GREMLIN Database
DUF4872 - Domain of unknown function (DUF4872)
PFAM: PF16169 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 174 (173)
Sequences: 3767 (2654)
Seq/√Len: 201.7
META: 0.875

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_E172_K3.6991.00
126_E173_A3.5901.00
61_R168_E3.5541.00
62_K66_E2.8691.00
133_L162_E2.5341.00
102_F131_G2.4281.00
68_R154_N2.4191.00
36_I111_A2.4031.00
68_R161_L2.4011.00
130_I170_A2.2961.00
61_R165_D2.2851.00
91_E135_R2.2821.00
127_M170_A2.2541.00
45_R49_N2.0611.00
122_E125_E1.9011.00
133_L136_E1.8471.00
91_E96_G1.7831.00
127_M130_I1.7311.00
157_A161_L1.7181.00
68_R157_A1.7161.00
105_A127_M1.7101.00
109_Q128_T1.7101.00
61_R164_A1.7101.00
91_E95_T1.6991.00
126_E130_I1.6881.00
40_I104_Y1.6701.00
98_G135_R1.6411.00
31_D34_K1.6171.00
133_L166_R1.6011.00
162_E166_R1.5971.00
35_A39_A1.5611.00
2_D5_R1.5241.00
94_G100_F1.5081.00
126_E129_E1.5001.00
130_I166_R1.4881.00
44_A48_L1.4681.00
90_Q138_A1.4681.00
37_R41_K1.4371.00
169_E173_A1.4281.00
159_L162_E1.4251.00
123_A170_A1.4231.00
154_N158_D1.4121.00
89_M93_I1.4001.00
36_I114_L1.3951.00
94_G97_G1.3891.00
66_E69_K1.3831.00
123_A126_E1.3741.00
37_R117_N1.3741.00
8_F18_N1.3661.00
33_R37_R1.3551.00
48_L57_V1.3521.00
64_A157_A1.3391.00
61_R161_L1.3131.00
97_G100_F1.3051.00
47_M127_M1.2961.00
86_I141_A1.2821.00
83_L141_A1.2821.00
123_A173_A1.2751.00
60_I164_A1.2611.00
165_D168_E1.2441.00
43_T104_Y1.2421.00
102_F132_D1.2171.00
104_Y107_F1.2071.00
129_E166_R1.2041.00
133_L159_L1.1971.00
70_W82_Y1.1961.00
158_D161_L1.1891.00
162_E165_D1.1871.00
61_R64_A1.1791.00
79_A153_Y1.1661.00
119_E122_E1.1561.00
166_R169_E1.1471.00
112_A121_L1.1411.00
125_E129_E1.1371.00
118_P122_E1.1361.00
60_I134_W1.1351.00
111_A115_L1.1261.00
113_E121_L1.1211.00
40_I120_L1.1161.00
41_K45_R1.0961.00
164_A168_E1.0901.00
68_R158_D1.0881.00
140_L159_L1.0721.00
88_R93_I1.0631.00
50_P55_F1.0611.00
96_G100_F1.0521.00
118_P121_L1.0511.00
95_T100_F1.0431.00
42_K46_D1.0401.00
126_E169_E1.0381.00
123_A130_I1.0351.00
165_D169_E1.0321.00
53_P62_K1.0081.00
115_L118_P0.9931.00
105_A124_S0.9791.00
105_A128_T0.9761.00
33_R114_L0.9700.99
46_D55_F0.9670.99
85_Q89_M0.9660.99
36_I115_L0.9530.99
51_P55_F0.9460.99
149_D152_D0.9450.99
64_A68_R0.9450.99
98_G105_A0.9400.99
104_Y127_M0.9390.99
140_L155_E0.9380.99
126_E170_A0.9370.99
139_L142_A0.9340.99
160_L163_I0.9140.99
59_G62_K0.9130.99
141_A145_S0.9120.99
47_M56_G0.9100.99
85_Q93_I0.9090.99
11_G14_A0.9060.99
128_T132_D0.9020.99
112_A115_L0.9000.99
40_I107_F0.8960.99
121_L125_E0.8880.99
85_Q88_R0.8870.99
52_I55_F0.8850.99
39_A43_T0.8830.99
13_P22_P0.8750.99
84_G88_R0.8700.99
90_Q93_I0.8680.99
17_G20_Y0.8670.99
91_E97_G0.8630.99
63_L160_L0.8620.99
109_Q121_L0.8610.99
155_E159_L0.8600.99
13_P16_K0.8570.99
145_S163_I0.8520.99
42_K45_R0.8500.99
22_P25_V0.8470.99
32_L114_L0.8410.99
112_A117_N0.8310.98
57_V164_A0.8250.98
155_E158_D0.8250.98
87_V141_A0.8190.98
140_L156_A0.8160.98
126_E166_R0.8150.98
19_M127_M0.8070.98
144_I148_R0.8000.98
137_F160_L0.7960.98
76_A80_R0.7920.98
78_D81_L0.7820.98
43_T171_F0.7740.98
137_F163_I0.7730.98
69_K72_E0.7720.97
75_G79_A0.7550.97
144_I156_A0.7540.97
65_K161_L0.7540.97
33_R115_L0.7530.97
6_A13_P0.7500.97
32_L35_A0.7490.97
91_E98_G0.7410.97
96_G103_L0.7380.97
117_N121_L0.7340.97
58_K61_R0.7280.96
136_E140_L0.7260.96
133_L163_I0.7200.96
5_R9_A0.7180.96
48_L168_E0.7180.96
135_R139_L0.7170.96
88_R92_E0.7090.96
166_R170_A0.7060.96
161_L165_D0.7060.96
149_D155_E0.7050.96
151_E155_E0.6990.96
28_K31_D0.6960.95
124_S131_G0.6920.95
52_I58_K0.6910.95
159_L166_R0.6890.95
39_A107_F0.6890.95
87_V142_A0.6890.95
144_I151_E0.6840.95
142_A146_K0.6730.94
47_M171_F0.6670.94
74_L78_D0.6650.94
98_G131_G0.6650.94
98_G102_F0.6610.94
36_I40_I0.6610.94
141_A156_A0.6590.94
64_A164_A0.6550.94
119_E173_A0.6520.94
91_E94_G0.6500.93
14_A90_Q0.6500.93
8_F11_G0.6490.93
75_G78_D0.6470.93
156_A159_L0.6420.93
121_L124_S0.6420.93
5_R8_F0.6400.93
91_E100_F0.6390.93
11_G16_K0.6350.93
104_Y111_A0.6320.92
107_F111_A0.6290.92
14_A18_N0.6250.92
44_A123_A0.6220.92
159_L163_I0.6210.92
46_D50_P0.6190.92
33_R116_G0.6130.91
87_V92_E0.6130.91
127_M171_F0.6100.91
102_F135_R0.6080.91
63_L66_E0.6040.91
161_L164_A0.5980.90
112_A118_P0.5970.90
171_F174_L0.5930.90
140_L144_I0.5900.90
47_M57_V0.5870.89
84_G145_S0.5820.89
169_E172_K0.5810.89
16_K20_Y0.5770.89
130_I163_I0.5760.89
2_D6_A0.5760.89
151_E154_N0.5730.88
57_V168_E0.5730.88
81_L84_G0.5710.88
158_D169_E0.5680.88
81_L85_Q0.5650.88
76_A79_A0.5650.88
104_Y110_E0.5630.87
129_E132_D0.5620.87
57_V60_I0.5590.87
63_L67_I0.5580.87
165_D172_K0.5580.87
12_A16_K0.5540.87
6_A18_N0.5540.87
135_R138_A0.5520.86
64_A161_L0.5520.86
117_N122_E0.5510.86
30_P33_R0.5500.86
54_N62_K0.5460.86
158_D162_E0.5450.86
78_D82_Y0.5430.85
30_P35_A0.5410.85
8_F17_G0.5370.85
91_E99_G0.5360.85
70_W78_D0.5360.85
93_I97_G0.5320.84
67_I86_I0.5320.84
61_R65_K0.5310.84
74_L77_K0.5300.84
56_G99_G0.5270.84
15_P20_Y0.5270.84
122_E173_A0.5250.84
18_N23_I0.5250.84
9_A15_P0.5240.83
34_K38_K0.5230.83
8_F16_K0.5220.83
136_E139_L0.5210.83
18_N22_P0.5200.83
26_P34_K0.5200.83
29_L33_R0.5140.82
159_L173_A0.5140.82
11_G17_G0.5140.82
102_F106_A0.5130.82
91_E102_F0.5080.82
39_A104_Y0.5060.81
62_K65_K0.5020.81
83_L144_I0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yviA 1 0.6207 18.6 0.927 Contact Map
3ikmA 1 0.7701 14.4 0.93 Contact Map
1nthA 5 0.7471 10.5 0.934 Contact Map
3pltA 2 0.3966 9 0.936 Contact Map
3us6A 1 0.6264 8.4 0.937 Contact Map
4eukB 1 0.6322 8.2 0.937 Contact Map
2wssS 1 0.7011 7.6 0.938 Contact Map
4g78A 1 0.592 7.4 0.939 Contact Map
2noxA 6 0.6437 6.4 0.941 Contact Map
2eqzA 1 0.408 6.2 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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