GREMLIN Database
TIC20 - Chloroplast import apparatus Tic20-like
PFAM: PF16166 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 180 (139)
Sequences: 716 (516)
Seq/√Len: 43.8
META: 0.564

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_A98_G5.3391.00
41_P113_T4.0091.00
120_D124_I3.9381.00
127_L131_I3.1051.00
89_L93_F2.9941.00
126_L129_L2.9861.00
107_H170_Y2.9191.00
49_G154_V2.4941.00
63_L67_P2.4181.00
109_I173_I2.2581.00
93_F97_L2.2361.00
62_L69_L2.1501.00
67_P78_P2.0660.99
95_L113_T2.0570.99
78_P83_Y2.0320.99
105_I109_I2.0300.99
45_P116_A1.8800.99
112_N165_S1.8590.99
158_V162_I1.8190.98
127_L134_P1.7990.98
74_L78_P1.7210.98
163_V167_L1.7170.98
78_P82_L1.7040.98
138_L141_L1.7010.98
165_S171_A1.6900.97
126_L130_F1.6750.97
63_L69_L1.6550.97
112_N160_Y1.6120.97
41_P166_L1.5770.96
86_F90_I1.5620.96
134_P138_L1.5260.95
127_L133_L1.4990.95
108_F165_S1.4930.95
137_G140_G1.4890.95
72_L78_P1.4650.94
131_I134_P1.4380.94
132_L137_G1.3580.92
120_D147_S1.3410.91
130_F134_P1.3120.90
127_L130_F1.2680.88
48_D86_F1.2660.88
123_L154_V1.2620.88
164_Q167_L1.2230.87
48_D88_G1.2160.86
87_G90_I1.2050.86
134_P137_G1.1850.85
129_L134_P1.1680.84
108_F170_Y1.1520.83
91_I94_A1.1260.82
119_L157_A1.1240.82
131_I137_G1.1230.82
126_L131_I1.1150.81
100_V113_T1.1050.80
161_S165_S1.0900.80
148_N151_F1.0900.80
76_L87_G1.0880.79
133_L178_E1.0860.79
70_Q81_S1.0720.78
67_P75_P1.0690.78
90_I97_L1.0660.78
76_L83_Y1.0480.77
149_T175_T1.0480.77
78_P84_R1.0020.73
107_H114_M0.9960.73
48_D119_L0.9920.73
126_L132_L0.9910.73
48_D124_I0.9720.71
55_F147_S0.9710.71
90_I93_F0.9670.71
52_F121_I0.9380.68
126_L134_P0.9320.68
39_A161_S0.9160.67
41_P46_L0.9140.66
112_N115_Q0.9100.66
43_L49_G0.9080.66
87_G91_I0.9080.66
62_L65_Q0.8990.65
73_L178_E0.8910.64
115_Q168_G0.8880.64
139_G142_L0.8810.64
92_F97_L0.8740.63
123_L148_N0.8720.63
79_L83_Y0.8680.62
37_L109_I0.8680.62
47_L83_Y0.8640.62
39_A106_S0.8550.61
157_A176_I0.8500.61
88_G132_L0.8420.60
80_L83_Y0.8390.60
139_G152_L0.8380.60
44_L105_I0.8380.60
95_L99_V0.8330.59
126_L133_L0.8290.59
101_R114_M0.8220.58
144_E148_N0.8170.58
43_L118_L0.8170.58
162_I173_I0.8030.56
42_Y97_L0.8020.56
134_P143_G0.8020.56
89_L102_N0.8020.56
46_L122_V0.7990.56
100_V125_L0.7990.56
35_R171_A0.7990.56
149_T153_G0.7980.56
96_F123_L0.7860.55
92_F95_L0.7850.55
100_V114_M0.7760.54
146_L149_T0.7750.54
126_L135_L0.7680.53
71_L77_L0.7560.52
168_G174_P0.7480.51
93_F103_P0.7480.51
98_G113_T0.7430.51
35_R99_V0.7430.51
172_E177_S0.7370.50
141_L145_T0.7320.50
127_L137_G0.7280.49
107_H125_L0.7170.48
41_P107_H0.7110.48
37_L43_L0.7060.47
75_P79_L0.6950.46
101_R172_E0.6790.44
68_F71_L0.6750.44
38_A73_L0.6750.44
44_L88_G0.6680.43
96_F100_V0.6640.43
125_L169_R0.6600.43
63_L126_L0.6600.43
66_F119_L0.6580.43
64_E166_L0.6530.42
53_G177_S0.6530.42
43_L120_D0.6480.42
63_L85_S0.6450.41
35_R101_R0.6440.41
108_F118_L0.6420.41
131_I147_S0.6410.41
86_F92_F0.6400.41
109_I175_T0.6390.41
50_L84_R0.6380.41
129_L133_L0.6320.40
70_Q84_R0.6280.40
134_P140_G0.6280.40
62_L67_P0.6270.40
46_L177_S0.6200.39
47_L88_G0.6170.39
62_L132_L0.6170.39
144_E176_I0.6140.38
65_Q161_S0.6120.38
158_V161_S0.6120.38
43_L122_V0.6100.38
64_E89_L0.6020.37
120_D169_R0.5940.37
116_A120_D0.5920.36
44_L120_D0.5880.36
88_G114_M0.5870.36
45_P120_D0.5840.36
37_L170_Y0.5830.36
144_E156_A0.5820.36
127_L132_L0.5810.35
103_P111_F0.5780.35
168_G173_I0.5770.35
48_D143_G0.5770.35
54_R80_L0.5760.35
46_L118_L0.5760.35
164_Q177_S0.5760.35
153_G164_Q0.5750.35
102_N125_L0.5740.35
87_G96_F0.5720.35
48_D164_Q0.5720.35
119_L124_I0.5700.35
164_Q172_E0.5680.34
130_F176_I0.5650.34
130_F133_L0.5610.34
149_T154_V0.5610.34
99_V102_N0.5600.34
76_L82_L0.5600.34
38_A47_L0.5590.34
135_L146_L0.5530.33
153_G159_L0.5520.33
46_L124_I0.5490.33
145_T149_T0.5470.33
65_Q68_F0.5420.32
50_L54_R0.5400.32
117_I148_N0.5400.32
122_V161_S0.5390.32
48_D87_G0.5390.32
63_L80_L0.5320.31
164_Q175_T0.5320.31
137_G141_L0.5320.31
143_G150_V0.5290.31
119_L133_L0.5280.31
36_I133_L0.5280.31
44_L96_F0.5250.31
63_L82_L0.5250.31
43_L162_I0.5230.31
73_L79_L0.5230.31
135_L161_S0.5200.30
79_L84_R0.5190.30
130_F169_R0.5180.30
47_L79_L0.5110.30
118_L171_A0.5070.29
163_V166_L0.5070.29
90_I165_S0.5070.29
66_F69_L0.5060.29
152_L171_A0.5030.29
39_A49_G0.5030.29
48_D54_R0.5000.29
45_P160_Y0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s8fA 1 0.3333 11.3 0.945 Contact Map
4quvA 2 0.6944 8.5 0.948 Contact Map
3mi9C 1 0 8.1 0.949 Contact Map
1tacA 1 0.1944 7.4 0.95 Contact Map
3c5xC 1 0 7 0.95 Contact Map
1vzmA 1 0.2333 2.2 0.961 Contact Map
4b03D 5 0.3889 1.6 0.964 Contact Map
5aftc 1 0.0889 1.1 0.967 Contact Map
3ukwC 1 0.1222 1.1 0.967 Contact Map
3aa1C 1 0.05 1.1 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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