GREMLIN Database
PMT_4TMC - C-terminal four TMM region of protein-O-mannosyltransferase
PFAM: PF16192 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 182 (177)
Sequences: 8460 (5917)
Seq/√Len: 444.8
META: 0.741

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_G123_L3.1791.00
160_Y164_T3.1161.00
172_A176_R2.9661.00
30_P105_F2.5871.00
159_F178_W2.5201.00
7_E11_Q2.3951.00
14_N18_G2.3701.00
56_G61_W2.3441.00
158_Y176_R2.2921.00
10_K14_N2.2861.00
116_Y119_A2.2811.00
93_I126_A2.2381.00
7_E10_K2.1661.00
158_Y175_A2.1121.00
27_Q110_T2.0431.00
32_S37_L2.0361.00
57_N155_L2.0361.00
148_Y152_V1.8751.00
42_Y54_L1.8221.00
59_L155_L1.8091.00
63_A148_Y1.7881.00
155_L159_F1.7881.00
11_Q14_N1.7741.00
60_I124_I1.6981.00
168_I172_A1.6821.00
124_I128_A1.6581.00
81_R84_R1.6131.00
109_R112_F1.5821.00
78_R84_R1.5711.00
13_Y17_T1.5551.00
47_D50_A1.5501.00
5_L9_Q1.5471.00
102_L105_F1.5441.00
23_T27_Q1.5421.00
48_T51_Q1.5281.00
67_A127_L1.5201.00
28_S40_V1.5051.00
63_A66_P1.4811.00
29_P32_S1.4811.00
169_P172_A1.4711.00
173_W177_M1.4491.00
43_Y165_G1.4451.00
60_I152_V1.4411.00
63_A127_L1.4191.00
156_F163_L1.4151.00
78_R82_R1.4101.00
24_H112_F1.4081.00
37_L179_L1.3511.00
59_L151_L1.3501.00
46_D49_G1.3431.00
171_D174_R1.3131.00
4_S7_E1.2941.00
40_V113_L1.2901.00
143_A146_G1.2871.00
68_L97_Y1.2851.00
79_L82_R1.2821.00
80_L84_R1.2761.00
112_F115_H1.2741.00
170_Y174_R1.2741.00
15_F19_L1.2711.00
68_L126_A1.2671.00
6_W10_K1.2601.00
120_L124_I1.2601.00
142_R146_G1.2581.00
90_A129_Y1.2551.00
101_Y105_F1.2501.00
168_I176_R1.2391.00
171_D175_A1.2311.00
97_Y119_A1.2271.00
98_A102_L1.2201.00
85_W89_R1.2161.00
36_L56_G1.2151.00
26_Y38_R1.2111.00
78_R81_R1.2101.00
128_A132_G1.2031.00
77_W81_R1.1891.00
96_G122_F1.1771.00
146_G150_A1.1751.00
145_V148_Y1.1541.00
82_R85_W1.1521.00
47_D51_Q1.1491.00
100_G119_A1.1441.00
175_A180_P1.1261.00
97_Y101_Y1.1211.00
73_G77_W1.1121.00
61_W113_L1.1071.00
59_L63_A1.0881.00
79_L83_R1.0761.00
160_Y166_L1.0651.00
20_T110_T1.0651.00
41_W53_Y1.0631.00
59_L152_V1.0561.00
65_L123_L1.0451.00
65_L69_L1.0431.00
172_A175_A1.0411.00
84_R89_R1.0311.00
97_Y116_Y1.0161.00
37_L181_S1.0101.00
109_R115_H1.0081.00
41_W44_Y1.0061.00
8_Y11_Q1.0061.00
77_W83_R1.0021.00
154_A157_A0.9961.00
79_L84_R0.9941.00
3_R7_E0.9891.00
40_V54_L0.9861.00
74_L78_R0.9721.00
157_A160_Y0.9661.00
135_L145_V0.9651.00
41_W45_E0.9491.00
71_L75_L0.9431.00
20_T23_T0.9381.00
159_F163_L0.9371.00
16_H19_L0.9341.00
67_A126_A0.9331.00
71_L90_A0.9211.00
59_L148_Y0.9201.00
135_L142_R0.9171.00
14_N17_T0.9151.00
34_P101_Y0.9111.00
55_L159_F0.9101.00
95_V99_A0.9051.00
80_L83_R0.9021.00
111_T115_H0.8801.00
131_L145_V0.8801.00
151_L155_L0.8701.00
131_L148_Y0.8681.00
162_I177_M0.8661.00
147_A151_L0.8641.00
108_P111_T0.8621.00
57_N163_L0.8591.00
26_Y41_W0.8581.00
117_L120_L0.8541.00
8_Y12_M0.8421.00
75_L78_R0.8411.00
103_P106_L0.8391.00
90_A93_I0.8391.00
52_I165_G0.8311.00
78_R83_R0.8301.00
36_L58_P0.8291.00
117_L121_P0.8261.00
144_V147_A0.8221.00
115_H119_A0.8111.00
153_V157_A0.8101.00
100_G104_W0.8061.00
73_G76_L0.8031.00
19_L23_T0.7861.00
94_L98_A0.7841.00
56_G113_L0.7781.00
36_L61_W0.7711.00
116_Y120_L0.7701.00
154_A158_Y0.7691.00
115_H118_P0.7691.00
60_I127_L0.7671.00
174_R177_M0.7651.00
152_V155_L0.7631.00
170_Y173_W0.7551.00
129_Y133_R0.7511.00
136_R139_R0.7511.00
102_L106_L0.7481.00
158_Y172_A0.7471.00
75_L79_L0.7411.00
57_N60_I0.7271.00
28_S32_S0.7221.00
71_L126_A0.7221.00
36_L113_L0.7141.00
68_L98_A0.7111.00
93_I125_L0.7021.00
116_Y123_L0.7001.00
92_F96_G0.6971.00
157_A161_P0.6941.00
114_Y119_A0.6941.00
80_L85_W0.6921.00
76_L80_L0.6901.00
116_Y121_P0.6851.00
143_A147_A0.6781.00
3_R6_W0.6601.00
136_R140_R0.6601.00
81_R85_W0.6581.00
72_L75_L0.6561.00
46_D51_Q0.6561.00
162_I176_R0.6480.99
44_Y53_Y0.6470.99
79_L85_W0.6460.99
23_T110_T0.6450.99
174_R180_P0.6420.99
54_L117_L0.6410.99
131_L149_L0.6380.99
162_I173_W0.6360.99
18_G21_A0.6360.99
132_G135_L0.6350.99
96_G100_G0.6330.99
5_L8_Y0.6330.99
70_V74_L0.6310.99
21_A110_T0.6290.99
91_G95_V0.6290.99
115_H120_L0.6270.99
36_L55_L0.6250.99
97_Y100_G0.6250.99
46_D50_A0.6220.99
109_R114_Y0.6140.99
74_L77_W0.6130.99
55_L113_L0.6100.99
104_W111_T0.6090.99
171_D176_R0.6070.99
30_P101_Y0.6040.99
64_G127_L0.6030.99
66_P69_L0.6020.99
110_T115_H0.6020.99
71_L74_L0.6000.99
136_R141_G0.5970.99
4_S8_Y0.5930.99
9_Q13_Y0.5910.99
11_Q18_G0.5890.99
70_V130_V0.5850.99
122_F129_Y0.5840.99
9_Q15_F0.5840.99
29_P111_T0.5760.99
167_P170_Y0.5680.99
55_L163_L0.5670.99
36_L62_W0.5650.99
138_R141_G0.5650.99
100_G103_P0.5640.99
44_Y49_G0.5640.99
43_Y52_I0.5610.99
111_T114_Y0.5600.99
107_I114_Y0.5590.99
156_F164_T0.5560.98
55_L58_P0.5550.98
28_S33_W0.5540.98
12_M16_H0.5540.98
170_Y177_M0.5530.98
60_I63_A0.5520.98
53_Y162_I0.5500.98
121_P124_I0.5470.98
130_V133_R0.5440.98
24_H38_R0.5410.98
103_P107_I0.5390.98
19_L110_T0.5380.98
34_P123_L0.5360.98
56_G62_W0.5360.98
111_T119_A0.5360.98
84_R90_A0.5320.98
93_I100_G0.5320.98
77_W80_L0.5300.98
117_L123_L0.5300.98
104_W107_I0.5280.98
162_I168_I0.5270.98
93_I129_Y0.5270.98
77_W82_R0.5260.98
38_R181_S0.5250.98
26_Y40_V0.5210.98
89_R92_F0.5210.98
109_R113_L0.5200.98
64_G67_A0.5190.98
129_Y132_G0.5150.97
27_Q108_P0.5140.97
6_W9_Q0.5100.97
166_L169_P0.5080.97
26_Y42_Y0.5060.97
145_V149_L0.5040.97
67_A130_V0.5040.97
9_Q12_M0.5030.97
132_G136_R0.5030.97
76_L84_R0.5010.97
143_A150_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jb0I 1 0.2088 5.5 0.946 Contact Map
4l6vi 1 0.2088 5.1 0.947 Contact Map
2ki9A 1 0.1813 3.1 0.953 Contact Map
1lghA 5 0.3077 2 0.957 Contact Map
2k1eA 3 0.544 1.6 0.96 Contact Map
4p02B 1 0.3736 1.5 0.96 Contact Map
2wscI 1 0.1648 1.5 0.96 Contact Map
2ks1B 1 0.2418 1.3 0.961 Contact Map
3lqvP 1 0.0879 1.3 0.962 Contact Map
4jc95 3 0.2308 1 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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