GREMLIN Database
DUF4873 - Domain of unknown function (DUF4873)
PFAM: PF16170 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (89)
Sequences: 922 (650)
Seq/√Len: 68.9
META: 0.723

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_G34_Y4.2421.00
31_D35_H3.3221.00
21_V40_V3.1401.00
60_R65_S3.0721.00
5_D22_R3.0461.00
8_A21_V3.0321.00
11_V60_R3.0211.00
61_T64_G2.6701.00
57_V68_A2.5181.00
39_R74_D2.4931.00
58_T65_S2.4201.00
9_T16_E1.9161.00
20_R41_A1.7961.00
74_D78_R1.7581.00
30_I75_P1.5760.99
58_T67_P1.5130.99
25_G37_Y1.4220.98
23_L81_V1.3600.98
8_A19_V1.3280.97
46_L51_G1.3100.97
59_L81_V1.2860.97
47_P77_G1.2710.97
42_A47_P1.2030.95
44_D58_T1.1970.95
79_Y89_F1.1580.94
22_R33_R1.1580.94
40_V81_V1.1260.93
56_T67_P1.1110.93
15_A45_E1.1080.93
30_I34_Y1.1080.93
85_G88_P1.1010.92
59_L68_A1.0770.92
25_G31_D1.0650.91
74_D80_R1.0540.91
47_P73_P1.0540.91
79_Y87_P1.0480.91
45_E67_P1.0460.90
69_R85_G1.0420.90
61_T72_E1.0130.89
11_V16_E1.0010.88
63_H90_P0.9970.88
72_E78_R0.9830.87
28_D31_D0.9670.87
39_R80_R0.9650.86
82_T87_P0.9650.86
11_V14_G0.9540.86
25_G30_I0.9500.86
5_D20_R0.9390.85
9_T62_P0.9320.85
50_V55_R0.9270.84
68_A81_V0.8910.82
37_Y72_E0.8890.82
35_H82_T0.8740.80
31_D69_R0.8520.79
72_E87_P0.8390.78
4_Y7_P0.8160.76
80_R83_G0.8100.75
83_G88_P0.8080.75
83_G89_F0.8020.74
84_V87_P0.8000.74
26_H37_Y0.7910.73
12_V15_A0.7830.73
24_R78_R0.7760.72
55_R82_T0.7720.72
31_D79_Y0.7570.70
32_G87_P0.7500.69
12_V49_L0.7500.69
45_E48_A0.7500.69
28_D33_R0.7490.69
21_V29_P0.7460.69
5_D46_L0.7430.69
54_R69_R0.7380.68
31_D87_P0.7350.68
35_H84_V0.7350.68
26_H34_Y0.7280.67
13_G16_E0.7200.66
50_V53_G0.7150.66
35_H71_S0.7110.65
12_V46_L0.7090.65
20_R23_L0.6980.64
65_S70_L0.6980.64
37_Y78_R0.6950.64
61_T78_R0.6920.63
8_A30_I0.6820.62
10_L19_V0.6760.61
3_G74_D0.6730.61
32_G72_E0.6680.60
71_S80_R0.6660.60
9_T60_R0.6630.60
11_V58_T0.6550.59
24_R30_I0.6540.59
41_A47_P0.6540.59
45_E56_T0.6400.57
66_A87_P0.6390.57
37_Y81_V0.6380.57
17_V75_P0.6350.57
72_E76_W0.6320.56
7_P18_P0.6290.56
65_S69_R0.6280.56
24_R34_Y0.6180.55
3_G39_R0.6170.54
31_D68_A0.6150.54
9_T15_A0.6100.54
23_L42_A0.6050.53
28_D71_S0.5960.52
14_G63_H0.5950.52
5_D35_H0.5900.51
27_F71_S0.5900.51
11_V67_P0.5860.51
8_A40_V0.5810.50
66_A84_V0.5700.49
44_D49_L0.5690.49
3_G58_T0.5680.49
23_L59_L0.5630.48
68_A77_G0.5600.48
3_G69_R0.5590.48
73_P76_W0.5580.47
54_R67_P0.5530.47
9_T17_V0.5520.47
7_P16_E0.5490.46
13_G27_F0.5420.45
37_Y74_D0.5420.45
35_H75_P0.5410.45
69_R90_P0.5390.45
24_R72_E0.5240.43
15_A28_D0.5230.43
48_A81_V0.5220.43
10_L75_P0.5180.43
43_D76_W0.5170.43
17_V48_A0.5110.42
35_H70_L0.5040.41
33_R84_V0.5030.41
73_P77_G0.5020.41
3_G17_V0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw7A 1 0.8352 31 0.904 Contact Map
1jz7A 4 0.9231 20.1 0.912 Contact Map
1yq2A 4 0.9231 16.5 0.916 Contact Map
3obaA 4 0.9231 11.3 0.922 Contact Map
3bgaA 2 0.9231 7.2 0.928 Contact Map
4pj0O 1 0.3736 5.5 0.932 Contact Map
3uv1A 2 0.967 5.4 0.932 Contact Map
3wu2O 1 0.3736 5.3 0.933 Contact Map
4s3qA 1 0.967 5.2 0.933 Contact Map
3r7fA 3 0.3516 4.1 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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