GREMLIN Database
DUF4893 - Domain of unknown function (DUF4893)
PFAM: PF16233 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 169 (169)
Sequences: 1407 (862)
Seq/√Len: 66.3
META: 0.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_F99_S2.8671.00
19_A157_W2.8161.00
80_F95_K2.8031.00
141_G153_L2.7811.00
95_K99_S2.6261.00
32_H35_D2.5131.00
154_V164_L2.4031.00
102_P116_F2.3831.00
20_W154_V2.3481.00
157_W163_K2.3251.00
116_F139_M2.3201.00
155_L167_I2.2641.00
141_G155_L2.2311.00
143_V153_L2.2291.00
23_A164_L2.1831.00
106_L143_V2.1741.00
5_A117_L2.0801.00
162_S165_D2.0591.00
77_Y99_S2.0571.00
77_Y80_F1.9841.00
1_W5_A1.9841.00
65_K161_E1.9831.00
19_A23_A1.9301.00
72_L77_Y1.9231.00
39_E43_L1.8821.00
77_Y95_K1.7681.00
56_P91_L1.7481.00
113_R142_V1.7381.00
58_S83_R1.7381.00
26_E163_K1.7361.00
83_R96_L1.7321.00
81_F96_L1.7131.00
5_A140_A1.6900.99
102_P167_I1.5640.99
72_L99_S1.5610.99
26_E73_D1.5610.99
33_A37_A1.5600.99
87_E105_R1.5370.99
102_P139_M1.5150.99
72_L75_V1.4610.98
93_F102_P1.4570.98
93_F167_I1.4290.98
65_K162_S1.3940.98
92_R105_R1.3720.98
133_Q136_E1.3670.98
39_E166_V1.3520.97
58_S81_F1.3510.97
68_A71_G1.3480.97
11_D15_R1.3410.97
117_L140_A1.3290.97
43_L166_V1.3200.97
25_A29_A1.3140.97
42_L45_P1.3140.97
65_K100_Q1.3090.97
50_P53_A1.3030.97
161_E165_D1.2990.97
146_I150_R1.2540.96
80_F97_T1.2510.96
86_A90_L1.2440.96
134_D137_R1.2420.96
9_D12_R1.2240.95
43_L47_A1.2220.95
17_R21_V1.1970.95
94_V103_V1.1970.95
120_L160_F1.1940.95
121_A128_A1.1780.94
7_A10_R1.1720.94
7_A11_D1.1490.93
158_P162_S1.1450.93
86_A89_G1.1400.93
132_G138_D1.1270.93
54_P84_V1.1170.92
8_A11_D1.1140.92
106_L114_L1.1120.92
139_M155_L1.1060.92
85_E94_V1.1000.92
69_K72_L1.0990.92
59_Y151_W1.0990.92
136_E159_H1.0950.92
81_F97_T1.0930.91
87_E92_R1.0870.91
72_L80_F1.0820.91
77_Y161_E1.0760.91
144_E154_V1.0760.91
19_A22_A1.0360.89
109_D115_V1.0280.89
52_P56_P1.0230.88
63_T165_D1.0210.88
84_V151_W1.0170.88
15_R18_A1.0090.88
107_F117_L0.9990.87
30_A73_D0.9920.87
165_D168_E0.9750.86
56_P86_A0.9740.86
58_S96_L0.9650.85
54_P114_L0.9630.85
24_L28_R0.9560.85
63_T167_I0.9510.85
38_A76_A0.9510.85
65_K77_Y0.9430.84
65_K74_Y0.9410.84
87_E90_L0.9400.84
85_E127_R0.9350.84
60_R79_P0.9270.83
85_E92_R0.9190.82
17_R46_D0.9170.82
15_R157_W0.9090.82
92_R103_V0.9020.81
18_A22_A0.8980.81
145_R150_R0.8950.81
55_P59_Y0.8850.80
61_C82_C0.8810.80
20_W54_P0.8770.79
54_P91_L0.8720.79
5_A11_D0.8670.79
43_L64_I0.8650.78
53_A56_P0.8630.78
22_A25_A0.8500.77
158_P161_E0.8480.77
31_G36_I0.8350.76
13_L115_V0.8350.76
150_R153_L0.8300.76
2_R85_E0.8200.75
109_D113_R0.8180.74
32_H73_D0.8090.74
54_P59_Y0.8040.73
14_R17_R0.8000.73
39_E64_I0.7990.73
68_A73_D0.7990.73
32_H36_I0.7970.73
26_E68_A0.7940.72
119_T129_L0.7860.72
28_R31_G0.7840.71
129_L134_D0.7840.71
138_D151_W0.7840.71
101_R124_D0.7780.71
110_D148_P0.7720.70
35_D38_A0.7690.70
81_F126_T0.7690.70
11_D14_R0.7520.68
122_L137_R0.7500.68
22_A163_K0.7500.68
16_W142_V0.7460.68
140_A163_K0.7380.67
120_L137_R0.7350.66
78_P93_F0.7350.66
163_K167_I0.7330.66
100_Q162_S0.7250.65
90_L105_R0.7230.65
39_E47_A0.7230.65
4_V10_R0.7150.64
45_P146_I0.7040.63
92_R129_L0.7020.63
121_A127_R0.7010.63
8_A159_H0.6960.62
152_R168_E0.6950.62
101_R123_G0.6930.62
91_L107_F0.6920.62
5_A13_L0.6870.61
146_I151_W0.6870.61
27_A67_G0.6860.61
114_L119_T0.6850.61
126_T143_V0.6810.60
10_R140_A0.6800.60
100_Q161_E0.6800.60
58_S97_T0.6770.60
3_A126_T0.6730.60
20_W164_L0.6700.59
75_V161_E0.6680.59
84_V145_R0.6630.58
21_V25_A0.6590.58
86_A91_L0.6580.58
45_P141_G0.6570.58
70_G73_D0.6560.58
105_R130_A0.6550.57
30_A33_A0.6550.57
83_R149_N0.6500.57
5_A10_R0.6460.56
56_P105_R0.6360.55
156_P162_S0.6330.55
78_P138_D0.6330.55
138_D159_H0.6320.55
3_A84_V0.6310.55
40_G47_A0.6290.54
53_A114_L0.6260.54
146_I149_N0.6210.54
23_A124_D0.6170.53
22_A26_E0.6160.53
75_V99_S0.6150.53
40_G43_L0.6110.52
92_R102_P0.6110.52
80_F135_P0.6090.52
20_W144_E0.6090.52
2_R14_R0.6050.52
50_P91_L0.6040.52
77_Y97_T0.6010.51
44_D47_A0.5940.50
42_L144_E0.5930.50
89_G92_R0.5910.50
52_P58_S0.5910.50
87_E108_P0.5900.50
19_A24_L0.5860.49
94_V148_P0.5860.49
15_R20_W0.5850.49
49_L52_P0.5790.49
60_R108_P0.5790.49
18_A34_A0.5770.48
18_A25_A0.5760.48
77_Y100_Q0.5730.48
8_A135_P0.5730.48
53_A84_V0.5680.47
65_K75_V0.5660.47
120_L139_M0.5640.47
16_W113_R0.5590.46
54_P145_R0.5580.46
36_I137_R0.5560.46
114_L136_E0.5540.46
138_D146_I0.5530.46
100_Q122_L0.5470.45
42_L59_Y0.5460.45
18_A21_V0.5450.45
91_L111_D0.5440.44
108_P114_L0.5440.44
36_I43_L0.5440.44
41_A126_T0.5410.44
89_G93_F0.5390.44
166_V169_L0.5380.44
35_D64_I0.5380.44
114_L142_V0.5300.43
155_L163_K0.5300.43
71_G80_F0.5290.43
6_T9_D0.5290.43
59_Y102_P0.5260.42
53_A91_L0.5250.42
42_L146_I0.5240.42
65_K165_D0.5210.42
42_L46_D0.5200.42
7_A15_R0.5190.42
57_G61_C0.5150.41
32_H76_A0.5150.41
100_Q125_E0.5130.41
35_D76_A0.5130.41
21_V96_L0.5120.41
86_A106_L0.5120.41
31_G74_Y0.5100.41
144_E150_R0.5090.40
13_L17_R0.5080.40
24_L42_L0.5080.40
102_P141_G0.5050.40
27_A31_G0.5030.40
95_K98_G0.5020.40
99_S122_L0.5010.40
41_A62_R0.5000.39
56_P112_R0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5bypA 1 0.574 23.1 0.946 Contact Map
1hjiB 1 0.1538 7.8 0.957 Contact Map
4qrlA 1 0.6095 6.7 0.958 Contact Map
4l9nA 2 0.3077 5.7 0.959 Contact Map
1n0zA 1 0.2663 4.2 0.962 Contact Map
2nnnA 2 0.2781 4 0.962 Contact Map
3swrA 1 0.3373 4 0.962 Contact Map
2c0hA 1 0.426 3.7 0.963 Contact Map
1iicA 1 0.426 3.6 0.963 Contact Map
4s39A 2 0.3669 3.1 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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