GREMLIN Database
DUF4855 - Domain of unknown function (DUF4855)
PFAM: PF16147 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 313 (309)
Sequences: 624 (561)
Seq/√Len: 31.9
META: 0.821

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_K91_E4.2981.00
102_K160_E4.2731.00
146_E149_E4.2271.00
189_H215_D3.9931.00
185_A189_H3.3941.00
185_A195_F3.3831.00
107_L147_V3.2331.00
104_K160_E3.1221.00
125_D129_F3.1061.00
146_E150_R3.0871.00
86_D157_K3.0711.00
145_D187_Y2.9441.00
73_D150_R2.8331.00
83_D156_Y2.7261.00
195_F214_F2.6931.00
35_D312_Y2.4871.00
121_D125_D2.4670.99
148_L151_F2.3900.99
266_L311_L2.3880.99
218_Y285_A2.3770.99
234_L272_A2.3390.99
217_A246_M2.2920.99
121_D126_G2.2400.99
121_D129_F2.2180.99
43_F85_L2.1680.99
125_D138_K2.1550.99
129_F139_A2.1460.98
86_D159_L2.1360.98
29_D33_K2.1010.98
93_K158_N2.0840.98
187_Y191_K2.0800.98
141_K187_Y2.0610.98
123_D138_K2.0080.98
72_L146_E2.0070.98
21_F85_L1.9740.97
109_I140_V1.9640.97
41_F103_R1.9600.97
267_Y310_D1.9170.97
109_I184_V1.9160.97
90_G158_N1.9150.97
89_V103_R1.8870.97
209_W217_A1.8290.96
273_G278_Y1.8230.96
237_A248_V1.8220.96
305_R309_D1.8180.96
273_G279_M1.8170.96
26_A92_A1.7940.95
34_K95_K1.7710.95
82_L107_L1.7600.95
83_D87_E1.7580.95
2_L106_V1.7540.95
224_F253_D1.7190.94
148_L164_F1.7160.94
72_L147_V1.7100.94
149_E153_A1.6840.93
5_I21_F1.6740.93
111_Y168_A1.6590.93
25_V41_F1.6520.93
208_D211_E1.6380.93
164_F193_L1.6350.92
44_L108_M1.6340.92
24_Y288_Q1.6270.92
141_K145_D1.6080.92
198_I249_E1.5920.91
255_R262_F1.5800.91
6_Y44_L1.5790.91
106_V196_Y1.5690.91
219_L240_L1.5580.90
82_L159_L1.4810.88
3_V24_Y1.4770.88
85_L105_V1.4770.88
169_E220_Q1.4740.88
88_A92_A1.4730.88
126_G129_F1.4580.87
274_V310_D1.4570.87
181_V212_L1.4440.87
219_L237_A1.4380.87
293_L311_L1.4280.86
220_Q251_E1.4250.86
122_L138_K1.4100.85
274_V279_M1.4100.85
82_L154_A1.3890.85
238_A273_G1.3830.84
51_G54_F1.3760.84
225_F269_Y1.3750.84
128_D131_F1.3590.83
165_Y251_E1.3510.83
148_L193_L1.3490.83
64_T67_D1.3440.83
209_W246_M1.3390.82
223_Y234_L1.3380.82
224_F255_R1.3370.82
145_D191_K1.3350.82
69_E73_D1.3340.82
137_I183_A1.3330.82
119_F273_G1.3250.82
25_V89_V1.3090.81
80_G84_A1.3010.80
16_W139_A1.2880.80
188_V195_F1.2770.79
2_L40_G1.2760.79
7_N74_R1.2430.77
108_M167_L1.2410.77
272_A276_Y1.2400.77
112_P140_V1.2320.77
238_A278_Y1.2250.76
120_G142_W1.2070.75
119_F142_W1.1870.74
71_Y75_L1.1860.74
110_P247_G1.1850.74
86_D158_N1.1760.73
165_Y220_Q1.1710.73
218_Y247_G1.1600.72
37_L312_Y1.1490.71
288_Q294_Y1.1430.71
219_L241_A1.1420.71
94_A157_K1.1400.71
221_P269_Y1.1340.70
202_G219_L1.1310.70
123_D129_F1.1290.70
79_G83_D1.1150.69
16_W106_V1.1120.69
17_T20_D1.1020.68
127_L131_F1.0960.68
200_Y203_A1.0960.68
18_K87_E1.0820.67
297_A305_R1.0790.66
86_D154_A1.0760.66
86_D156_Y1.0730.66
288_Q291_G1.0710.66
296_L307_L1.0640.65
206_Y219_L1.0640.65
218_Y283_A1.0600.65
263_R267_Y1.0540.65
110_P143_Y1.0510.64
305_R308_Y1.0500.64
220_Q287_Y1.0500.64
274_V312_Y1.0460.64
171_I212_L1.0440.64
42_L198_I1.0440.64
117_T130_S1.0440.64
3_V288_Q1.0430.64
231_D268_D1.0400.64
229_V233_R1.0380.63
138_K141_K1.0360.63
12_R45_E1.0280.63
250_M270_L1.0280.63
144_I191_K1.0130.61
36_W89_V1.0120.61
125_D131_F1.0110.61
137_I180_L1.0090.61
46_F58_Y1.0070.61
187_Y190_S0.9960.60
169_E251_E0.9940.60
144_I187_Y0.9920.60
147_V164_F0.9870.59
64_T116_Q0.9810.59
296_L311_L0.9790.59
237_A241_A0.9690.58
76_F195_F0.9550.57
68_W112_P0.9500.56
278_Y282_A0.9490.56
250_M286_Y0.9430.56
70_W74_R0.9370.55
46_F167_L0.9320.55
254_E292_A0.9300.55
208_D212_L0.9300.55
165_Y249_E0.9290.55
306_E310_D0.9230.54
195_F219_L0.9230.54
93_K101_Y0.9120.53
30_E33_K0.9080.53
27_Y34_K0.9080.53
184_V209_W0.9010.52
86_D90_G0.9010.52
112_P136_R0.8980.52
265_R269_Y0.8960.52
21_F43_F0.8950.52
82_L156_Y0.8950.52
122_L129_F0.8900.52
112_P166_W0.8810.51
144_I188_V0.8800.51
165_Y169_E0.8790.51
64_T118_D0.8760.50
199_P220_Q0.8720.50
266_L296_L0.8720.50
251_E287_Y0.8680.50
90_G157_K0.8610.49
75_L107_L0.8600.49
75_L81_N0.8570.49
1_D284_L0.8570.49
72_L149_E0.8560.49
65_K69_E0.8540.49
235_D276_Y0.8520.48
65_K121_D0.8520.48
119_F122_L0.8500.48
264_D268_D0.8460.48
131_F134_E0.8410.48
25_V92_A0.8350.47
126_G131_F0.8330.47
90_G93_K0.8300.47
223_Y272_A0.8250.46
36_W101_Y0.8240.46
45_E108_M0.8190.46
265_R272_A0.8190.46
127_L139_A0.8160.46
86_D100_D0.8150.45
225_F265_R0.8140.45
169_E199_P0.8100.45
247_G282_A0.8080.45
27_Y35_D0.8060.45
16_W42_L0.8050.45
54_F58_Y0.8050.45
233_R237_A0.8040.45
307_L311_L0.8000.44
225_F241_A0.7980.44
87_E90_G0.7920.44
27_Y308_Y0.7900.43
156_Y234_L0.7900.43
111_Y166_W0.7860.43
253_D289_G0.7860.43
267_Y271_D0.7840.43
156_Y228_D0.7840.43
227_E277_G0.7830.43
252_F256_V0.7820.43
271_D275_E0.7820.43
4_L198_I0.7810.43
271_D310_D0.7790.43
5_I41_F0.7790.43
84_A286_Y0.7770.42
65_K119_F0.7770.42
78_P83_D0.7740.42
19_E152_N0.7720.42
170_S212_L0.7700.42
150_R153_A0.7690.42
203_A208_D0.7690.42
90_G105_V0.7680.42
76_F84_A0.7680.42
302_P305_R0.7660.41
184_V195_F0.7650.41
200_Y289_G0.7650.41
223_Y293_L0.7630.41
43_F205_G0.7620.41
149_E154_A0.7590.41
1_D286_Y0.7590.41
26_A36_W0.7540.41
23_P297_A0.7500.40
27_Y312_Y0.7480.40
279_M312_Y0.7470.40
178_E208_D0.7450.40
198_I265_R0.7430.40
78_P154_A0.7420.40
111_Y177_D0.7360.39
198_I225_F0.7360.39
40_G218_Y0.7310.39
144_I164_F0.7300.39
206_Y240_L0.7290.39
170_S204_P0.7280.39
118_D128_D0.7260.38
62_P111_Y0.7240.38
71_Y108_M0.7230.38
288_Q292_A0.7210.38
220_Q249_E0.7190.38
159_L231_D0.7180.38
8_G217_A0.7130.37
304_D310_D0.7120.37
104_K162_A0.7100.37
247_G309_D0.7090.37
251_E269_Y0.7070.37
41_F71_Y0.7040.37
75_L180_L0.7040.37
247_G285_A0.7030.37
294_Y298_R0.7030.37
23_P294_Y0.7000.36
286_Y311_L0.6980.36
21_F25_V0.6920.36
119_F279_M0.6900.36
1_D159_L0.6890.36
31_D271_D0.6840.35
76_F257_L0.6820.35
119_F238_A0.6820.35
49_G70_W0.6820.35
170_S254_E0.6800.35
291_G295_D0.6790.35
11_H141_K0.6750.34
232_S236_D0.6740.34
123_D126_G0.6730.34
3_V9_G0.6720.34
201_Y233_R0.6700.34
220_Q225_F0.6690.34
42_L285_A0.6690.34
248_V278_Y0.6690.34
225_F251_E0.6680.34
79_G149_E0.6660.34
148_L191_K0.6660.34
108_M237_A0.6650.34
110_P147_V0.6650.34
44_L198_I0.6650.34
263_R307_L0.6610.33
299_S304_D0.6590.33
198_I251_E0.6590.33
72_L150_R0.6590.33
26_A34_K0.6580.33
65_K120_G0.6550.33
252_F292_A0.6540.33
235_D272_A0.6530.33
28_V305_R0.6530.33
136_R181_V0.6520.33
168_A177_D0.6520.33
36_W99_P0.6510.33
44_L167_L0.6500.33
71_Y245_G0.6490.33
165_Y199_P0.6450.32
7_N75_L0.6440.32
39_D165_Y0.6420.32
91_E151_F0.6400.32
124_G127_L0.6390.32
124_G245_G0.6360.32
239_A243_K0.6350.32
155_N161_L0.6340.32
273_G284_L0.6340.32
152_N182_K0.6320.31
77_A80_G0.6290.31
207_D244_Y0.6260.31
23_P85_L0.6240.31
147_V156_Y0.6220.31
68_W139_A0.6200.31
199_P251_E0.6200.31
92_A308_Y0.6190.30
37_L51_G0.6190.30
247_G266_L0.6170.30
272_A278_Y0.6140.30
52_R56_P0.6140.30
235_D239_A0.6140.30
169_E287_Y0.6130.30
91_E94_A0.6120.30
88_A96_L0.6120.30
199_P225_F0.6100.30
136_R201_Y0.6100.30
120_G135_D0.6100.30
45_E167_L0.6090.30
79_G87_E0.6090.30
44_L109_I0.6060.30
201_Y219_L0.6060.30
123_D131_F0.6050.30
201_Y236_D0.6040.29
20_D291_G0.6030.29
97_G155_N0.6020.29
109_I203_A0.5990.29
252_F311_L0.5990.29
144_I183_A0.5990.29
138_K250_M0.5980.29
15_D158_N0.5950.29
103_R312_Y0.5940.29
194_K215_D0.5930.29
309_D312_Y0.5900.28
106_V285_A0.5900.28
152_N300_T0.5890.28
140_V184_V0.5880.28
26_A95_K0.5860.28
23_P43_F0.5810.28
16_W24_Y0.5800.28
198_I220_Q0.5800.28
107_L188_V0.5780.28
274_V278_Y0.5780.28
107_L110_P0.5770.28
141_K190_S0.5770.28
27_Y136_R0.5760.28
1_D65_K0.5740.27
164_F187_Y0.5740.27
63_A139_A0.5720.27
25_V36_W0.5720.27
250_M266_L0.5720.27
51_G70_W0.5690.27
136_R307_L0.5680.27
166_W177_D0.5660.27
38_F286_Y0.5650.27
224_F265_R0.5630.27
100_D190_S0.5610.27
1_D19_E0.5600.27
92_A96_L0.5580.26
5_I24_Y0.5580.26
126_G138_K0.5550.26
235_D268_D0.5550.26
89_V92_A0.5530.26
200_Y205_G0.5530.26
152_N157_K0.5530.26
96_L123_D0.5530.26
66_E141_K0.5510.26
144_I210_K0.5500.26
28_V297_A0.5500.26
18_K96_L0.5500.26
116_Q234_L0.5490.26
83_D154_A0.5480.26
8_G247_G0.5480.26
92_A128_D0.5470.26
208_D246_M0.5460.26
69_E72_L0.5450.26
213_G233_R0.5440.26
7_N81_N0.5430.25
162_A180_L0.5430.25
151_F159_L0.5420.25
164_F188_V0.5420.25
44_L220_Q0.5420.25
39_D104_K0.5400.25
106_V163_G0.5380.25
221_P251_E0.5380.25
257_L303_E0.5370.25
119_F218_Y0.5370.25
74_R81_N0.5360.25
1_D7_N0.5360.25
270_L279_M0.5340.25
107_L270_L0.5340.25
105_V210_K0.5320.25
186_D223_Y0.5320.25
14_G20_D0.5310.25
234_L237_A0.5280.25
35_D140_V0.5270.24
137_I203_A0.5270.24
215_D247_G0.5260.24
1_D280_K0.5260.24
22_L91_E0.5250.24
7_N201_Y0.5250.24
218_Y311_L0.5230.24
119_F131_F0.5230.24
165_Y198_I0.5230.24
45_E51_G0.5220.24
93_K103_R0.5220.24
107_L116_Q0.5200.24
210_K245_G0.5190.24
100_D300_T0.5190.24
55_A58_Y0.5190.24
269_Y287_Y0.5180.24
38_F41_F0.5170.24
42_L156_Y0.5170.24
94_A155_N0.5170.24
27_Y69_E0.5150.24
124_G129_F0.5140.24
186_D190_S0.5140.24
270_L297_A0.5140.24
71_Y180_L0.5140.24
32_G138_K0.5130.24
143_Y209_W0.5130.24
79_G156_Y0.5130.24
289_G292_A0.5130.24
72_L107_L0.5120.24
308_Y312_Y0.5120.24
203_A207_D0.5110.24
201_Y240_L0.5100.23
205_G219_L0.5080.23
50_S67_D0.5070.23
248_V273_G0.5050.23
78_P123_D0.5050.23
161_L164_F0.5050.23
293_L296_L0.5040.23
63_A67_D0.5040.23
224_F252_F0.5040.23
10_Y14_G0.5040.23
144_I223_Y0.5030.23
185_A235_D0.5030.23
41_F85_L0.5020.23
239_A293_L0.5010.23
77_A160_E0.5010.23
169_E225_F0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bqcA 1 0.4537 75.1 0.957 Contact Map
1ceoA 1 0.4537 56.6 0.962 Contact Map
2whlA 1 0.4441 56.5 0.962 Contact Map
3w0kA 1 0.4441 51.5 0.963 Contact Map
4yheA 1 0.5112 51.2 0.964 Contact Map
3p6lA 2 0.5559 50.2 0.964 Contact Map
1h4pA 1 0.5655 50.2 0.964 Contact Map
3aofA 1 0.4633 48.1 0.964 Contact Map
3hjeA 1 0.4409 47.6 0.964 Contact Map
4aweA 1 0.5272 46.6 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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