GREMLIN Database
DUF4837 - Domain of unknown function (DUF4837)
PFAM: PF16125 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 295 (295)
Sequences: 3959 (3162)
Seq/√Len: 184.1
META: 0.913

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_S267_R4.1071.00
98_D101_E3.7611.00
200_R272_E3.4611.00
144_K160_D3.2691.00
96_A102_L3.1561.00
142_K148_S3.0631.00
259_T270_V2.9221.00
262_D267_R2.7691.00
97_P101_E2.6131.00
158_A168_R2.5261.00
196_I240_T2.5021.00
109_N112_K2.4721.00
170_E175_S2.3731.00
228_R239_E2.3701.00
200_R219_T2.3031.00
140_K160_D2.2711.00
177_N274_F2.2661.00
32_P39_P2.2471.00
133_E138_E2.2231.00
22_G26_R2.1471.00
257_S270_V2.1061.00
243_L252_G2.0061.00
104_E108_E1.9811.00
259_T268_L1.9681.00
17_W47_Q1.9581.00
218_I245_E1.9151.00
204_G272_E1.9011.00
205_K216_Y1.8951.00
64_L117_F1.8781.00
231_E234_G1.8231.00
12_M25_L1.8091.00
139_K143_E1.8071.00
17_W22_G1.8021.00
83_D87_K1.7751.00
240_T257_S1.7681.00
130_K150_K1.7641.00
229_E236_Y1.7601.00
24_A27_E1.7511.00
183_Y199_K1.7481.00
85_W91_V1.7391.00
184_P267_R1.7371.00
204_G219_T1.7331.00
6_N287_R1.7071.00
262_D265_N1.6921.00
199_K202_S1.6841.00
219_T272_E1.6801.00
134_S137_L1.6691.00
133_E150_K1.6641.00
23_D27_E1.6491.00
220_E245_E1.6441.00
271_I293_L1.6401.00
209_P246_V1.5941.00
231_E236_Y1.5911.00
181_Y200_R1.5811.00
12_M16_L1.5721.00
100_E104_E1.5681.00
261_V268_L1.5461.00
8_I117_F1.5271.00
17_W26_R1.5201.00
218_I247_E1.5061.00
141_L180_I1.5041.00
65_I91_V1.5011.00
183_Y259_T1.4971.00
145_F182_S1.4911.00
232_F237_A1.4911.00
14_D18_E1.4821.00
1_S88_P1.4521.00
49_P52_A1.4461.00
164_F207_Y1.4371.00
122_R294_K1.4371.00
14_D47_Q1.4291.00
227_V240_T1.4231.00
192_T195_N1.4051.00
256_V293_L1.4051.00
195_N199_K1.3841.00
183_Y270_V1.3801.00
28_I106_I1.3771.00
67_D95_S1.3671.00
90_L116_L1.3611.00
212_T215_S1.3581.00
241_R290_E1.3571.00
257_S272_E1.3521.00
183_Y268_L1.3491.00
28_I110_K1.3341.00
122_R126_Q1.3321.00
12_M66_V1.3311.00
251_M276_Y1.3271.00
30_A45_L1.3271.00
196_I259_T1.3171.00
38_Q282_K1.3161.00
275_V286_L1.3131.00
277_A280_K1.3041.00
68_I102_L1.2951.00
66_V102_L1.2911.00
92_V117_F1.2901.00
190_Q195_N1.2871.00
237_A260_F1.2811.00
81_K84_V1.2701.00
101_E104_E1.2681.00
115_D119_K1.2641.00
193_K227_V1.2641.00
227_V238_V1.2631.00
37_P243_L1.2511.00
201_D221_E1.2411.00
211_P246_V1.2371.00
171_T174_G1.2361.00
197_I201_D1.2111.00
33_V286_L1.1921.00
102_L106_I1.1881.00
25_L64_L1.1791.00
210_G215_S1.1661.00
24_A107_K1.1631.00
273_G289_L1.1561.00
43_F114_I1.1431.00
179_L204_G1.1361.00
48_I57_F1.1341.00
84_V91_V1.1271.00
277_A282_K1.1221.00
203_I207_Y1.1211.00
33_V42_L1.1161.00
237_A258_Y1.0991.00
62_N124_R1.0951.00
103_I107_K1.0951.00
241_R256_V1.0931.00
96_A105_L1.0871.00
210_G246_V1.0861.00
23_D26_R1.0851.00
63_I91_V1.0801.00
92_V113_I1.0751.00
119_K123_K1.0711.00
76_A97_P1.0691.00
53_F63_I1.0671.00
179_L208_I1.0651.00
185_Y236_Y1.0581.00
151_I178_I1.0551.00
230_T237_A1.0521.00
197_I221_E1.0481.00
11_V48_I1.0451.00
31_A114_I1.0441.00
118_K287_R1.0441.00
180_I271_I1.0421.00
24_A103_I1.0401.00
191_F261_V1.0351.00
242_G255_F1.0311.00
138_E148_S1.0311.00
280_K285_Y1.0301.00
111_D115_D1.0291.00
202_S206_K1.0241.00
134_S154_G1.0221.00
246_V249_D1.0181.00
37_P254_P1.0110.99
126_Q130_K1.0110.99
7_E46_R1.0080.99
64_L94_I1.0030.99
25_L66_V0.9950.99
122_R291_A0.9900.99
197_I240_T0.9880.99
154_G169_K0.9840.99
42_L114_I0.9780.99
29_F113_I0.9750.99
195_N198_A0.9720.99
185_Y261_V0.9720.99
121_E124_R0.9670.99
81_K93_Y0.9590.99
20_E103_I0.9580.99
99_E103_I0.9570.99
69_D72_K0.9550.99
21_V66_V0.9510.99
141_L165_V0.9500.99
12_M21_V0.9480.99
25_L106_I0.9410.99
152_P292_I0.9350.99
19_G22_G0.9320.99
30_A41_P0.9310.99
24_A28_I0.9300.99
258_Y294_K0.9210.99
46_R60_H0.9200.99
260_F269_I0.9190.99
263_E266_N0.9180.99
197_I219_T0.9180.99
235_K263_E0.9170.99
161_T207_Y0.9170.99
26_R45_L0.9150.99
222_A225_P0.9130.99
173_D280_K0.9120.99
8_I64_L0.9090.99
19_G23_D0.9090.99
10_V47_Q0.8950.99
151_I167_L0.8940.99
222_A245_E0.8940.99
181_Y272_E0.8930.99
195_N202_S0.8900.99
90_L117_F0.8850.99
145_F165_V0.8810.99
8_I29_F0.8800.99
107_K110_K0.8770.99
147_I269_I0.8770.99
11_V63_I0.8720.98
76_A101_E0.8690.98
123_K126_Q0.8670.98
82_K90_L0.8630.98
78_V105_L0.8630.98
215_S249_D0.8620.98
92_V116_L0.8560.98
75_K80_I0.8540.98
244_W251_M0.8530.98
80_I92_V0.8470.98
235_K260_F0.8470.98
163_N182_S0.8460.98
13_D50_P0.8430.98
125_L128_R0.8270.98
191_F236_Y0.8260.98
155_Y292_I0.8260.98
182_S269_I0.8250.98
186_T190_Q0.8250.98
11_V53_F0.8230.98
246_V251_M0.8230.98
177_N217_M0.8220.98
42_L118_K0.8110.98
261_V266_N0.8090.97
62_N117_F0.8080.97
67_D93_Y0.8080.97
109_N113_I0.8060.97
14_D49_P0.8060.97
181_Y270_V0.8010.97
145_F160_D0.8010.97
216_Y247_E0.8010.97
61_R121_E0.7980.97
20_E23_D0.7980.97
56_F59_K0.7970.97
26_R30_A0.7950.97
262_D266_N0.7920.97
209_P214_G0.7860.97
62_N120_A0.7850.97
277_A285_Y0.7840.97
20_E100_E0.7800.97
211_P249_D0.7790.97
21_V103_I0.7790.97
7_E44_D0.7760.97
90_L120_A0.7750.97
124_R128_R0.7740.97
76_A81_K0.7730.97
159_K209_P0.7730.97
286_L289_L0.7720.97
236_Y261_V0.7670.97
77_K95_S0.7660.97
168_R175_S0.7640.96
120_A123_K0.7620.96
141_L145_F0.7590.96
169_K176_Q0.7570.96
247_E250_F0.7550.96
27_E107_K0.7550.96
201_D219_T0.7520.96
149_L180_I0.7510.96
137_L151_I0.7510.96
190_Q268_L0.7510.96
174_G285_Y0.7480.96
2_S59_K0.7470.96
273_G293_L0.7450.96
105_L108_E0.7430.96
178_I292_I0.7430.96
74_T79_K0.7420.96
185_Y188_P0.7420.96
53_F57_F0.7410.96
221_E245_E0.7400.96
118_K122_R0.7400.96
32_P41_P0.7400.96
248_N251_M0.7400.96
135_K138_E0.7400.96
176_Q288_Q0.7400.96
7_E60_H0.7390.96
84_V93_Y0.7390.96
150_K295_T0.7350.96
76_A79_K0.7340.96
16_L21_V0.7330.96
190_Q199_K0.7300.95
166_W274_F0.7270.95
34_P241_R0.7260.95
135_K139_K0.7240.95
25_L29_F0.7170.95
134_S138_E0.7170.95
125_L129_L0.7160.95
149_L271_I0.7140.95
140_K144_K0.7130.95
189_D192_T0.7130.95
79_K93_Y0.7100.95
120_A124_R0.7090.95
212_T249_D0.7070.95
24_A106_I0.7030.94
185_Y190_Q0.7010.94
219_T255_F0.7000.94
41_P61_R0.7000.94
208_I274_F0.6980.94
166_W177_N0.6970.94
73_G79_K0.6960.94
130_K291_A0.6950.94
240_T259_T0.6940.94
43_F118_K0.6940.94
220_E223_Y0.6920.94
31_A34_P0.6920.94
80_I116_L0.6920.94
9_L46_R0.6910.94
145_F180_I0.6910.94
96_A101_E0.6830.94
146_G265_N0.6820.93
12_M47_Q0.6820.93
44_D283_R0.6790.93
83_D88_P0.6790.93
76_A80_I0.6780.93
164_F179_L0.6770.93
20_E25_L0.6770.93
2_S60_H0.6770.93
20_E99_E0.6760.93
141_L149_L0.6750.93
41_P283_R0.6750.93
9_L60_H0.6700.93
70_P73_G0.6690.93
16_L102_L0.6680.93
94_I105_L0.6680.93
246_V250_F0.6670.93
156_K168_R0.6670.93
208_I251_M0.6670.93
141_L167_L0.6640.93
229_E238_V0.6620.92
78_V94_I0.6620.92
215_S246_V0.6580.92
193_K240_T0.6550.92
175_S274_F0.6550.92
141_L147_I0.6520.92
13_D16_L0.6520.92
21_V102_L0.6520.92
183_Y190_Q0.6490.92
200_R257_S0.6480.92
104_E107_K0.6430.91
204_G207_Y0.6420.91
121_E125_L0.6420.91
159_K207_Y0.6400.91
236_Y263_E0.6400.91
201_D206_K0.6390.91
86_A89_Q0.6370.91
136_K139_K0.6370.91
15_E18_E0.6350.91
149_L178_I0.6340.91
185_Y195_N0.6300.90
192_T238_V0.6300.90
256_V273_G0.6290.90
16_L99_E0.6270.90
145_F267_R0.6250.90
145_F269_I0.6220.90
218_I221_E0.6210.90
140_K143_E0.6200.90
128_R132_Y0.6200.90
232_F258_Y0.6190.90
245_E252_G0.6190.90
155_Y289_L0.6180.90
133_E137_L0.6180.90
138_E142_K0.6170.90
185_Y268_L0.6150.89
156_K170_E0.6140.89
209_P216_Y0.6080.89
129_L147_I0.6050.89
213_E216_Y0.6050.89
73_G97_P0.6020.88
6_N284_D0.6020.88
74_T77_K0.6020.88
134_S150_K0.6010.88
8_I46_R0.5990.88
210_G217_M0.5980.88
12_M22_G0.5970.88
126_Q291_A0.5930.88
94_I109_N0.5920.88
110_K114_I0.5910.87
153_S156_K0.5880.87
83_D127_R0.5880.87
215_S251_M0.5860.87
201_D218_I0.5850.87
170_E177_N0.5840.87
208_I217_M0.5820.87
126_Q295_T0.5790.86
141_L144_K0.5780.86
55_G59_K0.5760.86
210_G251_M0.5760.86
105_L109_N0.5760.86
193_K197_I0.5760.86
166_W251_M0.5760.86
64_L113_I0.5750.86
239_E294_K0.5740.86
200_R255_F0.5710.86
33_V37_P0.5680.85
118_K284_D0.5640.85
214_G248_N0.5620.85
137_L167_L0.5610.85
204_G208_I0.5580.84
245_E249_D0.5570.84
129_L291_A0.5550.84
58_K85_W0.5550.84
182_S185_Y0.5540.84
215_S248_N0.5530.84
181_Y203_I0.5510.84
181_Y184_P0.5470.83
28_I32_P0.5460.83
178_I293_L0.5460.83
196_I238_V0.5460.83
10_V17_W0.5460.83
18_E22_G0.5450.83
107_K111_D0.5420.83
157_L160_D0.5390.82
172_P175_S0.5360.82
138_E151_I0.5360.82
166_W209_P0.5360.82
176_Q180_I0.5360.82
249_D276_Y0.5350.82
185_Y266_N0.5330.82
8_I44_D0.5330.82
164_F181_Y0.5330.82
147_I260_F0.5280.81
55_G58_K0.5280.81
75_K79_K0.5270.81
69_D76_A0.5270.81
77_K82_K0.5260.81
198_A221_E0.5250.81
78_V81_K0.5240.80
212_T248_N0.5230.80
21_V24_A0.5180.80
134_S153_S0.5160.79
112_K115_D0.5160.79
70_P76_A0.5160.79
184_P188_P0.5120.79
62_N66_V0.5120.79
176_Q289_L0.5090.79
155_Y280_K0.5090.79
194_E198_A0.5080.78
66_V78_V0.5060.78
138_E150_K0.5050.78
119_K294_K0.5030.78
2_S56_F0.5020.78
230_T239_E0.5020.78
77_K81_K0.5010.77
170_E250_F0.5010.77
287_R291_A0.5000.77
189_D195_N0.5000.77
34_P228_R0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lnjA 1 0.5254 78.7 0.939 Contact Map
1tu1A 2 0.4644 65.4 0.945 Contact Map
2xb3A 1 0.5017 64.4 0.945 Contact Map
3lydA 2 0.4983 53.3 0.949 Contact Map
1v2bA 1 0.4746 37.5 0.953 Contact Map
2p97A 6 0.1966 12.6 0.963 Contact Map
1xnlA 1 0.0949 10.2 0.964 Contact Map
1rmjA 1 0.1322 7.6 0.966 Contact Map
1a7tA 2 0.2271 7.3 0.967 Contact Map
1m2xA 2 0.2068 7.3 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0088 seconds.