GREMLIN Database
PhoLip_ATPase_N - Phospholipid-translocating ATPase N-terminal
PFAM: PF16209 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (59)
Sequences: 3715 (2365)
Seq/√Len: 307.9
META: 0.488

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_F48_L3.4641.00
45_L49_F2.7961.00
36_F40_R2.5091.00
34_N38_Q2.3601.00
29_T32_P2.2351.00
54_Q62_T2.1841.00
26_T29_T2.1431.00
28_L32_P1.9801.00
56_I59_I1.6541.00
10_N13_K1.6371.00
37_E40_R1.6011.00
34_N37_E1.4301.00
22_T43_A1.4111.00
21_R26_T1.3521.00
55_L64_P1.3501.00
54_Q61_P1.3321.00
33_K37_E1.2851.00
13_K16_P1.2431.00
19_K23_S1.2311.00
29_T33_K1.1761.00
11_K14_K1.1751.00
52_I55_L1.1741.00
30_F34_N1.1671.00
26_T32_P1.1601.00
34_N40_R1.1561.00
10_N14_K1.1221.00
38_Q44_N1.1131.00
24_K37_E1.0891.00
43_A53_L1.0631.00
46_Y50_I1.0621.00
51_A62_T1.0501.00
38_Q41_R1.0171.00
55_L60_S1.0171.00
8_E12_N0.9891.00
42_V45_L0.9861.00
9_E12_N0.9391.00
45_L53_L0.9171.00
54_Q57_P0.9151.00
9_E13_K0.9131.00
22_T41_R0.8761.00
49_F53_L0.8761.00
61_P66_T0.8431.00
52_I56_I0.8301.00
62_T66_T0.8261.00
22_T53_L0.8251.00
46_Y66_T0.8141.00
34_N66_T0.8041.00
30_F46_Y0.7961.00
43_A50_I0.7891.00
8_E11_K0.7861.00
55_L59_I0.7400.99
21_R33_K0.7390.99
50_I61_P0.7330.99
33_K64_P0.7010.99
32_P36_F0.6920.99
51_A55_L0.6910.99
39_F42_V0.6810.99
53_L59_I0.6780.99
22_T42_V0.6520.98
31_L34_N0.6510.98
22_T60_S0.6260.98
36_F48_L0.6220.98
41_R61_P0.6140.97
8_E49_F0.6070.97
23_S26_T0.5970.97
55_L58_G0.5900.97
37_E41_R0.5830.96
41_R53_L0.5820.96
15_Y30_F0.5720.96
24_K29_T0.5630.96
44_N56_I0.5620.95
51_A63_S0.5600.95
54_Q60_S0.5560.95
62_T65_Y0.5540.95
42_V46_Y0.5490.95
31_L35_L0.5460.95
48_L52_I0.5440.95
50_I54_Q0.5410.94
27_L32_P0.5400.94
63_S66_T0.5390.94
13_K19_K0.5350.94
41_R45_L0.5270.94
10_N17_S0.5210.93
38_Q61_P0.5170.93
43_A59_I0.5150.93
61_P64_P0.5100.93
27_L41_R0.5100.93
13_K42_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ar4A 1 0.9403 74.9 0.804 Contact Map
1mhsA 2 0.9403 22.4 0.862 Contact Map
3b8cA 1 0.9403 8.4 0.886 Contact Map
2p8rA 1 0.806 2.5 0.912 Contact Map
2og4A 1 0.806 2 0.916 Contact Map
2qdjA 1 0.8806 1.5 0.922 Contact Map
4i43B 1 0.806 1.4 0.923 Contact Map
3au8A 2 0 1.3 0.924 Contact Map
1r6vA 1 0.4925 1.2 0.926 Contact Map
3ua3A 2 1 1 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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