GREMLIN Database
DUF4836 - Domain of unknown function (DUF4836)
PFAM: PF16120 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 481 (475)
Sequences: 519 (475)
Seq/√Len: 21.8
META: 0.84

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_V95_F6.9781.00
179_G218_N4.5291.00
475_D478_E3.9991.00
180_D219_F3.8491.00
91_D94_K3.8441.00
290_L294_N3.8041.00
220_E223_K3.7951.00
421_L426_L3.6311.00
95_F135_L3.5661.00
9_A12_V3.5121.00
75_F84_G3.4031.00
63_E94_K3.3581.00
23_K180_D3.1631.00
16_N71_P2.9410.99
278_E281_K2.8520.99
159_Q164_S2.6800.99
87_A135_L2.6360.99
223_K470_E2.5710.98
67_D70_S2.5090.98
224_I471_L2.4990.98
187_S211_N2.3920.97
300_D304_K2.3750.97
64_S98_F2.3710.97
418_Y426_L2.3570.97
298_D301_D2.3270.97
447_A451_L2.3020.97
179_G216_T2.2870.96
238_K242_K2.2530.96
287_N290_L2.2510.96
6_P12_V2.2390.96
377_G384_Y2.2390.96
287_N294_N2.2390.96
222_G309_D2.2310.96
131_N134_A2.2270.96
183_F215_A2.2210.96
96_E100_K2.2190.96
170_D214_A2.2090.96
472_N476_K2.1860.95
71_P179_G2.1770.95
222_G475_D2.1260.95
179_G182_S2.1050.94
422_D425_A2.0990.94
165_I168_N2.0760.94
137_V383_L2.0600.94
355_K364_Y2.0350.93
263_N422_D2.0290.93
275_K278_E2.0100.93
451_L455_D2.0080.93
9_A16_N1.9900.92
217_L226_A1.9740.92
156_L159_Q1.9450.92
23_K219_F1.9380.91
457_L471_L1.9360.91
111_I130_W1.9350.91
6_P9_A1.9270.91
5_I12_V1.9190.91
227_K468_E1.9110.91
446_T450_L1.8920.90
174_L179_G1.8740.90
96_E118_S1.8680.90
221_K477_K1.8650.90
159_Q163_E1.8580.89
29_I32_S1.7960.88
277_Y387_N1.7910.88
274_E333_K1.7760.87
420_Y426_L1.7270.86
130_W134_A1.7140.85
210_D234_N1.7140.85
65_G308_G1.7130.85
169_K177_E1.7060.85
272_N275_K1.6900.84
450_L454_F1.6860.84
456_Y472_N1.6770.84
129_A153_A1.6760.84
447_A450_L1.6670.84
454_F461_G1.6500.83
16_N178_K1.6410.83
43_K348_L1.6200.82
174_L214_A1.6180.82
89_V132_D1.5970.81
273_G307_K1.5960.81
95_F98_F1.5920.81
12_V171_F1.5920.81
108_C120_T1.5770.80
239_K242_K1.5450.78
475_D479_N1.5400.78
235_K239_K1.5370.78
276_L299_L1.5310.78
457_L461_G1.5310.78
67_D88_K1.5100.77
65_G73_Y1.5020.76
364_Y384_Y1.4960.76
220_E225_V1.4960.76
6_P23_K1.4740.75
66_I91_D1.4660.75
171_F222_G1.4600.74
58_L192_E1.4470.74
28_D31_N1.4380.73
302_I305_A1.4350.73
20_L23_K1.4310.73
219_F479_N1.4270.73
290_L293_A1.4060.71
238_K241_L1.4060.71
291_E294_N1.4050.71
58_L83_I1.4040.71
20_L219_F1.4030.71
210_D341_L1.4010.71
326_F348_L1.3920.71
227_K388_D1.3880.70
240_L422_D1.3870.70
239_K243_K1.3860.70
11_F76_V1.3850.70
250_K255_L1.3770.70
136_L153_A1.3680.69
61_P65_G1.3540.69
333_K340_K1.3460.68
120_T242_K1.3380.68
221_K473_L1.3310.67
89_V135_L1.3310.67
229_K466_K1.3070.66
420_Y427_L1.3020.65
158_K421_L1.2990.65
165_I262_N1.2990.65
127_L162_E1.2980.65
73_Y90_K1.2980.65
285_G294_N1.2940.65
389_E393_K1.2820.64
161_E422_D1.2800.64
118_S130_W1.2750.64
299_L356_L1.2730.64
174_L216_T1.2660.63
21_A24_A1.2650.63
235_K421_L1.2620.63
255_L301_D1.2590.63
337_F340_K1.2590.63
239_K261_A1.2560.63
357_I360_G1.2560.63
447_A457_L1.2560.63
282_E287_N1.2550.62
270_N307_K1.2380.61
129_A157_F1.2320.61
96_E171_F1.2310.61
130_W248_K1.2280.61
137_V390_E1.2280.61
110_E120_T1.2270.61
71_P115_D1.2250.61
219_F481_L1.2240.60
84_G129_A1.2170.60
180_D222_G1.2140.60
355_K361_K1.2060.59
309_D313_A1.2000.59
180_D218_N1.1930.58
32_S35_F1.1920.58
130_W313_A1.1890.58
66_I195_K1.1860.58
60_D63_E1.1840.58
414_G477_K1.1840.58
452_K458_E1.1730.57
113_E215_A1.1710.57
287_N292_G1.1640.57
335_K340_K1.1610.56
286_F312_L1.1590.56
120_T128_V1.1580.56
234_N280_L1.1570.56
286_F294_N1.1560.56
66_I386_T1.1550.56
131_N157_F1.1520.56
98_F256_L1.1510.56
184_W246_K1.1510.56
114_E119_Y1.1490.56
235_K243_K1.1470.55
16_N389_E1.1400.55
325_K388_D1.1390.55
9_A171_F1.1350.55
132_D235_K1.1310.54
168_N259_I1.1290.54
130_W480_S1.1290.54
302_I310_I1.1250.54
96_E425_A1.1140.53
398_G421_L1.1070.53
130_W252_N1.1020.52
66_I149_L1.1000.52
229_K386_T1.0990.52
160_K196_S1.0990.52
220_E226_A1.0960.52
97_A176_K1.0950.52
232_S235_K1.0950.52
31_N35_F1.0930.52
180_D479_N1.0900.52
29_I35_F1.0890.51
365_V386_T1.0850.51
6_P219_F1.0840.51
6_P260_P1.0830.51
455_D459_I1.0820.51
89_V255_L1.0780.51
283_N290_L1.0690.50
131_N181_I1.0690.50
289_L293_A1.0680.50
233_S268_A1.0630.50
16_N20_L1.0580.49
37_K40_E1.0570.49
125_G311_A1.0490.49
77_S422_D1.0490.49
297_I302_I1.0450.49
27_N31_N1.0410.48
181_I217_L1.0400.48
218_N280_L1.0360.48
86_V136_L1.0360.48
306_F334_D1.0290.47
453_L456_Y1.0290.47
452_K464_K1.0290.47
125_G137_V1.0270.47
158_K265_A1.0260.47
49_E121_V1.0260.47
254_D331_E1.0250.47
267_L419_F1.0240.47
34_L37_K1.0220.47
131_N314_L1.0180.47
168_N231_Y1.0180.47
273_G330_A1.0120.46
66_I267_L1.0110.46
188_D379_K1.0110.46
420_Y425_A1.0080.46
313_A432_V1.0040.46
101_K146_T1.0030.46
451_L473_L1.0030.46
38_L267_L1.0020.46
167_S423_L0.9970.45
76_V90_K0.9930.45
260_P426_L0.9930.45
86_V306_F0.9930.45
93_D96_E0.9920.45
92_A96_E0.9900.45
130_W246_K0.9900.45
35_F41_E0.9870.45
7_K10_A0.9840.44
230_T312_L0.9840.44
182_S386_T0.9820.44
444_A447_A0.9770.44
243_K260_P0.9760.44
76_V312_L0.9760.44
376_F475_D0.9740.44
330_A334_D0.9700.43
91_D407_D0.9680.43
255_L305_A0.9640.43
131_N394_A0.9630.43
66_I218_N0.9620.43
320_K402_S0.9600.43
433_K436_L0.9570.43
89_V104_K0.9570.43
313_A406_S0.9560.43
345_K381_K0.9550.42
343_W346_S0.9540.42
261_A379_K0.9520.42
341_L353_G0.9510.42
443_E449_N0.9490.42
332_V340_K0.9490.42
249_G270_N0.9470.42
330_A378_V0.9450.42
358_K419_F0.9430.42
12_V73_Y0.9430.42
86_V179_G0.9410.42
169_K380_D0.9400.42
111_I118_S0.9380.41
443_E447_A0.9350.41
380_D473_L0.9350.41
177_E276_L0.9350.41
163_E412_I0.9340.41
190_L331_E0.9310.41
57_I334_D0.9280.41
17_L20_L0.9270.41
137_V288_N0.9240.40
284_P287_N0.9230.40
113_E307_K0.9230.40
115_D118_S0.9220.40
167_S171_F0.9160.40
61_P116_G0.9160.40
385_I425_A0.9130.40
99_L224_I0.9130.40
421_L427_L0.9120.40
162_E190_L0.9100.40
266_L310_I0.9090.39
85_L276_L0.9090.39
270_N273_G0.9090.39
26_L186_S0.9060.39
187_S191_P0.9060.39
244_Y271_V0.9060.39
7_K31_N0.9040.39
105_E130_W0.8990.39
22_E67_D0.8990.39
103_A127_L0.8990.39
130_W184_W0.8980.39
5_I18_K0.8970.39
450_L453_L0.8950.39
62_S217_L0.8940.39
136_L323_I0.8940.39
122_L256_L0.8930.38
306_F395_I0.8930.38
42_L303_L0.8920.38
334_D346_S0.8890.38
182_S216_T0.8850.38
234_N237_L0.8830.38
335_K362_N0.8820.38
132_D137_V0.8780.37
314_L432_V0.8780.37
20_L99_L0.8750.37
18_K169_K0.8740.37
178_K241_L0.8700.37
158_K279_L0.8690.37
240_L356_L0.8680.37
36_K41_E0.8680.37
33_E67_D0.8680.37
181_I387_N0.8670.37
11_F21_A0.8660.37
155_K399_S0.8660.37
36_K386_T0.8660.37
10_A67_D0.8640.37
4_A134_A0.8640.37
18_K69_K0.8620.36
455_D458_E0.8610.36
5_I9_A0.8590.36
135_L169_K0.8590.36
307_K333_K0.8550.36
4_A149_L0.8520.36
90_K267_L0.8520.36
93_D206_A0.8510.36
66_I409_A0.8490.36
275_K280_L0.8480.36
219_F260_P0.8470.36
171_F243_K0.8460.35
210_D304_K0.8460.35
386_T391_L0.8400.35
287_N296_G0.8390.35
171_F219_F0.8350.35
119_Y366_L0.8340.35
448_K466_K0.8330.35
191_P280_L0.8330.35
104_K422_D0.8330.35
188_D252_N0.8320.35
14_S182_S0.8310.35
252_N274_E0.8310.35
438_G445_A0.8310.35
258_Y382_V0.8310.35
285_G288_N0.8310.35
151_E227_K0.8300.35
176_K341_L0.8300.35
329_Y473_L0.8300.35
115_D154_K0.8260.34
443_E453_L0.8240.34
311_A384_Y0.8240.34
455_D461_G0.8230.34
269_M348_L0.8200.34
454_F468_E0.8140.34
443_E471_L0.8120.33
249_G272_N0.8090.33
307_K331_E0.8080.33
458_E461_G0.8080.33
240_L252_N0.8070.33
180_D209_K0.8060.33
5_I73_Y0.8050.33
188_D387_N0.8050.33
12_V141_T0.8050.33
100_K103_A0.8040.33
157_F270_N0.8000.33
15_I426_L0.7990.33
5_I159_Q0.7990.33
16_N90_K0.7970.33
128_V137_V0.7970.33
444_A448_K0.7950.32
58_L165_I0.7920.32
411_K418_Y0.7900.32
217_L224_I0.7900.32
211_N263_N0.7890.32
259_I368_S0.7860.32
220_E423_L0.7850.32
15_I20_L0.7850.32
456_Y461_G0.7830.32
277_Y281_K0.7820.32
99_L137_V0.7800.32
461_G465_Y0.7800.32
240_L280_L0.7780.31
12_V16_N0.7770.31
361_K364_Y0.7770.31
416_P426_L0.7760.31
183_F447_A0.7760.31
100_K133_K0.7750.31
52_E55_K0.7740.31
307_K427_L0.7720.31
4_A19_S0.7710.31
35_F42_L0.7710.31
386_T421_L0.7700.31
57_I471_L0.7680.31
41_E45_G0.7670.31
324_P329_Y0.7630.31
242_K245_A0.7580.30
87_A414_G0.7580.30
447_A469_F0.7570.30
174_L182_S0.7560.30
84_G136_L0.7550.30
267_L379_K0.7510.30
138_L237_L0.7510.30
93_D212_Y0.7490.30
138_L387_N0.7460.30
277_Y300_D0.7460.30
161_E415_K0.7450.30
264_L378_V0.7450.30
73_Y172_K0.7450.30
96_E138_L0.7440.29
243_K272_N0.7430.29
93_D158_K0.7420.29
423_L427_L0.7420.29
157_F302_I0.7410.29
239_K263_N0.7390.29
167_S256_L0.7390.29
15_I22_E0.7390.29
52_E56_K0.7360.29
148_E182_S0.7340.29
165_I229_K0.7340.29
272_N388_D0.7330.29
20_L220_E0.7320.29
463_G471_L0.7310.29
42_L99_L0.7290.29
112_K419_F0.7280.29
68_L380_D0.7280.29
438_G468_E0.7270.29
259_I421_L0.7240.28
259_I311_A0.7210.28
167_S275_K0.7190.28
388_D396_L0.7180.28
130_W395_I0.7160.28
57_I64_S0.7160.28
148_E196_S0.7160.28
66_I294_N0.7150.28
173_K176_K0.7140.28
462_D465_Y0.7130.28
231_Y383_L0.7130.28
148_E151_E0.7130.28
229_K333_K0.7130.28
7_K99_L0.7120.28
424_D474_K0.7090.28
53_L281_K0.7080.27
300_D386_T0.7080.27
286_F300_D0.7070.27
66_I89_V0.7070.27
335_K339_K0.7060.27
253_G270_N0.7060.27
260_P380_D0.7050.27
94_K290_L0.7050.27
458_E472_N0.7050.27
13_V190_L0.7050.27
254_D257_K0.7040.27
29_I34_L0.7030.27
350_L353_G0.7020.27
35_F309_D0.7010.27
264_L327_L0.7010.27
463_G480_S0.7000.27
171_F317_F0.6990.27
250_K270_N0.6980.27
28_D33_E0.6970.27
40_E43_K0.6960.27
127_L404_K0.6950.27
40_E376_F0.6940.27
232_S238_K0.6930.27
71_P95_F0.6920.27
281_K284_P0.6900.27
235_K245_A0.6890.26
12_V18_K0.6870.26
444_A456_Y0.6870.26
18_K59_K0.6850.26
74_L276_L0.6850.26
456_Y459_I0.6850.26
280_L378_V0.6840.26
116_G221_K0.6840.26
198_M203_P0.6820.26
68_L186_S0.6820.26
243_K282_E0.6820.26
158_K452_K0.6820.26
289_L341_L0.6810.26
451_L457_L0.6790.26
297_I305_A0.6770.26
81_N454_F0.6750.26
85_L105_E0.6740.26
21_A177_E0.6740.26
158_K284_P0.6700.25
286_F293_A0.6700.25
11_F135_L0.6690.25
447_A459_I0.6690.25
91_D314_L0.6680.25
235_K238_K0.6680.25
436_L440_G0.6670.25
160_K335_K0.6670.25
36_K162_E0.6660.25
171_F256_L0.6660.25
162_E272_N0.6650.25
91_D176_K0.6640.25
377_G392_A0.6630.25
18_K22_E0.6620.25
93_D426_L0.6610.25
86_V117_Y0.6600.25
149_L441_G0.6600.25
253_G384_Y0.6590.25
270_N302_I0.6590.25
129_A214_A0.6590.25
5_I23_K0.6580.25
447_A453_L0.6580.25
89_V125_G0.6570.25
89_V224_I0.6560.25
288_N291_E0.6540.25
58_L131_N0.6520.25
313_A316_D0.6510.25
96_E162_E0.6500.24
287_N291_E0.6470.24
16_N225_V0.6460.24
34_L41_E0.6460.24
283_N287_N0.6450.24
280_L433_K0.6450.24
267_L299_L0.6440.24
397_K404_K0.6430.24
59_K118_S0.6420.24
66_I135_L0.6420.24
416_P420_Y0.6420.24
91_D221_K0.6400.24
160_K422_D0.6400.24
390_E398_G0.6390.24
155_K159_Q0.6370.24
72_I95_F0.6370.24
87_A168_N0.6370.24
130_W180_D0.6360.24
18_K162_E0.6360.24
57_I137_V0.6360.24
393_K423_L0.6330.24
93_D412_I0.6330.24
85_L267_L0.6310.24
436_L457_L0.6310.24
282_E285_G0.6300.23
138_L380_D0.6300.23
92_A252_N0.6290.23
414_G426_L0.6290.23
410_S413_K0.6290.23
11_F250_K0.6280.23
280_L449_N0.6280.23
221_K469_F0.6280.23
55_K59_K0.6280.23
179_G213_I0.6270.23
275_K471_L0.6260.23
324_P330_A0.6250.23
97_A215_A0.6240.23
267_L387_N0.6240.23
375_Y380_D0.6210.23
66_I445_A0.6210.23
191_P480_S0.6200.23
22_E84_G0.6180.23
74_L196_S0.6180.23
72_I132_D0.6170.23
135_L377_G0.6160.23
460_Y463_G0.6160.23
6_P75_F0.6150.23
26_L29_I0.6150.23
158_K181_I0.6150.23
35_F39_K0.6130.23
379_K402_S0.6120.23
121_V242_K0.6120.23
123_G375_Y0.6120.23
310_I374_I0.6120.23
101_K149_L0.6110.23
27_N473_L0.6100.23
162_E214_A0.6080.22
24_A128_V0.6070.22
132_D236_E0.6060.22
128_V403_L0.6060.22
75_F210_D0.6050.22
277_Y331_E0.6030.22
273_G377_G0.6030.22
83_I139_G0.6030.22
155_K195_K0.6000.22
298_D306_F0.6000.22
165_I185_A0.5990.22
26_L35_F0.5980.22
89_V99_L0.5980.22
85_L462_D0.5960.22
327_L334_D0.5960.22
281_K300_D0.5950.22
341_L364_Y0.5930.22
163_E173_K0.5920.22
258_Y422_D0.5920.22
171_F225_V0.5910.22
16_N94_K0.5900.22
131_N330_A0.5900.22
91_D411_K0.5900.22
153_A172_K0.5890.22
5_I8_D0.5890.22
21_A25_G0.5890.22
454_F471_L0.5890.22
218_N246_K0.5880.21
276_L303_L0.5880.21
158_K359_K0.5860.21
40_E68_L0.5860.21
221_K274_E0.5850.21
73_Y175_L0.5840.21
460_Y472_N0.5830.21
123_G269_M0.5830.21
99_L380_D0.5820.21
309_D425_A0.5820.21
41_E85_L0.5820.21
394_A398_G0.5810.21
199_M204_K0.5800.21
169_K251_I0.5790.21
17_L25_G0.5790.21
74_L386_T0.5790.21
10_A379_K0.5780.21
209_K227_K0.5780.21
48_A51_K0.5780.21
94_K373_S0.5770.21
100_K218_N0.5760.21
89_V184_W0.5760.21
22_E27_N0.5750.21
110_E443_E0.5750.21
263_N266_L0.5730.21
90_K94_K0.5730.21
74_L313_A0.5730.21
370_G383_L0.5710.21
451_L468_E0.5710.21
42_L47_D0.5710.21
120_T299_L0.5700.21
142_G145_D0.5700.21
243_K246_K0.5690.21
54_L57_I0.5650.20
6_P20_L0.5650.20
16_N32_S0.5640.20
234_N362_N0.5630.20
99_L133_K0.5620.20
253_G413_K0.5610.20
473_L479_N0.5610.20
148_E380_D0.5600.20
6_P16_N0.5590.20
219_F223_K0.5590.20
100_K194_Y0.5580.20
85_L137_V0.5560.20
3_N53_L0.5560.20
307_K361_K0.5560.20
99_L103_A0.5550.20
297_I300_D0.5550.20
66_I98_F0.5540.20
303_L477_K0.5540.20
170_D231_Y0.5530.20
162_E185_A0.5530.20
55_K386_T0.5500.20
15_I375_Y0.5500.20
68_L167_S0.5480.20
173_K255_L0.5480.20
88_K270_N0.5470.20
16_N239_K0.5460.20
470_E474_K0.5450.20
477_K481_L0.5440.20
61_P408_F0.5440.20
445_A449_N0.5430.20
460_Y466_K0.5430.20
70_S137_V0.5430.20
450_L455_D0.5430.20
232_S332_V0.5420.19
115_D333_K0.5420.19
408_F432_V0.5410.19
12_V23_K0.5400.19
98_F117_Y0.5390.19
256_L313_A0.5390.19
463_G475_D0.5390.19
222_G479_N0.5360.19
449_N455_D0.5340.19
340_K347_K0.5340.19
20_L156_L0.5310.19
362_N394_A0.5310.19
183_F380_D0.5290.19
26_L32_S0.5280.19
155_K469_F0.5280.19
146_T463_G0.5270.19
379_K382_V0.5260.19
16_N92_A0.5250.19
173_K186_S0.5220.19
184_W392_A0.5210.19
57_I71_P0.5210.19
422_D443_E0.5190.19
17_L475_D0.5180.18
227_K409_A0.5180.18
302_I408_F0.5180.18
166_A423_L0.5180.18
20_L201_G0.5170.18
477_K480_S0.5170.18
449_N452_K0.5150.18
291_E341_L0.5130.18
386_T467_S0.5120.18
219_F222_G0.5120.18
92_A324_P0.5120.18
16_N375_Y0.5090.18
211_N214_A0.5090.18
449_N474_K0.5080.18
180_D481_L0.5080.18
52_E61_P0.5080.18
273_G298_D0.5070.18
284_P290_L0.5060.18
70_S146_T0.5050.18
270_N427_L0.5050.18
180_D184_W0.5040.18
145_D150_K0.5040.18
272_N392_A0.5040.18
157_F166_A0.5030.18
97_A101_K0.5020.18
277_Y386_T0.5010.18
364_Y368_S0.5010.18
260_P423_L0.5010.18
131_N418_Y0.5000.18
334_D358_K0.5000.18
99_L390_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3x1lC 3 0.1393 6.8 0.973 Contact Map
4dvcA 1 0.1913 2.8 0.978 Contact Map
3ewtE 1 0.0291 2.7 0.978 Contact Map
3l9kW 1 0.079 2.2 0.979 Contact Map
2grgA 1 0.183 2.2 0.979 Contact Map
2dkhA 2 0.2079 2.2 0.979 Contact Map
2zbkB 1 0.1019 2.1 0.979 Contact Map
1qhlA 1 0.1227 1.8 0.98 Contact Map
4od7A 1 0.1892 1.8 0.98 Contact Map
3kzqA 3 0.1975 1.7 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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