000.51
39_K115_P0.7960.51
60_T146_R0.7910.50
25_K78_E0.7870.50
60_T112_L0.7830.50
99_S144_N0.7830.50
158_A162_E0.7790.49
13_R57_T0.7770.49
72_V75_N0.7690.48
139_A149_L0.7690.48
159_P162_E0.7620.48
99_S114_G0.7570.47
4_G7_D0.7550.47
88_L148_Y0.7460.46
32_L134_Y0.7460.46
91_C119_Q0.7450.46
17_S155_E0.7440.46
60_T138_Y0.7420.46
22_Y61_Y0.7410.46
27_F53_E0.7380.46
54_G154_L0.7350.45
44_L110_A0.7330.45
14_F67_R0.7330.45
36_S43_R0.7310.45
91_C107_F0.7270.45
71_E74_R0.7240.44
27_F36_S0.7190.44
37_I99_S0.7180.44
3_P6_K0.7130.43
93_G116_D0.7080.43
56_L137_L0.7080.43
65_D78_E0.7070.43
32_L125_R0.7020.42
14_F75_N0.7020.42
135_V153_Q0.6990.42
85_A126_L0.6930.42
9_P22_Y0.6920.42
155_E158_A0.6900.41
10_L47_E0.6820.41
64_P147_V0.6750.40
111_I115_P0.6730.40
71_E163_L0.6730.40
126_L156_A0.6720.40
125_R132_D0.6680.39
62_E110_A0.6590.39
64_P122_L0.6580.39
16_G29_E0.6520.38
50_V134_Y0.6490.38
1_D22_Y0.6480.38
64_P139_A0.6400.37
13_R59_I0.6370.37
149_L156_A0.6350.37
41_S134_Y0.6340.37
23_E78_E0.6330.37
13_R17_S0.6300.36
5_S11_L0.6300.36
46_F49_S0.6290.36
150_H154_L0.6250.36
94_R113_Y0.6230.36
99_S107_F0.6230.36
155_E159_P0.6220.36
91_C99_S0.6150.35
130_E136_A0.6120.35
37_I101_L0.6110.35
160_L163_L0.6070.34
62_E146_R0.6040.34
76_Y149_L0.6040.34
76_Y137_L0.5950.33
94_R148_Y0.5940.33
96_C107_F0.5910.33
99_S119_Q0.5890.33
74_R79_A0.5870.33
22_Y86_E0.5860.33
100_N112_L0.5780.32
133_V155_E0.5780.32
12_P83_A0.5740.32
10_L95_D0.5710.31
105_D108_G0.5700.31
35_G116_D0.5680.31
135_V164_L0.5670.31
51_R66_G0.5660.31
133_V156_A0.5650.31
2_V5_S0.5620.31
16_G66_G0.5620.31
74_R128_R0.5550.30
112_L138_Y0.5550.30
32_L88_L0.5500.30
119_Q142_R0.5490.30
153_Q163_L0.5480.30
57_T155_E0.5470.30
15_P51_R0.5470.30
29_E117_D0.5450.30
62_E65_D0.5420.29
73_F137_L0.5420.29
24_Q57_T0.5400.29
70_L155_E0.5380.29
6_K62_E0.5380.29
75_N149_L0.5350.29
3_P56_L0.5350.29
93_G99_S0.5340.29
104_N112_L0.5330.29
48_K84_G0.5290.28
126_L133_V0.5290.28
122_L156_A0.5280.28
112_L142_R0.5270.28
28_D55_K0.5260.28
52_L68_S0.5240.28
21_D37_I0.5210.28
14_F62_E0.5200.28
118_Q139_A0.5170.27
42_G114_G0.5170.27
93_G103_A0.5140.27
11_L83_A0.5140.27
57_T73_F0.5110.27
16_G53_E0.5110.27
98_S113_Y0.5090.27
153_Q159_P0.5070.27
103_A119_Q0.5070.27
103_A116_D0.5050.27
33_P106_V0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1doiA 5 0.6721 7.5 0.958 Contact Map
1k8kE 1 0.5519 7.2 0.958 Contact Map
4j07A 3 0.541 4.8 0.962 Contact Map
2mj3A 1 0.5464 4.5 0.962 Contact Map
2wlbA 2 0.4918 4.3 0.962 Contact Map
2ra6A 2 0.4317 3.4 0.964 Contact Map
3ff2A 2 0.6011 3 0.965 Contact Map
1q9uA 2 0.6175 2.9 0.966 Contact Map
1b9rA 1 0.541 2.9 0.966 Contact Map
3j7yP 1 0.388 2.9 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.007 seconds.