GREMLIN Database
DUF4868 - Domain of unknown function (DUF4868)
PFAM: PF16162 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 188 (183)
Sequences: 1807 (1525)
Seq/√Len: 112.7
META: 0.806

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_R57_D3.4581.00
99_E111_K3.3811.00
176_K181_D2.8481.00
180_D185_S2.6611.00
156_K166_D2.6081.00
64_I69_L2.5541.00
137_L140_D2.3781.00
106_D109_D2.3561.00
180_D183_L2.1861.00
96_E99_E2.1591.00
16_K66_D2.1151.00
78_E123_R2.1051.00
77_F83_L2.0651.00
146_K149_P2.0451.00
141_I144_K2.0241.00
143_E146_K2.0141.00
71_I77_F1.9841.00
141_I149_P1.9491.00
105_S158_D1.9451.00
138_N141_I1.9111.00
137_L141_I1.9061.00
176_K182_Y1.8581.00
124_K181_D1.8511.00
108_E112_E1.8501.00
85_E88_K1.8421.00
90_A93_E1.8001.00
95_I107_F1.7701.00
75_S79_R1.7691.00
141_I145_L1.7391.00
99_E108_E1.7241.00
91_A94_K1.6941.00
124_K179_N1.6911.00
87_Y123_R1.6771.00
174_F178_L1.5961.00
136_Y141_I1.5911.00
91_A125_L1.5581.00
96_E111_K1.5101.00
8_V19_Y1.5041.00
156_K164_I1.5031.00
49_L53_V1.4891.00
165_I174_F1.4581.00
29_V33_S1.4461.00
154_E157_F1.4411.00
62_F77_F1.4381.00
62_F71_I1.4381.00
109_D112_E1.4361.00
4_I7_Y1.4281.00
6_G80_I1.4161.00
144_K148_V1.4131.00
139_E142_I1.4061.00
140_D145_L1.4021.00
180_D188_T1.3931.00
24_I29_V1.3861.00
63_L72_L1.3731.00
141_I146_K1.3471.00
137_L142_I1.3421.00
145_L149_P1.3311.00
172_K176_K1.3171.00
96_E100_E1.3091.00
20_A24_I1.3020.99
87_Y122_A1.2470.99
118_N123_R1.2470.99
120_R172_K1.2450.99
10_R17_K1.2280.99
99_E107_F1.1920.99
22_R61_D1.1860.99
28_K31_K1.1770.99
46_L78_E1.1580.99
76_N79_R1.1550.99
21_F64_I1.1470.99
24_I28_K1.1380.99
163_I167_D1.1360.99
144_K147_E1.1230.98
5_K23_K1.1200.98
142_I146_K1.1040.98
137_L149_P1.1040.98
153_L157_F1.0980.98
140_D143_E1.0920.98
180_D187_L1.0800.98
13_D16_K1.0630.98
96_E108_E1.0620.98
118_N122_A1.0590.98
29_V32_K1.0450.98
114_V165_I1.0440.98
20_A30_L1.0350.97
121_I125_L1.0340.97
22_R29_V1.0330.97
105_S162_K1.0290.97
119_K122_A1.0280.97
26_P33_S1.0270.97
91_A165_I1.0180.97
158_D164_I1.0180.97
74_K77_F1.0180.97
77_F94_K1.0160.97
22_R60_F1.0120.97
183_L188_T1.0090.97
124_K172_K0.9920.97
107_F111_K0.9900.97
167_D170_D0.9900.97
43_D96_E0.9870.97
98_I125_L0.9740.96
27_S32_K0.9710.96
138_N142_I0.9690.96
142_I145_L0.9690.96
139_E145_L0.9660.96
118_N172_K0.9610.96
77_F93_E0.9530.96
19_Y22_R0.9520.96
62_F80_I0.9500.96
32_K35_G0.9480.96
22_R25_S0.9480.96
46_L110_L0.9380.95
132_G135_L0.9330.95
65_I70_F0.9330.95
24_I31_K0.9310.95
93_E97_E0.9210.95
30_L35_G0.9170.95
90_A129_A0.9150.95
165_I171_L0.9120.95
136_Y139_E0.9080.94
119_K123_R0.9030.94
110_L114_V0.9020.94
14_G17_K0.9010.94
31_K34_K0.8960.94
10_R19_Y0.8920.94
85_E89_E0.8840.94
92_D111_K0.8540.92
84_E119_K0.8410.92
183_L187_L0.8380.92
66_D112_E0.8380.92
149_P153_L0.8370.92
21_F62_F0.8300.91
27_S34_K0.8280.91
115_G153_L0.8270.91
175_L179_N0.8260.91
74_K86_A0.8160.91
83_L183_L0.8100.90
125_L128_I0.8060.90
93_E96_E0.8020.90
154_E159_D0.8020.90
137_L145_L0.8020.90
110_L113_L0.7940.89
11_F15_D0.7910.89
104_I165_I0.7850.89
25_S30_L0.7850.89
74_K78_E0.7840.89
59_D73_N0.7830.89
87_Y119_K0.7810.89
94_K98_I0.7790.89
9_I13_D0.7760.88
121_I126_A0.7750.88
134_L137_L0.7740.88
4_I9_I0.7690.88
6_G10_R0.7670.88
71_I88_K0.7650.88
24_I30_L0.7640.88
10_R13_D0.7590.87
21_F25_S0.7590.87
147_E150_K0.7550.87
60_F78_E0.7540.87
118_N168_K0.7540.87
113_L121_I0.7530.87
16_K19_Y0.7530.87
139_E143_E0.7520.87
23_K26_P0.7510.87
91_A129_A0.7460.86
26_P32_K0.7420.86
152_G159_D0.7370.86
61_D77_F0.7360.86
167_D171_L0.7350.86
12_G15_D0.7330.85
60_F176_K0.7330.85
84_E128_I0.7220.85
145_L148_V0.7190.84
21_F30_L0.7190.84
27_S55_K0.7190.84
184_T187_L0.7180.84
105_S164_I0.7160.84
134_L138_N0.7120.84
141_I148_V0.7120.84
63_L105_S0.7090.83
152_G155_I0.7060.83
22_R27_S0.6970.82
146_K157_F0.6910.82
9_I12_G0.6910.82
28_K33_S0.6900.82
151_L155_I0.6840.81
24_I33_S0.6790.81
118_N121_I0.6780.81
121_I172_K0.6770.81
139_E161_G0.6760.80
61_D145_L0.6760.80
31_K35_G0.6750.80
26_P31_K0.6730.80
18_I32_K0.6730.80
38_L41_F0.6720.80
106_D111_K0.6720.80
99_E102_N0.6710.80
131_S134_L0.6650.79
91_A122_A0.6640.79
46_L57_D0.6630.79
88_K117_S0.6580.79
54_F58_P0.6570.79
53_V178_L0.6570.79
41_F67_G0.6530.78
90_A94_K0.6490.78
170_D174_F0.6490.78
55_K87_Y0.6480.78
15_D71_I0.6460.77
22_R59_D0.6460.77
148_V151_L0.6410.77
95_I125_L0.6400.77
157_F160_N0.6370.76
87_Y98_I0.6340.76
185_S188_T0.6300.76
99_E117_S0.6280.75
179_N185_S0.6270.75
21_F33_S0.6210.75
139_E146_K0.6190.74
9_I60_F0.6170.74
22_R26_P0.6170.74
136_Y142_I0.6110.73
168_K171_L0.6110.73
104_I107_F0.6090.73
91_A127_K0.6080.73
138_N148_V0.6070.73
45_T117_S0.6050.73
138_N145_L0.6030.72
44_N100_E0.6010.72
21_F26_P0.5960.72
145_L150_K0.5870.70
87_Y173_L0.5870.70
4_I80_I0.5850.70
5_K8_V0.5790.69
111_K115_G0.5790.69
66_D76_N0.5790.69
65_I103_L0.5730.69
5_K15_D0.5690.68
18_I73_N0.5680.68
165_I178_L0.5650.68
142_I148_V0.5640.67
56_I128_I0.5600.67
84_E176_K0.5590.67
8_V21_F0.5580.67
165_I168_K0.5540.66
126_A129_A0.5520.66
30_L33_S0.5410.64
6_G65_I0.5380.64
18_I23_K0.5360.63
117_S150_K0.5320.63
21_F80_I0.5300.63
83_L91_A0.5290.62
158_D161_G0.5270.62
122_A127_K0.5250.62
153_L156_K0.5200.61
43_D130_K0.5200.61
172_K179_N0.5190.61
21_F29_V0.5150.60
8_V25_S0.5150.60
157_F161_G0.5130.60
144_K158_D0.5100.60
54_F80_I0.5100.60
164_I167_D0.5080.59
54_F61_D0.5080.59
161_G165_I0.5070.59
35_G38_L0.5070.59
63_L120_R0.5070.59
50_D147_E0.5060.59
26_P29_V0.5050.59
156_K169_K0.5030.59
93_E157_F0.5030.59
83_L133_Y0.5020.58
100_E146_K0.5010.58
91_A95_I0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jyoA 2 0.5266 3.8 0.94 Contact Map
2mysB 1 0.2447 3.4 0.941 Contact Map
1mvfD 1 0.234 3.2 0.943 Contact Map
4uwjA 1 0.2819 3.1 0.943 Contact Map
4c68A 1 0.383 2 0.948 Contact Map
4c7iA 1 0.383 2 0.948 Contact Map
1iicA 1 0.3989 1.7 0.95 Contact Map
1sauA 1 0.3245 1.6 0.951 Contact Map
3fwbA 1 0.2872 1.6 0.951 Contact Map
1xtzA 3 0.2606 1.6 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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