GREMLIN Database
DUF4846 - Domain of unknown function (4846)
PFAM: PF16138 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 240 (239)
Sequences: 1708 (1424)
Seq/√Len: 92.1
META: 0.872

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_R87_K4.9391.00
145_L170_S4.4481.00
167_Q237_D3.0951.00
102_K107_Y3.0791.00
181_A189_I2.9711.00
58_D132_R2.9211.00
98_A138_V2.6541.00
93_T143_G2.5481.00
159_I180_V2.5141.00
89_H97_R2.5121.00
178_V193_A2.4671.00
28_L55_L2.4391.00
132_R136_D2.3661.00
77_E131_F2.3621.00
62_R136_D2.3431.00
161_I180_V2.3181.00
154_V240_R2.2991.00
70_A195_S2.2821.00
187_E218_S2.2771.00
91_N97_R2.2511.00
183_N187_E2.2441.00
165_F226_L2.2281.00
175_V205_L2.1901.00
47_N50_V2.1861.00
148_S239_K2.1541.00
72_M135_L2.1401.00
16_V22_A2.0461.00
107_Y120_K2.0131.00
104_A126_N1.9611.00
16_V26_R1.9581.00
31_K201_E1.8991.00
100_Y104_A1.8861.00
92_F98_A1.8761.00
182_E188_K1.8211.00
21_F176_I1.8211.00
13_R179_D1.8121.00
99_D102_K1.8031.00
92_F137_L1.7971.00
75_R79_L1.7901.00
159_I177_V1.7841.00
5_F52_A1.6951.00
94_S116_V1.6821.00
151_L164_V1.6701.00
48_Q51_H1.6671.00
187_E220_D1.6571.00
7_P189_I1.6461.00
102_K105_K1.6281.00
38_L44_E1.5921.00
128_Y132_R1.5851.00
65_Q73_R1.5721.00
76_A135_L1.5701.00
75_R90_F1.5541.00
62_R140_T1.5531.00
98_A109_P1.5491.00
71_V176_I1.5391.00
79_L84_R1.5251.00
190_F226_L1.4941.00
176_I193_A1.4731.00
109_P137_L1.4731.00
193_A202_I1.4541.00
31_K56_D1.4531.00
145_L168_G1.4501.00
12_E184_K1.4430.99
125_D130_S1.4070.99
128_Y131_F1.3830.99
39_L48_Q1.3680.99
111_V116_V1.3650.99
221_E226_L1.3580.99
65_Q132_R1.3570.99
51_H203_H1.3450.99
73_R77_E1.3420.99
80_Y85_Y1.3110.99
180_V188_K1.2910.99
23_E27_N1.2880.99
102_K118_W1.2830.99
165_F190_F1.2690.99
96_F109_P1.2560.99
210_D214_S1.2500.99
153_P239_K1.2470.98
44_E48_Q1.2420.98
65_Q77_E1.2390.98
22_A161_I1.2340.98
234_E237_D1.2320.98
159_I219_L1.2180.98
71_V164_V1.2140.98
148_S168_G1.2140.98
159_I190_F1.2130.98
189_I213_L1.2050.98
110_K119_V1.2000.98
88_I134_Y1.1950.98
28_L178_V1.1940.98
11_Y189_I1.1840.98
38_L201_E1.1650.98
80_Y128_Y1.1600.98
161_I178_V1.1600.98
2_E27_N1.1560.98
2_E26_R1.1430.97
189_I218_S1.1410.97
45_K230_E1.1410.97
89_H150_E1.1370.97
221_E235_K1.1320.97
26_R179_D1.1290.97
19_G23_E1.1020.97
190_F219_L1.0940.97
47_N230_E1.0910.96
36_P44_E1.0900.96
137_L140_T1.0780.96
59_V65_Q1.0740.96
155_D158_D1.0580.96
70_A202_I1.0510.96
103_W137_L1.0370.95
109_P116_V1.0310.95
33_D53_A1.0110.95
86_D101_S1.0060.94
16_V161_I1.0010.94
67_C144_T0.9870.94
39_L51_H0.9850.94
80_Y100_Y0.9810.94
225_E234_E0.9740.93
92_F116_V0.9730.93
77_E128_Y0.9630.93
91_N150_E0.9610.93
39_L45_K0.9460.92
223_G226_L0.9440.92
142_A146_S0.9400.92
154_V160_Q0.9390.92
1_I178_V0.9340.92
108_R124_P0.9260.92
59_V201_E0.9250.92
57_I132_R0.9210.91
7_P181_A0.9210.91
98_A116_V0.9200.91
122_A125_D0.9200.91
85_Y100_Y0.9160.91
20_S23_E0.9140.91
108_R122_A0.9130.91
58_D128_Y0.9050.91
85_Y104_A0.8970.90
98_A137_L0.8950.90
89_H99_D0.8900.90
35_S201_E0.8840.90
147_L166_I0.8830.90
101_S105_K0.8800.89
65_Q201_E0.8790.89
94_S118_W0.8770.89
57_I202_I0.8650.89
224_G236_G0.8640.89
5_F191_L0.8570.88
50_V230_E0.8510.88
79_L87_K0.8470.88
52_A206_K0.8460.87
60_G63_D0.8460.87
57_I65_Q0.8460.87
210_D218_S0.8430.87
11_Y187_E0.8430.87
125_D128_Y0.8390.87
13_R26_R0.8390.87
104_A125_D0.8360.87
69_D144_T0.8320.87
93_T146_S0.8300.86
24_Y33_D0.8270.86
39_L44_E0.8260.86
96_F111_V0.8250.86
55_L202_I0.8220.86
92_F109_P0.8220.86
72_M93_T0.8170.86
4_R53_A0.8130.85
210_D213_L0.8120.85
17_A23_E0.8110.85
60_G136_D0.8080.85
227_V232_T0.8070.85
35_S38_L0.8030.85
218_S221_E0.8020.85
16_V20_S0.8000.84
167_Q231_W0.8000.84
143_G168_G0.7960.84
1_I204_I0.7920.84
105_K120_K0.7900.84
37_V54_V0.7850.83
149_K166_I0.7790.83
66_Q69_D0.7780.83
192_L228_T0.7770.83
110_K117_S0.7760.83
127_S130_S0.7760.83
18_E23_E0.7740.82
150_E166_I0.7720.82
209_N213_L0.7710.82
124_P130_S0.7690.82
96_F116_V0.7660.82
224_G235_K0.7650.82
74_L176_I0.7650.82
205_L229_P0.7610.81
67_C197_M0.7560.81
57_I201_E0.7550.81
178_V204_I0.7510.80
82_Q87_K0.7500.80
151_L166_I0.7500.80
143_G170_S0.7470.80
110_K121_T0.7470.80
156_I165_F0.7430.80
109_P118_W0.7400.79
48_Q203_H0.7400.79
55_L178_V0.7330.79
65_Q136_D0.7280.78
130_S133_K0.7270.78
30_L34_G0.7240.78
96_F138_V0.7220.78
5_F53_A0.7220.78
39_L50_V0.7200.78
67_C173_H0.7190.78
101_S104_A0.7140.77
176_I202_I0.7090.77
96_F99_D0.7070.76
19_G82_Q0.6980.75
108_R125_D0.6960.75
71_V166_I0.6950.75
111_V114_N0.6950.75
71_V174_A0.6940.75
58_D136_D0.6930.75
31_K35_S0.6910.75
57_I139_F0.6840.74
96_F118_W0.6790.73
182_E186_G0.6770.73
11_Y183_N0.6750.73
165_F238_L0.6740.73
29_P55_L0.6730.73
104_A127_S0.6700.72
1_I5_F0.6680.72
45_K196_Y0.6680.72
32_P35_S0.6670.72
135_L202_I0.6660.72
50_V208_P0.6620.72
208_P217_Y0.6540.71
80_Y104_A0.6510.70
131_F135_L0.6470.70
174_A231_W0.6430.69
166_I239_K0.6430.69
194_Q197_M0.6420.69
55_L193_A0.6420.69
105_K124_P0.6410.69
220_D235_K0.6400.69
163_D240_R0.6400.69
126_N130_S0.6390.69
36_P51_H0.6390.69
93_T168_G0.6370.69
103_W109_P0.6340.68
37_V45_K0.6280.68
28_L57_I0.6280.68
177_V180_V0.6260.67
14_V26_R0.6260.67
24_Y81_S0.6260.67
45_K50_V0.6230.67
67_C172_G0.6160.66
25_L178_V0.6160.66
145_L148_S0.6100.65
70_A75_R0.6090.65
94_S114_N0.6070.65
196_Y230_E0.6060.65
93_T148_S0.6060.65
24_Y100_Y0.6050.65
147_L151_L0.6020.64
68_A171_P0.6010.64
207_N213_L0.6010.64
100_Y124_P0.5990.64
134_Y150_E0.5980.64
190_F218_S0.5960.63
68_A146_S0.5950.63
68_A147_L0.5950.63
50_V201_E0.5930.63
168_G171_P0.5900.63
58_D65_Q0.5890.63
92_F141_Y0.5890.63
12_E182_E0.5870.62
192_L205_L0.5860.62
165_F177_V0.5860.62
85_Y126_N0.5860.62
33_D52_A0.5850.62
93_T140_T0.5850.62
5_F8_P0.5810.62
24_Y109_P0.5810.62
197_M200_Q0.5790.61
55_L203_H0.5780.61
30_L53_A0.5780.61
92_F96_F0.5760.61
225_E232_T0.5760.61
25_L74_L0.5740.61
16_V23_E0.5740.61
63_D72_M0.5720.60
44_E51_H0.5710.60
99_D118_W0.5690.60
181_A213_L0.5680.60
103_W130_S0.5670.60
104_A130_S0.5660.60
100_Y131_F0.5660.60
190_F217_Y0.5640.59
194_Q203_H0.5640.59
159_I191_L0.5640.59
112_K117_S0.5630.59
5_F215_P0.5620.59
35_S52_A0.5600.59
195_S230_E0.5600.59
219_L226_L0.5600.59
24_Y27_N0.5590.59
94_S111_V0.5580.58
225_E236_G0.5570.58
25_L176_I0.5560.58
125_D133_K0.5540.58
65_Q76_A0.5520.58
220_D223_G0.5510.58
9_E14_V0.5500.57
99_D109_P0.5480.57
160_Q180_V0.5470.57
113_G116_V0.5460.57
100_Y109_P0.5440.57
104_A124_P0.5410.56
23_E26_R0.5400.56
69_D173_H0.5380.56
66_Q144_T0.5380.56
39_L230_E0.5370.56
144_T173_H0.5360.55
228_T233_F0.5350.55
15_P185_K0.5320.55
73_R139_F0.5290.54
22_A160_Q0.5280.54
94_S143_G0.5260.54
148_S237_D0.5260.54
107_Y118_W0.5260.54
196_Y200_Q0.5250.54
70_A151_L0.5250.54
59_V202_I0.5240.54
65_Q195_S0.5230.54
68_A169_G0.5230.54
24_Y57_I0.5200.53
224_G227_V0.5190.53
10_G183_N0.5160.53
91_N166_I0.5140.52
173_H194_Q0.5130.52
68_A142_A0.5120.52
36_P40_Y0.5110.52
104_A131_F0.5080.52
37_V50_V0.5080.52
121_T124_P0.5060.51
18_E27_N0.5060.51
33_D36_P0.5050.51
45_K194_Q0.5040.51
154_V158_D0.5040.51
45_K51_H0.5040.51
80_Y131_F0.5040.51
100_Y130_S0.5030.51
14_V182_E0.5020.51
98_A118_W0.5020.51
145_L192_L0.5020.51
59_V132_R0.5010.51
9_E15_P0.5010.51
82_Q85_Y0.5010.51
67_C196_Y0.5010.51
9_E18_E0.5000.50
165_F237_D0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2if6A 1 0.2875 43.1 0.959 Contact Map
2vobA 1 0.7458 35.5 0.961 Contact Map
2lktA 1 0.3083 27.7 0.963 Contact Map
4hz9A 1 0.4542 26.5 0.964 Contact Map
3vpiA 1 0.5042 21.3 0.965 Contact Map
4dpzX 1 0.25 17.8 0.966 Contact Map
2io8A 2 0.6542 17.5 0.967 Contact Map
4dotA 1 0.2125 17.4 0.967 Contact Map
1vr0A 2 0.3667 16 0.967 Contact Map
3h20A 2 0.4417 15.6 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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