DUF4836 - PFAM28P - GREMLIN Contacts

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DUF4836 - Domain of unknown function (DUF4836)

PFAM:	PF16120	Sequences: YTNAIPKDAAFVVSINLKSLAEKAGLNDIKNSELFKKLKEELKSGLDAEDKELLKKILKDPSESGIDLKSPIYLFVSPDGNNIGLVAKVKDADKFEAFLKKLAKEGICKEIKEEDGYSYTVLGDGWLVAWNDKALLVLGPTGGSDTEELKEQAKKLFKQKEEESIASNKDFKKLLKEKGDISFWASSDALPELYKSPMMLGLPKDADLKDNYIAATLNFEKGKIVAKSKTYSSNKELKKLLKKYAKAKGKINGDLLKYIPANNLALLAMNVNGEKLYELLKENPGFNNLLEGANAGIDLDDILKAFKGDIALALSDFSMKGPIPKFLLYAEVKDKDFLKKLYWLKSKLGLKKGSKLIKKGKNEYVLKSGGGPSIYFGVKDKVLYITNDEELAKAILKGSKKSLKDSDFASKIKGKPFYFYLDLDALLKLPLVKMLLDGFGGEEAATAKNLLKLFDYLEIYGDGKYKSEFELNLKDKKENSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	481 (475)
Sequences:	519 (475)
Seq/√Len:	21.8
META:	0.84

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
89_V	95_F	6.978	1.00
179_G	218_N	4.529	1.00
475_D	478_E	3.999	1.00
180_D	219_F	3.849	1.00
91_D	94_K	3.844	1.00
290_L	294_N	3.804	1.00
220_E	223_K	3.795	1.00
421_L	426_L	3.631	1.00
95_F	135_L	3.566	1.00
9_A	12_V	3.512	1.00
75_F	84_G	3.403	1.00
63_E	94_K	3.358	1.00
23_K	180_D	3.163	1.00
16_N	71_P	2.941	0.99
278_E	281_K	2.852	0.99
159_Q	164_S	2.680	0.99
87_A	135_L	2.636	0.99
223_K	470_E	2.571	0.98
67_D	70_S	2.509	0.98
224_I	471_L	2.499	0.98
187_S	211_N	2.392	0.97
300_D	304_K	2.375	0.97
64_S	98_F	2.371	0.97
418_Y	426_L	2.357	0.97
298_D	301_D	2.327	0.97
447_A	451_L	2.302	0.97
179_G	216_T	2.287	0.96
238_K	242_K	2.253	0.96
287_N	290_L	2.251	0.96
6_P	12_V	2.239	0.96
377_G	384_Y	2.239	0.96
287_N	294_N	2.239	0.96
222_G	309_D	2.231	0.96
131_N	134_A	2.227	0.96
183_F	215_A	2.221	0.96
96_E	100_K	2.219	0.96
170_D	214_A	2.209	0.96
472_N	476_K	2.186	0.95
71_P	179_G	2.177	0.95
222_G	475_D	2.126	0.95
179_G	182_S	2.105	0.94
422_D	425_A	2.099	0.94
165_I	168_N	2.076	0.94
137_V	383_L	2.060	0.94
355_K	364_Y	2.035	0.93
263_N	422_D	2.029	0.93
275_K	278_E	2.010	0.93
451_L	455_D	2.008	0.93
9_A	16_N	1.990	0.92
217_L	226_A	1.974	0.92
156_L	159_Q	1.945	0.92
23_K	219_F	1.938	0.91
457_L	471_L	1.936	0.91
111_I	130_W	1.935	0.91
6_P	9_A	1.927	0.91
5_I	12_V	1.919	0.91
227_K	468_E	1.911	0.91
446_T	450_L	1.892	0.90
174_L	179_G	1.874	0.90
96_E	118_S	1.868	0.90
221_K	477_K	1.865	0.90
159_Q	163_E	1.858	0.89
29_I	32_S	1.796	0.88
277_Y	387_N	1.791	0.88
274_E	333_K	1.776	0.87
420_Y	426_L	1.727	0.86
130_W	134_A	1.714	0.85
210_D	234_N	1.714	0.85
65_G	308_G	1.713	0.85
169_K	177_E	1.706	0.85
272_N	275_K	1.690	0.84
450_L	454_F	1.686	0.84
456_Y	472_N	1.677	0.84
129_A	153_A	1.676	0.84
447_A	450_L	1.667	0.84
454_F	461_G	1.650	0.83
16_N	178_K	1.641	0.83
43_K	348_L	1.620	0.82
174_L	214_A	1.618	0.82
89_V	132_D	1.597	0.81
273_G	307_K	1.596	0.81
95_F	98_F	1.592	0.81
12_V	171_F	1.592	0.81
108_C	120_T	1.577	0.80
239_K	242_K	1.545	0.78
475_D	479_N	1.540	0.78
235_K	239_K	1.537	0.78
276_L	299_L	1.531	0.78
457_L	461_G	1.531	0.78
67_D	88_K	1.510	0.77
65_G	73_Y	1.502	0.76
364_Y	384_Y	1.496	0.76
220_E	225_V	1.496	0.76
6_P	23_K	1.474	0.75
66_I	91_D	1.466	0.75
171_F	222_G	1.460	0.74
58_L	192_E	1.447	0.74
28_D	31_N	1.438	0.73
302_I	305_A	1.435	0.73
20_L	23_K	1.431	0.73
219_F	479_N	1.427	0.73
290_L	293_A	1.406	0.71
238_K	241_L	1.406	0.71
291_E	294_N	1.405	0.71
58_L	83_I	1.404	0.71
20_L	219_F	1.403	0.71
210_D	341_L	1.401	0.71
326_F	348_L	1.392	0.71
227_K	388_D	1.388	0.70
240_L	422_D	1.387	0.70
239_K	243_K	1.386	0.70
11_F	76_V	1.385	0.70
250_K	255_L	1.377	0.70
136_L	153_A	1.368	0.69
61_P	65_G	1.354	0.69
333_K	340_K	1.346	0.68
120_T	242_K	1.338	0.68
221_K	473_L	1.331	0.67
89_V	135_L	1.331	0.67
229_K	466_K	1.307	0.66
420_Y	427_L	1.302	0.65
158_K	421_L	1.299	0.65
165_I	262_N	1.299	0.65
127_L	162_E	1.298	0.65
73_Y	90_K	1.298	0.65
285_G	294_N	1.294	0.65
389_E	393_K	1.282	0.64
161_E	422_D	1.280	0.64
118_S	130_W	1.275	0.64
299_L	356_L	1.273	0.64
174_L	216_T	1.266	0.63
21_A	24_A	1.265	0.63
235_K	421_L	1.262	0.63
255_L	301_D	1.259	0.63
337_F	340_K	1.259	0.63
239_K	261_A	1.256	0.63
357_I	360_G	1.256	0.63
447_A	457_L	1.256	0.63
282_E	287_N	1.255	0.62
270_N	307_K	1.238	0.61
129_A	157_F	1.232	0.61
96_E	171_F	1.231	0.61
130_W	248_K	1.228	0.61
137_V	390_E	1.228	0.61
110_E	120_T	1.227	0.61
71_P	115_D	1.225	0.61
219_F	481_L	1.224	0.60
84_G	129_A	1.217	0.60
180_D	222_G	1.214	0.60
355_K	361_K	1.206	0.59
309_D	313_A	1.200	0.59
180_D	218_N	1.193	0.58
32_S	35_F	1.192	0.58
130_W	313_A	1.189	0.58
66_I	195_K	1.186	0.58
60_D	63_E	1.184	0.58
414_G	477_K	1.184	0.58
452_K	458_E	1.173	0.57
113_E	215_A	1.171	0.57
287_N	292_G	1.164	0.57
335_K	340_K	1.161	0.56
286_F	312_L	1.159	0.56
120_T	128_V	1.158	0.56
234_N	280_L	1.157	0.56
286_F	294_N	1.156	0.56
66_I	386_T	1.155	0.56
131_N	157_F	1.152	0.56
98_F	256_L	1.151	0.56
184_W	246_K	1.151	0.56
114_E	119_Y	1.149	0.56
235_K	243_K	1.147	0.55
16_N	389_E	1.140	0.55
325_K	388_D	1.139	0.55
9_A	171_F	1.135	0.55
132_D	235_K	1.131	0.54
168_N	259_I	1.129	0.54
130_W	480_S	1.129	0.54
302_I	310_I	1.125	0.54
96_E	425_A	1.114	0.53
398_G	421_L	1.107	0.53
130_W	252_N	1.102	0.52
66_I	149_L	1.100	0.52
229_K	386_T	1.099	0.52
160_K	196_S	1.099	0.52
220_E	226_A	1.096	0.52
97_A	176_K	1.095	0.52
232_S	235_K	1.095	0.52
31_N	35_F	1.093	0.52
180_D	479_N	1.090	0.52
29_I	35_F	1.089	0.51
365_V	386_T	1.085	0.51
6_P	219_F	1.084	0.51
6_P	260_P	1.083	0.51
455_D	459_I	1.082	0.51
89_V	255_L	1.078	0.51
283_N	290_L	1.069	0.50
131_N	181_I	1.069	0.50
289_L	293_A	1.068	0.50
233_S	268_A	1.063	0.50
16_N	20_L	1.058	0.49
37_K	40_E	1.057	0.49
125_G	311_A	1.049	0.49
77_S	422_D	1.049	0.49
297_I	302_I	1.045	0.49
27_N	31_N	1.041	0.48
181_I	217_L	1.040	0.48
218_N	280_L	1.036	0.48
86_V	136_L	1.036	0.48
306_F	334_D	1.029	0.47
453_L	456_Y	1.029	0.47
452_K	464_K	1.029	0.47
125_G	137_V	1.027	0.47
158_K	265_A	1.026	0.47
49_E	121_V	1.026	0.47
254_D	331_E	1.025	0.47
267_L	419_F	1.024	0.47
34_L	37_K	1.022	0.47
131_N	314_L	1.018	0.47
168_N	231_Y	1.018	0.47
273_G	330_A	1.012	0.46
66_I	267_L	1.011	0.46
188_D	379_K	1.011	0.46
420_Y	425_A	1.008	0.46
313_A	432_V	1.004	0.46
101_K	146_T	1.003	0.46
451_L	473_L	1.003	0.46
38_L	267_L	1.002	0.46
167_S	423_L	0.997	0.45
76_V	90_K	0.993	0.45
260_P	426_L	0.993	0.45
86_V	306_F	0.993	0.45
93_D	96_E	0.992	0.45
92_A	96_E	0.990	0.45
130_W	246_K	0.990	0.45
35_F	41_E	0.987	0.45
7_K	10_A	0.984	0.44
230_T	312_L	0.984	0.44
182_S	386_T	0.982	0.44
444_A	447_A	0.977	0.44
243_K	260_P	0.976	0.44
76_V	312_L	0.976	0.44
376_F	475_D	0.974	0.44
330_A	334_D	0.970	0.43
91_D	407_D	0.968	0.43
255_L	305_A	0.964	0.43
131_N	394_A	0.963	0.43
66_I	218_N	0.962	0.43
320_K	402_S	0.960	0.43
433_K	436_L	0.957	0.43
89_V	104_K	0.957	0.43
313_A	406_S	0.956	0.43
345_K	381_K	0.955	0.42
343_W	346_S	0.954	0.42
261_A	379_K	0.952	0.42
341_L	353_G	0.951	0.42
443_E	449_N	0.949	0.42
332_V	340_K	0.949	0.42
249_G	270_N	0.947	0.42
330_A	378_V	0.945	0.42
358_K	419_F	0.943	0.42
12_V	73_Y	0.943	0.42
86_V	179_G	0.941	0.42
169_K	380_D	0.940	0.42
111_I	118_S	0.938	0.41
443_E	447_A	0.935	0.41
380_D	473_L	0.935	0.41
177_E	276_L	0.935	0.41
163_E	412_I	0.934	0.41
190_L	331_E	0.931	0.41
57_I	334_D	0.928	0.41
17_L	20_L	0.927	0.41
137_V	288_N	0.924	0.40
284_P	287_N	0.923	0.40
113_E	307_K	0.923	0.40
115_D	118_S	0.922	0.40
167_S	171_F	0.916	0.40
61_P	116_G	0.916	0.40
385_I	425_A	0.913	0.40
99_L	224_I	0.913	0.40
421_L	427_L	0.912	0.40
162_E	190_L	0.910	0.40
266_L	310_I	0.909	0.39
85_L	276_L	0.909	0.39
270_N	273_G	0.909	0.39
26_L	186_S	0.906	0.39
187_S	191_P	0.906	0.39
244_Y	271_V	0.906	0.39
7_K	31_N	0.904	0.39
105_E	130_W	0.899	0.39
22_E	67_D	0.899	0.39
103_A	127_L	0.899	0.39
130_W	184_W	0.898	0.39
5_I	18_K	0.897	0.39
450_L	453_L	0.895	0.39
62_S	217_L	0.894	0.39
136_L	323_I	0.894	0.39
122_L	256_L	0.893	0.38
306_F	395_I	0.893	0.38
42_L	303_L	0.892	0.38
334_D	346_S	0.889	0.38
182_S	216_T	0.885	0.38
234_N	237_L	0.883	0.38
335_K	362_N	0.882	0.38
132_D	137_V	0.878	0.37
314_L	432_V	0.878	0.37
20_L	99_L	0.875	0.37
18_K	169_K	0.874	0.37
178_K	241_L	0.870	0.37
158_K	279_L	0.869	0.37
240_L	356_L	0.868	0.37
36_K	41_E	0.868	0.37
33_E	67_D	0.868	0.37
181_I	387_N	0.867	0.37
11_F	21_A	0.866	0.37
155_K	399_S	0.866	0.37
36_K	386_T	0.866	0.37
10_A	67_D	0.864	0.37
4_A	134_A	0.864	0.37
18_K	69_K	0.862	0.36
455_D	458_E	0.861	0.36
5_I	9_A	0.859	0.36
135_L	169_K	0.859	0.36
307_K	333_K	0.855	0.36
4_A	149_L	0.852	0.36
90_K	267_L	0.852	0.36
93_D	206_A	0.851	0.36
66_I	409_A	0.849	0.36
275_K	280_L	0.848	0.36
219_F	260_P	0.847	0.36
171_F	243_K	0.846	0.35
210_D	304_K	0.846	0.35
386_T	391_L	0.840	0.35
287_N	296_G	0.839	0.35
171_F	219_F	0.835	0.35
119_Y	366_L	0.834	0.35
448_K	466_K	0.833	0.35
191_P	280_L	0.833	0.35
104_K	422_D	0.833	0.35
188_D	252_N	0.832	0.35
14_S	182_S	0.831	0.35
252_N	274_E	0.831	0.35
438_G	445_A	0.831	0.35
258_Y	382_V	0.831	0.35
285_G	288_N	0.831	0.35
151_E	227_K	0.830	0.35
176_K	341_L	0.830	0.35
329_Y	473_L	0.830	0.35
115_D	154_K	0.826	0.34
443_E	453_L	0.824	0.34
311_A	384_Y	0.824	0.34
455_D	461_G	0.823	0.34
269_M	348_L	0.820	0.34
454_F	468_E	0.814	0.34
443_E	471_L	0.812	0.33
249_G	272_N	0.809	0.33
307_K	331_E	0.808	0.33
458_E	461_G	0.808	0.33
240_L	252_N	0.807	0.33
180_D	209_K	0.806	0.33
5_I	73_Y	0.805	0.33
188_D	387_N	0.805	0.33
12_V	141_T	0.805	0.33
100_K	103_A	0.804	0.33
157_F	270_N	0.800	0.33
15_I	426_L	0.799	0.33
5_I	159_Q	0.799	0.33
16_N	90_K	0.797	0.33
128_V	137_V	0.797	0.33
444_A	448_K	0.795	0.32
58_L	165_I	0.792	0.32
411_K	418_Y	0.790	0.32
217_L	224_I	0.790	0.32
211_N	263_N	0.789	0.32
259_I	368_S	0.786	0.32
220_E	423_L	0.785	0.32
15_I	20_L	0.785	0.32
456_Y	461_G	0.783	0.32
277_Y	281_K	0.782	0.32
99_L	137_V	0.780	0.32
461_G	465_Y	0.780	0.32
240_L	280_L	0.778	0.31
12_V	16_N	0.777	0.31
361_K	364_Y	0.777	0.31
416_P	426_L	0.776	0.31
183_F	447_A	0.776	0.31
100_K	133_K	0.775	0.31
52_E	55_K	0.774	0.31
307_K	427_L	0.772	0.31
4_A	19_S	0.771	0.31
35_F	42_L	0.771	0.31
386_T	421_L	0.770	0.31
57_I	471_L	0.768	0.31
41_E	45_G	0.767	0.31
324_P	329_Y	0.763	0.31
242_K	245_A	0.758	0.30
87_A	414_G	0.758	0.30
447_A	469_F	0.757	0.30
174_L	182_S	0.756	0.30
84_G	136_L	0.755	0.30
267_L	379_K	0.751	0.30
138_L	237_L	0.751	0.30
93_D	212_Y	0.749	0.30
138_L	387_N	0.746	0.30
277_Y	300_D	0.746	0.30
161_E	415_K	0.745	0.30
264_L	378_V	0.745	0.30
73_Y	172_K	0.745	0.30
96_E	138_L	0.744	0.29
243_K	272_N	0.743	0.29
93_D	158_K	0.742	0.29
423_L	427_L	0.742	0.29
157_F	302_I	0.741	0.29
239_K	263_N	0.739	0.29
167_S	256_L	0.739	0.29
15_I	22_E	0.739	0.29
52_E	56_K	0.736	0.29
148_E	182_S	0.734	0.29
165_I	229_K	0.734	0.29
272_N	388_D	0.733	0.29
20_L	220_E	0.732	0.29
463_G	471_L	0.731	0.29
42_L	99_L	0.729	0.29
112_K	419_F	0.728	0.29
68_L	380_D	0.728	0.29
438_G	468_E	0.727	0.29
259_I	421_L	0.724	0.28
259_I	311_A	0.721	0.28
167_S	275_K	0.719	0.28
388_D	396_L	0.718	0.28
130_W	395_I	0.716	0.28
57_I	64_S	0.716	0.28
148_E	196_S	0.716	0.28
66_I	294_N	0.715	0.28
173_K	176_K	0.714	0.28
462_D	465_Y	0.713	0.28
231_Y	383_L	0.713	0.28
148_E	151_E	0.713	0.28
229_K	333_K	0.713	0.28
7_K	99_L	0.712	0.28
424_D	474_K	0.709	0.28
53_L	281_K	0.708	0.27
300_D	386_T	0.708	0.27
286_F	300_D	0.707	0.27
66_I	89_V	0.707	0.27
335_K	339_K	0.706	0.27
253_G	270_N	0.706	0.27
260_P	380_D	0.705	0.27
94_K	290_L	0.705	0.27
458_E	472_N	0.705	0.27
13_V	190_L	0.705	0.27
254_D	257_K	0.704	0.27
29_I	34_L	0.703	0.27
350_L	353_G	0.702	0.27
35_F	309_D	0.701	0.27
264_L	327_L	0.701	0.27
463_G	480_S	0.700	0.27
171_F	317_F	0.699	0.27
250_K	270_N	0.698	0.27
28_D	33_E	0.697	0.27
40_E	43_K	0.696	0.27
127_L	404_K	0.695	0.27
40_E	376_F	0.694	0.27
232_S	238_K	0.693	0.27
71_P	95_F	0.692	0.27
281_K	284_P	0.690	0.27
235_K	245_A	0.689	0.26
12_V	18_K	0.687	0.26
444_A	456_Y	0.687	0.26
18_K	59_K	0.685	0.26
74_L	276_L	0.685	0.26
456_Y	459_I	0.685	0.26
280_L	378_V	0.684	0.26
116_G	221_K	0.684	0.26
198_M	203_P	0.682	0.26
68_L	186_S	0.682	0.26
243_K	282_E	0.682	0.26
158_K	452_K	0.682	0.26
289_L	341_L	0.681	0.26
451_L	457_L	0.679	0.26
297_I	305_A	0.677	0.26
81_N	454_F	0.675	0.26
85_L	105_E	0.674	0.26
21_A	177_E	0.674	0.26
158_K	284_P	0.670	0.25
286_F	293_A	0.670	0.25
11_F	135_L	0.669	0.25
447_A	459_I	0.669	0.25
91_D	314_L	0.668	0.25
235_K	238_K	0.668	0.25
436_L	440_G	0.667	0.25
160_K	335_K	0.667	0.25
36_K	162_E	0.666	0.25
171_F	256_L	0.666	0.25
162_E	272_N	0.665	0.25
91_D	176_K	0.664	0.25
377_G	392_A	0.663	0.25
18_K	22_E	0.662	0.25
93_D	426_L	0.661	0.25
86_V	117_Y	0.660	0.25
149_L	441_G	0.660	0.25
253_G	384_Y	0.659	0.25
270_N	302_I	0.659	0.25
129_A	214_A	0.659	0.25
5_I	23_K	0.658	0.25
447_A	453_L	0.658	0.25
89_V	125_G	0.657	0.25
89_V	224_I	0.656	0.25
288_N	291_E	0.654	0.25
58_L	131_N	0.652	0.25
313_A	316_D	0.651	0.25
96_E	162_E	0.650	0.24
287_N	291_E	0.647	0.24
16_N	225_V	0.646	0.24
34_L	41_E	0.646	0.24
283_N	287_N	0.645	0.24
280_L	433_K	0.645	0.24
267_L	299_L	0.644	0.24
397_K	404_K	0.643	0.24
59_K	118_S	0.642	0.24
66_I	135_L	0.642	0.24
416_P	420_Y	0.642	0.24
91_D	221_K	0.640	0.24
160_K	422_D	0.640	0.24
390_E	398_G	0.639	0.24
155_K	159_Q	0.637	0.24
72_I	95_F	0.637	0.24
87_A	168_N	0.637	0.24
130_W	180_D	0.636	0.24
18_K	162_E	0.636	0.24
57_I	137_V	0.636	0.24
393_K	423_L	0.633	0.24
93_D	412_I	0.633	0.24
85_L	267_L	0.631	0.24
436_L	457_L	0.631	0.24
282_E	285_G	0.630	0.23
138_L	380_D	0.630	0.23
92_A	252_N	0.629	0.23
414_G	426_L	0.629	0.23
410_S	413_K	0.629	0.23
11_F	250_K	0.628	0.23
280_L	449_N	0.628	0.23
221_K	469_F	0.628	0.23
55_K	59_K	0.628	0.23
179_G	213_I	0.627	0.23
275_K	471_L	0.626	0.23
324_P	330_A	0.625	0.23
97_A	215_A	0.624	0.23
267_L	387_N	0.624	0.23
375_Y	380_D	0.621	0.23
66_I	445_A	0.621	0.23
191_P	480_S	0.620	0.23
22_E	84_G	0.618	0.23
74_L	196_S	0.618	0.23
72_I	132_D	0.617	0.23
135_L	377_G	0.616	0.23
460_Y	463_G	0.616	0.23
6_P	75_F	0.615	0.23
26_L	29_I	0.615	0.23
158_K	181_I	0.615	0.23
35_F	39_K	0.613	0.23
379_K	402_S	0.612	0.23
121_V	242_K	0.612	0.23
123_G	375_Y	0.612	0.23
310_I	374_I	0.612	0.23
101_K	149_L	0.611	0.23
27_N	473_L	0.610	0.23
162_E	214_A	0.608	0.22
24_A	128_V	0.607	0.22
132_D	236_E	0.606	0.22
128_V	403_L	0.606	0.22
75_F	210_D	0.605	0.22
277_Y	331_E	0.603	0.22
273_G	377_G	0.603	0.22
83_I	139_G	0.603	0.22
155_K	195_K	0.600	0.22
298_D	306_F	0.600	0.22
165_I	185_A	0.599	0.22
26_L	35_F	0.598	0.22
89_V	99_L	0.598	0.22
85_L	462_D	0.596	0.22
327_L	334_D	0.596	0.22
281_K	300_D	0.595	0.22
341_L	364_Y	0.593	0.22
163_E	173_K	0.592	0.22
258_Y	422_D	0.592	0.22
171_F	225_V	0.591	0.22
16_N	94_K	0.590	0.22
131_N	330_A	0.590	0.22
91_D	411_K	0.590	0.22
153_A	172_K	0.589	0.22
5_I	8_D	0.589	0.22
21_A	25_G	0.589	0.22
454_F	471_L	0.589	0.22
218_N	246_K	0.588	0.21
276_L	303_L	0.588	0.21
158_K	359_K	0.586	0.21
40_E	68_L	0.586	0.21
221_K	274_E	0.585	0.21
73_Y	175_L	0.584	0.21
460_Y	472_N	0.583	0.21
123_G	269_M	0.583	0.21
99_L	380_D	0.582	0.21
309_D	425_A	0.582	0.21
41_E	85_L	0.582	0.21
394_A	398_G	0.581	0.21
199_M	204_K	0.580	0.21
169_K	251_I	0.579	0.21
17_L	25_G	0.579	0.21
74_L	386_T	0.579	0.21
10_A	379_K	0.578	0.21
209_K	227_K	0.578	0.21
48_A	51_K	0.578	0.21
94_K	373_S	0.577	0.21
100_K	218_N	0.576	0.21
89_V	184_W	0.576	0.21
22_E	27_N	0.575	0.21
110_E	443_E	0.575	0.21
263_N	266_L	0.573	0.21
90_K	94_K	0.573	0.21
74_L	313_A	0.573	0.21
370_G	383_L	0.571	0.21
451_L	468_E	0.571	0.21
42_L	47_D	0.571	0.21
120_T	299_L	0.570	0.21
142_G	145_D	0.570	0.21
243_K	246_K	0.569	0.21
54_L	57_I	0.565	0.20
6_P	20_L	0.565	0.20
16_N	32_S	0.564	0.20
234_N	362_N	0.563	0.20
99_L	133_K	0.562	0.20
253_G	413_K	0.561	0.20
473_L	479_N	0.561	0.20
148_E	380_D	0.560	0.20
6_P	16_N	0.559	0.20
219_F	223_K	0.559	0.20
100_K	194_Y	0.558	0.20
85_L	137_V	0.556	0.20
3_N	53_L	0.556	0.20
307_K	361_K	0.556	0.20
99_L	103_A	0.555	0.20
297_I	300_D	0.555	0.20
66_I	98_F	0.554	0.20
303_L	477_K	0.554	0.20
170_D	231_Y	0.553	0.20
162_E	185_A	0.553	0.20
55_K	386_T	0.550	0.20
15_I	375_Y	0.550	0.20
68_L	167_S	0.548	0.20
173_K	255_L	0.548	0.20
88_K	270_N	0.547	0.20
16_N	239_K	0.546	0.20
470_E	474_K	0.545	0.20
477_K	481_L	0.544	0.20
61_P	408_F	0.544	0.20
445_A	449_N	0.543	0.20
460_Y	466_K	0.543	0.20
70_S	137_V	0.543	0.20
450_L	455_D	0.543	0.20
232_S	332_V	0.542	0.19
115_D	333_K	0.542	0.19
408_F	432_V	0.541	0.19
12_V	23_K	0.540	0.19
98_F	117_Y	0.539	0.19
256_L	313_A	0.539	0.19
463_G	475_D	0.539	0.19
222_G	479_N	0.536	0.19
449_N	455_D	0.534	0.19
340_K	347_K	0.534	0.19
20_L	156_L	0.531	0.19
362_N	394_A	0.531	0.19
183_F	380_D	0.529	0.19
26_L	32_S	0.528	0.19
155_K	469_F	0.528	0.19
146_T	463_G	0.527	0.19
379_K	382_V	0.526	0.19
16_N	92_A	0.525	0.19
173_K	186_S	0.522	0.19
184_W	392_A	0.521	0.19
57_I	71_P	0.521	0.19
422_D	443_E	0.519	0.19
17_L	475_D	0.518	0.18
227_K	409_A	0.518	0.18
302_I	408_F	0.518	0.18
166_A	423_L	0.518	0.18
20_L	201_G	0.517	0.18
477_K	480_S	0.517	0.18
449_N	452_K	0.515	0.18
291_E	341_L	0.513	0.18
386_T	467_S	0.512	0.18
219_F	222_G	0.512	0.18
92_A	324_P	0.512	0.18
16_N	375_Y	0.509	0.18
211_N	214_A	0.509	0.18
449_N	474_K	0.508	0.18
180_D	481_L	0.508	0.18
52_E	61_P	0.508	0.18
273_G	298_D	0.507	0.18
284_P	290_L	0.506	0.18
70_S	146_T	0.505	0.18
270_N	427_L	0.505	0.18
180_D	184_W	0.504	0.18
145_D	150_K	0.504	0.18
272_N	392_A	0.504	0.18
157_F	166_A	0.503	0.18
97_A	101_K	0.502	0.18
277_Y	386_T	0.501	0.18
364_Y	368_S	0.501	0.18
260_P	423_L	0.501	0.18
131_N	418_Y	0.500	0.18
334_D	358_K	0.500	0.18
99_L	390_E	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3x1lC	3	0.1393	6.8	0.973	Contact Map
4dvcA	1	0.1913	2.8	0.978	Contact Map
3ewtE	1	0.0291	2.7	0.978	Contact Map
3l9kW	1	0.079	2.2	0.979	Contact Map
2grgA	1	0.183	2.2	0.979	Contact Map
2dkhA	2	0.2079	2.2	0.979	Contact Map
2zbkB	1	0.1019	2.1	0.979	Contact Map
1qhlA	1	0.1227	1.8	0.98	Contact Map
4od7A	1	0.1892	1.8	0.98	Contact Map
3kzqA	3	0.1975	1.7	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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