GREMLIN Database
DUF4860 - Domain of unknown function (DUF4860)
PFAM: PF16152 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 98 (95)
Sequences: 1498 (1350)
Seq/√Len: 138.5
META: 0.898

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_R74_P3.3081.00
55_Y77_E3.1431.00
26_G35_V3.0391.00
55_Y74_P3.0121.00
56_L78_L2.6081.00
28_F33_A2.2221.00
35_V48_Y2.1101.00
35_V46_E2.0381.00
11_A15_R1.9101.00
27_E30_G1.8921.00
61_T65_L1.8641.00
50_Y72_G1.7761.00
27_E32_D1.7581.00
10_I81_F1.6621.00
83_F93_I1.6381.00
39_E42_G1.6291.00
14_V91_L1.6291.00
46_E63_A1.6061.00
85_E89_G1.6031.00
24_S37_T1.6001.00
19_E22_A1.5461.00
84_E92_R1.5351.00
85_E91_L1.5271.00
68_S71_D1.4971.00
51_Y81_F1.4831.00
34_L83_F1.4391.00
40_I60_F1.4371.00
12_T16_Q1.3781.00
25_V83_F1.3561.00
44_T63_A1.3331.00
13_K16_Q1.3071.00
26_G33_A1.2541.00
31_G69_P1.2251.00
52_Y57_R1.2001.00
51_Y80_S1.1740.99
6_A56_L1.1570.99
48_Y61_T1.1210.99
37_T46_E1.1180.99
37_T63_A1.1070.99
51_Y56_L1.1050.99
52_Y69_P1.1030.99
78_L95_V1.0970.99
18_D21_G1.0950.99
51_Y78_L1.0500.99
13_K58_E1.0450.99
39_E44_T1.0450.99
9_Y13_K1.0140.99
37_T44_T1.0130.98
33_A69_P0.9850.98
59_L72_G0.9720.98
7_L11_A0.9670.98
82_S94_T0.9500.98
67_F71_D0.9480.98
29_D69_P0.9380.98
10_I93_I0.9330.97
7_L49_I0.9150.97
46_E64_G0.9060.97
43_E62_E0.9040.97
33_A48_Y0.8680.96
17_N36_L0.8660.96
18_D22_A0.8650.96
12_T76_L0.8620.96
39_E43_E0.8620.96
11_A14_V0.8600.96
50_Y59_L0.8560.96
8_S18_D0.8520.96
20_A39_E0.8400.95
13_K47_T0.8260.95
12_T73_Q0.8210.95
4_R35_V0.8150.94
62_E65_L0.8130.94
11_A16_Q0.7990.94
5_T16_Q0.7910.94
40_I43_E0.7890.93
32_D83_F0.7790.93
41_D44_T0.7670.92
36_L74_P0.7640.92
86_L92_R0.7540.92
79_D96_T0.7490.92
66_E87_E0.7460.91
84_E94_T0.7460.91
6_A16_Q0.7450.91
8_S12_T0.7370.91
32_D82_S0.7350.91
82_S92_R0.7240.90
11_A93_I0.7230.90
6_A75_I0.7200.90
5_T76_L0.7080.89
24_S35_V0.7010.89
22_A36_L0.6990.88
83_F91_L0.6940.88
9_Y58_E0.6930.88
22_A84_E0.6920.88
29_D68_S0.6870.88
28_F31_G0.6730.87
18_D36_L0.6690.86
14_V34_L0.6630.86
89_G92_R0.6600.85
57_R61_T0.6570.85
49_I58_E0.6570.85
23_V64_G0.6510.85
87_E90_L0.6490.85
45_Y60_F0.6390.84
5_T12_T0.6320.83
89_G94_T0.6320.83
8_S25_V0.6310.83
28_F68_S0.6250.82
13_K17_N0.6190.82
22_A86_L0.6170.81
7_L95_V0.6130.81
6_A78_L0.6110.81
4_R78_L0.6080.81
17_N38_E0.6050.80
3_E6_A0.5830.78
50_Y74_P0.5820.78
49_I78_L0.5770.77
61_T67_F0.5700.76
40_I45_Y0.5680.76
38_E41_D0.5680.76
12_T15_R0.5650.75
80_S96_T0.5640.75
12_T51_Y0.5630.75
2_D61_T0.5570.74
38_E43_E0.5570.74
14_V23_V0.5560.74
2_D12_T0.5540.74
9_Y75_I0.5510.74
88_D91_L0.5490.73
24_S46_E0.5460.73
59_L67_F0.5430.73
48_Y59_L0.5280.71
16_Q48_Y0.5270.70
17_N22_A0.5240.70
81_F93_I0.5230.70
87_E91_L0.5190.69
36_L78_L0.5180.69
23_V36_L0.5110.68
2_D56_L0.5080.68
28_F69_P0.5040.67
14_V17_N0.5020.67
3_E11_A0.5000.66
12_T48_Y0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u6xS 3 0.5204 10.9 0.902 Contact Map
4ghbA 5 0.9082 7.8 0.908 Contact Map
2cwsA 1 0.8673 5.1 0.916 Contact Map
2wzpR 3 0.3469 4.9 0.917 Contact Map
2p8gA 2 0.6122 4.6 0.918 Contact Map
2qx2A 1 0.4694 3.7 0.922 Contact Map
4pq0A 1 0.3367 3.4 0.923 Contact Map
4hn3A 3 0.5102 3.3 0.923 Contact Map
3v0rA 3 0.3571 3.3 0.924 Contact Map
4w8jA 2 0.8878 3.2 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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