GREMLIN Database
Jas - TPL-binding domain in jasmonate signalling
PFAM: PF16135 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (70)
Sequences: 649 (359)
Seq/√Len: 42.9
META: 0.085

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_V39_I3.3991.00
35_L53_L2.8411.00
16_G22_A2.0930.99
63_G69_P2.0840.99
20_D45_L1.9950.99
7_V10_W1.9560.99
14_D41_G1.9440.99
59_E73_I1.9360.99
59_E67_R1.9170.99
4_K35_L1.8820.99
19_L22_A1.7950.98
24_V59_E1.7360.98
11_L68_R1.7090.97
54_S60_A1.6830.97
56_S66_R1.6320.97
31_G53_L1.5710.96
59_E64_S1.4670.94
26_Y59_E1.4200.93
66_R72_H1.3630.91
29_R50_N1.3520.91
37_G49_C1.3090.89
5_R9_S1.3000.89
42_D69_P1.2340.86
38_Y42_D1.2220.86
11_L15_N1.2190.86
12_I43_G1.2160.86
27_R35_L1.1780.84
53_L74_Y1.1010.79
23_K36_E1.0940.79
31_G35_L1.0830.78
4_K33_K1.0640.77
24_V71_R1.0410.75
50_N67_R1.0240.74
29_R44_I1.0220.74
28_N31_G1.0010.73
4_K15_N1.0000.72
6_T11_L0.9930.72
64_S71_R0.9630.70
71_R74_Y0.9590.69
18_L53_L0.9540.69
64_S69_P0.9450.68
19_L70_Y0.9280.67
33_K54_S0.9220.66
26_Y62_A0.9190.66
55_P70_Y0.9100.65
27_R32_K0.9060.65
64_S70_Y0.9020.64
8_L54_S0.8940.64
21_G45_L0.8750.62
29_R67_R0.8730.62
44_I54_S0.8710.62
24_V62_A0.8610.61
30_G33_K0.8600.61
15_N67_R0.8590.61
28_N66_R0.8580.61
28_N65_K0.8500.60
49_C52_V0.8350.58
17_G39_I0.7930.55
43_G52_V0.7920.54
9_S17_G0.7730.53
37_G43_G0.7700.52
53_L63_G0.7460.50
10_W55_P0.7380.49
66_R70_Y0.7270.48
23_K40_T0.7230.48
30_G63_G0.7170.47
22_A64_S0.7160.47
32_K74_Y0.7010.46
46_C61_H0.7010.46
29_R35_L0.6950.45
17_G20_D0.6850.44
70_Y73_I0.6740.43
16_G72_H0.6680.43
4_K53_L0.6680.43
19_L59_E0.6550.42
19_L53_L0.6550.42
21_G53_L0.6540.41
11_L43_G0.6450.41
32_K36_E0.6390.40
64_S67_R0.6360.40
41_G51_K0.6330.40
37_G59_E0.6300.39
53_L72_H0.6260.39
60_A67_R0.6200.38
30_G36_E0.6160.38
47_S52_V0.6110.38
36_E52_V0.5980.36
68_R71_R0.5960.36
50_N60_A0.5830.35
5_R15_N0.5680.34
38_Y57_E0.5650.34
40_T51_K0.5580.33
18_L23_K0.5540.33
63_G66_R0.5460.32
21_G33_K0.5400.31
4_K14_D0.5370.31
38_Y67_R0.5320.31
64_S72_H0.5270.30
29_R65_K0.5230.30
40_T69_P0.5190.30
14_D37_G0.5140.29
17_G68_R0.5080.29
40_T54_S0.5030.29
60_A68_R0.5030.29
26_Y37_G0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lbmA 1 0.5541 38.6 0.867 Contact Map
3ql9A 1 0.4189 31.5 0.873 Contact Map
4qbbA 1 0.9595 12 0.896 Contact Map
4m0wA 1 0.973 5.5 0.91 Contact Map
1oqjA 1 0.7432 5.1 0.912 Contact Map
2zncA 2 0.8649 4.6 0.914 Contact Map
3fw3A 1 0.8649 3.9 0.917 Contact Map
1p4cA 3 0.3243 3.9 0.917 Contact Map
2wfvA 1 0.3108 3.8 0.917 Contact Map
1h5pA 1 0.8108 3.7 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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