GREMLIN Database
DUF4845 - Domain of unknown function (DUF4845)
PFAM: PF16137 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (85)
Sequences: 9547 (6588)
Seq/√Len: 714.5
META: 0.947

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_S84_D2.3441.00
3_V7_L2.2921.00
35_R39_K2.2841.00
38_D51_G2.0121.00
70_E84_D1.9991.00
13_K17_E1.9911.00
30_V34_R1.9631.00
75_L81_L1.9281.00
72_R82_L1.9141.00
9_Y13_K1.8701.00
79_V83_V1.8651.00
41_A46_I1.8311.00
72_R80_S1.7871.00
50_K53_D1.7801.00
18_S40_R1.7211.00
5_A83_V1.6971.00
29_S32_E1.6051.00
2_L83_V1.5941.00
59_E64_V1.5811.00
72_R84_D1.5801.00
32_E35_R1.5791.00
31_A35_R1.5271.00
5_A85_F1.5221.00
10_Y14_K1.4681.00
5_A73_V1.4661.00
37_F41_A1.4241.00
39_K42_D1.3991.00
28_A36_A1.3341.00
25_A28_A1.2991.00
15_A44_D1.2621.00
28_A32_E1.2521.00
35_R38_D1.2251.00
70_E82_L1.2001.00
48_S71_V1.1841.00
38_D42_D1.1591.00
55_E66_S1.1511.00
36_A40_R1.1511.00
57_T66_S1.1361.00
5_A71_V1.0911.00
57_T64_V1.0901.00
42_D45_D1.0711.00
73_V81_L1.0671.00
19_V65_I1.0491.00
7_L10_Y1.0181.00
8_E48_S1.0161.00
41_A54_L1.0061.00
6_Y10_Y1.0001.00
11_T44_D0.9751.00
68_A84_D0.9461.00
49_I53_D0.9451.00
12_V16_L0.9301.00
31_A34_R0.9171.00
22_E25_A0.9121.00
74_P80_S0.9111.00
16_L67_V0.9051.00
10_Y13_K0.8961.00
3_V10_Y0.8881.00
14_K18_S0.8861.00
17_E21_A0.8761.00
15_A40_R0.8721.00
19_V37_F0.8671.00
7_L11_T0.8641.00
33_I65_I0.8621.00
39_K43_I0.8541.00
37_F54_L0.8471.00
49_I67_V0.8441.00
22_E40_R0.8151.00
33_I56_I0.8091.00
19_V36_A0.8071.00
58_K63_V0.7951.00
74_P84_D0.7941.00
36_A39_K0.7741.00
14_K44_D0.7721.00
15_A18_S0.7691.00
59_E62_G0.7641.00
5_A9_Y0.7531.00
38_D50_K0.7531.00
54_L67_V0.7511.00
2_L79_V0.7351.00
30_V56_I0.7351.00
2_L81_L0.7211.00
19_V25_A0.7151.00
30_V63_V0.7141.00
73_V83_V0.7081.00
12_V67_V0.7021.00
2_L5_A0.7001.00
32_E36_A0.6991.00
15_A37_F0.6981.00
16_L65_I0.6961.00
8_E11_T0.6901.00
40_R44_D0.6871.00
24_G27_G0.6801.00
22_E36_A0.6761.00
23_P26_A0.6661.00
20_A23_P0.6591.00
11_T45_D0.6501.00
14_K17_E0.6501.00
2_L6_Y0.6481.00
70_E80_S0.6421.00
38_D52_K0.6421.00
34_R51_G0.6371.00
21_A24_G0.6371.00
22_E26_A0.6171.00
16_L54_L0.6161.00
40_R43_I0.6151.00
30_V58_K0.6131.00
42_D47_D0.6001.00
1_K73_V0.5961.00
20_A24_G0.5931.00
12_V46_I0.5891.00
33_I63_V0.5811.00
8_E71_V0.5741.00
1_K74_P0.5641.00
6_Y83_V0.5631.00
16_L66_S0.5531.00
1_K9_Y0.5531.00
12_V41_A0.5461.00
74_P83_V0.5321.00
13_K16_L0.5321.00
37_F46_I0.5311.00
11_T14_K0.5231.00
41_A44_D0.5201.00
18_S21_A0.5181.00
74_P77_G0.5171.00
15_A46_I0.5171.00
19_V33_I0.5141.00
3_V6_Y0.5020.99
8_E45_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pftA 1 0.5176 12.2 0.869 Contact Map
3l6iA 2 0.8353 10.7 0.873 Contact Map
2b1eA 1 0.4706 9.2 0.876 Contact Map
1q1vA 1 0.7529 7.7 0.88 Contact Map
4ye0A 2 0.6824 5.7 0.887 Contact Map
1q7hA 2 0.6706 5.7 0.887 Contact Map
3aabA 2 0.8588 5.7 0.887 Contact Map
1txlA 1 0.9647 5.5 0.888 Contact Map
1vqqA 1 0.9529 4.9 0.89 Contact Map
3woaA 1 0.4588 4.4 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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