GREMLIN Database
Keratin_2_head - Keratin type II head
PFAM: PF16208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (153)
Sequences: 732 (419)
Seq/√Len: 33.8
META: 0.007

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_G85_G3.0001.00
139_E144_Q2.7871.00
79_G83_F2.7681.00
3_S6_S2.7291.00
5_G9_V2.6591.00
22_V25_S2.4631.00
157_E160_R2.3410.99
45_G59_S2.2790.99
152_L157_E2.2650.99
72_G79_G2.2520.99
16_S25_S2.1420.99
87_F91_A2.1210.99
4_S10_P2.0820.98
141_T150_L2.0780.98
14_R24_R2.0770.98
79_G82_G2.0770.98
83_F87_F2.0620.98
63_A152_L2.0010.98
80_G83_F1.9830.98
103_G107_G1.8790.97
2_F6_S1.7910.96
97_G101_F1.7800.96
85_G89_G1.7760.96
153_E160_R1.7610.96
116_G120_G1.6800.94
135_G139_E1.6780.94
13_S16_S1.6020.93
101_F107_G1.5920.93
148_T151_N1.5770.92
101_F108_G1.5600.92
18_S22_V1.5290.91
136_G157_E1.5080.90
138_Q141_T1.4860.90
1_G5_G1.4350.88
34_F38_G1.4350.88
20_V23_S1.4330.88
26_G51_N1.4170.87
12_G45_G1.3760.86
5_G8_V1.3700.85
51_N65_G1.3630.85
92_G95_F1.3610.85
17_F22_V1.3340.84
141_T144_Q1.3340.84
132_C135_G1.3330.84
76_G79_G1.3290.84
129_F133_P1.3230.83
77_G80_G1.3210.83
82_G85_G1.3160.83
2_F8_V1.3050.83
23_S26_G1.2760.81
106_G121_G1.2260.78
17_F23_S1.1990.77
31_G35_G1.1930.76
12_G38_G1.1730.75
109_G126_G1.1630.75
133_P157_E1.1520.74
10_P151_N1.1500.74
137_I140_V1.1400.73
8_V11_G1.1310.72
151_N161_V1.1300.72
147_L155_D1.1060.71
93_G97_G1.1020.70
122_F125_G1.1000.70
54_G72_G1.0990.70
127_F131_V1.0900.70
4_S157_E1.0610.67
1_G10_P1.0560.67
8_V16_S1.0550.67
133_P142_V1.0480.67
12_G17_F1.0440.66
149_P155_D1.0340.65
81_G87_F1.0300.65
143_N151_N1.0170.64
45_G56_K1.0100.64
138_Q154_I1.0020.63
103_G109_G0.9940.62
120_G124_G0.9920.62
45_G49_L0.9740.61
143_N150_L0.9740.61
146_L149_P0.9720.61
3_S7_A0.9680.60
51_N160_R0.9670.60
140_V146_L0.9660.60
119_G148_T0.9650.60
132_C136_G0.9550.59
14_R19_S0.9500.59
154_I157_E0.9440.58
8_V15_S0.9410.58
13_S148_T0.9380.58
141_T148_T0.9300.57
57_R64_G0.9270.57
21_S31_G0.9270.57
130_P133_P0.9140.56
4_S9_V0.9030.55
4_S12_G0.8960.54
13_S23_S0.8860.53
124_G154_I0.8840.53
2_F160_R0.8800.53
9_V15_S0.8780.53
50_Y64_G0.8740.52
31_G37_G0.8720.52
13_S18_S0.8690.52
80_G84_G0.8650.52
139_E143_N0.8620.51
144_Q150_L0.8550.51
92_G104_G0.8490.50
135_G158_I0.8450.50
146_L155_D0.8410.50
5_G12_G0.8390.50
145_S151_N0.8300.49
115_G120_G0.8270.49
55_S58_I0.8220.48
75_F79_G0.8180.48
103_G108_G0.8130.47
49_L139_E0.8130.47
77_G83_F0.8130.47
17_F50_Y0.8120.47
16_S142_V0.8070.47
144_Q154_I0.8020.46
11_G28_G0.7990.46
37_G114_G0.7980.46
148_T152_L0.7960.46
17_F152_L0.7940.46
129_F152_L0.7930.46
136_G160_R0.7900.45
1_G9_V0.7890.45
127_F130_P0.7810.45
137_I147_L0.7800.45
148_T160_R0.7770.44
32_G52_L0.7770.44
61_S82_G0.7770.44
37_G40_G0.7760.44
98_G118_G0.7630.43
39_G43_G0.7600.43
15_S157_E0.7560.43
83_F89_G0.7540.42
141_T154_I0.7520.42
44_F158_I0.7510.42
1_G62_V0.7470.42
48_S54_G0.7450.42
152_L160_R0.7430.42
2_F122_F0.7400.41
15_S18_S0.7400.41
58_I138_Q0.7380.41
15_S23_S0.7380.41
40_G151_N0.7360.41
122_F127_F0.7350.41
106_G109_G0.7310.41
5_G10_P0.7240.40
147_L156_P0.7190.40
12_G23_S0.7170.39
133_P160_R0.7150.39
19_S24_R0.7140.39
108_G121_G0.7120.39
7_A14_R0.7070.39
40_G64_G0.7050.38
5_G17_F0.7020.38
22_V41_G0.7020.38
8_V13_S0.7010.38
137_I149_P0.6990.38
31_G34_F0.6970.38
77_G97_G0.6960.38
114_G117_F0.6950.38
148_T161_V0.6900.37
73_F79_G0.6890.37
75_F81_G0.6850.37
68_R97_G0.6830.37
87_F97_G0.6800.36
151_N158_I0.6790.36
75_F78_G0.6780.36
141_T160_R0.6780.36
136_G139_E0.6760.36
9_V13_S0.6750.36
2_F136_G0.6630.35
151_N154_I0.6580.35
8_V12_G0.6530.34
9_V62_V0.6490.34
78_G83_F0.6480.34
132_C160_R0.6430.34
55_S63_A0.6400.33
81_G125_G0.6390.33
10_P157_E0.6390.33
9_V12_G0.6390.33
57_R61_S0.6340.33
149_P156_P0.6330.33
16_S19_S0.6320.33
22_V26_G0.6320.33
2_F55_S0.6310.33
46_S51_N0.6300.33
138_Q160_R0.6240.32
140_V147_L0.6190.32
106_G129_F0.6170.32
15_S22_V0.6150.32
85_G93_G0.6110.31
8_V26_G0.6050.31
41_G143_N0.6040.31
28_G148_T0.6030.31
105_F109_G0.6010.31
120_G128_G0.5980.30
94_G161_V0.5950.30
16_S28_G0.5940.30
19_S25_S0.5910.30
42_G115_G0.5870.30
49_L56_K0.5800.29
24_R41_G0.5790.29
137_I155_D0.5730.29
14_R18_S0.5730.29
49_L135_G0.5720.29
34_F37_G0.5700.28
60_I134_P0.5600.28
5_G13_S0.5570.27
38_G41_G0.5560.27
77_G81_G0.5550.27
27_G144_Q0.5500.27
140_V149_P0.5380.26
11_G15_S0.5330.26
101_F109_G0.5310.26
15_S26_G0.5270.26
27_G128_G0.5260.25
130_P139_E0.5210.25
37_G159_Q0.5210.25
95_F122_F0.5180.25
137_I146_L0.5170.25
47_R56_K0.5160.25
89_G93_G0.5120.25
91_A97_G0.5100.24
1_G11_G0.5070.24
54_G135_G0.5050.24
49_L68_R0.5050.24
142_V145_S0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e7kA 1 0.1925 10.8 0.942 Contact Map
2pjhA 1 0.2298 6.6 0.948 Contact Map
2kelA 2 0.1056 6.3 0.948 Contact Map
1dl6A 1 0.1429 5.3 0.95 Contact Map
3lkxA 1 0.1863 5 0.951 Contact Map
1r6jA 1 0.1801 4.9 0.951 Contact Map
2lnmA 1 0.1615 4.6 0.952 Contact Map
3mcbB 1 0.1863 4.5 0.952 Contact Map
3n44F 1 0.236 4.4 0.952 Contact Map
4uu5A 1 0.205 4.2 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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