GREMLIN Database
DUF4859 - Domain of unknown function (DUF4859)
PFAM: PF16151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (112)
Sequences: 856 (744)
Seq/√Len: 70.3
META: 0.926

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_N83_E3.9591.00
81_Y94_G3.6671.00
66_D70_N3.6151.00
21_T24_E3.3851.00
101_K104_D3.3371.00
63_H110_Q2.9741.00
42_A65_F2.7441.00
82_S110_Q2.6621.00
45_P70_N2.5591.00
75_G78_A2.2711.00
6_T92_N2.1151.00
44_N48_T1.9041.00
78_A96_Y1.8241.00
85_D88_T1.7051.00
80_V108_I1.6310.99
95_Q100_L1.6010.99
58_A94_G1.5940.99
19_G22_P1.5790.99
100_L106_Y1.5720.99
10_D13_K1.5680.99
43_V111_A1.5110.99
63_H82_S1.5070.99
67_A79_Y1.5030.99
66_D72_C1.4840.99
79_Y99_K1.4810.99
96_Y99_K1.4730.99
85_D90_T1.4320.98
33_P36_G1.4130.98
56_S61_P1.3970.98
38_I112_L1.3350.98
82_S108_I1.3290.98
19_G25_I1.2930.97
41_Y113_V1.2930.97
58_A83_E1.2590.97
41_Y54_S1.2530.96
72_C77_G1.2320.96
56_S63_H1.2170.96
16_T19_G1.2130.96
64_W74_W1.2000.95
83_E92_N1.1900.95
35_G117_K1.1870.95
33_P37_K1.1490.94
2_Y74_W1.1450.94
44_N53_T1.1440.94
14_I19_G1.1290.94
24_E28_A1.1170.93
42_A45_P1.0730.92
20_L28_A1.0570.91
8_D11_L1.0560.91
71_V77_G1.0390.91
57_T83_E1.0360.90
56_S59_N1.0330.90
57_T71_V1.0270.90
58_A61_P1.0190.90
79_Y106_Y1.0180.90
82_S93_I1.0120.89
32_G35_G1.0080.89
72_C76_D0.9660.87
9_L14_I0.9560.87
84_F112_L0.9510.86
72_C78_A0.9460.86
108_I111_A0.9410.86
10_D16_T0.9360.85
25_I112_L0.9240.85
52_L55_N0.9160.84
41_Y57_T0.9130.84
57_T61_P0.9060.83
8_D13_K0.9000.83
3_S6_T0.8800.82
40_F110_Q0.8770.81
52_L113_V0.8680.81
42_A71_V0.8550.80
82_S91_F0.8370.78
65_F110_Q0.8360.78
23_S102_A0.8190.77
44_N70_N0.8130.76
57_T60_G0.8120.76
12_A19_G0.8090.76
10_D14_I0.8090.76
90_T105_T0.8030.75
12_A16_T0.7950.75
15_A22_P0.7950.75
74_W97_P0.7930.74
91_F110_Q0.7930.74
56_S64_W0.7840.74
4_G92_N0.7840.74
14_I84_F0.7840.74
21_T28_A0.7780.73
20_L26_A0.7700.72
9_L91_F0.7350.69
80_V110_Q0.7340.69
5_T8_D0.7330.69
47_G109_K0.7290.68
66_D77_G0.7240.68
21_T25_I0.7190.67
12_A86_P0.7130.66
100_L104_D0.7120.66
45_P68_D0.6940.64
34_S53_T0.6870.64
44_N73_S0.6840.63
40_F82_S0.6840.63
7_V43_V0.6560.60
86_P89_L0.6540.60
86_P101_K0.6490.59
87_D91_F0.6460.59
62_G103_G0.6450.59
87_D100_L0.6420.58
32_G36_G0.6390.58
6_T9_L0.6320.57
28_A37_K0.6290.57
44_N71_V0.6270.57
18_F41_Y0.6270.57
54_S96_Y0.6240.56
40_F91_F0.6180.55
34_S107_T0.6170.55
84_F88_T0.6170.55
79_Y83_E0.6120.55
67_A106_Y0.6120.55
15_A91_F0.6090.54
63_H108_I0.6090.54
18_F38_I0.6060.54
74_W96_Y0.6060.54
93_I108_I0.6030.54
14_I18_F0.6030.54
63_H97_P0.6010.53
18_F39_K0.5990.53
2_Y97_P0.5930.52
26_A89_L0.5920.52
30_G33_P0.5910.52
96_Y100_L0.5890.52
74_W94_G0.5880.52
18_F25_I0.5870.52
66_D79_Y0.5860.52
43_V109_K0.5850.51
22_P25_I0.5770.50
22_P26_A0.5750.50
12_A28_A0.5750.50
111_A114_Y0.5710.50
42_A61_P0.5690.50
2_Y7_V0.5690.50
67_A80_V0.5660.49
25_I42_A0.5640.49
40_F63_H0.5640.49
32_G81_Y0.5620.49
44_N47_G0.5620.49
32_G38_I0.5580.48
96_Y106_Y0.5550.48
15_A21_T0.5490.47
2_Y96_Y0.5410.46
11_L22_P0.5400.46
84_F91_F0.5370.46
20_L24_E0.5350.45
101_K106_Y0.5310.45
83_E94_G0.5300.45
58_A62_G0.5270.44
82_S113_V0.5270.44
40_F112_L0.5210.44
41_Y80_V0.5170.43
78_A99_K0.5160.43
28_A87_D0.5150.43
68_D87_D0.5110.43
41_Y85_D0.5070.42
13_K67_A0.5040.42
64_W97_P0.5020.41
13_K17_A0.5020.41
64_W81_Y0.5000.41
102_A117_K0.5000.41
30_G90_T0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ufmA 1 0.5167 10.6 0.907 Contact Map
4d0pA 1 0.4333 10.3 0.907 Contact Map
3j8bM 1 0.4333 9 0.909 Contact Map
2vf1A 10 0.775 5.9 0.917 Contact Map
4pu7B 2 0.3917 5.1 0.919 Contact Map
4wbhA 2 0 5 0.92 Contact Map
1wi9A 1 0.4917 4.5 0.921 Contact Map
3ipwA 1 0.3333 4.5 0.921 Contact Map
1cx1A 1 0.6333 4.3 0.922 Contact Map
2lnbA 1 0.45 4.2 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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